mind diet to prevent alzheimer disease and cognitive decline

81 Pages·2016·12.54 MB·English

by  Martha Clare

MIND DIET TO PREVENT ALZHEIMER
DISEASE AND COGNITIVE DECLINE
Martha Clare Morris, Sc.D.
Director, Section of Nutritional Epidemiology, Dept of Medicine
Rush University Medical Center
37th Lillian Fountain Smith Nutrition Conference, May 19-20, 2016 in
Fort Collins, Colorado.
Dr. Morris has no relevant
conflicts of interest to
disclose
OVERVIEW
1. Identify nutrients and foods important
in cognitive aging
2. Describe evidence and issues for
study interpretation
3. Describe evidence on dietary patterns
including Mediterranean, DASH and
MIND
Alzheimer’s Disease Prevalence
Exponential increase
50
with age
Oldest age categories
40
are fastest growing
No cure 30
AD
Ineffective treatment
20
Limited knowledge of
preventable risk 10
factors
0
65-74 75-84 85+
Prevalence of Alzheimer’s Disease in U.S.
Hebert LE, et al. Arch Neurol 2003;60:1119-1122.
Alzheimer’s Disease
Gradual decline in memory and other
cognitive abilities
Neuropathology linked to oxidative
damage:
Aβ plaques
Neurofibrillary tangles
Neuron loss
Synapse loss
Oxidative & Inflammatory Damage
Alzheimer’s disease involves oxidative &
inflammatory damage to brain tissue
Increased oxidation of lipid membranes
Increased inflammation
Severe disruption in functioning of cell
membranes
Strand breakage and chemical
alterations to DNA
aggregation of beta-amyloid peptides
into neuritic plaques

Alzheimer’s Disease Brain Normal Brain