Mechanisms of Disease: An Introduction to Clinical Science PDF
Preview Mechanisms of Disease: An Introduction to Clinical Science
This page intentionally left blank P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 Mechanisms of Disease http://avaxhome.ws/blogs/ChrisRedfield P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 Mechanisms of Disease An Introduction to Clinical Science SecondEdition StephenTomlinson CardiffUniveristy,UK AnthonyM.Heagerty UniveristyofManchester,UK AnthonyP.Weetman UniversityofSheffield,UK RayazA.Malik UniversityofManchester,UK CAMBRIDGEUNIVERSITY PRESS Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo Cambridge University Press The Edinburgh Building, Cambridge CB2 8RU, UK Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521818582 © Cambridge University Press 2008 This publication is in copyright. Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published in print format 2008 ISBN-13 978-0-511-38862-0 eBook (NetLibrary) ISBN-13 978-0-521-81858-2 hardback ISBN-13 978-0-521-52318-9 paperback Cambridge University Press has no responsibility for the persistence or accuracy of urls for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. Every effort has been made in preparing this book to provide accurate and up-to-date information that is in accord with accepted standards and practice at the time of publication. Nevertheless, the authors, editors and publisher can make no warranties that the information contained herein is totally free fromerror, not least because clinical standards are constantly changing through research and regulation. The authors, editors and publisher therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this book. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use. P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 Contents Listofcontributors page vii Prefacetothefirstedition xi Prefacetothesecondedition xiii 1 Molecularandcellbiology 1 JulianR.E.Davis 2 Gaucher’sdisease:amodeldisorderfor therapeuticexplorationofthelysosome 42 TimothyM.Cox 3 Obesity 69 J.Shakher,P.G.McTernanandSudheshKumar 4 Autoimmunemechanisms 85 AnthonyP.Weetman 5 Mechanismsofdisease–allergyand anaphylaxis 115 RichardS.H.Pumphrey 6 Infection–bacterial 136 StephenD.LawnandGeorgeE.Griffin 7 Infection–parasitic 160 MalcolmE.Molyneux 8 Theacutecoronarysyndrome 169 AnthonyM.Heagerty 9 Heartfailure 178 LudwigNeysesandMamtaH.Buch 10 Acuteneurodegeneration:cerebral ischaemiaandstroke 191 CraigJ.Smith,JerardRoss,NancyJ.Rothwell andPippaJ.Tyrrell v P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 vi Contents 11 Diabeticneuropathy 210 15 Trauma 275 AdamGreenstein,MoazMojaddidi,Andrew NickPayneandDavidW.Yates J.M.BoultonandRayazA.Malik 16 Theinteractionbetweenorganicand 12 Renalcellcarcinoma 226 psychiatricdisease 286 WasatMansoor ElseGuthrie 13 Alcoholicliverdisease 242 Index 305 JamesNeuberger Colourplatesectionfollowspage114. 14 Diet,healthanddisease 261 MichaelE.J.Lean P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 Contributors AndrewJ.M.Boulton,MDFRCP FacultyofMedicalandHumanSciences SchoolofMedicine ManchesterRoyalInfirmary Manchester,UK MamtaH.Buch MRICentralManchesterand ManchesterChildren’sUniversityHospitals ManchesterRoyalInfirmary Manchester,UK TimothyM.Cox,MAMScMDFRCPFMedSci UniversityofCambridgeand DepartmentofMedicine, UniversityofCambridgeNHSHospitals FoundationTrust Cambridge,UK JulianR.E.Davis,MDPhDFRCP EndocrineSciencesResearchGroup SchoolofClinical&LaboratorySciences UniversityofManchester Manchester,UK AdamGreenstein,BSc(Hons)ChBMRCP FacultyofMedicalandHumanSciences SchoolofMedicine ManchesterRoyalInfirmary Manchester,UK GeorgeE.Griffin,BScPhDFRCP(Lon,E)FMedSci StGeorge’s,UniversityofLondon London,UK vii P1:PCX Printer:YetToCome 9780521618168pre CUFX248A/Tomilson January17,2008 12:12 viii Contributors ElseGuthrie,MScMDMBChBFRCPsych RayazA.Malik,MDChBFRCPPhD ManchesterRoyalInfirmary DivisionofCardiovascularMedicineand Manchester,UK EndocrineSciences UniversityofManchester AnthonyM.Heagerty Manchester,UK CardiovascularResearchGroup DivisionofCardiovascularandEndocrine WasatMansoor,MBChBMRCPPhD Sciences ChristieHospital UniversityofManchester Manchester,UK Manchester,UK MoazMojaddidi,MBChB SudheshKumar,MDFRCP FacultyofMedicalandHumanSciences ClinicalSciencesResearchInstitute SchoolofMedicine WarwickMedicalSchool ManchesterRoyalInfirmary UniversityofWarwick Manchester,UK Coventry,UK MalcolmE.Molyneux,MD StephenD.Lawn,BMedSciMBBSMRCPMDDTM&H Malawi–Liverpool-WellcomeTrustClinicalResearch DipHIVMed Programme TheDesmondTutuHIVCentre CollegeofMedicine InstituteofInfectiousDiseaseandMolecular UniversityofMalawi Medicine Blantyre,Malawi FacultyofHealthSciences UniversityofCapeTown LudwigNeyses,MD SouthAfrica UniversityofManchester and Manchester,UK ClinicalResearchUnit DepartmentofInfectiousandTropicalDiseases JamesNeuberger,DMFRCP LondonSchoolofHygieneandTropical QueenElizabethHospitaland Medicine UniversityofBirmingham London,UK Birmingham,UK MichaelE.J.Lean,MAMDFRCP NickPayne UniversityofGlasgowand WythenshaweHospital GlasgowRoyalInfirmary Manchester,UK Glasgow,UK and RichardS.H.Pumphrey,MD UniversityofOtago HonoraryConsultantImmunologist Dunedin,NewZealand ManchesterRoyalInfirmary Manchester,UK P.G.McTernan DivisionofClinicalSciences JerardRoss WarwickMedicalSchool TheDepartmentofClinicalNeurosciences UniversityofWarwick WesternGeneralHospital Coventry,UK Edinburgh,UK
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