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12 AFIP ATLAS OF TUMOR PATHOLOGY 4 Series Melanocytic Tumors of the Skin David MB, ChB, FRCPA E. Elder, MD George Murphy, F. .;..• ;r• ' •/, AFIP ARP ForfreeInternetaccesstothisfascicle,goto: www.afip.org/publications/myfascicles Validfororiginal purchase only Serial #4F12-302844091 Melanocytic Tumors of the Skin AFIP Atlas of Tumor Pathology ARP iiiv m W PRESS Silver Spring Maryland , Editorial & Production Manager: Mirlinda Q. Caton Production Editor: Dian S. Thomas Editorial Assistant: Magdalena C. Silva Editorial Assistant. Alana N. Black Copyeditor: Audrey Kahn Available from the American Registry of Pathology Armed Forces Institute of Pathology ) Washington, DC 20306-6000 www.afip.org ^ ‘ ISBN 1-933477-10-5 978-1-933477-10-7 Copyright © 201 0 The American Registry of Pathology All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means: electronic, mechanical, photocopy, recording, or any other information storage and retrieval system without the written permission of the publisher. AFIP ATLAS OF TUMOR PATHOLOGY Fourth Series Fascicle 12 MELANOCYTIC TUMORS OF THE SKIN by David E. Elder, MB, ChB, FRCPA Professor of Pathology & LaboratoryMedicine University ofPennsylvania School ofMedicine Vice Chair for Anatomic Pathology Hospital ofthe University of Pennsylvania Philadelphia, Pennsylvania MD George Murphy, F. Professor ofPathology Harvard Medical School Director of Dermatopathology Brigham & Women's Hospital, Department ofPathology Boston, Massachusetts NATIONALINSTITUTES OFHEALTH NIH LIBRARY im JAN 16 BLDG 10, 10CENTER DR BETHESDA, MD. 20892-1150 Published by the American Registry ofPathology Washington, DC in collaboration with the Armed Forces Institute ofPathology Washington, DC 2010 AFIP ATLAS OF TUMOR PATHOLOGY EDITOR MD Steven G. Silverberg, Department of Pathology University ofMaryland School ofMedicine Baltimore, Maryland ASSOCIATE EDITOR ASSOCIATE EDITOR MD MD William A. Gardner, Leslie H. Sobin, American Registry ofPathology Armed Forces Institute of Pathology Washington, DC Washington, DC EDITORIAL ADVISORY BOARD MD Jorge Albores-Saavedra, Instituto National de Ciencias Medicas Mexico City, Mexico Ronald A. DeLellis, MD Lifespan Academic Medical Center Providence, Rhode Island William Frable, MD Virginia Commonwealth University J. Richmond, Virginia Kim R. Geisinger, MD Wake Forest University School of Medicine Winston-Salem, North Carolina Donald West King, MD National Library of Medicine Bethesda, Maryland MD Leonard B. Kahn, Long Island Jewish Medical Center New Hyde Park, New York MD James Linder, Cytyc Corporation Marlborough, Massachusetts MD Virginia A. LiVolsi, University of Pennsylvania Medical Center Philadelphia, Pennsylvania Elizabeth Montgomery, MD Johns Hopkins University School of Medicine Baltimore, Maryland MD Juan Rosai, Istituto Nazionale Tumori Milano, Italy Mark H. Stoler, MD University ofVirginia Health Sciences Center Charlottesville, Virginia MD William D. Travis, Memorial Sloan-Kettering Cancer Center New York, New York MD Noel Weidner, University of California San Diego Medical Center San Diego, California Mark R. Wick, MD University ofVirginia Medical Center Charlottesville, Virginia ManuscriptReviewedby: MD Ralph Tuthill, MarkJR.. Wick, MD EDITORS' NOTE The Atlas of Tumor Pathology has a long and distinguished history. It was first conceived at a cancer research meeting held in St. Louis in September 1947 as an attempt to standardize the nomenclature of neoplastic diseases. The first series was sponsored by the National Academy ofSciences-National Research Council. The organization ofthis Sisyphean effort was entrusted to the Subcommittee on Oncology of the Committee on Pathology, and Dr. Arthur Purdy Stout was the first editor-in- chief. Many ofthe illustrations were provided by the Medical Illustration Service of the Armed Forces Institute ofPathology (AFIP), the type was setby the Government Printing Office, and the final printing was done at the Armed Forces Institute of Pa- thology (hence the colloquial appellation "AFIP Fascicles"). The American Registry of Pathology (ARP) purchased the Fascicles from the Government Printing Office and sold them virtually at cost. Over a period of 20 years, approximately 15,000 copies each of nearly 40 Fascicles were produced. The worldwide impact of these publications over the years has largely surpassed the original goal. They quickly became among the most influential publications on tumor pathology, primarily because of their overall high quality, but also because their low cost made them easily accessible the world over to pathologists and other students of oncology. Upon completion of the first series, the National Academy of Sciences-National Research Council handed further pursuit of the project over to the newly created Universities Associated for Research and Education in Pathology (UAREP). A second series was started, generously supported by grants from the AFIP, the National Can- cer Institute, and the American Cancer Society. Dr. Harlan I. Firminger became the editor-in-chief and was succeeded by Dr. William H. Hartmann. The second series' Fascicles were produced as bound volumes instead of loose leaflets. They featured a more comprehensive coverage of the subjects, to the extent that the Fascicles could no longer be regarded as "atlases" but rather as monographs describing and illustrating in detail the tumors and tumor-like conditions of the various organs and systems. Once the second series was completed, with a success that matched that of the first, ARP, UAREP, and AFIP decided to embark on a third series. Dr. Juan Rosai was appointed as editor-in-chief, and Dr. Leslie H. Sobin became associate editor. A distinguished Editorial Advisory Board was also convened, and these outstanding pathologists and educators played a major role in the success of this series, the first publication of which appeared in 1991 and the last (number 32) in 2003. The same organizational framework applies to the current fourth series, but with UAREP no longer in existence, ARP plays the major role. New features include a hardbound cover, illustrations almost exclusively in color, and an accompanying electronic version of each Fascicle. There is also an increased emphasis (wherever appropriate) on the cytopathologic (intraoperative, exfoliative, and/or fine needle aspiration) and molecular features that are important in diagnosis and prognosis. What does not change from the three previous series, however, is the goal ofprovid- ing the practicing pathologist with thorough, concise, and up-to-date information on the nomenclature and classification; epidemiologic, clinical, and pathogenetic features; and, most importantly, guidance in the diagnosis of the tumors and tu- morlike lesions of all major organ systems and body sites. As in the third series, a continuous attempt is made to correlate, whenever pos- sible, the nomenclature used in the Fascicles with that proposedby the World Health Organization's Classification of Tumors, as well as to ensure a consistency of style throughout. Close cooperation between the various authors and their respective liaisons from the Editorial Board continues to be emphasized in order to minimize unnecessary repetition and discrepancies in the text and illustrations. Particular thanks are due to the members of the Editorial Advisory Board, the re- — viewers (at least two for each Fascicle), the editorial and production staff, and first — and foremost the individual Fascicle authors for their ongoing efforts to ensure that this series is a worthy successor to the previous three. MD Steven G. Silverberg, MD William A. Gardner, MD Leslie H. Sobin,