Medicinal Plants of the Asteraceae Family: Traditional Uses, Phytochemistry and Pharmacological Activities

232 Pages·2023·7.712 MB·English

by  Hari Prasad Devkota, Tariq Aftab

Hari Prasad Devkota
Tariq Aftab   Editors
Medicinal Plants
of the Asteraceae
Family
Traditional Uses, Phytochemistry and
Pharmacological Activities
Medicinal Plants of the Asteraceae Family
(cid:129)
Hari Prasad Devkota Tariq Aftab
Editors
Medicinal Plants
of the Asteraceae Family
Traditional Uses, Phytochemistry and
Pharmacological Activities
Editors
HariPrasadDevkota TariqAftab
HeadquartersforAdmissionsand DepartmentofBotany
Education AligarhMuslimUniversity
KumamotoUniversity Aligarh,UttarPradesh,India
Kumamoto,Japan
ISBN978-981-19-6079-6 ISBN978-981-19-6080-2 (eBook)
https://doi.org/10.1007/978-981-19-6080-2
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Preface
Medicinalplantshavelongbeenusedfortheprimaryhealthcareofhumans.Manyof
these plant speciesare also usedas components ofregularfoods, functional foods,
beverages, and cosmetics.Recent years have seen a growing interest in the natural
components in these medicinal plants that are being widely used in healthy food
industries,pharmaceutical,cosmetic,andaromaindustries.
Asteraceaeisoneofthelargestfamiliesoffloweringplantscomprisingmorethan
1600 plant genera and 32,000 plant species. Many plants belonging to this family
have a long history of being used as medicinal plants for the treatment of various
diseases.Manyofthemarealsousedinthepreparationoffoods,beverages,andalso
in pharmaceutical and cosmetic industries. Plants such as Artemisia annua have
playedanimportantroleinthediscoveryofnoveldrugs.
Thepurposeofthisbookistohighlightthevariousaspectsrelatedtotraditional
usesasfoodandmedicine,phytochemistry,andpharmacologicalactivitiesofwidely
used medicinal plants belonging to the Asteraceae family. It includes a total of
13 chapters with one chapter providing an overview of medicinal plants of the
Asteraceae family and 12 chapters dealing with individual medicinal plants. Com-
prehensivecompilationoftheknowledgerelatedtothetraditionalusesandmodern
scientificevidenceoftheseplantswillhelptounderstandtheirrelationandimpacton
human health. Proper understanding of current scientific knowledge will not only
helpinthecommercializationofproductsbasedontheseplantsbutalsotofindthe
research gaps that should be fulfilled in future for optimal use. It will also help in
increasing the awareness of the plant species regarding their conservation, cultiva-
tion,andsustainableutilization.
We would like to thank all the authors for their contribution in preparing the
chapters.WearealsothankfultoSpringerforthisopportunity.
Kumamoto,Japan HariPrasadDevkota
Aligarh,UttarPradesh,India TariqAftab
v
Contents
1 AnOverviewofMedicinalPlantsoftheAsteraceaeFamily
andTheirRoleinHumanHealth. . . . . . . . . . . . . . . . . . . . . . . . . . 1
HariPrasadDevkota
2 ArtemisiaannuaL.:TraditionalUses,Phytochemistry,
andPharmacologicalActivities. . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
KaiserIqbalWani,AndleebZehra,SadafChoudhary,M.Naeem,
M.MasroorA.Khan,RiyazuddeenKhan,andTariqAftab
3 ArtemisiaindicaWilld.:Ethnobotany,Phytochemistry,
PharmacologicalAttributes,andSafetyProfile. . . . . . . . . . . . . . . . 43
RupaSanyal,SharmilaPandey,SamapikaNandy,SaikatDewanjee,
AbdelRahmanAl-Tawaha,ErcanBursal,ProthaBiswas,
ManojKumar,Radha,AbilashValsalaGopalakrishnan,
Md.HabiburRahman,MahipalS.Shekhawat,
DevendraKumarPandey,TabarakMalik,andAbhijitDey
4 ArnicamontanaL.:TraditionalUses,BioactiveChemical
Constituents,andPharmacologicalActivities. . . . . . . . . . . . . . . . . 61
NishaGyawali,AsmitaRayamajhi,DeepaKarki,TamlalPokhrel,
andAchyutAdhikari
5 AstertataricusL.f.:EthnomedicinalUses,Phytochemistry,
andPharmacologicalActivities. . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
DeepakTimalsinaandHariPrasadDevkota
vii
viii Contents
6 Atractylodeslancea(Thunb.)DC.:Ethnobotany,Phytochemistry,
PharmacologicalAttributes,andSafetyProfile. . . . . . . . . . . . . . . . 89
RupaSanyal,AkashDeepPaul,TuyeleeDas,SaikatDewanjee,
AbdelRahmanAl-Tawaha,ErcanBursal,ProthaBiswas,
ManojKumar,Radha,SamapikaNandy,
AbilashValsalaGopalakrishnan,Md.HabiburRahman,
MahipalS.Shekhawat,DevendraKumarPandey,TabarakMalik,
andAbhijitDey
7 CarthamustinctoriusL.:TraditionalUses,Phytochemistry,
andPharmacologicalActivities. . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
GopalLamichhane,HariPrasadDevkota,KusumSai,
andPrakashPoudel
8 ChrysanthemummorifoliumRamat.:AMedicinalPlant
withDiverseTraditionalUses,BioactiveConstituents,
andPharmacologicalActivities. . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
JitendraPandey,TonkingBastola,BhawanaDhakal,AmritPoudel,
andHariPrasadDevkota
9 Crassocephalumcrepidioides(Benth.)S.Moore:Traditional
Uses,ChemicalConstituents,andBiologicalActivities. . . . . . . . . . 145
SilaGurung,PrakashPoudel,NamunaAdhikari,GopalLamichhane,
andRashmiThapa
10 Dolomiaeacostus(Falc.)KasanaandA.K.Pandey:Ethnomedicinal
Uses,BioactiveChemicalConstituents,andPharmacological
Activities. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
AbhayPrakashMishra,ManishaNigam,HariPrasadDevkota,
andMotlalepulaGilbertMatsabisa
11 Ecliptaprostrata(L.)L.:TraditionalUse,Phytochemistry,
andPharmacology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
RupaSanyal,SaheliNandi,SujataMandal,SaikatDewanjee,
AbdelRahmanAl-Tawaha,ErcanBursal,ProthaBiswas,
ManojKumar,Radha,SamapikaNandy,
AbilashValsalaGopalakrishnan,Md.HabiburRahman,
MahipalS.Shekhawat,DevendraKumarPandey,TabarakMalik,
andAbhijitDey
12 HelianthusannuusL.:TraditionalUses,Phytochemistry,
andPharmacologicalActivities. . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
ArpitSingh,ShivaramanPandey,RaviPrakashSrivastava,
HariPrasadDevkota,LavSingh,andGauriSaxena
13 Silybummarianum(L.)Gaertn.:TraditionalUses,Phytochemistry,
andPharmacologicalActivities. . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
DeepaKhatri,SumitBahadurBaruwalChhetri,
andHariPrasadDevkota
About the Editors
Hari Prasad Devkota currently works as Assistant Professor at Headquarters for
Admissions and Education, and Graduate School of Pharmaceutical Sciences,
KumamotoUniversity,Kumamoto,Japan.HecompletedhisPhDinPharmaceutical
SciencesfromGraduateSchoolofPharmaceuticalSciences,KumamotoUniversity,
in 2013. His main research interests are plant-derived bioactive natural products,
functional foods, and ethnopharmacology. To date, he has authored more than
150 articles including original research articles and review articles, 3 books, and
morethan20bookchapters.Dr.Devkotaiscurrentlyinvolvedasaneditorialboard
member of various international journals related to medicinal chemistry, pharma-
cology,andethnobotany. Dr.Devkotaalsoreceived KumamotoUniversityEduca-
tionAwardin2017and2019forhisactivitiesrelatedtomultidisciplinaryeducation
andsciencecommunication.
Tariq Aftab received his PhD in the Department of Botany at Aligarh Muslim
University,India,andiscurrentlyanAssistantProfessorthere.Heistherecipientof
aprestigiousLeibniz-DAADfellowshipfromGermany,RamanFellowshipfromthe
Government of India, and Young Scientist Awards from the State Government of
Uttar Pradesh (India) and Government of India. After completing his doctorate, he
hasworkedasResearchFellowatNationalBureauofPlantGeneticResources,New
Delhi,andasPost-doctorateFellowatJamiaHamdard,NewDelhi,India.Dr.Aftab
also worked as Visiting Scientist at Leibniz Institute of Plant Genetics and Crop
Plant Research (IPK), Gatersleben, Germany, and in the Department of Plant
Biology, Michigan State University, USA. He is a member of various scientific
associationsfromIndiaandabroad.
He has edited 10 books with international publishers, including Elsevier Inc.,
SpringerNature,andCRCPress(Taylor&FrancisGroup),coauthoredseveralbook
chapters, and published over 60 research papers in peer-reviewed international
journals. His research interests include physiological, proteomic, and molecular
studiesonmedicinalandaromaticplants.
ix
Chapter 1
An Overview of Medicinal Plants
of the Asteraceae Family and Their Role
in Human Health
HariPrasadDevkota
Abstract TheAsteraceaefamily,commonlyknownassunflowerfamily,isoneof
thelargestfamiliesoffloweringplantscomprisingmorethan1600plantgeneraand
32,000 plant species. Members of this family have long history of being used as
medicinal plants, ornamental flowers, vegetables, food ingredients, pigments, and
dyes along with many other purposes. Many members of this family are widely
studied for their bioactive chemical constituents, and phenolic acids, flavonoids,
terpenoids, volatile components, etc. are reported as majorcompounds. Pharmaco-
logical studies have revelated their potent antioxidant, anti-inflammatory,
antibacterial,anticancer,andantiparasiticactivities,amongothers.Extensivechem-
icalandpharmacologicalanalysisofthelessexploredspeciescanleadtodiscovery
anddevelopmentofnoveldrugmolecules,functionalfoodingredients,andcosmetic
products.
Keywords Sunflowerfamily·Flavonoids·Phenolicacids·Pharmacological
activities·Artemisia·Chrysanthemum
1.1 Introduction
Medicinal plants have been an important source of the primary healthcare for
prevention and treatment of diseases. Many of these plant species are also used as
components of foods, nutraceuticals, functional foods, beverages, cosmetics, dyes,
and many other purposes (Khanal et al. 2021). Medicinal plants are one of the
importantsourcesofmoderndrugdiscoveryanddevelopmentandmorethan30%of
thedrugscurrentlymarketedarederivedfromnaturalproducts(NewmanandCragg
2016;Atanasovetal.2021).
H.P.Devkota(*)
HeadquartersforAdmissionsandEducation,KumamotoUniversity,Kumamoto,Japan
GraduateSchoolofPharmaceuticalSciences,KumamotoUniversity,Kumamoto,Japan
PharmacyProgram,GandakiUniversity,Pokhara,Nepal
e-mail:[email protected]
©TheAuthor(s),underexclusivelicensetoSpringerNatureSingaporePteLtd.2022 1
H.P.Devkota,T.Aftab(eds.),MedicinalPlantsoftheAsteraceaeFamily,
https://doi.org/10.1007/978-981-19-6080-2_1
2 H.P.Devkota
TheAsteraceaefamily(synonym:Compositae),commonlyknownassunflower
family,isoneofthelargestfamiliesoffloweringplantscomprisingmorethan1600
plantgeneraand32,000plantspecies(POWO2022).PlantsoftheAsteraceaefamily
can be found from sea level to high mountains, and their main characteristic is the
presenceofcapitulacontainingmanyflorets(Willis2017).Manyofthisfamilyhave
longhistoryofbeingusedasmedicinalplantsforthetreatmentofvariousdiseasesas
some of them are reported to be cultivated from 3000 years ago (Rolnik and Olas
2021).Apartfrombeingmedicinallyimportant,theyalsohavegreatimportanceas
ornamentalflowers,vegetables,foodingredients,pigments,anddyes.Someofthese
plantsarealsopotentinsecticides.Manymembersofthisfamilyarewidelystudied
fortheirbioactivechemicalconstituentsandpharmacologicalactivities.Someofthe
plants have shown promising results as potential agents in the development of
moderndrugs.
1.2 Traditional Uses of the Plants of the Asteraceae Family
as Medicine, Food, Cosmetic, and Other Purposes
Asteraceae family plants have long history of use for various purposes. Having
beautiful flowers, many plant species of this family are cultivated for ornamental
purposes. Plants such as marigold (Tagetes erecta L.), French marigold (Tagetes
petula L.), sunflower (Helianthus annuus L.), pot marigold (Calendula officinalis
L.),andcornflower(CentaureacyanusL.)arecultivatedallovertheworldfortheir
beautiful flowers (Fig. 1.1). Many of these plants are also used in cultural and
religiousceremoniesandfunctions.
HundredsofplantspeciesoftheAsteraceaefamilyareusedasmedicinal plants
andasimportantingredientsintraditionalmedicines.Manyofsuchspeciesareinthe
form of herbal tea prepared from flowers or other plant parts or as one of the
ingredients in the traditional medicine formulations. Echinacea (Echinacea
purpurea (L.) Moench), chamomile (Matricaria chamomilla L.), Tatarian aster
(Aster tataricus L.f.), dandelion (Taraxacum officinale F.H.Wigg.), and plants of
Cirsium and Artemisia genera are some of the common examples among many
(Fig. 1.2). Their traditional uses vary from one species to another species and also
depend upon the ethnic knowledge of these species in various communities. Some
common uses are for the treatment of fever, cold, allergy, inflammation, etc.
(Watanabe et al. 2021). Many plants of Artemisia genus are used to treat cough,
cold, gastrointestinal disorders, bacterial and parasitic diseases, etc. (Nigam et al.
2019).Theyoungleavesarealsousedtotreatcutsandwounds.
Dandelion is widely used as a diuretic agent (Rolnik and Olas 2021). Blessed
milkthistle(Silybummarianum(L.)Gaertn.)andfalsedaisy(Ecliptaprostrata(L.)
L.) are well known as potent hepatoprotective agents (Ball and Kowdley 2005;
TimalsinaandDevkota2021).VariousspeciesofArctiumgenusarecommonlyused
asmedicinalspeciesandhaveanti-inflammatoryanddiureticproperties(Wangetal.