Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells PDF
Preview Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells
Andreas Dietzel E ditor Microsystems for Pharmatechnology Manipulation of Fluids, Particles, Droplets, and Cells Microsystems for Pharmatechnology Andreas Dietzel Editor Microsystems for Pharmatechnology Manipulation of Fluids, Particles, Droplets, and Cells Editor AndreasDietzel InstituteofMicrotechnology TechnischeUniversita¨tBraunschweig Braunschweig,Germany PVZ—CenterofPharmaceuticalEngineering TechnischeUniversita¨tBraunschweig Braunschweig,Germany ISBN978-3-319-26918-4 ISBN978-3-319-26920-7 (eBook) DOI10.1007/978-3-319-26920-7 LibraryofCongressControlNumber:2015958783 SpringerChamHeidelbergNewYorkDordrechtLondon ©SpringerInternationalPublishingSwitzerland2016 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthis book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained hereinorforanyerrorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com) Preface Astheworldbecomesincreasinglyconcernedaboutaffordablehealthcare,fastand effectivescreeningmethodsfordrugsindifferentformulationsarerequiredinthe course of their development. Moreover, a more personalized medicine demands production of drugs in very small volumes. For both, the microfluidic approach seemsideallysuited.Withminiaturizedsystemsthatcanberealizedbymicrofab- rication processes, new tools for research and development but also new products become available. New and better technologies for screening, for production by micro-reaction technology and micro-bioreactors, for small-scale processing of drug formulations, as well as for drug delivery are under development. Inter- disciplinary research involving typical engineering disciplines and life science disciplines is the key for a further development of this field. This challenge has been accepted by the Center of Pharmaceutical Engineering (PVZ) of the TU Braunschweigestablishedin2012whereresearchgroupsfromthepharmaceutical sciences, from biology, from process engineering, and from microtechnology intensively collaborate. Many but not all chapters of this book are written by authorsactiveinthisresearchcenter. Thebookshallprovideacomprehensivestate-of-the-artreviewofmicrofluidic approaches and applications in pharma technology. It shall help students and postgraduate students with an interdisciplinary interest from both the pharmaceu- ticalfieldandtheengineeringfieldbutalsoprocessdevelopersinthepharmaceu- tical industry and scientists with an overview of technologies and applications in thisgrowingfieldofresearch. I am grateful to all the authors for their excellent contributions to this book. I want to thank the management team of the PVZ, in particular Christel Mu¨ller- GoymannandArnoKwade,thekeypersonstobringtheirvisionandideasintothe reality of the new research center PVZ and Heike Bunjes, with whom I enjoy leadingthepostgraduateprogram“μ-Props”inwhichtopicsofthisbookcontinue inongoingresearch.SpecialthanksgotoSabineKral-Aulichwhofarinexcessof whatIcouldexpecthelpedmeincompletingthebookbykeepingcontactwiththe v vi Preface authors and with the publisher and by working on all the details and adjustments necessary to bring the manuscripts and this book into a suitable format without losingherpatience. Braunschweig,Germany AndreasDietzel September2015 Contents 1 ABriefIntroductiontoMicrofluidics. . . . . . . . . . . . . . . . . . . . . 1 A.Dietzel 2 FabricationofMicrofluidicDevices. . . . . . . . . . . . . . . . . . . . . . . 23 M.Leester-Scha¨del,T.Lorenz,F.Ju¨rgens,andC.Richter 3 SurfaceFunctionalizationofMicrofluidicDevices. . . . . . . . . . . . 59 M.Eichler,C.-P.Klages,andK.Lachmann 4 Microbioreactors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 R.Krull,S.Llad(cid:1)o‐Maldonado,T.Lorenz,S.Demming, andS.Bu¨ttgenbach 5 MicrosystemsforEmulsification. . . . . . . . . . . . . . . . . . . . . . . . . 153 H.BunjesandC.C.Mu¨ller-Goymann 6 On-ChipFabricationofDrugDeliverySystems. . . . . . . . . . . . . 181 M.Windbergs 7 MicrosystemsforDispersingNanoparticles. . . . . . . . . . . . . . . . . 197 C.Schilde,T.Gothsch,S.Beinert,andA.Kwade 8 ParticlesinMicrofluidicSystems:Handling,Characterization, andApplications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 T.P.Burg 9 RespiratoryDrugDelivery. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 H.Wachtel vii viii Contents 10 DrugDeliveryThroughMicroneedles. . . . . . . . . . . . . . . . . . . . . 275 R.Luttge 11 OrganonChip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 N.Beißner,T.Lorenz,andS.Reichl Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341 Contributors S. Beinert TU Braunschweig, Institut fu¨r Partikeltechnik, Braunschweig, Germany N. Beißner Institut fu¨r Pharmazeutische Technologie, Technische Universita¨t Braunschweig,Braunschweig,Germany PVZ—Center of Pharmaceutical Engineering, Technische Universita¨t Braunschweig,Braunschweig,Germany H. Bunjes Institut fu¨r Pharmazeutische Technologie, Technische Universita¨t Braunschweig,Braunschweig,Germany PVZ—Center of Pharmaceutical Engineering, Technische Universita¨t Braunschweig,Braunschweig,Germany T.P.Burg MaxPlanckInstituteforBiophysicalChemistry,G€ottingen,Germany S. Bu¨ttgenbach IMT—Institute of Microtechnology, Technische Universita¨t Braunschweig,Braunschweig,Germany S. Demming IMT—Institute of Microtechnology, Technische Universita¨t Braunschweig,Braunschweig,Germany GlobalTechnologyChemicalIntermediates,BASFSE,Ludwigshafen,Germany A. Dietzel IMT—Institute of Microtechnology, Technische Universita¨t Braun- schweig,Braunschweig,Germany PVZ—Center of Pharmaceutical Engineering, Technische Universita¨t Braunschweig,Braunschweig,Germany M. Eichler Fraunhofer IST—Institute for Surface Engineering and Thin Films, Braunschweig,Germany T. Gothsch TU Braunschweig, Institut fu¨r Partikeltechnik, Braunschweig, Germany ix
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