Rapid Review Series Series Editor Edward F. Goljan, MD Behavioral Science, Second edition Vivian M. Stevens, PhD; Susan K. Redwood, PhD; Jackie L. Neel, DO; Richard H. Bost, PhD; Nancy W. Van Winkle, PhD; Michael H. Pollak, PhD BiochemiStry, third edition John W. Pelley, PhD; Edward F. Goljan, MD GroSS and developmental anatomy, third edition N. Anthony Moore, PhD; William A. Roy, PhD, PT hiStoloGy and cell BioloGy, third edition E. Robert Burns, PhD; M. Donald Cave, PhD microBioloGy and immunoloGy, third edition Ken S. Rosenthal, PhD; Michael J. Tan, MD, FACP neuroScience James A. Weyhenmeyer, PhD; Eve A. Gallman, PhD patholoGy, third edition Edward F. Goljan, MD pharmacoloGy, third edition Thomas L. Pazdernik, PhD; Laszlo Kerecsen, MD phySioloGy Thomas A. Brown, MD laBoratory teStinG in clinical medicine Edward F. Goljan, MD; Karlis Sloka, DO uSmle Step 2 Michael W. Lawlor, MD, PhD uSmle Step 3 David Rolston, MD; Craig Nielsen, MD Rapid Review MicRobiology iMMunology and Third EdiTion Ken S. Rosenthal, phd Professor Department of Microbiology and Immunology Northeastern Ohio Universities Colleges of Medicine and Pharmacy Rootstown, Ohio Adjunct Professor FIU Herbert Wertheim College of Medicine Florida International University Miami, Florida Michael J. Tan, Md, Facp Assistant Professor of Internal Medicine Northeastern Ohio Universities Colleges of Medicine and Pharmacy Rootstown, Ohio Clinical Physician Infectious Diseases and HIV Summa Health System Akron, Ohio 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 RAPid Review MicRoBiology And iMMunology, iSBn: 978-0-323-06938-0 ThiRd ediTion Copyright © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the copyright clearance center and the copyright licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. in using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. with respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. it is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data Rosenthal, Ken S. Rapid review microbiology and immunology / Ken S. Rosenthal, Michael J. Tan.—3rd ed. p. ; cm.—(Rapid review) Rev. ed. of: Microbiology and immunology / Ken S. Rosenthal, James S. Tan. 2nd ed. c2007. includes index. iSBn 978-0-323-06938-0 1. Medical microbiology—outlines, syllabi, etc. 2. Medical microbiology—examinations, questions, etc. 3. immunology—outlines, syllabi, etc. 4. immunology—examinations, questions, etc. 5. Physicians— licenses—united States—examinations—Study guides. i. Tan, Michael J. ii. Rosenthal, Ken S. Microbiology and immunology. iii. Title. iv. Title: Microbiology and immunology. v. Series: Rapid review series. [dnlM: 1. viruses—examination Questions. 2. Bacteria—examination Questions. 3. communicable diseases—immunology—examination Questions. Qw 18.2 R815r 2011] QR46.R7535 2011 616.9’041—dc22 2009045667 Acquisitions Editor: James Merritt Developmental Editor: christine Abshire Publishing Services Manager: hemamalini Rajendrababu Project Manager: gopika Sasidharan Design Direction: Steve Stave Printed in the united States of America last digit is the print number: 9 8 7 6 5 4 3 2 1 S P erieS reface The First and Second Editions of the Rapid Review Series have received high critical acclaim from students studying for the United States Medical Licensing Examination (USMLE) Step 1 and consistently high ratings in First Aid for the USMLE Step 1. The new editions will continue to be invaluable resources for time-pressed students. As a result of reader feedback, we have improved upon an already successful formula. We have created a learning system, including a print and electronic package, that is easier to use and more concise than other review products on the market. SPECIAL FEATURES Book • Outline format: Concise, high-yield subject matter is presented in a study-friendly format. • High-yield margin notes: Key content that is most likely to appear on the exam is reinforced in the margin notes. • Visual elements: Full-color photographs are utilized to enhance your study and recognition of key pathology images. Abundant two-color schematics and summary tables enhance your study experience. • Two-color design: Colored text and headings make studying more efficient and pleasing. New! Online Study and Testing Tool • A minimum of 350 USMLE Step 1–type MCQs: Clinically oriented, multiple- choice questions that mimic the current USMLE format, including high-yield images and complete rationales for all answer options. • Online benefits: New review and testing tool delivered via the USMLE Consult platform, the most realistic USMLE review product on the market. Online feedback includes results analyzed to the subtopic level (discipline and organ system). • Test mode: Create a test from a random mix of questions or by subject or keyword using the timed test mode. USMLE Consult simulates the actual test-taking experience using NBME’s FRED interface, including style and level of difficulty of the questions and timing information. Detailed feedback and analysis shows your strengths and weaknesses and allows for more focused study. • Practice mode: Create a test from randomized question sets or by subject or keyword for a dynamic study session. The practice mode features unlimited attempts at each question, instant feedback, complete rationales for all answer options, and a detailed progress report. • Online access: Online access allows you to study from an internet-enabled computer wherever and whenever it is convenient. This access is activated through registration on www.studentconsult.com with the pin code printed inside the front cover. v vi Series Preface Student Consult • Full online access: You can access the complete text and illustrations of this book on www.studentconsult.com. • Save content to your PDA: Through our unique Pocket Consult platform, you can clip selected text and illustrations and save them to your PDA for study on the fly! • Free content: An interactive community center with a wealth of additional valuable resources is available. P reface Rapid Review Microbiology and Immunology, Third Edition provides updated, relevant material in an easy-to-read and understandable outline format, with excellent figures and summary tables to help you SEE and REMEMBER the concepts. KEY WORDS and CONCEPTS are highlighted to promote RAPID recognition and recall. For RAPID study, the relevant facts for all of the microbes are summarized in tables. TRIGGER WORDS for each of the microbes spark RAPID word associations on exam questions and in the clinic. Case scenarios and clinical presentations are offered to help you think in terms of the USMLE Step 1 exam. Most importantly, questions are provided online to reinforce your knowledge and help you practice taking the exam. These questions have been carefully written, reviewed, and edited for content to emulate USMLE Step 1 questions. Detailed answers continue the review process. Rapid Review Microbiology and Immunology can be an important part of your training for the USMLE exam. Success on the exam requires more than a thorough knowledge of the subject. As with any big challenge—a race, match, or championship game—a positive winning attitude as well as mental, physical, and emotional preparedness are necessary. Make sure to go into the exam strong. Good luck on the examination. vii This page intentionally left blank A R cknowledgment of evieweRs The publisher expresses sincere thanks to the medical students and faculty who provided many useful comments and suggestions for improving both the text and the questions. Our publishing program will continue to benefit from the combined insight and experience provided by your reviews. For always encouraging us to focus on our target, the USMLE Step 1, we thank the following: Bhaswati Bhattacharya, MD, MPH, Columbia University, Rosenthal Center for Complementary and Alternative Medicine Natasha L. Chen, University of Maryland School of Medicine Patricia C. Daniel, PhD, University of Kansas Medical Center Kasey Edison, University of Pittsburgh School of Medicine Charles E. Galaviz, University of Iowa College of Medicine Georgina Garcia, University of Iowa College of Medicine Dane A. Hassani, Rush Medical College Harry C. Kellermier, Jr., MD, Northeastern Ohio Universities College of Medicine Joan Kho, New York Medical College Michael W. Lawlor, Loyola University Chicago Stritch School of Medicine Ronald B. Luftig, PhD, Louisiana State University Health Science Center Christopher Lupold, Jefferson Medical College Michael J. Parmely, PhD, University of Kansas Medical Science Center Mrugeshkumar K. Shah, MD, MPH, Tulane University Medical School, Harvard Medical School/Spaulding Rehabilitation Hospital John K. Su, MPH, Boston University School of Medicine, School of Public Health Ryan Walsh, University of Illinois College of Medicine at Peoria ix
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