Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy PDF
Preview Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy
Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy Dhyan Chandra Editor Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy 1 3 Editor Dhyan Chandra, Associate Professor Pharmacology and Therapeutics Center for Genetics and Pharmacology Roswell Park Cancer Institute Buffalo New York USA ISBN 978-1-4614-9325-9 ISBN 978-1-4614-9326-6 (eBook) DOI 10.1007/978-1-4614-9326-6 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013954159 © Springer Science+Business Media New York 2013 This work is subject to copyright. 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Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Preface The mitochondrion, an organelle within cells, has long been considered to be the powerhouse of the cell because of its central role in energy production. However, in the last two decades it has become clear that mitochondria also play a key role in cell survival and cell death. More recent findings further implicate a broader perspective on the role of mitochondria in multiple cellular signaling. Defects in mitochondria are associated with the genesis of multiple diseases, including cancer. One of the key functions of mitochondria is to induce cell death in multiple types of cells under physiological or environmental stresses. However, their cell-death– inducing function may be defective in cancer, causing survival and proliferation of cancer cells. Although one of the drawbacks of current cancer therapy is resistance to cell death as a result of defective mitochondrial pathways, these defects provide an opportunity to target tumor mitochondria selectively to induce cancer cell death. Selectively targeting tumor mitochondrial pathways may also decrease toxicity to normal tissues possessing normal functional mitochondria, and thus further enhance therapeutic efficacy. During the last decade there has been significant emphasis on preventing or cu- ring cancer with natural remedies involving the use of naturally derived phytoche- micals, which possess anticancer properties with minimal toxicity. Although further studies are warranted, significant progress has been made investigating the role of mitochondria in controlling cancer cell death and proliferation in response to phy- tochemicals. This book describes the current status of the impact of phytochemicals on cancer cell death and survival. The key role of mitochondria in cancer preven- tion and therapy is also illustrated. The book contains contributions from multiple researchers working in the areas of cancer, phytochemistry, and mitochondria. This comprehensive collection of information will be useful to a broadbased audience with a focus on cancer research, prevention, and treatment. I highly acknowledge the unwavering support and enthusiasm of all the authors and am grateful for their contributions of the chapters in the area of their expertise. I also owe a debt of gratitude to numerous researchers who reviewed the chapters and provided constructive criticism. Buffalo, New York, USA Dhyan Chandra, Associate Professor v Contents 1 OxPhos Defects and Their Role in Cancer Initiation and Progression .......................................................................................... 1 Nagendra Yadava, Ahmed Khalil and Sallie S. Schneider 2 Estrogen Receptor—Tumor Suppressor Protein p53 Signaling Crosstalk as Potential Targets of Xenoestrogens ................... 27 Gokul M. Das 3 Mitochondrial Regulation of Cell-Death ................................................. 33 Richard Jäger and Howard O. Fearnhead 4 Cell-Death—Inducing Mechanisms of Cancer Chemopreventive Agents ........................................................................... 61 Vijay Mohan, Dhanya Nambiar, Raosaheb K. Kale and Rana P. Singh 5 Dietary Phytochemicals Target Cancer Stem Cells for Cancer Chemoprevention .................................................................... 85 Dunne Fong and Marion M. Chan 6 Basic and Translational Research on Dietary Phytochemicals and Cancer Prevention .................................................. 127 Ashraful Hoque and Xiao-Chun Xu 7 Mitochondrial Reactive Oxygen Species in Proapoptotic Effect of Promising Cancer Chemopreventive Phytochemicals ............ 157 Anuradha Sehrawat and Shivendra V. Singh 8 T herapeutic Action of Phytochemicals on Cancer Stem Cells ............... 171 O. Leis, J. Gumuzio and Angel G. Martin vii viii Contents 9 Phytochemicals, microRNAs, and Cancer: Implications for Cancer Prevention and Therapy......................................................... 187 Sanjeev K. Srivastava, Sumit Arora, Seema Singh and Ajay P. Singh 10 Optical Imaging of Mitochondria for Canc er Therapy .......................... 207 Jonathan F. Lovell 11 Targeting Cellular Signaling for Cancer Prevention and Therapy by Phytochemicals ...................................................................... 219 Fang Hao, Neelu Yadav and Dhyan Chandra Index .................................................................................................................. 245 Contributors Sumit Arora Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Marion M. Chan Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA, USA Dhyan Chandra Department of Pharmacology and Therapeutics, Center for Genetics and Pharmacology Roswell Park Cancer Institute, Buffalo, New York, USA Gokul M. Das Department of Pharmacology and Therapeutics, Center for Genetics and Pharmacology, Roswell Park Cancer Institute, Buffalo, NY, USA Howard O. Fearnhead Pharmacology and Therapeutics, NUI Galway, Galway, Ireland Dunne Fong Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA J. Gumuzio Regulation of Cell Growth Laboratory, Fundacion Inbiomed, San Sebastian, Spain Fang Hao Department of Pharmacology and Therapeutics, Center for Genetics and Pharmacology Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, USA Ashraful Hoque Department of Clinical Cancer Prevention, Unit 1360, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Richard Jäger University of Applied Sciences Bonn-Rhein-Sieg, Rheinbach, Germany Raosaheb K. Kale School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India ix x Contributors Ahmed Khalil Pioneer Valley Life Sciences Institute, Springfield, MA, USA Department of Biology, University of Massachusetts, Amherst, MA, USA O. Leis Regulation of Cell Growth Laboratory, Fundacion Inbiomed, San Sebastian, Spain Jonathan F. Lovell Department of Chemical and Biological Engineering, University at Buffalo, Buffalo, USA Department of Biomedical Engineering, University at Buffalo, Buffalo, USA Angel G. Martin Fundación Inbiomed, San Sebastian, Gipuzkoa, Spain Vijay Mohan School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India Dhanya Nambiar Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India Anuradha Sehrawat Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Seema Singh Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Ajay P. Singh Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, USA Rana P. Singh School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India School of Life Sciences, Jawaharlal Nehru University, New Delhi, India Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India Shivendra V. Singh Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Sallie S. Schneider Pioneer Valley Life Sciences Institute, Springfield, MA, USA Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA Sanjeev K. Srivastava Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA Neelu Yadav Department of Pharmacology and Therapeutics, Center for Genetics and Pharmacology Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, USA Contributors xi Nagendra Yadava Pioneer Valley Life Sciences Institute, Springfield, MA, USA Division of Endocrinology, Diabetes and Metabolism, Baystate Medical Center of Tufts University School of Medicine, Springfield, MA, USA Department of Biology, University of Massachusetts, Amherst, MA, USA Xiao-Chun Xu Department of Clinical Cancer Prevention, Unit 1360, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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