Micro Total Analysis Systems 2002: Proceedings of the μTAS 2002 Symposium, held in Nara, Japan, 3–7 November 2002 Volume 2 PDF
Preview Micro Total Analysis Systems 2002: Proceedings of the μTAS 2002 Symposium, held in Nara, Japan, 3–7 November 2002 Volume 2
MICRO TOTAL ANALYSIS SYSTEMS 2002 Micro Total Analysis Systems 2002 Proceedings of the IlTAS 2002 Symposium, held in N ara, Japan, 3-7 November 2002 Volume 2 edited by Yoshinobu Baba The University of Tokushima, Tokushima, Japan Shuichi Shoji Waseda University, Tokyo, Japan and Albert van den Berg University ofTwente, Enschede, The Netherlands SPRINGER-SCIENCE+BUSINESS MEDIA, RV, Library of Congress Cataloging-in-Publication Data. ISBN 978-94-010-3953-6 ISBN 978-94-010-0504-3 (eBook) DOI 10.1007/978-94-010-0504-3 Printed on acid-free paper All Rights Reserved © 2002 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 2002 Softcover reprint of the hardcover 1 st edition 2002 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. PROGRAM COMMITTEE IJTAS2002 Yoshinobu Baba University of Tokushima David Beebe University of Wisconsin-Madison Albert van den Berg MESA + Research Institute, University of Twente D. Jed Harrison University ofA lberta Klavs F. Jensen Massachusetts Institute of Technology Thomas Laurell Lund Institute of Technology, Lund University Andreas Manz Imperial College of London M. Allen Northrup Microfluidic Systems Inc. J. Michael Ramsey Oak Ridge National Laboratory Shuichi Shoji Waseda University Takehiko Kitamori University of Tokyo Sabeth Verpoorte University of NeucMtel PREFACE The Sixth International Conference on Miniaturized Chemical and Biochemical Analysis Systems, known as IlTAS2002, will be fully dedicated to the latest scientific and technological developments in the field of miniaturized devices and systems for realizing not only chemical and biochemical analysis but also synthesis. The first IlTAS meeting was held in Enschede in 1994 with approximately 160 participants, bringing together the scientists with background in analytical and biochemistry with those with Micro Electro Mechanical Systems (MEMS) in one workshop. We are grateful to Piet Bergveld and Albert van den Berg of MESA Research Institute of the University of Twente for their great efforts to arrange this exciting first meeting. The policy of the meeting was succeeded by late Prof. Dr. Michael Widmer in the second meeting, IlTAS'96 held in Basel with 275 participants. The first two meetings were held as informal workshops. From the third workshop, IlTAS'98 (420 participants) held in Banff, the workshop had become a worldwide conference. Participants continued to increase in IlTAS2000 (about 500 participants) held in Enschede and IlTAS2001 (about 700 participants) held in Monterey. The number of submitted papers also dramatically increased in this period from 130 in 1998, 230 in 2000 to nearly 400 in 2001. From 2001, IlTAS became an annual symposium. The steering committee meeting held in Monterey, confirmed the policy of former IlTAS that quality rather than quantity would be the key-point and that the parallel-session format throughout the 3.5 days would be maintained. The upcoming IlTAS2002 is the first meeting specialized on this field that is held in Asia. Again there is a very large increase in submitted abstracts (over 450), especially from the Asian Countries such as Japan, Korea, Taiwan, and China. The program committee had a very hard work to do and had to select 66 abstracts as oral presentations and more than 250 abstracts as poster presentations, an acceptance rate slightly over 70 %. In addition, we have excellent invited speakers from North America, Europe and Asia. The co-chairs of IlTAS2002 wish everyone will understand the consistent IlTAS policy and agree that the program committee did a very excellent job in selecting abstracts and arranging the program. This is the first IlTAS meeting in Asia, we do hope the meeting will contribute to spread the latest knowledge of IlTAS to Asia as well as North America and Europe. Recent trend that appeared in the previous IlTAS2001 is that the contributions are much more focused on the actual applications than on the basic studies. Microfluidc components, devices and integrated systems are still a main stream in the MEMS field. A droplet base fluidics, nanofluidics and a gas-liquid two phase flow are the new topics. Integration of the flow devices for a total system is obvious. Plastic micro fabrication, using PDMS are currently used and miniaturization technologies proceeds to realize the structure of nanometer scale. The interest in materials for biochemical and biomedical applications and nanotechnologies is showing remarkable growth. The genomics and proteomics analysis and separation science remain high from the previous meeting. The vii interests of the clinical diagnosis and cellular analysis have considerably increased. Devices and systems developments that address highly sensitive measurements of chemical and biochemical molecules continued in the micro-optics, mass spectroscopy and electrochemical detection. We would like to express our great gratitude to program committee members of the 12 steering committee members and Takehiko Kitamori for their really tough work. We would like to greatly thank D. Jed Harrison, Albert van den Berg and J. Mike Ramsey for sharing their experiences with previous meetings and providing many useful suggestions. We also thank Hiroyuki Fujita, Takehiko Kitamori and other local organizing committee members. The excellent arrangement could not be done without the efforts by June Echizen of the secretariat of IlTAS2002 and her colleagues. Finally we wish to thank the most important people of all, the invited speakers, the technical contributors and participants! We hope all participants will enjoy IlTAS2002. Yoshinobu Baba Shuichi Shoji IlTAS2002 Co-Chairman August 10, 2002 viii CONTENTS VOLUME 1 Day 1 Keynote 1 EXPLORING FET CONCEPTS FOR LAB-ON-A-CHIP ............................................. 1 P. Bergveld Cell Growth and Monitoring MONITORING OF CELL GROWTH, OXYGEN AND pH IN MICROFERMENTORS .................................................................................................. 7 Nicolas Szita, Andrea Zanzotto, Paolo Boccazzi, Anthony J. Sinskey, Martin A. Schmidt and Klavs F. Jensen OBSERVATION OF RESPONSE TO STIMULI IN OSCILLATING CELLS PATTERNED BY MICROFABRICATED STRUCTURE ........................................... 10 Atsuko Takamatsu and Teruo Fujii ON-CHIP AGAROSE MICROCHAMBER (AMC) ARRAY CELL-CULTIVATION SYSTEM FOR TOPOGRAPHICAL CONTROL OF NEURAL NETWORK ............ 13 Hiroyuki Moriguchi, Kazunori Takahashi, Tomoyuki Kaneko and Kenji Yasuda Separation, General INTEGRATED SIZE EXCLUSION AND REVERSED-PHASE ELECTROCHROMATOGRAPHY .............................................................................. 16 Abebaw B. Jemere, Richard D. Oleschuk and D. J. Harrison DISPERSION ANALYSIS OF A SOLID-PHASE MICROEXTRACTION CHIP BY COMPUTATIONAL FLUID DYNAMICS .................................................................. 19 Jonas Bergkvist, Simon Ekstrom, Johan Nilsson and Thomas Laurel! INTERFACING MICROCHIP CE WITH ICPMS FOR ELEMENT SPECIATION ................................................................................................................ 22 Qi Jun Song, Gillian M. Greenway and Tom McCreedy Gels for Biochemical Analysis ELECTRODELESS DIELECTROPHORETIC TRAPPING AND SEPARATION OF CELLS ........................................................................................................................... 25 Chia-Fu Chou, Margaret Morgan, Frederic Zenhausern, Christelle Prinz and Robert H. Austin Si02 NOZZLE ARRAY-BASED PATCH-CLAMP MICROSYSTEM ....................... 28 T. Lehnert, R. Netzer, U. Bischoff and M. A. M. Gijs A PROGRAMMABLE CELL ASSAY PLATFORM FOR KINETIC STUDIES OF A SINGLE CELL .............................................................................................................. 31 Antoine Daridon, William Throndset, Ian Liau, Kevin Farrel!, Flora Tseng, Shervin Javadi and Ian Manger ix Micro Analysis Systems AN INTEGRATED MICRODIALYSIS-BASED SYSTEM ........................................ 34 D. G. Pijanowska, A. l.Sprenkels, l. Bomer, W. Olthuis and P. Bergveld USER-ASSEMBLY, FULLY INTEGRATED MICRO CHEMICAL LABORATORY USING BIOCHEMICAL IC CHIPS FOR WEARABLEIIMPLANTABLE APPLICATIONS ........................................................................................................... 37 Koji Ikuta, Atsushi Takahashi, Kota Ikeda and Shoji Maruo MICROFLUIDIC REACTOR ARRAY FOR MULTISTEP DROPLET REACTIONS ................................................................................................................. 40 Masumi Yamada, Nobuyuki Sugiyama and Minoru Seki Keynote 2 SINGLE MOLECULAR DETECTION OF DNAJPROTEIN AND ITS APPLICATION TO BIOCHIPS .................................................................................... 43 Tomoji Kawai DNA Separation DNA SEPARATION IN GRADIENT OF CONFINED NANOSPACE GENERATED BY NANOPARTICLES IN A MICROCHANNEL.. .................................................... 45 Noritada Kaji, Mari Tabuchi, Yukio Nagasaki, Kazunori Kataoka, Kenichi Yoshikawa and Yoshinobu Baba SELF-ASSEMBLED MAGNETIC COLLOIDS FOR DNA SEPARATIONS IN MICROFLUIDIC DEVICES ........................................................................................ 48 Patrick S. Doyle, Claus Filtterer, Nicolas Mine, Cecile Goubault, Jerome Bibette and lean-Louis Viovy A MICROFABRICATED DEVICE FOR SEPARATING -200KILO-BASE-PAIR DNA MOLECULES IN -15 SECONDS ...................................................................... 51 Lotien Richard Huang, Jonas O. Tegenfeldt, lames C. Sturm, Robert H. Austin and Edward Cox Droplet Base Fluidics AIRBORN CHEMISTRY LEVITATED PROTEIN DROPLETS AS A NOVEL ANALYTICAL TOOL FOR NUCLEATION SCREENING IN MACROMOLECULAR CRYSTALLISATION ........................................................... 54 Sabina Santesson, Eila S. Cedergren-Zeppezauer, Thomas lohansson, Thomas Laurell, lohan Nilsson and Staffan Nilsson ON-LINE MONITORING OF AIRBORNE CHEMISTRY IN LEVITATED DROPLETS: IN-SITU SYNTHESIS AND APPLICATION OF SERS ACTIVE Ag-SOLS FOR TRACE ANALYSIS BY RAMAN SPECTROMETRy ..................... 58 Nicolae Leopold, Michael Haberkorn, Thomas Laurell, Johannes Nielson, losefa R. Baena and Bernhard Lendl x CHIP-TO-WORLD INTERFACES FOR HIGH-THROUGHPUT LAB-ON-A-CHIP DEVICES ...................................................................................................................... 61 Sebastian Bohm, Theo Veenstra, Albert van den Berg, Nghia Chiem and John Gilbert Day 1 Posters Fluid Mechanics & Design Tools THE MEMS MODELING SYSTEM BY COLLABORATION OF MULTI-SCALE SIMULATORS AND APPLICATION TO THE MICROREACTOR .......................... 64 Tatsuya Yamaue, Taku Ozawa, Eisuke Nishitani, Makoto Sasaki, Shinji Shibano, Takashi Taniguchi, Yuichi Masubuchi and Masao Doi FEM STUDY OF COULTER COUNTER WITH WATER-BASED ADAPTABLE APERTURE ................................................................................................................... 67 J. H. Nieuwenhuis and M. J. Vellekoop MICROMANIPULATING MAGNETIC PARTICLES IN MICROFLUIDIC SySTEMS ..................................................................................................................... 70 E. Brunet, B. Michaud, F. Okkels and P. Tabeling OPTIMAL DESIGN OF MICROMIXER USING NONHOMOGENEOUS MULTILAYER LAMINAR FLOW .............................................................................. 73 Masaki Kanai, Daisuke Uchida, Satoshi Sugiura, Hironobu Sato, Yoshikazu Mori, Katsumasa Sakamoto, Hiroaki Nakanishi and Shuichi Shoji COMPUTATIONAL SIMULATIONS OF FLUID FLOW DYNAMICS, AND BEAD PACKING IN SOLID PHASE EXTRACTION MICROSYSTEMS ........................... 76 Paul D. Senkans, Vern de Biasi and David A. Barrow THE LOW-VOLTAGE CASCADE EOF PUMP: COMPARING THEORY WITH PUBLISHED DATA ...................................................................................................... 79 Anders Brask, Goran Goranovif: and Henrik Bruus UNIVERSAL JOULE HEATING MODEL IN ELECTROPHORETIC SEPARATION MICROCHIPS ..................................................................................... 82 Yi Wang, Qiao Lin and Tamal Mukherjee MATHEMATICAL MODEL OF INTERFACIAL LAYER IN ULTRA-FINE LIQUID DROP BASED ON MOLECULAR DYNAMICS SIMULATION ............... 85 Satoyuki Kawano, Tomoyuki Shiga and Kazuhiro Nakanishi DEVELOPMENT OF MICROMIXER BASED ON INSTABILITY OF INTERFACE BETWEEN TWO IMMISCIBLE LIQUIDS .......................................... 88 Satoyuki Kawano, Hirofumi Shintaku, Isaku Kanno and Hidetoshi Kotera THEORETICAL STUDY OF AC ELECTROOSMOTIC FLOWS IN NON-UNIFORMLY CHARGED MICROCHANNELS .............................................. 91 Sung Jae Kim, Hyo Sook Cha, In Seok Kang and Byung Jun Yoon Xl NUMERICAL SIMULATION OF MIXING IN A MICRO-CHANNEL WITH NON-UNIFORM ZETA POTENTIAL SURFACE ...................................................... 94 Seungbae Hong, Luc G. Frechette and Vijay Modi INJECTION OF SAMPLE BANDS FROM OPEN CHANNELS INTO PACKED SEPARATION COLUMNS .......................................................................................... 97 Robert H. Nilson, Stewart K. Griffiths and Anup K. Singh MICROSCALE MEASUREMENTS OF FLOW BOUNDED BY AIR-WATER INTERFACES ............................................................................................................. 100 J. M. Bauer and D. J. Beebe VIRTUAL FLOW CHANNEL: A NOVEL MICRO-FLUIDICS SYSTEM WITH ORTHOGONAL, DYNAMIC CONTROL OF SAMPLE FLOW DIMENSIONS .... 103 J. H. Nieuwenhuis, J. Bastermeijer, P. M. Sarro and M. J. Vellekoop Micro Machining Methods MICROFABRICATION OF 3-D OBLIQUE STRUCTURES BY INCLINED UV LITHOGRAPHy ......................................................................................................... 106 Manhee Han, Woonseob Lee, Sung-Keun Lee and Seung S. Lee A NEW FABRICATION TECHNIQUE OF A DNA ELECTROPHORESISCHIP BY SILICON MICROMACHINING TECHNOLOGY ................................................... 109 J. Tsuda, Y. Tada, G. Hashiguchi, K. Hirano, N. Kaji and Y. Baba PRECISION PATTERNING OF PDMS THIN FILMS: A NEW FABRICATION METHOD AND ITS APPLICATIONS ...................................................................... 112 Kee Suk Ryu and Chang Liu FABRICATION OF MICROFLUIDIC CHANNELS WITH SYMMETRIC CROSS-SECTIONS FOR INTEGRATED NMR ANALySIS ................................... 115 A. Homsy, J. Lichtenberg, C. Massin, F. Vincent, P. -A. Besse, R. S. Popovic, N. F. de Rooij and E. Verpoorte PRECISE AND FEASIBLE FABRICATION PROCESS OF MICROFLUIDIC DEVICES ON A BOROSILICATE GLASS CHIP .................................................... 118 Y. Sugiyama, Y. Otsu, T. Ichiki and Y. Horiike LAMINATED ELECTRODES CHIP FOR PULSE-IMMUNOASSAY .................... 121 Takeshi Ooi, Yusuke Okabe, Masayuki Nakao and Keisuke Iwata FABRICATION OF ON-CHIP SORTER DEVICES WITH SUB-MICROMETER SCALE CHANNELS AND SELF-ALIGNED MICROELECTRODES ................... 124 T. Hara, T. Ichiki, Y. Horiike and K. Yasuda POWDER HANDLING DEVICE FOR DRUG FORMULATIONS ......................... 127 Torsten Vilkner and Andreas Manz xii
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