Mitochondria and Cancer PDF
Preview Mitochondria and Cancer
Mitochondria and Cancer Keshav K. Singh Leslie C. Costello l Editors Mitochondria and Cancer Editors KeshavK.Singh LesileC.Costello DepartmentofCancerGenetics DivisionofOncology/DentalSchool,and RoswellParkCancerInstitute TheGreenebaunCancerCenter BLSCBuilding,Room#3-316 UniversityofMaryland ElmandCarltonStreets 650WestBaltimoreStreet Buffalo,NY14263,USA Baltimore,MD21201,USA [email protected] [email protected] ISBN978-0-387-84834-1 e-ISBN978-0-387-84835-8 DOI:10.1007/978-0-387-84835-8 LibraryofCongressControlNumber:2008940646 #SpringerScience+BusinessMedia,LLC2009 Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewritten permissionofthepublisher(SpringerScience+BusinessMedia,LLC,233SpringStreet,NewYork, NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Usein connectionwithanyformofinformationstorageandretrieval,electronicadaptation,computersoftware, orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden. Theuseinthispublicationoftradenames,trademarks,servicemarksandsimilarterms,eveniftheyare notidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubject toproprietaryrights. Coverillustration:courtesyofDr.XuejunSun,Ph.D. Printedonacid-freepaper. 987654321 springer.com Preface We are entering into an era of re-awakening of the importance and interest in the role of altered intermediary metabolism in the development and progression of malignancy.Therefore,thisbookMitochondriaandCanceristimelyandrelevant tocontemporaryandfutureresearch,training,andeducation.Thehallmarkstudies ofOttoWarburgetal.(1926)sparkedtheeraoftumorcellmetabolism.Fromthen until around 1980, studies of intermediary metabolism of normal and malignant cells were major areas of research and of graduate and postgraduate training in biomedical sciences. This period was dominated by mitochondrial studies and by thoseextraordinaryoutstandingscientistswhowereaffectionatelyreferredtoasthe “mitochondriacs”.However,the advent, development,and subsequent dominance of molecular genetics/molecular biology and molecular technology in biomedical researchwereaccompaniedbythenearlycompletesubmersionofinterestinareas ofintermediarymetabolismandtumorcellmetabolism.Forthepast30orsoyears, graduateandpostgraduatetraining,experienceandfocusinbiochemistry,metabo- lism, enzymology, cell physiology have declined, being displaced by the domi- nanceofmoleculartechnologies.Therecentrevelationsandadvancesinmolecular genetics/molecularbiologyandthedevelopmentofmolecularandnanotechnology providenewdimensionstoapplytotheunderstandingandelucidationoftheroleof intermediarymetabolism andmitochondrialfunctioninthedevelopmentand pro- gression of cancers. To address the issues of tumor metabolism, the present and future generations of researchers must integrate the knowledge and methods of biochemistrywiththeknowledgeandtechnologyofmolecularbiology. The focus on mitochondria is central to discussions and issues of intermediary metabolism. The genetic transformation of normal functional cells to neoplastic cellsimposestheneedforalterationsinintermediarymetabolismandmitochondri- al function to provide the bioenergetic/synthetic/growth requirements for the pro- gression of the neoplastic cell to malignancy. In the absence of the metabolic transformation,theneoplasticmalignantcellwillnotachieveitsmalignantpoten- tial. Thus, it is critical to establish the role of the mitochondria in the malignant process.Moreover,specificalterationsindifferentcancertypesmustbeidentified. Such information will provide new approaches to the treatment and perhaps prevention of differing cancers. The advent of Metabolomics for the detection of v vi Preface cancer and progression of malignancy is dependent upon the elucidation and identificationofalteredmetabolismandmitochondrialfunction.Thus,thisexciting journey incancerresearchhas barelybegunandhasalongwaytogo.Thisbook, Mitochondria and Cancer, and its subject matter provide a roadmap and the preparationtoproceedonthisjourney. Wearegreatlyindebtedtothecontributingauthorsfortheirenthusiasticsupport andwritingachapterintheirareaofexpertise.WearegratefultoMs.DonnaOvak for secretarial help and our families for their patience and support in putting together this book. This book is dedicated to past, present, and future “mitochon- driacs”aroundtheworld. Buffalo,NY KeshavK.Singh Baltimore,MD LeslieC.Costello Contents MitochondriaandCancer ....................................................... 1 KjerstinM.Owens,J.S.Modica-Napolitano,andKeshavK.Singh WarburgandhisLegacy ....................................................... 23 MichaelRistowandTimJ.Schulz TheLipogenicSwitchinCancer ............................................... 39 KoenBrusselmansandJohannesV.Swinnen CitrateMetabolisminProstateandOtherCancers ......................... 61 RentyB.FranklinandLeslieC.Costello IntegrationofGenetic,Proteomic,andMetabolicApproachesin TumorCellMetabolism ........................................................ 79 LeslieC.CostelloandRentyB.Franklin MitochondrialRespirationandDifferentiation .............................. 93 RobertoScatena,PatriziaBottoni,andBrunoGiardina IntegrationofEnergyMetabolismandControlofApoptosis inTumorCells ................................................................ 103 JohnG.PastorinoandJanB.Hoek EnergyGeneratingPathwaysandtheTumorSuppressorp53 ........... 131 ChadA.Corcoran,YingHuang,andM.SaeedSheikh MitochondrialTumorSuppressors .......................................... 151 BoraE.Baysal MitochondriainHematology ................................................ 163 StefanieZanssen vii viii Contents MitochondriaandOncocytomas ............................................. 193 J.Lima,V.Ma´ximo,P.Soares,R.Portugal,S.Guimara˜es, andM.Sobrinho-Simo˜es MitochondriaasTargetsforCancerTherapy .............................. 211 StephenJ.RalphandJiriNeuzil ReversingtheWarburgEffect:MetabolicModulationasa NovelCancerTherapy ........................................................ 251 GopinathSutendraandEvangelosD.Michelakis MitochondrialNanotechnologyforCancerTherapy ...................... 265 VolkmarWeissig,GerardG.M.D’Souza,Shing-MingCheng, andSarathiBoddapati Index ........................................................................... 281 Contributors BoraE.Baysal Department of Pathology, Yale University School of Medicine, 310 Cedar Street, NewHaven,CT06520-8023,USA,[email protected] SarathiBoddapati Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA PatriziaBottoni Dipartimento di Medicina di Laboratorio, Universita` Cattolica del Sacro Cuore, LargoA.Gemelli8,00168Rome,Italy KoenBrusselmans LaboratoryforExperimentalMedicineandEndocrinology,KatholiekeUniversiteit Leuven,Leuven,Belgium Shing-MingCheng Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA ChadA.Corcoran Department of Pharmacology, State University of New York, Upstate Medical University,Syracuse,NY13210,USA LeslieC.Costello DepartmentofBiomedicalSciences,UniversityofMaryland,650WestBaltimore Street,Baltimore,MD21201,USA,[email protected] GerardG.M.D’Souza Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA RentyB.Franklin DepartmentofBiomedicalSciences,UniversityofMaryland,650WestBaltimore Street,Baltimore,MD21201,USA,[email protected] ix x Contributors BrunoGiardina Dipartimento di Medicina di Laboratorio, Universita` Cattolica del Sacro Cuore, LargoA.Gemelli8,00168Rome,Italy S.Guimara˜es DepartmentofPathology,HospitalS.Joa˜o,Porto,Portugal JanB.Hoek DepartmentofPathology,AnatomyandCellBiology,ThomasJeffersonUniversity, 1020LocustStreet,269JAH,Philadelphia,PA19107,USA,[email protected] YingHuang Department of Pharmacology, State University of New York, Upstate Medical University,Syracuse,NY13210,USA J.Lima Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP),Porto,Portugal V.Ma´ximo Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP),Porto,Portugal and DepartmentofPathology,MedicalFacultyofUniversityofPorto,Porto,Portugal EvangelosD.Michelakis Department of Medicine, University of Alberta, Edmonton, AB, Canada, [email protected] J.S.Modica-Napolitano DepartmentofBiology,MerrimackCollege,315TurnpikeStreet,NorthAndover, MA01845,USA JiriNeuzil Apoptosis Research Group, School of Medical Science, Griffith University, Southport,QLD,Australia and Molecular Therapy Group, Institute of Molecular Genetics, Academy of Sciences oftheCzechRepublic,Prague,CzechRepublic KjerstinM.Owens Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets,Buffalo,NY14263,USA Contributors xi JohnG.Pastorino Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, 2 Medical Center Drive, Science Center, Room 316, Stratford, NJ 08084, USA,[email protected] R.Portugal DepartmentofPathology,HospitalS.Joa˜o,Porto,Portugal StephenJ.Ralph Genomic Research Centre, School of Medical Science, Griffith University, Southport,QLD,Australia,s.ralph@griffith.edu.au MichaelRistow Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena,Germany,[email protected] RobertoScatena Dipartimento di Medicina di Laboratorio, Universita` Cattolica del Sacro Cuore, LargoA.Gemelli8,00168Rome,Italy,[email protected] TimJ.Schulz Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena,Germany M.SaeedSheikh Department of Pharmacology, State University of New York, Upstate Medical University,Syracuse,NY13210,USA,[email protected] KeshavK.Singh Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets,Buffalo,NY14263,USA,[email protected] P.Soares Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP),Porto,Portugal and DepartmentofPathology,MedicalFacultyofUniversityofPorto,Porto,Portugal ManuelA.C.Sobrinho-Simo˜es Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP),Porto,Portugal,[email protected] and DepartmentofPathology,MedicalFacultyofUniversityofPorto,Porto,Portugal DepartmentofPathology,HospitalS.Joa˜o,Porto,Portugal
The list of books you might like
