Modern Trends in Human Leukemia III: Newest Results in Clinical and Biological Research

577 Pages·1979·14.934 MB·English

by  W. C. Moloney (auth.), Dr. Rolf Neth, Dr. Robert C. Gallo, Dr. Peter-Hans Hofschneider, Dr. Klaus Mannweiler (eds.)

Haematology and Blood Transfusion
23 --------------
Hamatologie und Bluttransfusion
Edited by
H. Heimpel, U1m . D. Huhn, Munchen
G. Ruhenstroth-Bauer, Munchen
Modem Trends in
Human Leukemia ill
Newest Results
in Clinical and Biological Research
9th Scientific Meeting of "Gesellschaft Deutscher Naturforscher
und Arzte" Together with the "Deutsche Gesellschaft fUr Hiima
tologie" Wilsede, June 19-23, 1978
Edited by
R Neth, RC. Gallo, P.-H. Hofschneider
and K. Mannweiler
With 171 figures and 128 tables
Springer-Verlag Berlin Heidelberg New York 1979
Dr. Rolf Neth, Universitats-Kinderklinik, Molekularbiologisch
hamatologische Arbeitsgruppe, MartinistraBe 52, 0-2000
Hamburg 20, Federal Republic of Germany
Dr. Robert C. Gallo, National Cancer Institute, Laboratory of
Tumor Cell Biology, Bethesda, Maryland 20014, USA
Dr. Peter-Hans Hofschneider, Max-Planck-Institut fUr Bio
chemie, 0-8033 Martinsried bei Munchen, Federal Republic
of Germany
Dr. Klaus Mannweiler, Heinrich-Pette-Institut fUr Experi
mentelle Virologie und Immunologie an der Universitat
Hamburg, MartinistraBe 52, 0-2000 Hamburg 20, Federal Re
public of Germany
Supplement to
BLUT - Journal for Blood Research
Organ of the"Deutsche Gesellschaft fUr Hamatologie und Onkologie der
Deutschen Gesellschaft fUr Bluttransfusion und Immunohamatologie" and of
the "Osterreichischen Gesellschaft fUr Hamatologie und Onkologie"
ISBN-13: 978-3-540-08999-5 e-ISBN-13: 978-3-642-67057-2
DOl: 10.1007/978-3-642-67057-2
Library of Congress Cataloging in Publication Data. Main entry under title:
Modem trends in human leukemia III. (Haematology and blood transfusion:
23) »Supplement to Blu!.« Includes bibliographies and index. I. Leukemia
Congresses. I. Neth. Rolf. II. Hofschneider. Peter-Hans. 19?9. III. Mannweiler,
Klaus. IV. Gesellschaft Deutscher Naturforscher und Arzte. V. Deutsche
Hamatologische Gesellschaft. VI. Blu!. VII. Series: Hamatologie und Blut
transfusion: Bd. 23. RC643.M6 616.1'55 79-11442
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© Springer-Verlag Berlin Heidelberg 1979
The use of registered names, trademarks etc. in this publication does not imply
even in the absence of a specific statement, that such names are exempt from
the relevant protective laws and regulations and therefore free for general use.
Scientific Organisation of the Sessions
Clinical Aspects
Henderson, Edward S., Roswell Park Memorial Institute,
Medicine A, 666 Elm Street, Buffalo, New York 14263, USA
Cell Biology
Moore, Malcolm A S., Memorial Sloan-Kettering Cancer
Center, 1275 York Avenue, New York, New York 10021, USA
Molecular Biology
Hardesty, Boyd A, Department of Chemistry, Clayton Foun
dation Biochemical Institute, Austin, Texas 78712, USA
Immunology
Mitchison, Nicholas A, Department of Zoology, Tumour
Imm unology Unit, Gower Street, London WC 1 E6 BT, Great
Britain
Virology
Gallo, Robert c., National Cancer Institute, Laboratory of
Tumor Cell Biology, Bethesda, Maryland 20014, USA
Exchange of Genetic Material
Hofschneider, Peter-Hans, Max-Planck-Institut fUr Bioche
mie, D-8033 Martinsried bei Munchen, Federal Republic of
Germany
Contents
Participants of the Meeting . XIII
Wilsede Scholarship Holders XVII
Preface ............ . XIX
Acknowledgement ..... . . XXII
Frederick Stohlman Jr. Memorial Lecture
Moloney, W. c.: Memorial Tribute to Dr. Frederick
Stohlman, Jr. . . . . . . . . . . . . . . . . . . . . . . .. 3
Gallo, R c.: Cellular and Virological Studies Directed
to the Pathogenesisofthe Human MyelogenousLeukemias 7
Pinkel, D.: Treatment of Childhood Acute Lymphocytic
Leukemia . . . . . . . . . . . . . . . . . . . . . . . . .. 25
Clinical Aspects
Miller, R W.: Epidemiology of Leukemia 37
Rowley, J. D.: Chromosome Abnormalities in Leukemia 43
Fialkow, P.J.: Use of Glucose-6-Phosphate Dehydro
genase Markers to Study Human Myeloproliferative Di-
sorders .......................... . 53
Georgii, A: Histopathology of Bone Marrow in Human
Chronic Leukemias. . . . . . . . . . . . . . . . . 59
Gale, R P.: Bone Marrow Transplantation in Acute
Leukemia: Current Status and Future Directions 71
Bekesi, J. G., Holland, J. F.: Impact of Specific Immuno-
therapy in Acute Myelocytic Leukemia ........ . 79
McCredie, K. B., Keating, M. J., Dicke, K. A, Bodey,
G. P., Smith, T., Freireich, E.J.: Treatment of Adult Acute
Myeloblastic Leukemia ................. . 89
Preisler, H.D., Rustum, Y.M.: Prediction of Therapeutic
Response in Acute Myelocytic Leukemia ....... . 93
Lister, T. A, Roberts, M. M., Brearley, R L., Cullen,
M. H., Greaves, M. F.: Prognostic Factors in Adult Acute
Lymphoblastic Leukemia ................ . 99
VIII Contents
Catovsky, D., Costello, Ch., O'Brien, M., Cherchi, M.:
Ultrastructure and Cell Marker Studies in Lymphoproli
ferative Disorders. . . . . . . . . . . . . . . . . . . . .. 107
Freeman, A I., Brecher, M. L., Wang, J. J., Sinks, L. F.:
Intermediate Dose Methotrexate (10M) in Childhood
Acute Lymphocytic Leukemia (ALL) .......... 115
Wiemik, P. H., Edwards, L. S., Sarin, P. S.: Marrow Ter
minal Deoxynucleotidyl Transferase Activity in Adult
Acute Leukemia .. . . . . . . . . . . . . . . . . . . .. 125
Mertelsmann, R, Koziner, B., Filippa, D. A, Grossbard,
E., Incefy, G., Moore, M.A S., Clarkson, B. D.: Clinical
Significance ofTdT, Cell Surface Markers and CFU-C in
297 Patients with Hematopoietic Neoplasias ...... 131
Smyth, J. F.: Biochemical Determinants for Antileu-
kemia Drug Treatment .................. 139
Chandra, P., Komhuber, B., Ebener, 0.: Biological and
Clinical Effects of a Partially Thiolated Polycytidylic
Acid (MPC): A Potent Inhibitor of DNA Synthesis in RNA
Tumor Viruses ....................... 145
Wiemik, P. H.: Summary of Clinical Poster Sessions 157
Henderson, E. S.: Progress in Acute Leukemia 1975-1978 163
Cell Biology
Moore, M. AS.: Regulatory Interactions in Normal and
Leukemic Myelopoieses . . . . . . . . . . . . . . . . .. 171
Quesenberry, P. J., Zuckerman, K, Coppola, M., Foun
tebuoni, A, Sullivan, R, Rappeport, J. M., Levitt, L.:
Leukemic Inhibition of Normal Hematopoiesis 181
Boggs, D. R: Clonal Diseases of the Myeloid Stem Cell
Systems . . . . . . . . . . . . . . . . . . . . . . . . . .. 191
Greenberg, P., Mara, B. S.: Intramedullary Influences on
in Vitro Granulopoiesis in Human Acute Myeloid leu
kemia . . . . . . . . . . . . . . . . . . . . . . . . . . .. 199
Adamson, J. W.: Analysis of Myeloproliferative Dis-
orders Using Cell Markers in Culture ......... 205
Biermann, E., Neth, R, Grosch-Womer, I., Hausmann,
K, Heinisch, B., Hellwege, H. H., Kotke, A, Skrandies,
G., Winkler, K: Morphologic Characteristics of Human
Blood Cells in Semi-Solid Marrow Cultures ...... 211
Hoelzer, D., Harriss, E. B., Kurrle, E., Schmucker, H.,
Hellriegel, K P.: Differentiation Ability of Peripheral
Blood Cells from Patients with Acute Leukemia or Blast
Crisis in Chronic Myelocytic Leukemia ......... 217
Contents IX
Dexter, T. M., Teich, N. M.: Modification of the Prolife
rative and Differentiation Capacity of Stem Cells Fol
lowing Treatment with Chemical and Viral Leukemo-
gens . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 223
Testa, N. G., Dexter, T. M., Teich, N. M.: Characteriza
tion of Myelomonocytic Leukemia Cells Induced by in
Vitro Infection of Bone Marrow with FL V . . . . .. 231
Yefenof, E.: Epstein Barr Virus (EBV) and Complement
(C3) Interactions With Human Lymphoid Cells 237
Molecular Biology
Duesberg, P., Mellon, P., Pawson, A, Bister, K., Vogt,
P.K.: Anatomy of the RNA and Gene Products of MC29
and MH2, two Defective Avian Tumor Viruses Causing
Acute Leukemia and Carcinoma: Evidence for a new
Class of Transforming Genes . . . . . . . . . . . . . .. 241
Erikson, R. L., Brugge, l S., Erikson, E., Collett, M. S.:
Studies on the Structure and Function of the Avian Sar-
coma Virus Transforming Gene Product ........ 261
Von der Helm, K., Wille, W., Rungger, D., Willecke, K.:
The in Vitro Translation of Rous Sarcoma Virus RNA
and Function of the Viral Protein During the Viral Re-
plication .......................... 271
Carrasco, L., Harvey, R., Blanchard, c., Smith, A E.:
Regulation of Translation of Eukaryotic Virus mRNAs 277
Kramer, G., Pinphanichakarn, P., Hardesty, B.: Control of
Eukaryotic Protein Synthesis by Phosphorylation 283
Kerr, I. A, Williams, B. R. G., Hovanessian, A G.,
Brown, R. E., Martin, E. M., Gilbert, C. S., Birdsall,
N. J. M.: Cell-free Protein Synthesis and Interferon Ac-
tion: Protein Kinase(s) and an Oligonucleotide Effector,
pppA2'pS'A2'p5'A . . . . . . . . . . . . . . . . . . . .. 291
Koch, G., Weber, c., Bilello, l: Alterations in Transla
tional Control Mechanisms in Friend Erythroleukemic
Cells During DMSO Induced Differentiation ..... 295
Bilello, lA, Warnecke, G., Koch, G.: Inhibition of Poly
peptide Chain Initiation by Inducers of Erythroid Dif-
ferentiation in Friend Erythroleukemic Cells ..... 303
Dolei, A, Capobianchi, M. R., Cioe, L., Colletta, G., Vec-
chio, G., Rossi, G. B., Affabris, E., Belardelli, F.: Possible
Role of the Friend Virus Life Cycle in Differentiating
Friend Leukemia Cells Treated with Interferon 307
x
Contents
Jones, c.: Genetic Analysis of Human Cell Surface
Structures . . . . . . . . . . . . . . . . . . . . . . . . .. 3 13
Wilson, E. L., Reich, E.: Effect of Vitamin A on Plasmi
nogen Activator Synthesis by Chick Em bryo Fibroblasts 319
Hardesty, B.: The Molecular Biology of Differentiation
and Transformation: An Emerging Field Theory? 325
Immunology
Greaves, M. F.: Leukemic Cell Phenotypes in Man: Re
lationship to "Target" Cells for Leukemogenesis and
Differentiation Linked Gene Expression ........ 335
Rodt, H., Netzel, B., Thiel, E., Hoffmann-Fezer, G.,
Thierfelder, S.: Characterization of Antigens on Acute
Lymphoblastic Leukemias . . . . . . . . . . . . . . . .. 347
Kabisch, H., Arndt, R, Becker, W. M., Thiele, H.-G.,
Landbeck, G., Winkler, K., Grossner, G.: Common All
Associated Antigen from Cell Surface and Serum: Mo-
lecular Properties and Clinical Relevance ....... 353
Brown, G., Joshua, D.E., Bastin, J., Mason, D.Y., Barn
stable, c.J.: Monoclonal Antibodies to Human Cell Sur-
face Antigens . . . . . . . . . . . . . . . . . . . . . . .. 365
Bach, F. H., Sondel, P. M., Zarling, J. M.: Elicitation of
Anti-Leukemia Cytotoxic Responses . . . . . . . . . .. 369
Oliver, R T. D., Lee, S. K.: Histocompatibility Antigens
and T Cell Responses to Leukemia Antigens ..... 377
Knight, RA., Ganguly, A., Morgan, D.A., Souhami,
R L., Gallo, R c.: T Cell Function in Myelogenous Leu-
kemia . . . . . . . . . . . . . . . . . . . . . . . . . . .. 381
Kurth, R, Gelderblom, H., Huesgen, A., Katz, F., Seiler,
F., Steward, M. W., Vettermann, W.: Recognition of Si-
mian Sarcoma Virus Antigen by Human Sera 385
Snyder, H. W., Jr., Fox, M., Pincus, T., Aeissner, E.: Stu-
dies of Human Serological Reactivity with Type C Virus
and Viral Poteins . . . . . . . . . . . . . . . . . . . . .. 395
Hogg, N., Hope, J., Teich, N., Wallace, D.: A Search for
Type-C Virus Expression in Man ............ 401
Keisari, Y., Witz, J. P.: Tumor Cell Mediated Degrada-
tion in Vitro of Antitumor Antibodies ......... 407
DeLamarter, J. F., Stoye, J., Schumann, G., Moroni, c.:
Evidence Supporting a Physiological Role for Endogen-
ous C-Type Virus in the Immune System 413
Witz, J.P.: Immunological Aspects . . . . . . . . . . .. 417
Contents XI
Virology
Weiss, R A.: Introduction to Oncogenesis by RNA Tu-
mor Viruses . . . . . . . . . . . . . . . . . . . . . . . .. 423
Graf, T., Kirchbach, A. v., Beug, H.: Mechanism of Leu
kemogenesis and of Target Cell Specificity by Defective
Avian Leukemia Viruses: A Hypothesis ........ 429
Jarrett, 0.: Infectious Leukemias in Domestic Animals 439
Bumy, A., Bex, F., Bruck, c., Cleuter, Y., Dekegel, D.,
Ghysdael, J., Kettmann, R, Leclercq, M., Mammerickx,
M., Portetelle, D.: Biochemical and Epidemiological
Studies on Bovine Leukemia Virus (BL V) ....... 445
Essex, M., Grant, C. K., Cotter, S. M., Sliski, A. H., Har-
dy, W. D., Jr.: Leukemia Specific Antigens: FOCMA and
Immune Surveillance ................... 453
Roloson, G.1., Chambers, C. A., Haagensen, D. E., Jr.,
Montelaro, R c., Bolognesi, D. P.: A Single Genetic Lo-
cus Determines the Efficacy of Serum Therapy Against
Murine Adenocarcinoma 755a ... . . . . . . . . . .. 469
Hillova, J., Hill, M.: The Search for Infectious Viral
DNA in Human Leukemic Cells ............ 483
Teich, N., Boss, M., Dexter, T. M.: Infection of Mouse
Bone Marrow Cells with Abelson Murine Leukemia Vi-
rus and Establishment of Producer Cell Lines 487
Nooter, K., Zurcher, c., Coolen, c., Bentvelzen, P.: Co
cultivation as a Tool for the Detection of Oncoviruses in
Childhood Leukemia. . . . . . . . . . . . . . . . . . .. 491
Chandra, P., Steel, L. K., Cavdar, A. 0.: Evidence for the
Presence of an Oncomaviral Reverse Transcriptase in
an Orbital Tumor Associated to Acute Myelomonocytic
Leukemia in Children: Biochemical and Immunological
Characterization of the Enzyme ............. 497
Jensen, F. c.: Inactivation and Lysis of Oncomaviruses
by Human and Primate Complement .......... 501
Exchange of Genetic Material
Saedler, H., Ghosal, D., Nevers, P.: The Role of Gene
Rearrangement in Evolution ............... 507
Comelis, G.: Bacterial Transposons ........... 513
Zur Hausen, H.: The Virus-Cell Gene Balance. Model of
Cancerogenesis . . . . . . . . . . . . . . . . . . . . . .. 523
XII Contents
Haseltine, W. A., Pedersen,F. S., Sahagan, B. G., Rosen-
berg, Z. F., Kozlov, 1.: Comparative Analysis of RNA
Tumor Virus Genomes' . . . . . . . . . . . . . . . . .. 529
Wong-Staal, F., Josephs, S., Dalla Favera, R, Gallo, R:
Detection of Integrated Type-C Viral DNA Fragments
in Two Primates (Human and Gibbon) by the Restric-
tion Enzyme Blotting Technique . . . . . . . . . . . .. 553
Doehmer, 1., Breindl, M., Willecke, K., Jaenisch, R: Ge-
netic Transmission of Moloney Leukemia Virus: Map-
ping of the Chromosomal Integration Site ....... 561
Bacheler, L. T., Fan, H.: Integration Sites for Moloney
Murine Leukemia Virus DNA in Infected Mouse Cells 569
Bauer, G., Mattersberger, H., Soo, R, Jendis, J., Hof
schneider, P. H.: Release of Particle Associated RNA
Dependent DNA Polymerases by Primary Chicken and
Quail Embryo Cells .................... 575
Boccara, M., Kelly, F.: Pluripotent Teratocarcinoma -
Simian Virus 40 Transformed Mouse Fibroblasts Soma-
tic Cell Hybrids ...................... 581
Summary of the Meeting
Rapp, F.: Summary of Meeting on Modem Trends in
Human Leukemia III 589
Subject Index . . . . . . . . . . . . . . . . . . . . . . .. 593