MHC + X: Complex Formation and Antibody Induction

267 Pages·1988·6.61 MB·English

by  Hyekyung Yang

Pavol Ivanyi (Ed,)
MHC+X
Complex Formation and Antibody Induction
With 63 Figures and 47 Tables
Springer-Verlag Berlin Heidelberg New York
London Paris Tokyo
PAVOL IVANYI, MD PhD
Central Laboratory of the Netherlands
Red Cross Blood Transfusion Service and
Laboratory for Experimental and Clinical Immunology
University of Amsterdam
1006 AD Amsterdam, The Netherlands
Proceedings of the Workshop-Symposium meeting held in Ommen/Amsterdam,
7~ 9 October 1987
Figure on the front cover: A blackboard drawing of Dr. j. L. Strominger
based on the data of Bjorkman, P.j. Saper, M. A. Samraoui, B., Bennett,
W.S., Strominger,j.L., and Wiley, D.C. (Nature, 329: 506,1987)
ISBN-13:978-3-642-74028-2 e-ISBN 13:978-3-642-74026-8
001: 10.1007/978-3-642-74026-8
Library of Congress Cataloging-in-Publication Data
MHC + X: complex formation and antibody induction/P.lvanyi, ed. p. cm. "Proceedings
of the workshop-symposium meeting held in Ommen/Amsterdam, 7-9 October
1987"-T.P. verso. Includes bibliographies and index.
ISBN-13:978-3-642-74028-2 (u. S.: alk. paper)
1. Major histocompatibility complex-Congresses, 2. MHC antibodies-Congresses,
3.lmmunoglobulins-Synthesis-Congresses. 4.lmmune response-Regulation-Congres
ses. I. Ivanyi, P. (Pavol). 1930- . II. Title: MCH plus X.
OR184.3.M53 1988 616.0T-dc19 88-26562 CIP
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Preface
After the discovery of the function of MHC molecules, namely to
provide the context for T cell recognition of foreign antigens, in
1974 Zinkernagel and Doherty made the first drawing of MHC+X
(Fig.1 from Zinkernagel and Doherty, Nature, 251: 547, 1974). Over
the next 18 years a very large number of similar drawings ensued,
some of real artistic beauty. One side of the problem, the nature of
the T cell receptor, was unraveled; however, we still do not know
exactly what kind of a structure the T cell receptor recognizes, al
though in 1987 we learned so much about the structure of MHC
molecules and antigen presentation. In schematic presentations no
one is now placing the foreign antigen beside the MHC molecule,
but rather on top of it, as pointed out by J. L. Strominger at the
MHC + X meeting in Paris. The complex of MHC and antigen is
named MHC + X, but the precise meaning of this formula remains a
"problem perplex", as illustrated in these proceedings by Peter Par
ham.
When planning the Ommen/Amsterdam meeting at the begin
ning of 1987, its major aim was seen as to discuss the question of
whether MHC + X can induce antibodies and, consequently, their
specificity. In other terms, whether - in analogy to antigen specific
MHC restricted T cells - MHC restricted antibodies also exist. There
must be no more hesitation about the existence of a new phenome
non, namely that injections of syngeneic virus infected cells in some
situations can induce MHC (class 1) specific antibodies. What is dis
puted and remains unclear is the mechanism by which these antibo
dies are triggered and, especially, what is their specificity. For our
meeting the problem was formulated as "MHC specific antibodies
induced by foreign antigen." We made every effort to bring together
researchers who have tackled these questions and contributed to a
solution of the problem. A reputable if not complete representation
was achieved, and I believe that this series of articles will guide
interested immunologists through the data scattered in the litera
ture.
VI Preface
Three other topics were included in the program: alloreactive Cll
induced by virus injections, naturally occurring MHC specific antibo
dies, and the antigenic determinants formed by the complex of
tJ2-microglobulin and the class I heavy chain. It is probably the first
time that data from various laboratories on these topics, appear in
one volume.
During the preparation of the meeting it became obvious that
very important new information is accruing on the nature of
MHC + X. A few presentations highlight recent developments on the
topic of peptide binding to MHC molecules. However, in this
volume the term MHC + X is extended by the inclusion of informa
tion other than that concerning only the binding of peptides into the
MHC groove. These data show that the MHC molecule possibly
interacts with other ligands as well (endorphins, volatiles, insulin
receptor). Thus while MHC + peptide data are represented to a
rather limited extent, the other "nonimmunological" functions of the
MHC molecules are brought fully to the reader's attention.
It was very interesting to organize this type of meeting at a time
when so much news is accumulating on MHC function.
I am thankful to the Research Director of the ClB (Prof. Dr. V. P.
EijsvoogeD and the Head of the Department of Immunohematology
(Prof. Dr. C. P. Engelfriet) for encouragement and help in organizing
the meeting. The assistance of the local organizing committee
(Femia Kievits, Marlies lutkie, T.J. F. Buunen, L. P. de Waal, and
O. Weiler) was invaluable, and the secretarial assistance of Wanda
Winkel was most helpful. Encouragement, advice, and support from
Springer-Verlag were of the utmost importance to the preparation of
the meeting and the proceedings.
Amsterdam, January 1988 PAVOL IVANYI
Acknowledgments
This meeting was organized and financially supported by the Dr.
Karl Landsteiner Foundation of the Central Laboratory of the Nether
lands Red Cross Blood Transfusion Service, Amsterdam.
Financial support was kindly provided by:
- Abbot Diagnostics Division, Amstelveen
v.,
- Ahrend B. Amsterdam
v.,
- Amstelstad B. Zwanenburg
v.,
- Beun de Ronde B. Abcoude
- Clean Air Techniek, Woerden
- Costar Europe Ltd., Badhoevedorp
- Depex, De Bilt
- Geostick Nederlandse Etikettenfabrik B. V., Uithoorn
v.,
- Gibco Europe B. Breda
- Harlan CPB, Indianapolis
- Koningin Wilhelmina Fonds, Amsterdam
- Linde Verpakkingsindustrie B. V., Denekamp
- F. Meinders, Amsterdam
- Nedalco, Bergen op Zoom
- Nier Stichting Nederland, Bussum
- Omnilabo Nederland B. V., Tiel
- Pharmacia Nederland B. V., Woerden
v.,
- Retsch N. Ochten
- Springer Verlag, Heidelberg
- Nederlandse Organisatie voor Zuiver Wetenschappelijk
Onderzoek (ZWO), Den Haag
v.,
- Zedek B. Deventer
Table of Contents
Induction of Allospecific Cytotoxic T Cells by Virus Infections
In Vivo
H. YA NC and R. M. WELSH. . . . . . . . . . . . . . . . . . . . . 1
Naturally Occurring H-2 Specific Antibodies
P.IVANYI, R. CERNY-PROVAZNIK, and P. C. VAN MOURIK 7
Naturally Occurring Anti-MHC Class I Antibodies in the Rat
E.GUNTHER ............................. 14
Naturally Occurring HLA Antibodies
M.M.ToNCIO, Y.MITSUISHI, AURLACHER, and S.MAYER . . . 18
Anti-Class I and Anti-Class II Antibodies with Monomorphic
Reaction Patterns in Non-alloimmunized Human Subjects
F.AMECLlO, R. SORRENTINO, A DOLEI, N. TANICAKI, and R. TOSI. .. 23
Antisera to "Modifying Factor" in Patients with Ankylosing
Spondylitis: The Present Situation
A VAN LEEUWEN, F. P. M.J. VAN BREE, c.J. BEUKELMAN, and
J.J. VAN ROOD. . . . . . . . . . . . . . . . . . . .. ...... 30
Recognition by Human B Cells of Foreign Antigen
in the Context of the MHC: a Review
E. GOULMY, A VAN LEEUWEN, and J.J. VAN ROOD . . . . . . . . . . . 34
Searching for MHC-Restricted Antibodies: Antibodies Induced
by Injections with Syngeneic Cells Coated with Sendai Virus,
Trinitrophenyl, and Xenogeneic P2-Microglobulin Are Not
Restricted by the Mouse MHC
F. KIEVITS, W.J. BOERENKAMP, and P.IVANYI . . . . . . . . . . . . .. 38
x
Table of Contents
Searching for MHC-Restricted Monoclonal Antibodies
Recognizing the Determinants Seen by Anti-Influenza Virus
Cytotoxic T-Lymphocyte Receptors
W. L. TA MMINEN and B. H. BARBER . . . . . . . . . . . . . . . . .. 50
Immunization with Fibroblasts Transfected
with a Cloned Retroviral DNA Induces H-2 Specific Antibodies
in Syngeneic Recipients
M. PLA, A. OPOlSKI, A. ROCCA, and L. DEGOS . . . . . . . . . . .. 61
Sendai Virus Infection of Tumor Cells Increases the Production
of Auto reactive H-2 Specific Antibodies in Syngeneic Recipients
A. OPOlSKI, L. DEGOS, and M. PLA. . . . . . . . . . . . . . . . .. 66
Immunization with Fibroblasts Expressing Human
P2-Microglobulin Induces H-2 Specific Antibodies in Syngeneic
Recipients
A. ROCCA, L. DEGOS, and M. PLA . . . . . . . . . . . . . . . . 72
MHC- Specific Monoclonal Antibodies Induced by Injection
of Syngeneic Leukemia Cells
W. SCHMIDT . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Monoclonal Antibodies to Murine tumors as Probes for Genetic
Analysis of Individually Specific Tumor Antigens
P. L. WARD and H. SCHREIBER. . . . . . . . . . . . . . . . . . . .. 85
Syngeneic Monoclonal Antibodies Against Chemically
Induced Tumors
A. GARRIDO, I. ALGARRA, C. DElGADO, A. CABALLERO, M. PEREZ,
and F. GARRIDO. . . . . . . . . . . . . . . . . . . . . .. ... 93
Effect of Anti-HLA Class I Monoclonal Antibodies on the
Proliferation of T Cells Induced by PHA-P. Comparison with the
Effect on T Cell Activation via the CD2 and CD3 Pathways
S.FERRONE, M.DE FELICE, M.C.TuRCO, L.CORBO, and S.VENUTA ... 100
A Monoclonal Antibody Induced by H-2 Syngeneic ConA
Blasts: Its Reactivity Pattern with Mouse and Human MHC
Class I Antigens
M.CRAMER, R.MiERAu, W.KUON, E.WEISS, and P.J.ROBINSON ... 107
+
A Problem Perplex, MHC X
P. PARHAM .............................. 114
Table of Contents XI
MHC -Restricted Antibodies: Facts and Interpretation
P.IVANYI and F.KIEVITS. . . . . . . . . . . . . . . .. . ..... 119
Biochemistry of HLA-B27 in Transfected Cells and
Transgenic Mice
E.J. BAAS, P.J. F. M. DERHAAC, and H. L. PLOECH .... .128
Interaction of the Qa Region with fJ2-Microglobulin and with
Non-Qa Genes in Determination of Qa Phenotype
M. OUDSHOORN-SNOEK, S. RACHOEBIER, L. FLAHERTY, and P. DEMANT 134
fJ2-Microglobulin and fJ-Galactosidase: A Real and a Surrogate
Minor Histocompatibility Antigen
H.-G. RAMMENSEE and U. T HEOPOLD ................. 138
Two Conformations of Ld Distinguished by Their Abilities
to Bind fJrMicroglobulin Are Synthesized, Processed, and
Expressed on the Cell Surface
N. B. MYERS, D. R. LEE, and T. H. HANSEN ........... '. ... 149
Selective Increase of the Expression of HLA Class I Molecules by
HLA-A3, HLA-B7, and HLA-Cw3 Transfected P815 Mastocytoma
Celis, with Subsequent Transfection by the Human
fJ2-Microglobulin Gene
B.PERARNAU, A GILLET, M.BARAD, R.HAKEM, and F.ALEMONNIER .. 161
Exposure of the W6/32-Defined Determinant on Mouse Cells Is
Dependent on the Interaction of Certain H-2 Heavy Chains with
Human or Bovine fJ2-Microglobulin
F. KIEVITS, W.J. BOERENKAMP, and P.IVANYI .............. 166
The Role of fJ2-Microglobulin and Class I HLA Heavy Chain in
Cytomegalovirus Infection
J.E.GRUNDY, j.AMcKEATINC, and P.D.GRIFFITHS .......... 171
Structural Requirements of an Ovalbumin-Derived
Immunogenic Peptide for T Cell Activation and Interaction
with lAd
A. SEnE, S. Buus, and H. M. GREY .................. 178
Analysis of Specificities Recognized by Monoclonal Antibodies
and Cytotoxic T-Lymphocytes Using Chimeric H-2 Molecules
J.P.ABASTADO,j.MARYANSKI, C.jAULIN, and P.KOURILSKY ....... 186
The Conformational Flexibility and fJrMicroglobulin Interaction
Dynamics of the H-2Kb Heavy Chain
B.H.BARBER, M.H.SMITH, H.ALLEN, and D.B.WILLIAMS ....... 193
XII Table of Contents
Models for MHC -Restricted T Cell Recognition of a Synthetic
H-2Ld Peptide
E. S. SONG, R. LINSK, and R. S. GOODENOW . . . . . . . . . . . . . . 206
Endorphin Receptors and HLA Class I Molecules
F. H.J. CLAAS, W. VERDUYN, M. MOMMAAS-KIENHUIS,
W. M. A. VERHOEVEN, J. M. VAN REE, and J.J. VAN ROOD ....... 214
MHC Class I-Insulin Receptor Interaction in the Cell Membrane
M. L. PHilLIPS, M. L. MOUlE, and C. C. YIP .............. 218
Soluble Classical Class I MHC Antigens in Solution in the Body
Fluids
P. B. SINGH, R. E. BROWN, and B.J. ROSER ............... 226
Is There Room for a Neutralistic View on MHC Polymorphism?
L. P. D~ WAAl ............................ 241
Subject Index ............................. 245