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Medicinal and Natural Product Chemistry PDF

260 Pages·2016·20.56 MB·English
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Medicinal and Natural Product Chemistry Allegra Smith Medicinal and Natural Product Chemistry Medicinal and Natural Product Chemistry Edited by Allegra Smith Medicinal and Natural Product Chemistry Edited by Allegra Smith This book contains information obtained from authentic and highly regarded sources. Copyright for all individual chapters remain with the respective authors as indicated. All chapters are published with permission under the Creative Commons Attribution License or equivalent. A wide variety of references are listed. Permission and sources are indicated; for detailed attributions, please refer to the permissions page and list of contributors. Reasonable efforts have been made to publish reliable data and information, but the authors, editors and publisher cannot assume any responsibility for the validity of all materials or the consequences of their use. The publisher’s policy is to use permanent paper from mills that operate a sustainable forestry policy. Furthermore, the publisher ensures that the text paper and cover boards used have met acceptable environmental accreditation standards. Trademark Notice: Registered trademark of products or corporate names are used only for explanation and identification without intent to infringe. Published by University Publications, 5 Penn Plaza, 19th Floor, New York, NY 10001, USA © 2017 University Publications International Standard Book Number: 978-1-9789-2679-0 Copyright of this ebook is with University Publications, rights acquired from the original print publisher, NY Research Press. Contents Preface VII Chapter 1 Polyphenolic Composition and Evaluation of Antioxidant Activity, Osmotic Fragility 1 and Cytotoxic Effects of Raphiodon echinus (Nees & Mart.) Schauer Antonia Eliene Duarte, Emily PanseraWaczuk, Katiane Roversi, Maria Arlene Pessoa da Silva, Luiz Marivando Barros, Francisco Assis Bezerra da Cunha, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Aline Augusti Boligon, Adedayo Oluwaseun Ademiluyi, Jean Paul Kamdem, João Batista Teixeira Rocha and Marilise Escobar Burger Chapter 2 Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties 16 Eduardo Soriano, Cory Holder, Andrew Levitz and Maged Henary Chapter 3 Isolation of Terpenoids from the Stem of Ficus aurantiaca Griff and their Effects on Reactive Oxygen Species Production and Chemotactic Activity of Neutrophils 31 Shukranul Mawa, Ibrahim Jantan and Khairana Husain Chapter 4 Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale 45 Ling-Shang Wu, Min Jia, Ling Chen, Bo Zhu, Hong-Xiu Dong, Jin-Ping Si, Wei Peng and Ting Han Chapter 5 Synthesis and Properties of Bis-Porphyrin Molecular Tweezers: Effects of Spacer Flexibility on Binding and Supramolecular Chirogenesis 59 Magnus Blom, Sara Norrehed, Claes-Henrik Andersson, Hao Huang, Mark E. Light, Jonas Bergquist, Helena Grennberg and Adolf Gogoll Chapter 6 Reduced Reactivity of Amines against Nucleophilic Substitution via Reversible Reaction with Carbon Dioxide 83 Fiaz S. Mohammed and Christopher L. Kitchens Chapter 7 Flavones Isolated from Scutellariae radix Suppress Propionibacterium 94 Acnes-Induced Cytokine Production In Vitro and In Vivo Po-Jung Tsai, Wen-Cheng Huang, Ming-Chi Hsieh, Ping-Jyun Sung, Yueh-Hsiung Kuo and Wen-Huey Wu Chapter 8 Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic DKR of 2-Arylthiazol-4-yl-alanines 105 Denisa Leonte, László Csaba Bencze, Csaba Paizs, Monica Ioana Toșa, Valentin Zaharia and Florin Dan Irimie _______________________ WORLD TECHNOLOGIES _____________________ Chapter 9 Preparative Isolation of Two Prenylated Biflavonoids from the Roots and Rhizomes of Sinopodophyllum emodi by Sephadex LH-20 Column and High-Speed Counter-Current Chromatography 120 Yan-Jun Sun, Li-Xin Pei, Kai-Bo Wang, Yin-Shi Sun, Jun-Min Wang, Yan-Li Zhang, Mei-Ling Gao and Bao-Yu Ji Chapter 10 Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug 133 Sobhi M. Gomha, Taher A. Salaheldin, Huwaida M. E. Hassaneen, Hassan M. Abdel-Aziz and Mohammed A. Khedr Chapter 11 Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives 150 Eman M. Flefel, Hebat-Allah S. Abbas, Randa E. Abdel Mageid and Wafaa A. Zaghary Chapter 12 New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex 165 K. Schum. Bly. ex Rowl. (Cactaceae) Jéssica K. S. Maciel, Otemberg S. Chaves, Severino G. Brito Filho, Yanna C. F. Teles, Marianne G. Fernandes, Temilce S. Assis, Pedro Dantas Fernandes, Alberício Pereira de Andrade, Leonardo P. Felix, Tania M. S. Silva, Nathalia S. M. Ramos, Girliane R. Silva and Maria de Fátima Vanderlei de Souza Chapter 13 Solubilization Behavior of Polyene Antibiotics in Nanomicellar System: Insights from Molecular Dynamics Simulation of the Amphotericin B and Nystatin Interactions with Polysorbate 80 178 Meysam Mobasheri, Hossein Attar, Seyed Mehdi Rezayat Sorkhabadi, Ali Khamesipour and Mahmoud Reza Jaafar Chapter 14 Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives 204 Dan Liu, Tian Luan, Jian Kong, Ying Zhang and Hai-Feng Wang Chapter 15 Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids from Corn Silk on STZ-Induced Diabetic Mice 212 Yan Zhang, Liying Wu, Zhongsu Ma, Jia Cheng and Jingbo Liu Chapter 16 Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions 223 El Sayed H. El Ashry, Yeldez El Kilany, Nariman M. Nahas, Assem Barakat, Nadia Al-Qurashi, Hazem A. Ghabbour and Hoong-Kun Fun Chapter 17 Detecting and Quantifying Biomolecular Interactions of a Dendritic Polyglycerol Sulfate Nanoparticle Using Fluorescence Lifetime Measurements 234 Alexander Boreham, Jens Pikkemaat, Pierre Volz, Robert Brodwolf, Christian Kuehne, Kai Licha, Rainer Haag, Jens Dernedde and Ulrike Alexiev Permissions List of Contributors �I �������� _______________________ WORLD TECHNOLOGIES _____________________ Preface The world is advancing at a fast pace like never before. Therefore, the need is to keep up with the latest developments. This book was an idea that came to fruition when the specialists in the area realized the need to coordinate together and document essential themes in the subject. That’s when I was requested to be the editor. Editing this book has been an honour as it brings together diverse authors researching on different streams of the field. The book collates essential materials contributed by veterans in the area which can be utilized by students and researchers alike. Medicinal and natural product chemistry is generally considered as a discipline concerned with biological molecules but it is essentially the chemistry of carbon compounds. A large number of organic compounds are either derived or completely synthesized in laboratories. This book discusses many such advanced compounds, their manufacturing processes, structures and properties. Some of the topics included are drug design to combinatorial synthesis and parallel synthesis, applications of compound collections, compound preparation, molecular diversity assessments, etc. The ever growing need for advanced technology is the reason that has fueled the research in this field in recent times. Such selected concepts that redefine medicinal and natural product chemistry have been presented in this book. The extensive content presented in the book provides the readers with a thorough understanding of this subject. It will serve as a resource guide for professionals, researchers and students engaged in this field. Each chapter is a sole-standing publication that reflects each author´s interpretation. Thus, the book displays a multi-facetted picture of our current understanding of applications and diverse aspects of the field. I would like to thank the contributors of this book and my family for their endless support. Editor _______________________ WORLD TECHNOLOGIES _____________________ _______________________ WORLD TECHNOLOGIES _____________________ Polyphenolic Composition and Evaluation of Antioxidant Activity, Osmotic Fragility and Cytotoxic Effects of Raphiodon echinus (Nees & Mart.) Schauer Antonia Eliene Duarte 1,2, Emily Pansera Waczuk 2, Katiane Roversi 3, Maria Arlene Pessoa da Silva 4, Luiz Marivando Barros 1,2, Francisco Assis Bezerra da Cunha 1,2, Irwin Rose Alencar de Menezes 5, José Galberto Martins da Costa 6, Aline Augusti Boligon 7, Adedayo Oluwaseun Ademiluyi 2,8, Jean Paul Kamdem 2,9, João Batista Teixeira Rocha 2,* and Marilise Escobar Burger 3,* Academic Editor: Derek J. McPhee 1 Centro de Ciências Biológicas e da Saúde-CCBS, Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Pimenta, Crato CEP 63.100-000, CE, Brazil;

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