Medicinal and Natural Product Chemistry

260 Pages·2016·20.56 MB·English

Medicinal and Natural

Product Chemistry

Allegra Smith

Medicinal and Natural Product Chemistry

Medicinal and Natural Product
Chemistry

Edited by Allegra Smith

Medicinal and Natural Product Chemistry
Edited by Allegra Smith

This book contains information obtained from authentic and highly regarded sources. Copyright for all individual chapters
remain with the respective authors as indicated. All chapters are published with permission under the Creative Commons
Attribution License or equivalent. A wide variety of references are listed. Permission and sources are indicated; for detailed
attributions, please refer to the permissions page and list of contributors. Reasonable efforts have been made to publish reliable
data and information, but the authors, editors and publisher cannot assume any responsibility for the validity of all materials
or the consequences of their use.

The publisher’s policy is to use permanent paper from mills that operate a sustainable forestry policy. Furthermore, the
publisher ensures that the text paper and cover boards used have met acceptable environmental accreditation standards.

Trademark Notice: Registered trademark of products or corporate names are used only for explanation and identification
without intent to infringe.

Published by University Publications,
5 Penn Plaza,
19th Floor,
New York, NY 10001, USA

© 2017 University Publications

International Standard Book Number: 978-1-9789-2679-0

Copyright of this ebook is with University Publications, rights acquired from the original print publisher, NY Research Press.

Contents

Preface
VII

Chapter 1
Polyphenolic Composition and Evaluation of Antioxidant Activity, Osmotic Fragility

1
and Cytotoxic Effects of Raphiodon echinus (Nees & Mart.) Schauer
Antonia Eliene Duarte, Emily PanseraWaczuk, Katiane Roversi, Maria Arlene
Pessoa da Silva, Luiz Marivando Barros, Francisco Assis Bezerra da Cunha,
Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Aline Augusti
Boligon, Adedayo Oluwaseun Ademiluyi, Jean Paul Kamdem, João Batista
Teixeira Rocha and Marilise Escobar Burger

Chapter 2
Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and
Photophysical Properties
16
Eduardo Soriano, Cory Holder, Andrew Levitz and Maged Henary

Chapter 3
Isolation of Terpenoids from the Stem of Ficus aurantiaca Griff and their Effects
on Reactive Oxygen Species Production and Chemotactic Activity of Neutrophils
31
Shukranul Mawa, Ibrahim Jantan and Khairana Husain

Chapter 4
Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic
Fungus DO14 from Dendrobium officinale
45
Ling-Shang Wu, Min Jia, Ling Chen, Bo Zhu, Hong-Xiu Dong, Jin-Ping Si,
Wei Peng and Ting Han

Chapter 5
Synthesis and Properties of Bis-Porphyrin Molecular Tweezers: Effects of Spacer
Flexibility on Binding and Supramolecular Chirogenesis
59
Magnus Blom, Sara Norrehed, Claes-Henrik Andersson, Hao Huang, Mark E. Light,
Jonas Bergquist, Helena Grennberg and Adolf Gogoll

Chapter 6
Reduced Reactivity of Amines against Nucleophilic Substitution via Reversible
Reaction with Carbon Dioxide
83
Fiaz S. Mohammed and Christopher L. Kitchens

Chapter 7
Flavones Isolated from Scutellariae radix Suppress Propionibacterium

94
Acnes-Induced Cytokine Production In Vitro and In Vivo
Po-Jung Tsai, Wen-Cheng Huang, Ming-Chi Hsieh, Ping-Jyun Sung, Yueh-Hsiung Kuo
and Wen-Huey Wu

Chapter 8
Heterocycles 36. Single-Walled Carbon Nanotubes-Bound N,N-Diethyl
Ethanolamine as Mild and Efficient Racemisation Agent in the Enzymatic
DKR of 2-Arylthiazol-4-yl-alanines
105
Denisa Leonte, László Csaba Bencze, Csaba Paizs, Monica Ioana Toșa,
Valentin Zaharia and Florin Dan Irimie

_______________________ WORLD TECHNOLOGIES _____________________

Chapter 9
Preparative Isolation of Two Prenylated Biflavonoids from the Roots and
Rhizomes of Sinopodophyllum emodi by Sephadex LH-20 Column and
High-Speed Counter-Current Chromatography
120
Yan-Jun Sun, Li-Xin Pei, Kai-Bo Wang, Yin-Shi Sun, Jun-Min Wang, Yan-Li Zhang,
Mei-Ling Gao and Bao-Yu Ji

Chapter 10
Synthesis, Characterization and Molecular Docking of Novel Bioactive
Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug
133
Sobhi M. Gomha, Taher A. Salaheldin, Huwaida M. E. Hassaneen,
Hassan M. Abdel-Aziz and Mohammed A. Khedr

Chapter 11
Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile
and Nicotinonitrile Derivatives
150
Eman M. Flefel, Hebat-Allah S. Abbas, Randa E. Abdel Mageid and Wafaa A. Zaghary

Chapter 12
New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex

165
K. Schum. Bly. ex Rowl. (Cactaceae)
Jéssica K. S. Maciel, Otemberg S. Chaves, Severino G. Brito Filho, Yanna C. F. Teles,
Marianne G. Fernandes, Temilce S. Assis, Pedro Dantas Fernandes, Alberício Pereira
de Andrade, Leonardo P. Felix, Tania M. S. Silva, Nathalia S. M. Ramos, Girliane R. Silva
and Maria de Fátima Vanderlei de Souza

Chapter 13
Solubilization Behavior of Polyene Antibiotics in Nanomicellar System: Insights
from Molecular Dynamics Simulation of the Amphotericin B and Nystatin
Interactions with Polysorbate 80
178
Meysam Mobasheri, Hossein Attar, Seyed Mehdi Rezayat Sorkhabadi,
Ali Khamesipour and Mahmoud Reza Jaafar

Chapter 14
Synthesis and Anti-Tumor Activities of 4-Anilinoquinoline Derivatives
204
Dan Liu, Tian Luan, Jian Kong, Ying Zhang and Hai-Feng Wang

Chapter 15
Anti-Diabetic, Anti-Oxidant and Anti-Hyperlipidemic Activities of Flavonoids
from Corn Silk on STZ-Induced Diabetic Mice
212
Yan Zhang, Liying Wu, Zhongsu Ma, Jia Cheng and Jingbo Liu

Chapter 16
Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by
Alkylation Reactions
223
El Sayed H. El Ashry, Yeldez El Kilany, Nariman M. Nahas, Assem Barakat,
Nadia Al-Qurashi, Hazem A. Ghabbour and Hoong-Kun Fun

Chapter 17
Detecting and Quantifying Biomolecular Interactions of a Dendritic Polyglycerol
Sulfate Nanoparticle Using Fluorescence Lifetime Measurements
234
Alexander Boreham, Jens Pikkemaat, Pierre Volz, Robert Brodwolf, Christian Kuehne,
Kai Licha, Rainer Haag, Jens Dernedde and Ulrike Alexiev

Permissions

List of Contributors

�I ��������

_______________________ WORLD TECHNOLOGIES _____________________

Preface

The world is advancing at a fast pace like never before. Therefore, the need is to keep up with the latest developments.
This book was an idea that came to fruition when the specialists in the area realized the need to coordinate together
and document essential themes in the subject. That’s when I was requested to be the editor. Editing this book has
been an honour as it brings together diverse authors researching on different streams of the field. The book collates
essential materials contributed by veterans in the area which can be utilized by students and researchers alike.

Medicinal and natural product chemistry is generally considered as a discipline concerned with biological molecules
but it is essentially the chemistry of carbon compounds. A large number of organic compounds are either derived or
completely synthesized in laboratories. This book discusses many such advanced compounds, their manufacturing
processes, structures and properties. Some of the topics included are drug design to combinatorial synthesis and
parallel synthesis, applications of compound collections, compound preparation, molecular diversity assessments,
etc. The ever growing need for advanced technology is the reason that has fueled the research in this field in
recent times. Such selected concepts that redefine medicinal and natural product chemistry have been presented
in this book. The extensive content presented in the book provides the readers with a thorough understanding
of this subject. It will serve as a resource guide for professionals, researchers and students engaged in this field.

Each chapter is a sole-standing publication that reflects each author´s interpretation. Thus, the book displays a
multi-facetted picture of our current understanding of applications and diverse aspects of the field. I would like to
thank the contributors of this book and my family for their endless support.

Editor

_______________________ WORLD TECHNOLOGIES _____________________

_______________________ WORLD TECHNOLOGIES _____________________

Polyphenolic Composition and Evaluation of
Antioxidant Activity, Osmotic Fragility and Cytotoxic
Effects of Raphiodon echinus (Nees & Mart.) Schauer

Antonia Eliene Duarte 1,2, Emily Pansera Waczuk 2, Katiane Roversi 3,
Maria Arlene Pessoa da Silva 4, Luiz Marivando Barros 1,2, Francisco Assis Bezerra da Cunha 1,2,
Irwin Rose Alencar de Menezes 5, José Galberto Martins da Costa 6, Aline Augusti Boligon 7,
Adedayo Oluwaseun Ademiluyi 2,8, Jean Paul Kamdem 2,9, João Batista Teixeira Rocha 2,* and
Marilise Escobar Burger 3,*

Academic Editor: Derek J. McPhee

1
Centro de Ciências Biológicas e da Saúde-CCBS, Departamento de Ciências Biológicas,
Universidade Regional do Cariri (URCA), Pimenta, Crato CEP 63.100-000, CE, Brazil;