Microencapsulation in the food industry : a practical implementation guide PDF
Preview Microencapsulation in the food industry : a practical implementation guide
Microencapsulation in the Food Industry A Practical Implementation Guide Microencapsulation in the Food Industry A Practical Implementation Guide Edited by Anilkumar G. Gaonkar Niraj Vasisht Atul Ramesh Khare Robert Sobel AMSTERDAM(cid:1)BOSTON(cid:1)HEIDELBERG(cid:1)LONDON(cid:1)NEWYORK(cid:1)OXFORD(cid:1)PARIS SANDIEGO(cid:1)SANFRANCISCO(cid:1)SINGAPORE(cid:1)SYDNEY(cid:1)TOKYO AcademicPressisanimprintofElsevier Dedicated with love to our Parents, Wives, and Children AcademicPressisanimprintofElsevier 525BStreet,Suite1800,SanDiego,CA92101-4495,USA 32JamestownRoad,LondonNW17BY,UK 225WymanStreet,Waltham,MA02451,USA Copyrightr2014ElsevierInc.Allrightsreservedexcept: Chapter10Copyrightr2014ThorstenBrandau. Chapter19Copyrightr2014CommonwealthScientificandIndustrialResearchOrganisation(CSIRO). 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Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluating andusinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuch informationormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers, includingpartiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assume anyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability, negligenceorotherwise,orfromanyuseoroperationofanymethods,products,instructions,orideas containedinthematerialherein. Trademarks/RegisteredTrademarks Brandnamesmentionedinthisbookareprotectedbytheirrespectivetrademarksandareacknowledged. BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary LibraryofCongressCataloging-in-Publication Data AcatalogrecordforthisbookisavailablefromtheLibraryofCongress ISBN:978-0-12-404568-2 ForinformationonallAcademicPresspublications visitourwebsiteathttp://store.elsevier.com/ PrintedandboundintheUnitedStatesofAmerica 14 15 16 17 18 10 9 8 7 6 5 4 3 2 1 Foreword Over 60 years have passed since the invention and implementation of industrially significant microencapsulation pro- cesses by NCR for carbonless paper applications. During this time, thousands of patents and academic papers have been written and published along with over 50 books on this topic. Yet, with all this effort, there is a tremendous inter- est inthis field. Every year conferences andshort coursesare offered that are well attended.Every year at mycompany we field over 300 calls from companies that are excited and intrigued about how microencapsulation can provide their product or idea intellectual and physical protection in their markets. The use of microencapsulation methodologies for markets as diverse as the food, pharmaceutical, industrial, personal and home care, and agribusiness sectors, has made this area diverse, broad, and challenging to understand. Furthermore, the many techniques that are used in this field tend to have very specific limitations, advantages, and trade secret modifications that compound the challenges to both newandexperiencedpractitioners. Ten years ago, Dr. Anilkumar Gaonkar, with the help of many contributors to this book, organized the Pre-IFT meeting short course on microencapsulation especially targeted for the food industry professionals. This short course continued as a yearly offering from the IFT. Five years ago some of the contributors to this book and I realized that a newshortcourseonmicroencapsulationcouldbeusefultothegeneralpublic.Dr.MarcMeyersspearheadedtheorgani- zation of that course and it included many of the authors that are in this book. What was unique about these courses was the focus on a wide range of microencapsulation methods combined with applied examples and some of the practi- cal issues that are easy to overlook considering the breadth and variety of the process solutions. This book addresses these tremendously important issues such as the economics of microencapsulation, scale-up issues, and a whole section on the materials that are used in microencapsulation. Through overviews, process descriptions, materials that can be used to provide the encapsulation, production and regulatory issues, and finally interesting application examples, the editors and contributors of this book have provided a clear and complete reference to this complicated area for both the microencapsulationproducersandtheusersofmicroencapsulation. For over half a century, microencapsulation has been an exciting and industrially significant area to work in. New materials, better process controls, and a continuing need to protect and deliver active ingredients on demand will push this field tonew heights. This bookwill provideyou, the reader, with a reference tothe technology and challenges and, hopefully,expandyourthinkingand,ultimately,thebreadthofthetechnology. Goodreading,gooddreaming,andgoodinnovation. WillieHendrickson,Ph.D. CEO AVEKAGroup xiii Preface The world of Microencapsulation has seen exponential growth over the past fifty years, and particularly more so over the last decade. We, the authors, have held hands over the years, providing our scientific insight to evolving product development demands as attendees at international conferences and workshops. It was June 2011 when one of us, Anilkumar, had an epiphany (cid:1) it would be quite helpful for the attending audience if we captured our collective learn- ing,experiences,andpractices,alongwithourmicroencapsulationcolleaguesaroundtheworld,andcreatedahandbook of practical wisdom all in one place. The rest was history, and this was the genesis of our adventure together. A team of qualified experts was sought with a core team to create, compile, edit, and format each selection. We thank Elsevier forseeingourvisionandappreciatetheirpatienceingettingthebookreadyforprint. We recognized that the fundamental researchers and scientists were seeking technology nuances. Finding these nug- gets in this much-evolved field of science is difficult. Honestly, one would be misleading the reader if we state that what is presented in the chapters is simply science. Microencapsulation is an art and a science, and we hope that the bookhasdonejusticeinbalancingthetwoacts. Afew earlier pieces ofliterature inthe field ofmicroencapsulation have tappedinbasicconcepts, and fundamentals ofunderstandingoftheprocesstechnologies.Weunderstandthattoday’sreaderiswellversedinsuchfundamentalcon- cepts and basics. We felt that a focus on industrial applications pertinent to the 21st century would yield greater value to the reader. This involves exploring novel excipients, process technologies, analytical and characterization methods, and regulatory roadmaps. We believe thatthis extends our understanding ofthe functionality ofthe finalmicroencapsu- latedproduct. The thirst of today’s learners relates to finding unique solutions to some very specific product needs. As research and development is not a static practice, the field of encapsulation has traversed from the micro-scale level to new developments in the area of nano-scaled encapsulation. These developments have found many applications in health foods,nutraceuticals,dietaryandconsumerhealth,andwellnessproducts. Thisbookiscomprisedof7partsand42chapters.Wehaveattemptedtobridgefundamentalconceptstotheknowl- edge of new and novel processing techniques, choice of materials along with the selection process, testing and evalua- tion of materials, regulatory aspects, scale-up, packaging, economics, and application-specific uses of microencapsulation in the food industry. We have chosen to include the expired and active intellectual property highlighting this field of research as it applies to the food and nutraceutical industries. The content and format allows ustocreateanIndustrialApplicationHandbookcapturingtheartandscienceofthisfieldtothefoodindustry. The book provides a single source consolidation of information pertaining to new challenges in the food industry that can potentially be solved by microencapsulation technology. The projected audience encompasses college students, scientists, engineers, professionals, business managers, technical leaders, marketing personnel, and small business own- ers serving the food and nutraceutical industries. Most of the contributors to this book are from industry and a few are fromacademia.Hundredsofyearsofcollectiveexperience ofthe authors fromseveralcountrieshave shapedthisbook. We hope that the readers of this book will be enriched with knowledge of the current and emerging trends on microen- capsulationoffoodingredients. TheEditors xv About the Editors Anilkumar G. Gaonkar is currently working as a VP, R&D Asia Pacific at Mondele¯z India Foods (formerly Cadbury India Ltd.) in Mumbai, India on an expat assignment. He has been a Mondele¯z International Fellow at Mondele¯z International’s (Legacy Kraft Foods) R&D Center in Glenview, IL, USA. Anil has 27 years of R&D experience with Kraft and Mondele¯z. Prior to joining Kraft, he worked at the University of Minnesota, St. Paul, MN, Auburn University, Auburn, AL., and Institute for Chemical Research, Kyoto University, Kyoto, Japan for about 8 years. His areasofresearchinterestincludemicroencapsulation,controlleddelivery,emulsions,foams,colloids,surfacechemistry, fatsandoils,eggscience,andsaladdressings. Anil received his B.Sc. degree in chemistry and M.Sc. degree in physical chemistry from the Karnatak University, Dharwad,IndiaandPh.D.degreeinchemistryfromPoonaUniversity,Pune,India. Anilhas authoredorco-authoredover60journalarticles,proceedingpapersandabstracts.Heisaninventorandco- inventor of more than 30 US and foreign patents and many patents are pending. Anil received numerous awards for innovation, productivity, and leadership. He has organized and co-chaired several national and international symposia as well as lectured at numerous conferences, symposia, and short courses. He has edited four books in the area of food characterization,interactions,andprocessing. Anilisplanningtoretire inDecember2014,beaconsultant,anddedicate majorityofhisretiredlifehelpingtheunderprivilegedpeopleinIndia. Niraj Vasishtis currently serving asChiefTechnicalOfficer andSeniorVice PresidentofProductDevelopmentat Bio Delivery Sciences International, Inc. He heads the chemistry, manufacturing and control operations and oversees the product design, formulation development, quality control, process engineering,validation and stability testing of the drug product and CTM and commercial manufacturing operations at our vendor sites worldwide. In his current role, he is responsible for technical suitability of drug delivery platforms and candidate molecules suitable for the technology. Dr.VasishtservesasBDSI’sproductdevelopmentrepresentativeforFDAinteractionsforNDAandMAAfilings. He is known worldwide for his expertise inmicroencapsulation based controlled release anddrug deliverytechnolo- gies. He has 20 years of industry experience and has taught microencapsulation courses in profession al society meet- ings,andcoursesallaroundtheworld. From 1994 to 2005, Dr.Vasisht held positions of increasing responsibility at Southwest Research Institute where he ultimately served as the Director of Microencapsulation, Pharmaceutical Development and Nanomaterials and was responsible for leading the group that provides research and development and product development services to food, nutriceutical,pharmaceutical,andconsumerhealthcompanies. He is an inventor on multiple patents in the field of microencapsulation. Dr.Vasisht received a Bachelor’s in Chemical Engineering from the Indian Institute of Technology at Kanpur, a Master’s of Science from the University of New Hampshire and a Doctorate in Chemical Engineering from Rensselaer Polytechnic Institute. He resides in Cary, NorthCarolina,withhiswifeandthreesons. Atul Khare is Principal, Khare Innovation Consulting, with 21 years research and development management experi- ence in food and pharma/medical device industry with expertise in developing and commercializing new technologies. His research competencies are in the development of encapsulated delivery systems for controlled release of flavor and functional ingredients in different food applications such as chewing gum, cereals and beverages. Atul has held leader- ship positions at Akorn Inc., FONA International Inc. and Baxter Healthcare Corporation. Atul is a professional mem- ber of IFT. Atul received a Ph.D. in Chemical Engineering from Purdue University and his MBA from The University of Chicago Booth School of Business. Atul has authored or co-authored over 50 journal articles, proceeding papers and abstracts,and5patents. xvii xviii AbouttheEditors Robert Sobel is currently serving FONA International as a Vice President of Research and Innovation in the develop- ment of new and novel flavor encapsulation delivery systems and taste modification technologies. He has 15 years of industrial flavor R&D experience at FONA International, located in Geneva, Illinois, USA. Prior to joining FONA International,Robertwasaneducatorwithinbothsecondaryandundergraduatesettingsteachingchemistryandphysics. Robert received a B.S. in chemistry with a minor in physics from Northern Illinois University, his M.A. in educa- tional leadership from Aurora University, and his Ph.D. in chemistry from Northern Illinois University. Graduate researchemphasisincludesphysicalchemistryandunifiedseparationscience. Robert has published manuscripts in Analytical Chemica Actica, The Journal of Chemical Education and Perfumer & Flavorist. He is cited as an inventor on many patents and patents pending in the art of microencapsulation. He has given a variety of technical symposia on analysis of flavor encapsulates, challenges of microencapsulation of flavors, proteins and polysaccharides as microencapsulating agents, real-time reaction monitoring and flavor analysis using surface acoustic wave microsensor arrays and artificial neural networks, and design of experiments for scalability and qualityimprovementofspraydryingflavorants.RobertresidesinElburn,Illinois,withhiswifeandtwodaughters. List of Contributors Anwar Ahniyaz, SP Technical Research Institute of Karin Nordstro¨m Dyvelkov, GEA Niro, GEA Process Sweden,Stockholm,Sweden EngineeringA/S,Soeborg,Denmark Ahmad Akashe, Ingredient Research Department, Ulla Elofsson, SP Technical Research Institute of Research&Nutrition,Mondele¯zInternational,Glenview, Sweden,Stockholm,Sweden Illinois,USA Maria Jose´ Fabra, Novel Materials and Nanotechnology Stephen Atkin, University of Hull, Hull, UK and Group, Institute of Agrochemistry and Food SporomexLtd,Hull,UK Technology,Paterna(Valencia), Spain Mary Ann Augustin, CSIRO Preventative Health Charles Frey, Coating Place, Inc., Verona, Wisconsin, National Research Flagship, CSIRO Animal, Food and USA HealthSciences,Werribee,Victoria,Australia Anilkumar G. Gaonkar, Ingredient Research Stephen Beckett, University of Hull, Hull, UK and Department, Research & Nutrition, Mondele¯z SporomexLtd.,Hull,UK International, Glenview, Illinois, USA; Kraft Foods Cory J. Berkland, Orbis Biosciences, Kansas City, Group, Inc., Research and Nutrition, Glenview, Kansas, USA; University of Kansas, Department of Illinois, USA; Mondele¯z International, Glenview, PharmaceuticalChemistry,Lawrence,Kansas,USA Illinois,USA ThorstenBrandau, BRACEGmbH,Alzenau,Germany Vero´nica Paula Dueik Gonza´lez, University of Toronto, Erin Burnside, FONA International, Geneva, Illinois, Toronto,Ontario,Canada USA Michael Gundlach, FONAInternational,Geneva,Illinois, Keith R. Cadwallader, Department of Food Science and USA Human Nutrition, University of Illinois, Urbana, Moti Harel, Advanced BioNutrition Corporation, Illinois,USA Columbia,Maryland,USA Stefano Ceriali, Global Coffee Technology Department, Jenni Harrington, Buhler Inc., Plymouth, Minnesota, Research & Development, Mondele¯z International, USA Banbury,Oxfordshire,UK Jennifer Hoffmann, FONA International, Geneva, Sylvie Cloutier, DSM Nutritional Products (Legacy Illinois,USA Ocean Nutrition Canada Ltd.), Dartmouth, Nova Scotia,Canada Michael Jacob, Glatt Ingenieurtechnik GmbH, Weimar, Germany Douglas Dale, DuPont Industrial Biosciences, Palo Alto, California,USA Irwin C. Jacobs, Jacobs Controlled Release Consulting, LLC,Defiance,Missouri,USA Alberto Diego-Taboada, University of Hull, Hull, UK andSporomexLtd,Hull,UK Mikael Ja¨rn, SP Technical Research Institute of Sweden,Stockholm,Sweden Levente L. Diosady, University of Toronto, Toronto, Ontario,Canada Vaios T. Karathanos, Harokopio University, Athens, Greece Joseph D. Donovan, Department of Food Science and Human Nutrition, University of Illinois at Urbana- Atul Ramesh Khare, KhareConsulting, Palatine, Illinois, Champaign,Urbana,Illinois,USA USA Nathan H. Dormer, Orbis Biosciences, Kansas City, Spyros J. Konteles, Technological Educational Institute Kansas,USA ofAthens,Athens,Greece xix xx ListofContributors Jose Maria Lagaron, Novel Materials and Efstathia I. Paramera, Harokopio University, Athens, Nanotechnology Group, Institute of Agrochemistry and Greece FoodTechnology,Paterna(Valencia),Spain Rufino Perez, United States Agency for International Anders Larsson, SP Technical Research Institute of Development,Washington,DC,USA Sweden,Stockholm,Sweden Rocio Pe´rez-Masia´, NovelMaterialsandNanotechnology Soo-Yeun Lee, Department of Food Science and Human Group,InstituteofAgrochemistryandFoodTechnology, Nutrition, University of Illinois at Urbana-Champaign, Paterna(Valencia),Spain Urbana,Illinois,USA MartinSchaefer, BuhlerAG,Switzerland YoungSoo Lee, Department of Food Science and Human MilindSingh, OrbisBiosciences,KansasCity,Kansas,USA Nutrition, University of Illinois at Urbana-Champaign, Jakob Sloth, GEA Niro, GEA Process Engineering A/S, Urbana,Illinois,USA Soeborg,Denmark Jason Z. Li, Ingredion Incorporated, Bridgewater, New Robert Sobel, FONA International, Geneva, Illinois, Jersey,USA USA;RonaldT.DodgeCompany,Dayton,Ohio,USA Yao Olive Li, California State Polytechnic University, Emiel Speets, Vesuvius GmbH, Foseco Foundry Pomona,California,USA Division,Borken,Germany Amparo Lopez-Rubio, Novel Materials and Chin-PingSu, FONAInternational,Geneva,Illinois,USA Nanotechnology Group, Institute of Agrochemistry and FoodTechnology,Paterna(Valencia),Spain Karim Tallua, Encapsula NanoSciences, Brentwood, Tennessee,USA Lubica Macakova, SP Technical Research Institute of Sweden,Stockholm,Sweden Qiong Tang, Advanced BioNutrition Corporation, Columbia,Maryland,USA Grahame Mackenzie, University of Hull, Hull, UK and SporomexLtd.,Hull,UK Courtney S. Thompson, Encapsula NanoSciences, Brentwood,Tennessee,USA Yang Meng, DSM Nutritional Products, Dartmouth, NovaScotia,Canada Rohan V. Tikekar, Program in Food Science, Drexel University,Philadelphia,Pennsylvania,USA Marc A. Meyers, Meyers Consulting, LLC, Richboro, Pennsylvania,USA Farah Jean-Jacques Toublan, Stepan Company, Northfield,Illinois,USA Anna Millqvist-Fureby, SP Technical Research Institute ofSweden,Stockholm,Sweden Niraj Vasisht, BioDelivery Sciences International, Inc., Raleigh,NorthCarolina,USA Zahra Mirafzali, Encapsula NanoSciences, Brentwood, Tennessee,USA Ronald J. Versˇicˇ, Ronald T. Dodge Company, Dayton, Ohio,USA LindaL.Moran, DepartmentofFoodScienceandHuman Nutrition,UniversityofIllinois,Urbana,Illinois,USA Dave Wallick, The Dow Chemical Company, Midland, Michigan,USA Michael Nickerson, Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, Anthony Wragg, Global Coffee Technology Saskatchewan,Canada Department, Research & Development, Mondele¯z International,Banbury,Oxfordshire,UK Nitin Nitin, Department of Food Science and Technology, University of California-Davis, Davis, CuieYan, PepsiCoInc.,Purchase,NewYork,USA California,USA Yun Yin, Department of Food Science and Human Nutrition,UniversityofIllinois,Urbana,Illinois,USA Christine Maree Oliver, CSIRO Preventative Health National Research Flagship, CSIRO Animal, Food and Bary Zeller, IngredientResearchDepartment,Research& HealthSciences,Werribee,Victoria,Australia Nutrition, Mondele¯z International, Glenview, Illinois, USA James Oxley, Southwest Research Institute, San Antonio,TX,USA Wei Zhang, DSM Nutritional Products (Legacy Ocean Nutrition Canada Ltd.), Dartmouth, Nova Scotia, Graciela W. Padua, Department of Food Science and Canada Human Nutrition, University of Illinois, Urbana, Illinois,USA
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