ebook img

Metal Nanoparticles: Synthesis and Applications in Pharmaceutical Sciences PDF

304 Pages·2018·6.722 MB·English
Save to my drive
Quick download
Download
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.

Preview Metal Nanoparticles: Synthesis and Applications in Pharmaceutical Sciences

MetalNanoparticles Metal Nanoparticles SynthesisandApplicationsinPharmaceuticalSciences EditedbySreekanthThotaandDebbieC.Crans Editors AllbookspublishedbyWiley-VCHare carefullyproduced.Nevertheless,authors, Prof.SreekanthThota editors,andpublisherdonotwarrantthe FundaçãoOswaldoCruz–Centerfor informationcontainedinthesebooks, TechnologicalDevelopmentinHealth includingthisbook,tobefreeoferrors. (CDTS) Readersareadvisedtokeepinmindthat Av.Brazil,4036–PrédiodaExpansão statements,data,illustrations,procedural 8Andar–Sala814 detailsorotheritemsmayinadvertently Manguinhos beinaccurate. RiodeJaneiro21040-361 Brazil LibraryofCongressCardNo.:appliedfor Prof.DebbieC.Crans BritishLibraryCataloguing-in-Publication ColoradoStateUniversity Data DepartmentofChemistry Acataloguerecordforthisbookisavail- 1872Campusdelivery ablefromtheBritishLibrary. CO UnitedStates Bibliographicinformationpublishedby theDeutscheNationalbibliothek CoverCredits:shutterstock/KaterynaKon TheDeutscheNationalbibliothek liststhispublicationintheDeutsche Nationalbibliografie;detailed bibliographicdataareavailableonthe Internetat<http://dnb.d-nb.de>. ©2018Wiley-VCHVerlagGmbH&Co. KGaA,Boschstr.12,69469Weinheim, Germany Allrightsreserved(includingthoseof translationintootherlanguages).Nopart ofthisbookmaybereproducedinany form–byphotoprinting,microfilm,or anyothermeans–nortransmittedor translatedintoamachinelanguage withoutwrittenpermissionfromthe publishers.Registerednames,trademarks, etc.usedinthisbook,evenwhennot specificallymarkedassuch,arenottobe consideredunprotectedbylaw. PrintISBN:978-3-527-33979-2 ePDFISBN:978-3-527-80706-2 ePubISBN:978-3-527-80708-6 MobiISBN:978-3-527-80707-9 oBookISBN:978-3-527-80709-3 CoverDesign SchulzGrafik-Design, Fußgönheim,Germany Typesetting SPiGlobal,Chennai,India PrintingandBinding Printedonacid-freepaper 10987654321 v Contents 1 Introduction 1 SreekanthThotaandDebbieC.Crans 1.1 HistoryofMetalComplexes 1 1.1.1 Introduction 1 1.1.2 MetalComplexes 1 1.1.3 MetalComplexesinMedicine 2 1.2 Nanotechnology 2 1.2.1 Introduction 2 1.2.2 DevelopmentofNanotechnology 2 1.2.3 NanotechnologyinMedicine 3 1.3 Nanoparticles 4 1.3.1 Introduction 4 1.3.2 DevelopmentofNanoparticles 5 1.3.2.1 Liposome-BasedNanoparticles 5 1.3.2.2 PolymericNanoparticles 5 1.3.2.3 MetalNanoparticles 5 1.3.3 NanoparticlesinScienceandMedicine 6 1.4 Nanotechnology-SupportedMetalNanoparticles 7 Acknowledgment 7 References 7 2 MethodsforPreparationofMetalNanoparticles 15 SiavashIravani 2.1 Introduction 15 2.2 MethodsforPreparationofMetallicNPs 15 2.2.1 PhysicalandChemicalMethods 15 2.2.2 GreenandBio-basedStrategies 19 2.3 Conclusion 24 References 24 3 MetalNanoparticlesasTherapeuticAgents:AParadigmShift inMedicine 33 MahendraRai,DipaliNagaonkar,andAvinashP.Ingle 3.1 Introduction 33 vi Contents 3.2 MetalNanoparticlesinDiagnostics 35 3.2.1 NanoparticlesasBiolabels 35 3.2.2 NanoparticulateDetectionofProteins 35 3.2.3 Nanobiosensing 36 3.2.4 InvivoImaging 37 3.3 AdvancedDrugDelivery 38 3.4 Nanoparticle-MediatedGeneTransfer 39 3.5 NanotechnologyinRegenerativeTherapies 41 3.5.1 TissueEngineeringandImplants 41 3.5.2 BoneRegenerationMaterials 41 3.5.3 InDentistry 42 3.5.4 CellTherapy 43 3.6 Nanoparticles–EssentialOilsCombinationAgainstHuman Pathogens 43 3.7 Conclusion 44 Acknowledgment 44 References 44 4 NanoparticlesforImaging 49 YerraRajeshwar 4.1 Introduction 49 4.2 Nanoparticles 49 4.3 NanoparticlesasDiagnosticProbes 52 4.3.1 NanoparticlesasBloodPoolContrastAgents 52 4.3.2 ImagingforMPS 54 4.3.3 CellLabelingandTracking 57 4.3.4 LabelingImplants,Transplants,andGrafts 60 4.3.5 Nano-andMicroparticlesforMolecularImaging 62 4.4 Nanoparticle-BasedTheranostics 67 4.4.1 NanoparticlesforImaging-GuidedInterventions 67 4.4.2 Nano-orMicroparticlesforImaging-GuidedHyperthermia Treatment 67 4.4.3 Imaging-GuidedDrugDelivery 69 4.5 Conclusion 70 References 71 5 Soft-Oxometalates:ANewStateofOxometalatesandTheir PotentialApplicationsasNanomotors 83 ApabritaMallickandSoumyajitRoy 5.1 IntroductiontoSoft-Oxometalates(SOMs) 83 5.1.1 ClassificationofSoft-Oxometalates 84 5.1.1.1 SpontaneouslyFormedSoft-Oxometalates 84 5.1.1.2 DesignedSoft-Oxometalates 84 5.2 ApplicationofSoft-Oxometalates 85 5.2.1 ControlofMorphologyofSOMs 85 5.2.2 SOMsinCatalysis 86 5.2.3 SOMsinPatterning 86 Contents vii 5.3 ActiveNano/microMotors 89 5.3.1 CatalyticMotors 89 5.3.2 MagneticallyPropelledMotors 89 5.3.3 ElectricallyPropelledMotors 90 5.3.4 LightDrivenMotors 90 5.3.5 UltrasonicallyDrivenMotors 90 5.4 Micro-OptomechanicalMovement(MOM)inSoft-Oxometalates 90 5.5 AutonomousMovementsInducedinHeptamolybdate SOMs 92 5.6 SOMsasWaterOxidationCatalysts 94 5.7 Conclusion 95 Acknowledgment 95 References 95 6 MedicinalApplicationsofMetalNanoparticles 101 AyanK.Barui,RajeshKotcherlakota,andChittaR.Patra 6.1 Overview 101 6.2 IntroductionandBackground 101 6.2.1 HistoryofMedicinalUseofMetals,MetalIons,and Complexes 103 6.2.2 NanotechnologyandNanomedicine 104 6.2.3 ApplicationofDisease-SpecificNanomedicine 105 6.2.4 ImportanceofMetalNanoparticlesinBiology 105 6.3 BiomedicalApplicationsofMetalNanoparticles 106 6.3.1 DeliveryofBiomoleculesUsingMetalNanoparticles 107 6.3.1.1 DrugDelivery 107 6.3.1.2 NucleicAcidDelivery 112 6.3.1.3 ImmunologicalMoleculeDelivery 113 6.3.2 AnticancerActivitiesofMetalNanoparticles 114 6.3.3 AntiangiogenicTherapyUsingMetalNanoparticles 116 6.3.4 ProangiogenicPropertiesofMetalNanoparticles 117 6.3.5 MetalNanoparticlesinBioimaging 119 6.3.6 BiosensingApplicationsofMetalNanoparticles 120 6.3.7 AntimicrobialActivityofMetalNanoparticles 122 6.3.8 MetalNanoparticlesinNeurodegenerativeDiseases 124 6.3.9 MetalNanoparticlesinTissueEngineering 126 6.3.10 MetalNanoparticlesinDiabetes 126 6.3.11 MetalNanoparticlesforRetinalDisorder 127 6.3.12 Anti-InflammatoryEffectsofMetalNanoparticles 127 6.3.13 BiologicallySynthesizedNanoparticlesforBiomedical Applications 128 6.4 PharmacokineticsofMetalNanoparticles 129 6.5 StatusofMetalNanoparticlesinClinicalStudy 131 6.6 FutureProspectofMetalNanoparticlesinMedicine 132 Acknowledgment 133 Abbreviations 133 References 135 viii Contents 7 MetalNanoparticlesinNanomedicine:Advantagesand Scope 155 TapanK.Sau,ArunangshuBiswas,andParijatRay 7.1 Introduction 155 7.1.1 TherapeuticUseofMetals:HistoricalPerspective 155 7.1.2 NanomedicinesandMetals 156 7.2 AdvantagesAssociatedwithMetalNanosystems 157 7.2.1 MetalsasNanosystems 158 7.2.1.1 SmallSizeandLargeSurfaceArea-to-VolumeRatio 158 7.2.1.2 ShapeandMorphologyDependence 159 7.2.2 VarietiesofMetalNanoparticles,Synthesis,andFabrication Techniques 159 7.2.3 Inertness,Biocompatibility,andEaseofSurfaceModifications 160 7.2.4 OpticalProperties:LocalizedSurfacePlasmonResonance (LSPR) 162 7.2.5 LargeScatteringandAbsorptionCrossSectionsandPhotothermal Effects 166 7.2.6 EnhancedLocalElectromagneticField:Surface-Enhanced Spectroscopies 167 7.3 ApplicationsandScope 169 7.3.1 TargetedDrugDeliveryandControlledRelease 169 7.3.2 PhotothermalandPhotodynamicTherapiesandCancer Treatment 173 7.3.3 AntimicrobialandWoundHealingEffects 175 7.3.4 ClinicalDiagnostics 177 7.3.4.1 MedicalImaging 178 7.4 ConcludingRemarks 185 Acknowledgments 185 References 185 8 ApplicationsofMetalNanoparticlesinMedicine/Metal NanoparticlesasAnticancerAgents 203 WenjieMeiandQiongWu 8.1 AdvantagesofMetalNanoparticles 203 8.1.1 StabilityandHomogeneity 203 8.1.2 LuminescenceProperty 204 8.1.3 Biocompatibility 204 8.1.4 MetabolicPathways 204 8.2 MetalNanoparticlesasAnticancerAgents 205 8.3 GoldNanoparticles 205 8.3.1 AuNPsasTherapeuticAgents 206 8.3.1.1 AuNPsinPlasmonicPhotothermalTherapy 206 8.3.1.2 AuNPsinPhotodynamicTherapy 207 8.3.1.3 AuNPsasaTherapeuticAgent 207 8.3.2 AuNPsasDrugCarriers 208 8.3.2.1 TargetedDeliveryofAnticancerDrugs 208 8.3.2.2 DeliveryofGenes 209 Contents ix 8.3.3 AuNPsinCancerImaging 209 8.4 SilverNanoparticles(AgNPs) 210 8.4.1 SynthesisofAgNPs 210 8.4.1.1 ChemicalMethods 210 8.4.1.2 PhysicalMethods 210 8.4.1.3 BiologicalMethods 210 8.4.2 AgNPsasInhibitorinChemotherapy 211 8.4.2.1 AgNPsasPromisingInhibitorAgainstTumor 211 8.4.3 AgNPsasDrugCarrier 212 8.4.4 AgNPsinCellularImagingandClinicDiagnostics 213 8.4.5 CytotoxicityofAgNPs 213 8.5 CopperNanoparticles 214 8.5.1 SynthesisofCuNPs 214 8.5.2 AntibacterialActivity 214 8.5.3 AnticancerActivity 214 8.5.4 MolecularImaging 215 8.5.5 DrugCarrier 216 8.6 Conclusion 217 Acknowledgments 217 References 217 9 NobleMetalNanoparticlesandTheirAntimicrobial Properties 225 LiniHuoandPeiyuanLi 9.1 Introduction 225 9.2 SynthesisofAntibacterialNobleMetalNanoparticles 225 9.2.1 PhysicalMethods 225 9.2.2 ChemicalMethods 226 9.2.3 GreenSynthesisMethods 227 9.3 AntibacterialNanomaterialsandTheirAntibacterialMechanism 227 9.3.1 MechanismsofNanoparticlesAntibacterialActivity 228 9.4 ConcludingRemarksandFutureOutlook 229 References 230 10 MetalNanoparticlesandTheirToxicity 237 IvanPachecoandCristinaBuzea 10.1 IntroductiontoMetalNanoparticlesToxicity 237 10.2 MetalNanoparticleInternalizationandBiodistribution 238 10.3 PhysicochemicalPropertiesofMetalNanoparticles 240 10.4 NanoparticleSizeandToxicity 241 10.4.1 SizeandUniformityofMetalNanoparticles 241 10.4.2 NanoparticleSize-DependentToxicity 241 10.5 NanoparticleCompositionandToxicity 244 10.5.1 NanoparticlesComposition 244 10.5.2 ComparativeToxicityofMetalNanoparticles 246 10.5.3 ToxicityofSilverNanoparticles 249 10.5.4 ToxicityofMetalOxides 249 x Contents 10.5.4.1 TitaniumDioxideNanoparticlesToxicity 249 10.5.4.2 ZincOxideNanoparticlesToxicity 250 10.5.4.3 CopperOxideNanoparticleToxicity 250 10.5.4.4 CeriumOxideNanoparticlesToxicity 250 10.6 NanoparticleMorphologyandToxicity 251 10.6.1 NanoparticlesMorphology 251 10.6.2 NanoparticleMorphology-DependentToxicity 252 10.7 NanoparticleCrystallineStructureandToxicity 254 10.7.1 NanoparticleCrystallineStructure 254 10.7.2 CrystallineStructure-DependentToxicity 255 10.8 NanoparticleSurfaceandToxicity 255 10.8.1 HydrophobicityandHydrophilicity 255 10.8.2 CatalyticActivity 256 10.8.3 SurfaceFunctionalization-DependentToxicity 256 10.8.4 SurfaceCharge-DependentToxicity 257 10.9 NanoparticleMagnetismandToxicity 257 10.9.1 MagnetismofNanoparticlesMagneticinBulkForm 257 10.9.2 MagnetismofNanoparticlesNonmagneticinBulkForm (Au,Pt,Pd) 261 10.9.3 MagneticNanoparticlesToxicity 261 10.9.3.1 IronOxideNanoparticlesToxicity 262 10.9.3.2 CobaltandNickelCompoundsNanoparticlesToxicity 262 10.9.4 GoldandPlatinumNanoparticleToxicity 263 10.9.4.1 GoldNanoparticlesToxicity 263 10.9.4.2 PlatinumNanoparticleToxicity 263 10.10 InteractionofNanoparticlesWithinOrganisms 264 10.10.1 FormationofProteinCorona 264 10.10.2 MetalNanoparticleUptakebyCells 265 10.10.3 NanoparticlesCrossingthePlacentalBarrier 267 10.10.4 NanoparticlesAssociationtoCardiovascularDiseases 267 10.10.5 CentralNervousSystemInteractionwithNanoparticles 270 10.10.6 ImmuneSystemInteractionwithNanoparticles 270 10.10.7 Liver,Kidneys,andOtherOrganInteractionwithNanoparticles 271 10.11 OtherNovelPropertiesofMetalNanoparticles 272 10.11.1 OpticalProperties 272 10.11.2 MeltingTemperature 274 10.12 Conclusions 276 References 276 Index 295

See more

The list of books you might like

Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.