Mesoporous Materials for Advanced Energy Storage and Conversion Technologies

363 Pages·2017·8.215 MB·English

by  San Ping Jiang, Jian Liu

FUNCTIONAL HYDROGELS
IN DRUG DELIVERY
Key Features and Future Perspectives

FUNCTIONAL HYDROGELS
IN DRUG DELIVERY
Key Features and Future Perspectives
Editors
Umile Gianfranco Spizzirri and Giuseppe Cirillo
Department of Pharmacy, Health and Nutritional Sciences
University of Calabria
Rende (CS)
Italy
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A SCIENCE PUBLISHERS BOOK
A SCIENCE PUBLISHERS BOOK
Cover illustration reproduced by permission of Drs. Derya Aydın, Mohammad Alipour and Seda Kizilel (authors
of Chapter 1).
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Names: Liu, Jian (Chemical engineer), editor. | Jiang, San Ping, editor.
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Includes bibliographical references and index.
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Preface
Pharmaceutical application of hydrophilic materials has emerged as one
of the most significant trends in the area of nanotechnology. “Intelligent”
polymeric devices able to undergo morphological modifications in response
to an internal or external stimulus, such as pH, redox balance, temperature,
magnetic field, and light have been actively pursued. In an effort to further
improve the performances of the drug delivery device, stimuli-responsive
hydrogels responsive to a combination of two or more signals have
recently been developed by incorporating different stimulus responsive
elements into a network via polymerization processes. Notably, these
combined responses take place either simultaneously at the pathological
site, or sequentially from hydrogel preparation, hydrogel transporting
pathways, to cellular compartments. These stimuli responsive polymeric
materials lead to superior in vitro and/or in vivo therapeutic efficacy, with
programmed site-specific feature and remarkable potential for targeted
therapy. This book highlights the recent developments in the synthesis of
stimuli-responsive hydrogels for applications in the pharmaceutical field,
with a particular focus on the correlation between the hydrogel physical
feature and the precision situ-controlled delivery of bioactive compounds.
In this analysis, each chapter includes the last updates about the different
materials employed and the improvement of their physico-chemical and
biological properties to fabricate high performing carriers for specific use,
including stimuli-responsive materials, molecularly imprinted polymers,
carrier for the delivery of high MW drugs. Furthermore, the peculiar features
of specific administration routes (e.g., oral, parenteral, vaginal, ocular and
pulmonary) will be exploited with the aim to improve the efficiency of
hydrogel devices.

Contents
Preface v
1.Design of Stimuli-Responsive Drug Delivery Hydrogels: 1
Synthesis and Applications
Derya Aydın, Mohammad Alipour and Seda Kizilel
2.Nanocomposite Hydrogels as Drug Delivery Systems 24
Teresa del Castillo Castro, María Mónica Castillo Ortega,
Dora Evelia Rodríguez Félix and José Carmelo Encinas Encinas
3. Vesicles, Micelles and Cyclodextrins Immobilized into 52
Hydrogel: Multi-component Devices for Controlled
Drug Delivery
Lorena Tavano and Rita Muzzalupo
4.Molecularly Imprinted Hydrogels for the Selective Release 64
of Therapeutics
Piotr Luliński and Marcin Woźnica
5.Prodrugs and Bioconjugate Hydrogels: A Valuable Strategy 88
for the Prolonged-Delivery of Drugs
Ankit Jain, Anamika Sahu, Aviral Jain and Arvind Gulbake
6. Carbohydrate based Hydrogels for Controlled Release of 113
Cancer Therapeutics
S. Eswaramma, K.S.V. Krishna Rao, Qian Zhong and
K. Madhusudana Rao
7.Porous Hydrogels as Carrier for Delivery of 154
Macromolecular Drugs
Ecaterina Stela Dragan, Ana Irina Cocarta and Maria Valentina Dinu
8. Biopolymer-based Interpenetrating Network Hydrogels for 197
Oral Drug Delivery
Sabyasachi Maiti and Sougata Jana
9.Stimuli-Responsive Hydrogels for Parenteral Drug Delivery 234
Gayatri C. Patel
viii Functional Hydrogels in Drug Delivery: Key Features and Future Perspectives
10.Hydrogels for Vaginal Drug Delivery 259
Željka Vanić and Nataša Škalko-Basnet
11.Advances in Composite Hydrogels for Ocular Drug 303
Delivery and Biomedical Engineering Application
Andreza Maria Ribeiro and Ivan Antonio Neumann
12.Hydrogels for Pulmonary Drug Delivery 327
Ibrahim M. El-Sherbiny, Mohammed Sedki, Habiba Soliman and
Magdi H. Yacoub
Index 353
Design of Stimuli-Responsive Drug
Delivery Hydrogels
Synthesis and Applications
Derya Aydın, Mohammad Alipour and Seda Kizilel*
ABSTRACT
Stimuli-responsive hydrogels have become popular in medicine and
polymer science as useful ‘smart’ devices due to their various properties
such as overall biocompatibility, high drug loading capacity, and controlled
molecule delivery. By tuning the polymer side chains and degree of
crosslinking, these gels may exhibit swelling/shrinking behaviour
in response to environmental stimuli such as light, pH, chemicals,
temperature, mechanical strain, and electrical field. Sensitivity of these
hydrogels enables precise control over fundamental material properties
such as physical structure, porosity, swelling behaviour, mechanical
strength and drug permeability. Temperature and pH alterations are
examples of physiological deviations that are commonly considered for
the design of responsive hydrogels, specifically for site-specific controlled
drug delivery. A class of hydrogels known as multi-responsive hydrogels
can respond to more than one stimuli which make them tunable and
controllable with improved biomimetic properties well-suited for
controlled and site specific drug delivery. Despite all these attractive
properties of stimuli-responsive hydrogels, slow response time may cause
some limitations in practical applications. Reduced hydrogel thickness
may decrease the response time of the gel to a stimulus; however, this
Department of Chemical and Biological Engineering, Koc University, Sariyer, Istanbul, Turkey,
34450.
* Corresponding author