Description:Content: I. Introduction; 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando; II. Polyketide Biosynthesis in Plants and Microorganisms; 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds; 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J. Cox; 4. Searching for Polyketides in Insect Pathogenic Fungi - Donna M. Gibson, Stuart B. Krasnoff, and Alice C.L. Churchill; 5. Polyketide Biosynthesis in Fungi - Kenneth C. Ehrlich; 6. Biochemical and Molecular Analysis of the Biosynthesis of Fumonisins - Liangcheng Du, Fengan Yu, Xiangcheng Zhu, Kathia Zaleta-Rivera, Ravi S. Bojja, Yousong Ding, Han Yi, and Qiaomei Wang; 7. Benzoic Acid-Specific Polyketide Synthases from Plants L. Beerhues, B. Liu, T. Raeth, T. Klundt, T. Beuerle, and M.Bocola; 8. Engineered Biosynthesis of Plant Polyketides - Ikuro Abe; 9. Expression and Function of Aromatic Polyketide Synthase Genes in Raspberries (Rubus idaeus sp.) - Geza Hrazdina and Desen Zheng; 10. Molecular and Biochemical Characterization of Novel Polyketide Synthases Likely to be Involved in the Biosynthesis of Sorgoleone - Daniel Cook, Franck E. Dayan, Agnes M. Rimando, N.P. Dhammika Nanayakkara, Zhiqiang Pan, Stephen O. Duke, and Scott R. Baerson; III. Structural Organization and Reaction Mechanisms Utilized by Polyketide Synthases; POLYKETIDE BIOSYNTHESIS BEYOND THE TYPE I, II, AND III POLYKETIDE SYNTHASE PARADIGMS: A PROGRESS REPORT - BEN SHEN, YI-QIANG CHENG, STEVEN D. CHRISTENSON, HUI JIANG, JIANHUA JU, HYUNG-JIN KWON, SI-KYU LIM, WEN LIU, KOICHI NONAKA, JEONG-WOO SEO, WYATT C. SMITH, SCOTT STANDAGE, GONG-LI TANG, STEVEN VAN LANEN, AND JIAN ZHANG; 12. Structural Enzymology of Aromatic Polyketide Synthase - Tyler Paz Korman, Brian Douglas Ames, and Shiou-Chuan Tsai; 13. Mechanisms of Type III Polyketide Synthase Functional Diversity. From 'Steric Modulation' to the 'Reaction Partitioning' Model - Michael B. Austin and Joseph P. Noel; IV. Biotechnological Advances in Polyketide Biosynthesis; 14. Novel Polyketides from Genetic Engineering (and lessons we have learned from making them) - Leonard Katz, Jonathan Kennedy, Sarah C. Mutka, John R. Carney, Karen S. MacMillan, and Sumati Murli; 15. Biosynthesis of the Antifungal Polyketide Antibiotic Soraphen A in Sorangium cellulosum and Streptomyces lividans - Istvan Molnar, Ross Zirkle, and James M. Ligon; 16. Engineering Starter Units in Aromatic Polyketides - Wenjun Zhang and Yi Tang; 17. Aspergillus flavus Genomics for Discovering Genes Involved in Aflatoxin Biosynthesis - Jiujiang Yu and Thomas E. Cleveland