Memory Loss, Alzheimer's Disease and Dementia: A Practical Guide for Clinicians PDF
Preview Memory Loss, Alzheimer's Disease and Dementia: A Practical Guide for Clinicians
Memory Loss, Alzheimer’s Disease, and Dementia A Practical Guide for Clinicians THIRD EDITION Andrew E. Budson, MD Neurology Service, Section of Cognitive & Behavioral Neurology, Veterans Affairs Boston Healthcare System, Boston, MA Alzheimer’s Disease Research Center & Department of Neurology, Boston University School of Medicine, Boston, MA Harvard Medical School, Boston, MA The Boston Center for Memory, Newton, MA Paul R. Solomon, PhD Department of Psychology, Program in Neuroscience, Williams College, Williamstown, MA The Boston Center for Memory, Newton, MA Table of Contents Title page Any screen, Any time, Anywhere Copyright Praise for the First Edition Praise for the Second Edition Preface to the Third Edition How To Use This Book Acknowledgments Disclosures About the Authors Video Table of Contents Section I: Evaluating the Patient With Memory Loss or Dementia 1. Why Diagnose and Treat Memory Loss, Alzheimer’s Disease, and Dementia? Helping the Patient Helping the Family or Other Caregiver Saving Money Planning for the Future Quality Versus Quantity References 2. Evaluating the Patient With Memory Loss or Dementia Talking With The Family In the Clinic At the Bedside History Review of Systems Medical History Allergies to Medications Social History Family History Physical Examination Cognitive Tests and Questionnaires Screening in the Clinic Laboratory Studies Structural Imaging Studies Functional Imaging Studies Tests that Suggest Alzheimer’s Disease Summary References 3. Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia A Three-Step Approach The Spectrum of Cognitive Changes Is Dementia Present? Is Mild Cognitive Impairment Present? Is Subjective Cognitive Decline Present? Which Clinical Syndrome is Present? What is the Underlying Pathology? References Section II: Differential Diagnosis of Memory Loss and Dementia 4. Alzheimer’s Disease Prevalence, Prognosis, and Definition Alzheimer’s Pathology Neurochemistry Diagnostic Criteria Risk Factors, Pathology, and Pathophysiology Common Signs, Symptoms, and Stages Things to Look for in the History Things to Look for on the Physical and Neurological Examination Pattern of Impairment on Cognitive Tests Laboratory Studies Structural Imaging Studies Molecular and Functional Imaging Studies Differential Diagnosis Treatments References 5. Primary Age-Related Tauopathy Prevalence, Pathology, Genetics, and Definition Clinical Features, History, and Pattern of Impairment on Cognitive Tests Things to Look for on the Physical and Neurological Examination Laboratory Studies Structural Imaging Studies Functional and Molecular Imaging Studies Differential Diagnosis Treatments References 6. Limbic-predominant Age-related TDP-43 Encephalopathy Prevalence, Prognosis, and Definition Clinical Diagnosis Pathology, Pathophysiology, and Genetics Common Signs, Symptoms, and Stages Things to Look for in the History Things to Look for on the Physical and Neurological Examination Pattern of Impairment on Cognitive Tests Laboratory Studies Structural Imaging Studies Functional and Molecular Imaging Studies Differential Diagnosis Treatments References 7. Vascular Cognitive Impairment and Vascular Dementia Prevalence, Prognosis, and Definition Criteria Risk Factors, Pathology, and Pathophysiology Common Signs, Symptoms, and Stages Things to Look for in the History Things to Look for on the Physical and Neurological Examination Pattern of Impairment on Cognitive Tests Laboratory Studies Structural Imaging Studies Functional and Molecular Imaging Studies Differential Diagnosis Treatments (see also Table 7.1) References 8. Dementia With Lewy Bodies Prevalence, Prognosis, and Definition Criteria and Diagnosis Risk Factors, Pathology, and Pathophysiology Common Signs, Symptoms, and Stages Things to Look for in the History Things to Look for on the Physical and Neurological Examination Pattern of Impairment on Cognitive Tests Laboratory, Sleep, and Electroencephalography Studies Structural Imaging Studies Functional Imaging Studies Differential Diagnosis Treatments (Table 8.2) References 9. Primary Progressive Aphasia and Apraxia of Speech Prevalence, Definition, and Pathology Criteria Common Signs, Symptoms, and Stages (Table 9.2) Things to Look for in the History Things to Look for on the Physical and Neurological Examination
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