Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management PDF
Preview Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management
METASTATIC DISEASES Novel Approaches in Diagnosis and Therapeutic Management METASTATIC DISEASES Novel Approaches in Diagnosis and Therapeutic Management Edited by Sandeep Arora, PhD Co-Edited by Tapan Behl, PhD Sukhbir Singh, PhD Neelam Sharma, PhD Saurabh Gupta, PhD First edition published 2022 Apple Academic Press Inc. CRC Press 1265 Goldenrod Circle, NE, 6000 Broken Sound Parkway NW, Palm Bay, FL 32905 USA Suite 300, Boca Raton, FL 33487-2742 USA 4164 Lakeshore Road, Burlington, 2 Park Square, Milton Park, ON, L7L 1A4 Canada Abingdon, Oxon, OX14 4RN UK © 2022 Apple Academic Press, Inc. Apple Academic Press exclusively co-publishes with CRC Press, an imprint of Taylor & Francis Group, LLC Reasonable efforts have been made to publish reliable data and information, but the authors, editors, and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library and Archives Canada Cataloguing in Publication CIP data on file with Canada Library and Archives Library of Congress Cataloging‑in‑Publication Data Names: Arora, Sandeep, 1967- editor. | Behl, Tapan, editor. | Singh, Sukhbir, 1984- editor. | Sharma, Neelam, 1986- editor. | Gupta, Saurabh (Pharmacologist), editor. Title: Metastatic diseases : novel approaches in diagnosis and therapeutic management / edited by Sandeep Arora ; co-edited by Tapan Behl, Sukhbir Singh, Neelam Sharma, Saurabh Gupta. Description: 1st edition. | Palm Bay, FL : Apple Academic Press, 2021. | Includes bibliographical references and index. | Summary: “Metastatic Diseases: Novel Approaches in Diagnosis and Therapeutic Management opens new horizons for exploring modern therapeutic entities and emerging targets for combating the deadly disease of cancer. The authors provide a review of cancer along with descriptions of its molecular level mechanisms and emphasize the role of promising new therapies, including herbal therapies that can be utilized for the treatment of metastatic diseases. The chapters look at specific approaches that have been researched and developed and that have almost reached the standardization stage. One of the approaches focuses on intracellular mechanisms, particularly proteins, and the pathway involving or being regulated by the proteins that limit the metastatic cellular growths. In particular phosphoprotein enriched astrocytes are being extensively tried. Also discussed is transerythretin protein, which has been significantly studied for its involvement in formation and transportation of proteins in metastatic diseases. Other receptors and approaches examined include CXCR4, autophagy-inhibiting drugs, phosphoprotein-enriched astrocytes, spatiotemporal genetic analysis, tyrosine kinase inhibitors, and more. Also considered are advances in diagnostic systems like intra vital microscopy and molecular imaging, which further add to the arsenal in metastatic diseases, diagnosis, and management along with techniques like SAGA. These diagnostic methods and innovative methods of intervention by modification of epigenetic control of the immune system using immune checkpoint inhibitor s and phytopharmaceuticals provide newer and better dimensions to treatment of metastatic diseases. Key features: Discusses promising new therapies, including herbal therapies, for the treatment of metastatic diseases Explains the new areas that are widely explored by scientists, researchers, and scholars throughout the globe Explores new therapeutic molecules for cancer treatment The selection of appropriate treatment strategies presented in this volume provide deep insight into the adverse effects and contraindications that will be of immense benefit in the treatment and management of detrimental effects of this deadly disease. The volume will be beneficial for major laboratories working on cancer research and will also serve as a guide for researchers to explore new targets that can be beneficial for mankind”-- Provided by publisher. Identifiers: LCCN 2020049549 (print) | LCCN 2020049550 (ebook) | ISBN 9781771889179 (hardcover) | 9781774638071 (softcover) | ISBN 9781003043249 (ebook) Subjects: MESH: Neoplasm Metastasis--diagnosis | Neoplasm Metastasis--drug therapy Classification: LCC RC263 (print) | LCC RC263 (ebook) | NLM QZ 203 | DDC 616.99/4--dc23 LC record available at https://lccn.loc.gov/2020049549 LC ebook record available at https://lccn.loc.gov/2020049550 ISBN: 978-1-77188-917-9 (hbk) ISBN: 978-1-77463-807-1 (pbk) ISBN: 978-1-00304-324-9 (ebk) DOI: 10.1201/9781003043249 About the Editor Sandeep Arora, PhD Dean, Chitkara College of Pharmacy, Chitkara University, Punjab, India; Professor, Healthcare, Chitkara University, Rajpura, Punjab, India Sandeep Arora, PhD, MPharm, is Dean/Director of the Chitkara College of Pharmacy at Chitkara University, Punjab, India, as well Professor of Healthcare at Chitkara University, Rajpura, Punjab, India. He is also an industrial consul- tant. Dr. Arora is a seasoned pharma and academic professional with over 27 years of experience in pharma operations, quality management, academ- ics, training, research, and consultancy planning and administration. An avid researcher and writer, he has published four books and 150 research publi- cations (h index 17). He holds 18 patents and four trademarks, and has one registered company to his credit. He is an honorary editor of the journal Advanced Drug Review, editor of the Journal of Pharmaceutical Technology, Research, and Management, and honorary technical director and advisor to Natural Solutions, Mumbai, India. He and his team has received an IEDC (International Economic Development Council), Government of India, pro- totyping grant for his project related to the management of acute respira- tory distress syndrome in COVID during Novate+ 2020, held at Chitkara University, Punjab, India. He and his team were shortlisted and eligible to apply for sustainability allowance from the Startup Himachal HACKATHON 2020, his project held at Chitkara University. He has delivered sessions as expert or keynote speaker and has chaired international conferences (University of Florida, Pfizer-IPA CPD Sessions, OMICS, and Conference Series Conferences at Thailand) on various topics relevant to pharmaceutical industry trends, technology, phytopharmaceuticals, regulatory affairs, etc. In addition to his pharmaceutical degrees, he also has certifications in business development, business strategy, EHS, and pharmacy technology. About the Co-Editors Tapan Behl, PhD Associate Professor, Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India Tapan Behl, PhD, MPharm, is currently working as an Associate Professor in the Department of Phar- macology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India. Dr. Behl carries a professional experience of over eight years in academics and research. His areas of interest include diabetes and associated complications, rheumatoid arthritis, preclinical ethical considerations, molecular pharmacology, phar- macotherapy for diabetic complications of the eye, drug transfusion across ocular barriers, and neuropathic pain and rheumatoid arthritis. Dr. Behl has more than 75 publications in various international and national journals of repute. He is also the author of two international books and has various book chapters to his credit. He has been invited as a guest speaker at various international and national conferences. Dr. Behl represents India as a voting delegate during the IUPHAR meeting and selection of IUPHAR 2026 in Kyoto, Japan. Dr. Behl has received many prestigious honors and awards for his work and academic excellence, including Academician of the Year Award–2018, Fellow of Society of Biomedical Laboratory Scientists, etc. He is also serving as a reviewer of many reputed journals in his field. Dr. Behl is also engaged in guiding students for their doctoral (PhD) work. viii About the Co-Editors Sukhbir Singh, PhD Associate Professor, Chitkara College of Pharmacy, Chitkara University, Punjab, India; Associate Head, Centre of Excellence, Phytopharmaceutical, Chitkara College of Pharmacy, Chitkara University, Punjab, India. Sukhbir Singh, PhD in Pharmaceutical Science, is a pharmaceutical research professional with more than 12 years of experience in academics and research. Presently, he is Associate Professor and Associate Head, Centre of Excellence, Phytopharmaceutical, at the Chitkara College of Pharmacy, Chitkara University, Punjab, India. He is associated with industry-oriented courses held in collaboration with Chitkara University and established pharmaceutical industries, such as Dr. Reddy’s Laboratories. He has 100 publications in various national and international journals (h-index 12 and I 10-index 13) and has published four books and 10 book chapters. He also has filed 12 patents to his credit. He has presented/ published 40 review/research abstracts in various national/international conferences. He is also engaged with for consultancy projects on herbal/ homeopathic formulations. He is an associate editor of Open Access Journal of Pharmaceutical Research. In 2017, he was been honored with a Research Excellence Award by the Honorable Chancellor of Chitkara University. He and his team has received an IEDC (International Economic Development Council), Government of India, prototyping grant for his project related to the management of acute respiratory distress syndrome in COVID during Novate+ 2020, held at Chitkara University, Punjab, India. He and his team were shortlisted and eligible to apply for sustainability allowance from the Startup Himachal HACKATHON 2020, his project held at Chitkara Univer- sity. He has guided 16 MPharmacy students and 6 PhD students. His areas of interest in research are nanotechnology/liposome/niosomes/SEDDS based formulation development and solubility enhancement of BCS class II drugs. He has expertise in operation of various statistical analyses tools. About the Co-Editors ix Neelam Sharma, PhD Associate Professor, Chitkara College of Pharmacy, Chitkara University, Punjab, India; Associate Head, Centre of Excellence, Pharma Tech and Nanotechnology, Chitkara College of Pharmacy, Chitkara University, Punjab, India Neelam Sharma, PhD in Pharmaceutical Science, is a pharmaceutical research professional with experience of more than 10 years in academics and research. Currently, she Associate Professor at the Chitkara College of Pharmacy, Chitkara University, Punjab, and Associate Head, Centre of Excellence, Pharma Tech and Nanotechnology, Chitkara College of Pharmacy, Chitkara University, Punjab, India. She has 90 publications in various national and international journals, three books, and 10 book chapters, and has filed 12 patents to her credit (h-index 9 and I-10-index 9. She has presented and published 40 review/research abstracts in various national/international conferences. She is engaged in four consul- tancy projects on herbal/homeopathic formulations. In 2016, she has been awarded a Certificate of Inventorship for her novel invention. She has super- vised 10 M. Pharmacy students, and three students are pursuing PhDs under her guidance. She and her team (Dr. Sandeep Arora and Dr. Sukhbir Singh) have an IEDC (International Economic Development Council), Government of India, prototyping grant for the project related to the management of acute respiratory distress syndrome in COVID during Novate+ 2020, held at Chit- kara University, Punjab, India, with an opportunity to pitch for university funding for research by Chitkara University Punjab. She and her team are shortlisted and eligible to apply for sustainability allowance from Startup Himachal HACKATHON 2020, for her project held at Chitkara University, Punjab. Her areas of interest in research are novel drug delivery systems such as nanoparticles, liposomes, phytosomes and solubility enhancement of BCS class II drugs. She also has expertise in operation of various statistical analyses tools.
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