Metabolism Of Human Diseases PDF
Preview Metabolism Of Human Diseases
Eckhard Lammert Martin Zeeb Editors Metabolism of Human Diseases Organ Physiology and Pathophysiology Metabolism of Human Diseases Eckhard Lammert (cid:129) Martin Zeeb Editors Metabolism of Human Diseases Organ Physiology and Pathophysiology Editors Eckhard Lammert Martin Zeeb Department of Biology CardioMetabolic Diseases Research Institute of Metabolic Physiology Boehringer Ingelheim Pharma German Diabetes Center GmbH & Co KG Heinrich Heine University Düsseldorf Biberach Düsseldorf Germany Germany ISBN 978-3-7091-0714-0 ISBN 978-3-7091-0715-7 (eBook) DOI 10.1007/978-3-7091-0715-7 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2014940716 © Springer-Verlag Wien 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Martin Zeeb and Eckhard Lammert Part I Brain Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Lorraine V. Kalia Major Depressive Disorder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Donatella Marazziti, Grazia Rutigliano, Stefano Baroni, and Liliana Dell’Osso Schizophrenia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Peter F. Buckley and Adriana Foster Epilepsy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Wesley Plinke and Detlev Boison Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Giulia Ambrosi, Silvia Cerri, and Fabio Blandini Alzheimer’s Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Milos D. Ikonomovic and Steven T. DeKosky Migraine and Cluster Headache. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Massimo Leone and Paola Di Fiore Multiple Sclerosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Markus Kipp Down Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 Maria D. Torres and Jorge Busciglio Part II Eye Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Anja Mataruga and Frank Müller Age-Related Macular Degeneration. . . . . . . . . . . . . . . . . . . . . . . . . . 67 Monika Fleckenstein and Frank G. Holz v vi Contents Glaucoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Samuel D. Crish and Christine M. Dengler-Crish Part III Teeth and Bones Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Kazuhiko Kawasaki and Kenneth M. Weiss Dental Caries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 Colin Robinson Osteoporosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 Emmanuel Biver and René Rizzoli Part IV Joints Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 Jessica Bertrand and Jan Hubert Osteoarthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 Camille Roubille, Johanne Martel-Pelletier, and Jean-Pierre Pelletier Rheumatoid Arthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 Marianna Meroni, Elena Bernero, and Maurizio Cutolo Part V Gastrointestinal Tract Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 Satish Keshav and Philip Allan Peptic Ulcer Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 Peter C. Konturek and Stanislaw J. Konturek Gastroenteritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 Christina Quigley and Xi Jiang Lactose Intolerance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 Anthony K. Campbell and Stephanie B. Matthews Colorectal Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149 Kishore Vipperla and Stephen J. O’Keefe Part VI Pancreas Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157 Alexandra E. Folias and Matthias Hebrok Diabetes Mellitus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 Alena Welters and Eckhard Lammert Contents vii Part VII Liver Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 Dieter Häussinger Cirrhosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 Matteo Rosselli and Massimo Pinzani Part VIII Fat Tissue Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 Gabriele Schoiswohl, Jules Aljammal, and Erin E. Kershaw Metabolic Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199 Kana Inoue, Norikazu Maeda, and Tohru Funahashi Part IX Lung Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 Martin Zeeb, Andreas Schnapp, and Michael-Paul Pieper Asthma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 Kenji Izuhara, Shoichi Suzuki, Kazuhiko Arima, Shoichiro Ohta, Masako Inamitsu, and Ken-ichi Yamamoto Chronic Obstructive Pulmonary Disease (COPD) . . . . . . . . . . . . . . 221 Irena Konstantinova and Andrew C. Pearce Community-Acquired Pneumonia . . . . . . . . . . . . . . . . . . . . . . . . . . . 227 Salvador Sialer, Leonardo F. Difrancesco, Teresa Foix Fabregas, and Antoni Torres Part X Heart Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235 Axel Gödecke Atherosclerotic Heart Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 Massimo Slavich and Juan Carlos Kaski Heart Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251 Roman Pfi ster and Erland Erdmann Part XI Blood Vessels Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261 Victor W.M. van Hinsbergh, Rick Meijer, and Etto C. Eringa Stroke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267 Dwi Setyowati Karolina and Kandiah Jeyaseelan viii Contents Varicose Veins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 Rishi Mandavia, Muzaffar A. Anwar, and Alun H. Davies Part XII Blood Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 Deena Iskander and Barbara J. Bain Sickle Cell Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 Daniel A. Dworkis and Martin H. Steinberg Hyperlipidemia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295 Paul Durrington and Handrean Soran Part XIII Immune System Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305 Christian Münz Fever . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 Bruno Conti and Tamas Bartfai Sepsis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 319 Jean-Charles Preiser and Jean-Louis Vincent Allergies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 Norbert Meyer and James Yun Part XIV Kidney Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331 Markus M. Rinschen, Linus A. Völker, and Paul T. Brinkkötter Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 Colleen Flynn and George L. Bakris Chronic Kidney Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345 Golaun Odabaei, George A. Kaysen, and Shubha Ananthakrishnan Gout. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351 Sonia Nasi and Alexander So Urinary Tract Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357 Matt S. Conover, Michael E. Hibbing, and Scott J. Hultgren Kidney Stones. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361 Andreas Neisius and Glenn M. Preminger Contents ix Part XV Reproductive System Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369 Danny J. Schust and Donald R. Gullicks Breast Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379 Tanja Fehm and Eugen Ruckhäberle Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 385 Rahul Aggarwal and Eric Small Part XVI Cancer Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 393 Zachary E. Stine and Chi V. Dang Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
The list of books you might like
