ELSEVIER Contents of volume 116 Volume 116 No. 1 July 10 2000 Volume 116 Nos. 2 July 31 2000 Adenovirus-mediated gene transfer to cerebral circulation H. Ooboshi, S. Ibayashi, D.D. Heistad, M. Fujishima (Fukuoka, Japan lowa, IA) Modulation of bone remodeling by active vitamin D: its role in treatment Of osteoporosis K. Ikeda, E. Ogata (Aichi, Tokyo, Japan) Association of a Leu’’— Pro polymorphism of the transforming growtl factor-$| with genetic susceptibility to osteoporosis and spinal os teoarthritis Y. Yamada (Obu, Japan) Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi Y. Morimitsu, K. Hayashi, Y. Nakagawa, H. Fujii Horio, K Uchida, T. Osawa (Nagoya, Japan) Induction of glutathione S-transferase by prostaglandins K. Uchida (Nagoya, Japan) Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention J.A. Joseph, N.A. Denisova, D. Bielinski, D.R. Fisher, B. Shukitt-Hale (Boston, MA) Water soluble nortropane alkaloids in crude drugs, edible fruits and vegetables: biological activities and therapeutic applications N. Asano (Kanazawa, Japan) \ review of age-related changes in energy regulation and suggested mecha nisms S.B. Roberts (Boston, MA) Will antioxidants fulfill their expectations for the treatment of Alzheimer disease C.A. Rottkamp, A. Nunomura, K. Hirai, L.M. Sayre, G. Perry, M.A Smith (Cleveland, OH) Mechanism underlying anti-a tic activity of a ( — )deprenyl-related propargylamine, rasagiline W. Maruyama, T. Yamamoto, K. Kitani, M.C. Carrillo, M. Youdin M. Naoi (Aichi, Nagoya, Gifu, Japan; Rosario, Argentina: Haifa Israel) Novel approaches in diagnosis and therapy of Creutzfeldt—Jakob disease W.E.G. Miller, J.-L. Laplanche, H. Ushijima, H.C. Schréder (Mainz Germany; Paris, France: Tokyo, Japan) Author index Subject index Volume contents eyo