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VOLUME 4, ISSUE 9 SEPTEMBER 2020 M A S S MONTHLY APPLICATIONS IN STRENGTH SPORT ERIC HELMS | GREG NUCKOLS | MICHAEL ZOURDOS | ERIC TREXLER The Reviewers Eric Helms Eric Helms is a coach, athlete, author, and educator. He is a coach for drug-free strength and physique competitors at all levels as a part of team 3D Muscle Journey. Eric regularly publishes peer- reviewed articles in exercise science and nutrition journals on physique and strength sport, in addition to writing for commercial fitness publications. He’s taught undergraduate- and graduate-level nutrition and exercise science and speaks internationally at academic and commercial conferences. He has a B.S. in fitness and wellness, an M.S. in exercise science, a second Master’s in sports nutrition, a Ph.D. in strength and conditioning, and is a research fellow for the Sports Performance Research Institute New Zealand at Auckland University of Technology. Eric earned pro status as a natural bodybuilder with the PNBA in 2011 and competes in unequipped powerlifting, weightlifting, and strongman. Greg Nuckols Greg Nuckols has over a decade of experience under the bar and a B.S. in exercise and sports science. Greg earned his M.A. in exercise and sport science from the University of North Carolina at Chapel Hill. He’s held three all-time world records in powerlifting in the 220lb and 242lb classes. He’s trained hundreds of athletes and regular folks, both online and in-person. He’s written for many of the major magazines and websites in the fitness industry, including Men’s Health, Men’s Fitness, Muscle & Fitness, Bodybuilding.com, T-Nation, and Schwarzenegger.com. Furthermore, he’s had the opportunity to work with and learn from numerous record holders, champion athletes, and collegiate and professional strength and conditioning coaches through his previous job as Chief Content Director for Juggernaut Training Systems and current full-time work on StrongerByScience.com. Michael C. Zourdos Michael (Mike) C. Zourdos, Ph.D., CSCS, has specializations in strength and conditioning and skeletal muscle physiology. He earned his Ph.D. in exercise physiology from The Florida State University (FSU) in 2012 under the guidance of Dr. Jeong-Su Kim. Prior to attending FSU, Mike received his B.S. in exercise science from Marietta College and M.S. in applied health physiology from Salisbury University. Mike served as the head powerlifting coach of FSU’s 2011 and 2012 state championship teams. He also competes as a powerlifter in the USAPL, and among his best competition lifts is a 230kg (507lbs) raw squat at a body weight of 76kg. Mike owns the company Training Revolution, LLC., where he has coached more than 100 lifters, including a USAPL open division national champion. Eric Trexler Eric Trexler is a pro natural bodybuilder and a sports nutrition researcher. Eric has a PhD in Human Movement Science from UNC Chapel Hill, and has published dozens of peer-reviewed research papers on various exercise and nutrition strategies for getting bigger, stronger, and leaner. In addition, Eric has several years of University-level teaching experience, and has been involved in coaching since 2009. Eric is the Director of Education at Stronger By Science. Table of Contents 6 B Y G R E G N U C K O L S “Genetic Variability” in Training Responses: A Misunderstood Concept A recent twin study attempted to estimate the degree to which divergent training responses are influenced by “nature” versus “nurture.” In this article, I’ll discuss why those estimates are way harder to pin down than typically assumed. 25 B Y M I C H A E L C . Z O U R D O S How Does Your Preferred Training Time Affect Performance? There doesn’t seem to be a huge difference in long-term muscle and strength gains between morning and afternoon/evening training. However, acute performance may be better when training at your preferred time of day, whether in the AM or PM. This article covers a new study that tackled the preferred time angle. 36 B Y E R I C H E L M S Training Plans Are Important, but Not Foolproof While often debated and complicated, periodization is just planning training with respect to time. For competitors, the important time points are competitions. In this article, I review a weightlifting meet preparation case series. As you’ll see, planning is critical, but not foolproof. 51 B Y E R I C T R E X L E R The Tortoise Versus the Hare, Revisited: Who Wins the Fat Loss Race? For people with fat loss goals, rapid drops in body weight seem appealing, but fast weight loss could theoretically come with notable trade offs. This month, a new meta-analysis compared the effects of faster or slower weight loss on resting metabolic rate and a variety of body composition outcomes. Read on to find out what the research says about optimal rates of weight loss. 65 B Y G R E G N U C K O L S Do Oral Contraceptives Affect Exercise Performance? Many female athletes worry that oral contraceptives will hinder their performance. A recent meta-analysis suggests that those fears are reasonable, though the degree to which oral contraceptives affect performance is likely to be trivial. 80 B Y M I C H A E L C . Z O U R D O S The Inherent Benefit of Tracking Velocity A new study suggests that merely viewing velocity can enhance acute performance. Therefore, an inherent benefit of velocity-based training may simply be seeing the velocity. However, this article explains that this intrinsic benefit may manifest to a greater extent in some exercises than in others. 91 B Y E R I C T R E X L E R Is Beta-Alanine Under-Dosed in Every Study? Beta-alanine was initially propped up as “the next creatine,” but that enthusiasm has largely dissipated in the lifting world. However, the results of a new meta-analysis may suggest that virtually every beta-alanine study to date has been under-dosed. Read on to find out how much this study impacts our understanding of beta-alanine supplementation. 104 B Y G R E G N U C K O L S Do You Need to Go to Failure When Training with Low Loads? A recent study was the first to compare low-load training to failure versus low-load training near failure. Do you need to actually reach failure with low loads to maximize hypertrophy? The current study leaves us with a resounding “maybe.” 123 B Y M I C H A E L C . Z O U R D O S VIDEO: Pre-Training Stretching: An Update Acute static stretching decreases strength performance, right? Not so fast. Stretching can negatively affect performance, but the detriment is in the dosage. Also, new data suggests that you can quickly counteract the negative physiological effects of static stretching. This video provides a thorough update on the topic. 125 B Y E R I C H E L M S VIDEO: Autoregulation at the Mesocycle Level Most research-based autoregulation strategies are useful within session for manipulating load and volume. A few others can be used to modify session order or session selection in a flexible template. However, there are few research-based strategies for autoregulation between micro and macro cycles of training. Session RPE has the potential to do just that, and in this video we discuss how to do so. Letter From the Reviewers elcome to the September 2020 issue of MASS! W This month, Eric Helms reviewed a case series documenting changes in physiology and performance in a pair of elite weightlifters preparing for competition. Eric Trexler reviewed a meta-analysis comparing fast and slow rates of weight loss, and a meta-analysis examining the effects of beta-alanine supplementation on muscle carnosine levels. A cool takeaway from the beta-alanine meta is that we may be underestimating the possible effects of beta-alanine supplementation, since supplementation protocols used in the literature are probably insufficient to maximize muscle carnosine levels. Mike reviewed a study examining whether velocity feedback improves performance during strength-oriented and power-oriented sessions, and a study examining the degree to which time-of-day affects resistance training performance. Finally, Greg reviewed a meta-analysis looking at the effects of hormonal contraceptives on exercise performance, a study examining hypertrophic responses in low-load failure versus low-load non-failure training, and a twin study investigating the degree to which genetics impact strength and endurance training outcomes. Also, we’ve made a small change to some of our interpretation sections this month. Whenever we want to get into the weeds regarding methodology or statistics, we’re going to start using a separate subheading. It’s a small change, but it should be helpful for readers with different goals and expectations. If you’re someone who’s really into research, you can travel down the nerdy little rabbit holes with us. If you read MASS for more focused research discussions and more actionable takeaways, the new subheads will let you know what parts of the article you can skip without missing any actionable information. Hopefully this little tweak will help MASS be a little more useful for everyone. Sincerely, The MASS Team Eric Helms, Greg Nuckols, Mike Zourdos, and Eric Trexler 5 Study Reviewed: Fitness and Strength Responses to Distinct Exercise Modes in Twins: Studies of Twin Responses to Understand Exercise as a Therapy (STRUETH) study. Marsh and Thomas et al. (2020) “Genetic Variability” in Training Responses: A Misunderstood Concept BY GREG NUCKOLS A recent twin study attempted to estimate the degree to which divergent training responses are influenced by “nature” versus “nurture.” In this article, I’ll discuss why those estimates are way harder to pin down than typically assumed. 6 KEY POINTS 1. The presently reviewed study was a crossover twin study. Sets of monozygotic (“identical” or “maternal”) and dizygotic (“fraternal”) twins underwent 12 weeks of strength training and 12 weeks of endurance training in a randomized order, and the two training blocks were separated by a 12-week washout period. 2. The researchers wanted to compare the degree to which baseline performance and responsiveness to training are influenced by genetic versus environmental factors. 3. Genetics probably have a larger impact on our pre-training performance (our strength and aerobic fitness before doing any training) than they have on our ability to respond positively to training. 4. The statistical framework that researchers often use to study genetic contributions to different traits is based on a set of very shaky assumptions. Therefore, any estimate of genetic contributions to a particular trait should be taken with a pretty large grain of salt. 5. Regardless of their origins, we know that responses to training exhibit enormous variability. It’s worth acknowledging this variability, regardless of its source, but primarily focusing on things within our control. ’m sure that you’ve seen people claim are world-class sprinters that have two copies I that they have “bad genetics” for lifting, of the “bad” version of the gene (3). or that so-and-so has “good genetics” for Since individual genes don’t tell us too much, lifting. This verbiage invites a few questions: the next option is to look at twin studies, which “What does it mean to have ‘good’ or ‘bad’ are supposed to be able to tell us how much of genetics for lifting,” “How do we know that the variability in performance is attributable someone has ‘good’ or ‘bad’ genetics for lift- to “nature” (genetics) versus “nurture” (envi- ing,” and most importantly, “How much of ronment). The presently reviewed study (1) the variability we see in training responses is takes that approach. Groups of monozygotic truly due to variation is genetics?” and dizygotic twins went through a crossover As it turns out, it’s hard to pin down solid an- study, performing 12 weeks of strength train- swers to any of those questions. Research has ing and 12 weeks of endurance training in a established that some particular allele vari- randomized order, with a 12-week washout ants are predictive of success in strength and period between programs. Researchers com- power sports (2), but each allele variant only pared the similarities between monozygotic explains a small amount of the variability in versus dizygotic twins to estimate the degree performance. For example, the ACTN3 gene to which their baseline strength, baseline aer- is the gene that seems to be most strongly as- obic fitness, changes in strength, and changes sociated with success in sprinting, but there in aerobic fitness were attributable to genet- 7 ic versus environmental factors. The authors one form of training would also respond suggest that the vast majority of the variabil- positively to the other form of training. ity could be explained by environmental fac- 3. The genetic contribution to the variance tors, rather than genetic factors. Read on to in baseline strength and aerobic capacity find out why I’m not incredibly confident in would be different than the genetic contri- the authors’ interpretation. bution to training effects. Purpose and Hypotheses Subjects and Methods Purpose Subjects The purpose of this study was to estimate the 34 pairs of twins completed the study (in- genetic and environmental contributions to cluding baseline testing and training inter- resistance and aerobic exercise trainability. ventions), including 24 pairs of monozygotic Hypotheses twins (i.e. “identical” or “maternal” twins) The authors hypothesized that: and 10 pairs of dizygotic twins (i.e. “frater- nal” or “non-identical”), out of an initial 40 1. Exercise responsiveness would follow twin pairs that enrolled. They were mostly the principle of specificity (e.g. strength young (24.9 ± 5.4 years old) nonsmokers, but gains would be larger following resis- were relatively unfit, and exercised less than tance training, and gains in aerobic per- 150 minutes per week. Their baseline infor- formance would be larger following en- mation can be seen in Table 1. durance training). Experimental Design 2. People would respond positively to at least one form of training (either aerobic This was a randomized crossover study, or resistance training), and responders to meaning each twin pair was assigned to com- 8 plete either a resistance training or endurance and reps per set decreased during the strength training program, followed by a washout pe- training program (from sets of 12-15 reps with riod, followed by the completion of the other 60-70% of 1RM in weeks 1-3, to sets of 5 training program. The training periods and with 80-90% of 1RM in weeks 10-12). Sub- the washout period were all 12 weeks long. jects alternated between upper and lower body So, for example, if you were a subject in this training days, with one main exercise per day study, you and your twin may be randomized (bench press, standing military press, leg press, to complete the resistance training program squats, and deadlifts), followed by supplemen- first; you’d do the resistance training pro- tal exercises (which aren’t exhaustively list- gram for 12 weeks, not train for 12 weeks, ed). The endurance training began with four and then do the endurance training program weeks of low-intensity work (at 60% of max for 12 weeks. heart rate), followed by four weeks of training that alternated between high intensity interval Testing was carried out at the start and end of training (up to 90% of max heart rate) and low- each training phase. The testing consisted of er intensity training, finishing with four weeks leg press 1RM, bench press 1RM, and VO2m- of longer-duration moderate intensity training ax (a measure of maximal aerobic power; 4). just below lactate threshold. Subjects trained The strength training and endurance training three times per week, and all training sessions protocols were periodized. Intensity increased lasted approximately one hour. 9 The authors note that monitoring was per- Based on the training responses observed in the formed to equate the workload within each monozygotic and dizygotic twins, the authors twin pair. For resistance training: “Number calculated the degree to which each training of repetitions, number of sets, weight and outcome was influenced by genetic effects, rate of perceived exertion (RPE) were re- shared environmental effects, and individual corded for every session to allow the trainers environmental effects. In the interpretation to monitor the work load undertaken by the section of this article, I’ll explain how those participants. The main purpose of this moni- calculations are performed, and why we may toring was to ensure individual workload was want to take them with a grain of salt. equal within twin pairs.” For endurance train- ing: “Training intensity was personalised and Findings matched within the twin pair for each session Unsurprisingly, subjects gained more and monitored via continuous heart rate (HR) strength in both the leg press and bench press assessment. Target HRs were calculated from HR at a percentage of the initial graded exer- following resistance training than endurance cise VO2max test, so that they were individ- training. Conversely, VO2max and time to ualised, but matched, for intensity between exhaustion increased more following endur- individuals and within-twin pairs.” ance training than resistance training. 10

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