Micro/Nano Devices for Blood Analysis PDF
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Micro/Nano Devices for Blood Analysis Edited by Rui A. Lima, Graça Minas and Susana Catarino Printed Edition of the Special Issue Published in Micromachines www.mdpi.com/journal/micromachines Micro/Nano Devices for Blood Analysis Micro/Nano Devices for Blood Analysis Special Issue Editors Rui A. Lima Grac¸a Minas Susana Catarino MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade Special Issue Editors Rui A. Lima Grac¸aMinas SusanaCatarino Minho University MinhoUniversity UniversidadedoMinho Portugal Portugal Portugal Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Micromachines(ISSN2072-666X)from2018to2019(availableat: https://www.mdpi.com/journal/ micromachines/specialissues/micronanodevicesforbloodanalysis). Forcitationpurposes,citeeacharticleindependentlyasindicatedonthearticlepageonlineandas indicatedbelow: LastName,A.A.; LastName,B.B.; LastName,C.C.ArticleTitle. JournalNameYear,ArticleNumber, PageRange. ISBN978-3-03921-824-0(Pbk) ISBN978-3-03921-825-7(PDF) Cover image courtesy of Rui A. Lima, Grac¸a Minas and Susana Catarino. (cid:2)c 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher areproperly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents AbouttheSpecialIssueEditors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii SusanaO.Catarino,Grac¸aMinasandRuiLima EditorialfortheSpecialIssueonMicro/NanoDevicesforBloodAnalysis Reprintedfrom:Micromachines2019,10,708,doi:10.3390/mi10100708 . . . . . . . . . . . . . . . . 1 SusanaO.Catarino,RaquelO.Rodrigues,DianaPinho,Joa˜oM.Miranda,Grac¸aMinasand RuiLima Blood Cells Separation and Sorting Techniques of Passive Microfluidic Devices: From FabricationtoApplications Reprintedfrom:Micromachines2019,10,593,doi:10.3390/mi10090593 . . . . . . . . . . . . . . . . 5 Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Miho Tanaka, Mitsuru Tanaka, ShigeruMurata,SuguruMiyauchiandToshiyukiHayase Viscosity Estimation of a Suspension with Rigid Spheres in Circular Microchannels Using ParticleTrackingVelocimetry Reprintedfrom:Micromachines2019,10,675,doi:10.3390/mi10100675 . . . . . . . . . . . . . . . . 25 NaokiTakeishi,HiroakiIto,MakotoKanekoandShigeoWada DeformationofaRedBloodCellinaNarrowRectangularMicrochannel Reprintedfrom:Micromachines2019,10,199,doi:10.3390/mi10030199 . . . . . . . . . . . . . . . . 38 VeraFaustino, RaquelO.Rodrigues, DianaPinho, Elı´sioCosta, AliceSantos-Silva, Vasco Miranda,JoanaS.AmaralandRuiLima A Microfluidic Deformability Assessment of Pathological Red Blood Cells Flowing in a HyperbolicConvergingMicrochannel Reprintedfrom:Micromachines2019,10,645,doi:10.3390/mi10100645 . . . . . . . . . . . . . . . . 53 LilianaVilasBoas,VeraFaustino,RuiLima,Joa˜oMa´rioMiranda,Grac¸aMinas,CarlaSofia VeigaFernandesandSusanaOliveiraCatarino AssessmentoftheDeformabilityandVelocityofHealthyandArtificiallyImpairedRedBlood CellsinNarrowPolydimethylsiloxane(PDMS)Microchannels Reprintedfrom:Micromachines2018,9,384,doi:10.3390/mi9080384 . . . . . . . . . . . . . . . . . 68 YangJunKangandByungJunKim Multiple and Periodic Measurement of RBC Aggregation and ESR in Parallel Microfluidic ChannelsunderOn-OffBloodFlowControl Reprintedfrom:Micromachines2018,9,318,doi:10.3390/mi9070318 . . . . . . . . . . . . . . . . . 84 J.Ponmozhi,J.M.R.Moreira,F.J.Mergulha˜o,J.B.L.M.CamposandJ.M.Miranda Fabrication and Hydrodynamic Characterization of a Microfluidic Device for Cell Adhesion TestsinPolymericSurfaces Reprintedfrom:Micromachines2019,10,303,doi:10.3390/mi10050303 . . . . . . . . . . . . . . . . 101 ShukeiSugita,RisaMunechikaandMasanoriNakamura Multinucleation of Incubated Cells and Their Morphological Differences Compared to MononuclearCells Reprintedfrom:Micromachines2019,10,156,doi:10.3390/mi10020156 . . . . . . . . . . . . . . . . 117 v MasanoriNakamura,DaichiOnoandShukeiSugita Mechanophenotyping of B16 Melanoma Cell Variants for the Assessment of the Efficacy of (-)-EpigallocatechinGallateTreatmentUsingaTaperedMicrofluidicDevice Reprintedfrom:Micromachines2019,10,207,doi:10.3390/mi10030207 . . . . . . . . . . . . . . . . 127 ZhigangGao,ZongzhengChen,JiuDeng,XiaoruiLi,YueyangQu,LinglingXu,YongLuo, YaoLu,TingjiaoLiu,WeijieZhaoandBingchengLin Measurement of Carcinoembryonic Antigen in Clinical Serum Samples Using a Centrifugal MicrofluidicDevice Reprintedfrom:Micromachines2018,9,470,doi:10.3390/mi9090470 . . . . . . . . . . . . . . . . . 141 YuanFang,NingmeiYu,YuquanJiangandChaoliangDang High-PrecisionLens-LessFlowCytometeronaChip Reprintedfrom:Micromachines2018,9,227,doi:10.3390/mi9050227 . . . . . . . . . . . . . . . . . 151 vi About the Special Issue Editors Rui A. Lima is Associate Professor at the Department of Mechanical Engineering, University of Minho (UMinho), and Researcher at the Mechanical Engineering and Resource Sustainability Center (MEtRICs, UMinho) and Transport Phenomena Research Center (CEFT), FEUP, University of Porto. His research is mostly centered on the area of microfluidics, nanofluidics, and blood flow in biomedical microdevices. Currently, he lectures as part of several Master courses in Mechanical and Industrial Engineering. In the past, he has delivered lectures as part of several Master courses in Biomedical Technology, including Cardiovascular Biomechanics and Micro/Nanotechnologies and Biomedical Applications at the Braganc¸a Polytechnic Institute (IPB). Currently, he also supervises several PhD and Master students in the field of Mechanical and Biomedical Engineering. Grac¸a Minas is Associate Professor and Deputy Director at the Department of Industrial Electronics, as well as Researcher at the CMEMS-UMinho (Center for Microelectromechanical Systems), University of Minho, Portugal. Her research is mostly centered on the area of biomedical microdevices, specifically, in lab-on-a-chip integration of electronic circuits, optical filters, solid-state integrated sensors, biosensors, and actuators in those LOC devices. She is also developing organ-on- a-chip systems that aim to mimic human responses to various chemicals in vitro. She has published more than 130 articles and 7 patents. She supervised 2 postdoctoral fellows, 11 PhD theses (7 finished), 40 Master theses, and numerous research fellows (in the scope of project grants). Furthermore, she has participated in 18 national and European projects and has been Principal Investigator in 8 of them (6 completed). Susana Catarino received her PhD degree in Biomedical Engineering in 2014 from the University of Minho, Portugal. She is currently Researcher at the Center for Microelectromechanical Systems (CMEMS-UMinho) at the same University. From October 2016, she was also Visiting Assistant Professor at the same institution, lecturing at the Dept. of Industrial Electronics in the areas of Modeling and Simulation for Microtechnologies, Electronics, Microsensors, and Microactuators. She has published more than 40 articles in international journals, conferences, and book chapters, and 1 patent. She currently supervises 2 PhD thesis, 10 Master theses (7 completed), and 1 research fellow. She has also participated in 6 funded projects, in which she was Principal Investigator in 2 of these. Her research interests include diagnosis and lab-on-a-chip devices, optical and acoustic sensors and actuators, and numerical studies of acoustic streaming and microfluidic devices. vii micromachines Editorial / Editorial for the Special Issue on Micro Nano Devices for Blood Analysis SusanaO.Catarino1,*,GraçaMinas1,*andRuiLima2,3,* 1 CenterforMicroElectromechanicalSystems(CMEMS-UMinho),UniversityofMinho,CampusdeAzurém, 4800-058Guimarães,Portugal 2 CEFT,FaculdadedeEngenhariadaUniversidadedoPorto(FEUP),RuaRobertoFrias, 4200-465Porto,Portugal 3 MEtRICs,MechanicalEngineeringDepartment,UniversityofMinho,CampusdeAzurém, 4800-058Guimarães,Portugal * Correspondence:[email protected](S.O.C.);[email protected](G.M.);[email protected](R.L.) Received:14October2019;Accepted:15October2019;Published:18October2019 Thedevelopmentofmicrodevicesforbloodanalysisisaninterdisciplinarysubjectthatdemands anintegrationofseveralresearchfieldssuchasbiotechnology,medicine,chemistry,informatics,optics, electronics,mechanics,andmicro/nanotechnologies. Overthelastfewdecades,therehasbeenanotablyfastdevelopmentintheminiaturizationof mechanicalmicrodevices,laterknownasmicroelectromechanicalsystems(MEMS),whichcombine electricalandmechanicalcomponentsatamicroscalelevel.Theintegrationofmicroflowandoptical componentsinMEMSmicrodevices,aswellasthedevelopmentofmicropumpsandmicrovalves, havepromotedtheinterestofseveralresearchfieldsdealingwithfluidflowandtransportphenomena happeningatmicroscaledevices. Microfluidicsystemshavemanyadvantagesovermacroscalebyofferingtheabilitytowork with small sample volumes, providing good manipulation and control of samples, decreasing reactiontimesandallowingparalleloperationsinonesinglestep. Despitetheenormousscientific achievementsthatmicrofluidicshavehadinthelastdecadesinthefieldofbiomedicalapplications, thistechnologyisstillconsideredinanearlystage,withsomepullbacks,suchasthedifficultyto achieveacost-effectivelarge-scaleproduction,andalackofcompleteunderstandingofthephysicsof fluidsatthemicroscaleleveloverthebiologicalspecies.Consequently,enormouseffortshavebeen performedinmicrofabricationandmicrofluidicsresearchtoenhancethepotentialofmicrodevicesto developportableandpoint-of-carediagnosticdevices,particularlyforbloodanalysis. Inthisspecialissue,Catarinoetal.[1]presentonereviewpaperonanoverviewofthetechniques usedforsortingandseparationofredbloodcells(RBCs)andtherespectivemicro-andnanofabrication techniques,aswellasexamplesoflab-on-a-chipdeviceswithhighpotentialfortheintegrationof separationanddetectiontoolsinasinglemicrofluidicplatform[1]. Additionally,thespecialissuealsocontains10researchpaperscoveringdifferentsubjectsrelated tomicrofluidicstructuresandcellscharacterization.Particularly,Kawaguchietal.[2]haveproposed amethodtoassessthechangesintherheologicalpropertiesofasuspensioncontainingfluorescent particles. Ononeside,theauthorsusedamicrochannelwithacircularcrosssectionandmeasured thedistributionofsuspendedmicroparticlesintheradialdirectionfromtherecordedimages.Onthe otherside,theauthorsevaluatedthenon-Newtonianrheologicalpropertiesofthesuspensionusing thevelocitydistributionobtainedbytheparticletrackingvelocimetry(PTV)andapower-lawfluid model[2]. Three of the research papers focus are focused on assessing the deformability of RBCs in microchannels [3–5]. Takeishi et al. [3] numerically investigated the dynamics of RBCs flowing atdifferentvelocitiesinanarrowrectangularmicrochannel, fordifferentcapillary(Ca)numbers. Micromachines2019,10,708;doi:10.3390/mi10100708 1 www.mdpi.com/journal/micromachines
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