Meyler's Side Effects of Herbal Medicines(Meylers Side Effects)

312 Pages·2008·3.7 MB·English

by  Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon)

Meyler’s Side Effects of Herbal Medicines
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Meyler’s Side Effects of
Herbal Medicines
Editor
J K Aronson, MA, DPhil, MBChB, FRCP, FBPharmacolS, FFPM (Hon)
Oxford, United Kingdom
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Contents
Preface vii
Herbal Medicines - Introduction and General Information 1
Herbal Medicines - Acanthaceae - Zygophyllaceae 31
Compounds found in Herbal products 237
Index of drug names 297
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Preface everyfouryears.The15theditionwaspublishedin2006,
inbothhardandelectronicversions.
This volume covers the adverse effects of herbal medi-
cines.ThematerialhasbeencollectedfromMeyler’sSide
Effects of Drugs: The International Encyclopedia of Monograph structure
Adverse Drug Reactions and Interactions (15th edition,
2006,insixvolumes),whichwasitselfbasedonprevious This volume starts with a general section on the adverse
editions of Meyler’s Side Effects of Drugs, and from the effects of herbal medicines, which is followed by mono-
SideEffectsofDrugsAnnuals(SEDA)28,29,and30.The graphs on individual herbal products, each of which has
main contributors of this material were JK Aronson, thefollowingstructure:
PAGMdeSmet,EErnst,andMPittler. (cid:2) Family:eachmonographisorganizedunderafamilyof
plants(forexampleLiliaceae).
(cid:2) Genera:thevariousgenerathatareincludedunderthe
A brief history of the Meyler series
family name are tabulated (for example the family
Liliaceaecontains94genera);themajorsourceofinfor-
Leopold Meyler was a physician who was treated for
mation on families and genera is the Plants National
tuberculosis after the end of the Nazi occupation of The
Database(http://plants.usda.gov/index.html).
Netherlands.AccordingtoProfessorWimLammers,writ-
(cid:2) Species:ineachmonographsomespeciesaredealtwith
ing a tribute in Volume VIII (1975), Meyler got a fever
separately. For example, in the monograph on
from para-aminosalicylic acid, but elsewhere Graham
Liliaceae, four species are included under their Latin
Dukes has written, based on information from Meyler’s
names and major common names—Sassafras albidum
widow, that it was deafness from dihydrostreptomycin;
(sassafras), Allium sativum (garlic), Colchicum autum-
perhaps it was both. Meyler discovered that there was
nale (autumn crocus), and Ruscus aculeatus (butcher’s
no single text to which medical practitioners could look
broom).
for information about unwanted effects of drug therapy;
Louis Lewin’s text ‘‘Die Nebenwirkungen der Each monograph includes the following information in
Arzneimittel’’ (‘‘The Untoward Effects of Drugs’’) of varyingamounts:
1881 had long been out of print (SEDA-27, xxv-xxix).
(cid:2) Alternativecommonnames;themajorsourcesofthisinfor-
Meyler therefore determined to make such information
mation are A Modern Herbal by Mrs M Grieve (1931;
availableandpersuadedtheNetherlandspublishingfirm
http://www.botanical.com/botanical/mgmh/mgmh.html)
of Van Gorcum to publish a book, in Dutch, entirely
and The Desktop Guide to Complementary and
devoted to descriptions of the adverse effects that drugs
Alternative Medicine: an Evidence-Based Approach
could cause. He went on to agree with the Elsevier
by E Ernst, MH Pittler, C Stevenson, and A White
Publishing Company, as it was then called, to prepare
(Mosby, 2001).
and issue an English translation. The first edition of 192
(cid:2) Activeingredients;themajorsourceofthisinformation
pages(SchadelijkeNevenwerkingenvanGeneesmiddelen)
is the Dictionary of Plants Containing Secondary
appearedin1951andtheEnglishversion(SideEffectsof
MetabolitesbyJohnSGlasby(Taylor&Francis,1991).
Drugs)ayearlater.
(cid:2) Uses,includingtraditionalandmodernuses.
The book was a great success, and a few years later
(cid:2) Adverseeffects.
Meyler started to publish what he called surveys of
(cid:2) References.
unwantedeffectsofdrugs.Eachsurveycoveredaperiod
oftwotofouryears.Theywerelabelledasvolumesrather Thefamilies ofplants andtheirspeciesthatare the sub-
than editions, and after Volume IV had been published jectsofmonographsarelistedinTable2(p.14)byalpha-
Meyler could no longer handle the task alone. For sub- beticalorderoffamily.ThesamedataarelistedinTable3
sequent volumes he recruited collaborators, such as (p. 17) by alphabetical order of species. Other mono-
Andrew Herxheimer. In September 1973 Meyler died graphscoveroneoftheBasidiomycetes(Lentinusedodes,
unexpectedly, and Elsevier invited Graham Dukes to shiitake)andalgae.Table4(p.20)givestheLatinequiva-
takeovertheeditingofVolumeVIII. lents of the common names. To locate a plant by its
DukespersuadedElsevierthatthepublishedliterature common name, convert the common name into the
was too large to be comfortably encompassed in a four- Latin name using Table 4 and then find out to which
yearlycycle,andhesuggestedthatthevolumesshouldbe familyitbelongsbyconsultingTable3.
producedannuallyinstead.Thefour-yearlyvolumecould
then concentrate on providing a complementary critical
encyclopaedic survey of the entire field. The first Side Drug names
EffectsofDrugsAnnualwaspublishedin1977.Thefirst
encyclopaedic edition of Meyler’s Side Effects of Drugs, Drugs have usually been designated by their recom-
which appeared in 1980, was labelled the ninth edition, mended or proposed International Non-proprietary
andsincethenanewencyclopaediceditionhasappeared Names (rINN or pINN); when these are not available,
viii Preface
chemical names have been used. In some cases brand Cross-references
nameshavebeenused.
ThevariouseditionsofMeyler’sSideEffectsofDrugsare
citedinthetextasSED-l3,SED-14,etc;theSideEffectsof
DrugsAnnualsarecitedasSEDA-1,SEDA-2,etc.
Spelling
JKAronson
Forindexingpurposes,Americanspellinghasbeenused,
Oxford,May2008
e.g.anemia,estrogenratherthananaemia,oestrogen.
Herbal Medicines – Introduction and General Information