Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (Meylers Side Effects)

703 Pages·2009·5.45 MB·English

by  Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon)

Meyler’s Side Effects of Analgesics and
Anti-inflammatory Drugs
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Meyler’s Side Effects of
Analgesics and Anti-
inflammatory Drugs
Editor
J K Aronson, MA, DPhil, MBChB, FRCP, FBPharmacolS, FFPM (Hon)
Oxford, United Kingdom
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Contents
Preface vii
Opioid Receptor Agonists and Antagonists 1
Salicylates, Paracetamol, and Other Non-Opioid Analgesics 165
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) 223
Glucocorticoids and Disease – Modifying Antirheumatic Drugs 371
Drugs Used in the Treatment of Gout 669
Index of drug names 687
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Preface andsincethenanewencyclopaediceditionhasappeared
everyfouryears.The15theditionwaspublishedin2006,
This volume covers the adverse effects of analgesic inbothhardandelectronicversions.
medicines.ThematerialhasbeencollectedfromMeyler’s
Side Effects of Drugs: The International Encyclopedia of
Adverse Drug Reactions and Interactions (15th edition,
Monograph structure
2006, in six volumes), which was itself based on previous
editions of Meyler’s Side Effects of Drugs, and from the Each of the monographs on herbal products in this
SideEffectsofDrugsAnnuals(SEDA)28,29,and30.The volumehasthefollowingstructure:
main contributors of this material were JK Aronson,
(cid:2) Family:eachmonographisorganizedunderafamilyof
PAGMdeSmet,EErnst,andMPittler.
plants(forexampleLiliaceae).
(cid:2) Genera:thevariousgenerathatareincludedunderthe
A brief history of the Meyler series family name are tabulated (for example the family
Liliaceaecontains94genera);themajorsourceofinfor-
Leopold Meyler was a physician who was treated for mation on families and genera is the Plants National
tuberculosis after the end of the Nazi occupation of The Database(http://plants.usda.gov/index.html).
Netherlands.AccordingtoProfessorWimLammers,writ- (cid:2) Species:ineachmonographsomespeciesaredealtwith
ing a tribute in Volume VIII (1975), Meyler got a fever separately. For example, in the monograph on
from para-aminosalicylic acid, but elsewhere Graham Liliaceae, four species are included under their Latin
Dukes has written, based on information from Meyler’s names and major common names—Sassafras albidum
widow, that it was deafness from dihydrostreptomycin; (sassafras), Allium sativum (garlic), Colchicum autum-
perhaps it was both. Meyler discovered that there was nale (autumn crocus), and Ruscus aculeatus (butcher’s
no single text to which medical practitioners could look broom).
for information about unwanted effects of drug therapy;
Each monograph includes the following information in
Louis Lewin’s text ‘‘Die Nebenwirkungen der
varyingamounts:
Arzneimittel’’ (‘‘The Untoward Effects of Drugs’’) of
1881 had long been out of print (SEDA-27, xxv-xxix). (cid:2) Alternativecommonnames;themajorsourcesofthisinfor-
Meyler therefore determined to make such information mation are A Modern Herbal by Mrs M Grieve (1931;
availableandpersuadedtheNetherlandspublishingfirm http://www.botanical.com/botanical/mgmh/mgmh.html)
of Van Gorcum to publish a book, in Dutch, entirely and The Desktop Guide to Complementary and
devoted to descriptions of the adverse effects that drugs Alternative Medicine: an Evidence-Based Approach
could cause. He went on to agree with the Elsevier by E Ernst, MH Pittler, C Stevenson, and A White
Publishing Company, as it was then called, to prepare (Mosby, 2001).
and issue an English translation. The first edition of 192 (cid:2) Activeingredients;themajorsourceofthisinformation
pages(SchadelijkeNevenwerkingenvanGeneesmiddelen) is the Dictionary of Plants Containing Secondary
appearedin1951andtheEnglishversion(SideEffectsof MetabolitesbyJohnSGlasby(Taylor&Francis,1991).
Drugs)ayearlater. (cid:2) Uses,includingtraditionalandmodernuses.
The book was a great success, and a few years later (cid:2) Adverseeffects.
Meyler started to publish what he called surveys of
Thefamilies ofplants andtheirspeciesthatare the sub-
unwantedeffectsofdrugs.Eachsurveycoveredaperiod
jects of monographs are listed in Table 3 (p. 000) by
oftwotofouryears.Theywerelabelledasvolumesrather
alphabetical order of family. The same data are listed in
than editions, and after Volume IV had been published
Table 4 (p. 000) by alphabetical order of species. Other
Meyler could no longer handle the task alone. For sub-
monographs cover the Basidiomycetes (Lentinus edodes,
sequent volumes he recruited collaborators, such as
shiitake) and algae. Table 5 (p. 000) gives the Latin
Andrew Herxheimer. In September 1973 Meyler died
equivalents of the common names. To locate a plant by
unexpectedly, and Elsevier invited Graham Dukes to
its common name, convert the common name into the
takeovertheeditingofVolumeVIII.
Latin name using Table 5 and then find out to which
DukespersuadedElsevierthatthepublishedliterature
familyitbelongsbyconsultingTable4.
was too large to be comfortably encompassed in a four-
yearlycycle,andhesuggestedthatthevolumesshouldbe
producedannuallyinstead.Thefour-yearlyvolumecould
then concentrate on providing a complementary critical Drug names
encyclopaedic survey of the entire field. The first Side
EffectsofDrugsAnnualwaspublishedin1977.Thefirst Drugs have usually been designated by their recom-
encyclopaedic edition of Meyler’s Side Effects of Drugs, mended or proposed International Non-proprietary
which appeared in 1980, was labelled the ninth edition, Names (rINN or pINN); when these are not available,
ª2010ElsevierB.V.Allrightsreserved.
viii Preface
chemical names have been used. In some cases brand Cross-references
nameshavebeenused.
ThevariouseditionsofMeyler’sSideEffectsofDrugsare
citedinthetextasSED-l3,SED-14,etc;theSideEffectsof
DrugsAnnuals1–22arecitedasSEDA-1,SEDA-2,etc.
Spelling
JKAronson
Forindexingpurposes,Americanspellinghasbeenused, OxfordMay2008
e.g.anemia,estrogenratherthananaemia,oestrogen.
ª2010ElsevierB.V.Allrightsreserved.
OPIOID RECEPTOR AGONISTS AND ANTAGONISTS