Methods in Mammary Gland Biology and Breast Cancer Research PDF
Preview Methods in Mammary Gland Biology and Breast Cancer Research
Methods in Mammary Gland Biology and Breast Cancer Research Committee on Mammary Gland Biology Sandra A. Haslam, Chair Margaret C. Neville, Executive Secretary Carlos Arteaga Margot M. Ip Bonnie B. Asch Edison Liu Dale E. Bauman Ian Mather Kermit Carraway Daniel Medina Robert Clarke Malcolm Peaker Joanne T. Emerman Jeffrey Rosen Armond Goldman David Salomon Bernd Groner ~oyd Schanbacher Howard Hosick Charles Streuli Nancy E. Hynes Barbara K. Vonderhaar Methods in Mammary Gland Biology and Breast Cancer Research Edited by Margot M. Ip and Bonnie B. Asch Roswell Park Cancer Research Institute Buffalo, New York Springer Science+Business Media, LLC Library of Congress Cataloging-in-Publication Data Methods in mammary gland biology and breast cancer researchledited by Margot M. lp and Bonnie B. Asch. p. cm. Result of a meeting held in 1997 entitled: "Gordon Conference on Mammary Gland Biology". lncludes bibliographical references and index. ISBN 978-1-4613-6927-1 ISBN 978-1-4615-4295-7 (eBook) DOI 10.1007/978-1-4615-4295-7 1. Breast-Cancer-Laboratory manuals. 2. Breast-Physiology-Laboratory manuals. 1. Ip, Margot M. II. Asch, Bonnie B. III. Gordon Conference on Mammary Gland Biology (1997) RC280.B8 M48 2000 616.99' 449-dc21 00-025889 A publication of the Committee on Mammary Gland Biology ISBN 978-1-4613-6927-1 ©2ooo Springer Science+Business Media New York OriginalJy published by Kluwer Academic/Plenum Publishers in 2000 10987654321 A C.I.P. record for this book is available from the Library of Congress AU rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, Of otherwise, without written permission from the Publisher. Contributors Domenico Accili Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Cheryl A. Ammerman Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109-0984 Neal Beeman Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado 80262 Joel Brody Department of Anatomy, University of California, San Francisco, California 94143 Gerald R. Cunha Department of Anatomy, University of California, San Francisco, California 94143 Trevor Dale Institute of Cancer Research, The Breakthrough Toby Robins Breast Cancer Centre, London, SW3 6JB England Charles W. Daniel Department of Biology, University of California, Santa Cruz, California 95065 Kathleen M. Darcy GOG Statistical and Data Office, Roswell Park Cancer Institute, Buffalo, New York 14263 Michele L. Dziubinski Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109-0984 Connie J. Eaves Department of Medical Genetics, University of British Columbia, Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada Stephen B. Edge Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263 Joanne T. Emerman Department of Anatomy, University of British Columbia, Vancou- ver, British Columbia V6T 1Z3 Canada Stephen P. Ethier Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109-0984 v vi Contributors Priscilla A. Furth Institute of Human Virology and Division of Infectious Diseases, Department of Medicine and Department of Physiology, University of Maryland Medical School, Baltimore, Maryland 21201 Erika Ginsburg Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Michael N. Gould University of Wisconsin Comprehensive Cancer Center and McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53792 Raphael C. Guzman Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 Lothar Hennighausen Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Gloria H. Heppner Karmanos Cancer Institute and School of Medicine, Detroit, Michi- gan 48201 Yun Kit Hom Department of Anatomy, University of California, San Francisco, California 94143 Russell C. Hovey Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Thelma C. Hurd Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263 Walter Imagawa Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 Margot M. Ip Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263 Frances Kittrell Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas 77030 Ping-Ping H. Lee Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263 Michael Lewis Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado 80262 Minglin Li Institute of Human Virology and Division of Infectious Diseases, Depart ment of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201 Daniel Medina Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas 77030 Fred R. Miller Karmanos Cancer Institute and School of Medicine, Wayne State University, Detroit, Michigan 48201 Contributors vii Shigeki Miyamoto Department of Pharmacology, University of Wisconsin Clinical Science Center, Madison, Wisconsin 53792 Satyabrata Nandi Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 Margaret C. Neville Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado 80262 Duy-Ai Nguyen Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado 80262 Susan B. Rasmussen Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Elizabeth A. Repasky Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263 Gertraud W. Robinson Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Edmund B. Rucker III Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Jerome Schaack Department of Physiology, University of Colorado Health Sciences Center, Denver, Colorado 80262 Gary B. Silberstein Department of Biology, University of California, Santa Cruz, California 95065 Harry K. Slocum Tissue Procurement Facility, Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263 Gilbert H. Smith Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 John Stingl Department of Anatomy, University of British Columbia, Vancouver, British Columbia V6T lZ3 Canada Henry J. Thompson Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Lakewood, Colorado 80214 Todd A. Thompson University of Wisconsin Comprehensive Cancer Center and McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53792 Barbara K. Vonderhaar Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Kay-Uwe Wagner Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; Current address: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805 viii Contributors Steven Weber-Hall Institute of Cancer Research, The Breakthrough Toby Robins Breast Cancer Centre, London, SW3 6JB England Yan Xu Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263 Jason Yang Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, California 94720 Lawrence J. T. Young Center for Comparative Medicine, University of California-Davis, Davis, California 95616 Peter Young Department of Anatomy, University of California, San Francisco, Califor- nia 94143 Danilo Zangani Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263 Foreword from the Committee on Mammary Gland Biology The Committee on Mammary Gland Biology was formed in the 1980s to promote research and communication among scientists in all the varied specialities necessary to understand the development, function, and diseases of the mammary gland. It has met regularly since that time, with a constantly shifting membership, mainly in conjunction with the Gordon Con ference on Mammary Gland Biology. In 1987 the Committee sponsored the publication of a book The Mammary Gland, edited by Charles Daniel and Margaret Neville. In 1993 the Com mittee recognized the need for more extensive communication among members of the com munity of mammary gland biologists and founded the Journal of Mammary Gland Biology and Neoplasia, a review journal currently in its fifth year of publication. The present book grew out of a meeting of the Editorial Board of The Journal of Mammary Gland Biology and Neoplasia at the 1997 Gordon Conference on Mammary Gland Biology, at which a number of members expressed their frustration with the lack of a generally available source for methods for investigation of the mammary gland and breast cancer. The advantages of such an organ for studies of the development and for modeling of mammary tumorigenesis in vitro and in vivo, if we are to develop a rational approach to breast cancer, were universally clear. What was not clear were the technical details involved in the use of this marvelous organ to advance our understanding of both develop ment and carcinogenesis. This need was reaffirmed at a second meeting ofthe Editorial Board held in Bethesda two weeks later. Soon thereafter Margot Ip and Bonnie Asch agreed to edit this volume, and they began what seemed like an endless task of recruiting authors, review ing and editing submitted chapters for consistency and clarity, collecting diskettes and per mission forms, and, finally, making sure that every article provided meaningful and up-to-date information. The Committee on Mammary Gland Biology is now happy to present this long overdue compilation of methods in the field. Some, like transplantation into the cleared fat pad, are old enough to earn the appellation classic. Others, like the use of viral. transduction, are still under development. Some are quite difficult and require considerable experience. Others are almost a matter of common sense, once the details of the approach are presented. This book is intended as a bench manual, so materials are carefully described and each step of the procedure carefully laid out in a volume that will lie flat on the laboratory bench. Where pitfalls and limitations are present, they are outlined. Where a technique shows promise that has not yet been realized, potential uses are illustrated. We feel sure that the techniques presented here will promote outstanding research, as well as the development of new ix x Foreword approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc., in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology
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