Management of Early Stage Breast Cancer: Basics and Controversies

279 Pages·2021·5.769 MB·English

by  Beena Kunheri, D. K. Vijaykumar

Management of Early
Stage Breast Cancer
Basics and Controversies
Beena Kunheri
D. K. Vijaykumar
Editors
123
Management of Early Stage Breast Cancer
Beena Kunheri • D. K. Vijaykumar
Editors
Management of Early
Stage Breast Cancer
Basics and Controversies
Editors
Beena Kunheri D. K. Vijaykumar
Department of Radiation Oncology Department of Breast and Gynecological
Amrita Institute of Medical Sciences Oncology
and Research Centre Amrita Institute of Medical Sciences
Amrita Vishwa Vidyapeetham University Amrita Vishwa Vidyapeetham University
Kochi Kochi
Kerala Kerala
India India
ISBN 978-981-15-6170-2 ISBN 978-981-15-6171-9 (eBook)
https://doi.org/10.1007/978-981-15-6171-9
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We would like to dedicate this book to
All the amazing women we have met and
those we have not who battle with the
dark days.
Our teachers who inspire and teach us to
remain humble in our pursuit of knowledge.
Our families and special friends for the
continued love and support they have
selflessly given.
Foreword

It gives me immense pleasure to write a foreword for an excellent educative exercise
done by Dr. Beena and Dr. Vijaykumar.
The management of early breast cancer has always been an area of keen interest
for practicing oncologists. The management schema of early breast cancer has
dynamically evolved over decades. There has been a paradigm shift in the manage-
ment algorithm of early breast cancer, and interestingly there are still several con-
troversies in its management.
The book compiled, written, and authored by Dr. Beena and Dr. Vijaykumar cov-
ers every area from epidemiology, screening, various treatment modalities to
rehabilitation.
Dr. Beena Kunheri has a special interest in breast cancer, and I am glad she has
taken up this task and I am sure it would greatly guide practicing oncologists. Dr.
Beena is a leading clinician and academic with several original publications to
her credit.
Dr. D.K. Vijaykumar is an eminent oncosurgeon and has a special interest in
breast cancer surgery. He is one of the pioneers in sentinel node surgery for breast
cancer in India.
Although we have access to the internet, social media, smart phones, and tablet
computers, I still feel that concise information on a dedicated and important topic
like early breast cancer, written by experts in that field, would be quite useful and
handy for an immediate reference.
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viii Foreword
I found it quite comprehensive, covering all aspects of early breast cancer. It
provides valuable information and covers all the necessary components of early
breast cancer management.
I congratulate Dr. Beena and Dr. Vijaykumar on this wonderfully done exercise,
and I wish them good luck for their future endeavors too.
P. Vijay Anand Reddy, MBBS, MD
Director, Apollo Cancer Institute
Hyderabad, TS, India
Past President, Association of Radiation Oncologists of India
Hyderabad, TS, India
Preface
It is indeed a great pleasure to publish the first edition of this book on Early Breast
Cancer. Breast cancer is the most common cancer in women in developed and
developing countries like India. In India it accounts for the major proportion of
oncologists’ work. The incidence of breast cancer has steadily increased since the
1970s across the globe. However due to the effective implementation of screening
programs, early detection, and effective treatment, breast cancer mortality has
decreased in developed countries. In developing countries, early detection and
improvement in overall survival are yet to be achieved.
With the rapidly advancing trends in the treatment and care of women with breast
cancer, it has become increasingly difficult for busy clinicians to keep up to date
with the latest guidelines and newer approaches to treatment. We have carefully
chosen experts from specific fields to author each chapter so that this serves as a
comprehensive textbook.
The textbook covers a broad range of topics including:
• Epidemiology
• Prevention
• Early detection and diagnosis
• Prognostic and predictive markers
• Molecular biology
• Newer pathological and molecular subtypes
• Receptor mechanism
• Genetics
• Developments in imaging modalities
• Surgical treatments
• Radiation treatments
• Drug therapies
• Advances in management including precision and personalized treatment
The closing chapter highlights the importance of psychological well-being in
cancer treatment. It is included to make physicians aware of the psychosocial issues
associated with breast cancer diagnosis and how best to provide psychological sup-
port for better outcomes.
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x Preface
We believe our book should find a place in all oncology departments as a com-
prehensive resource for students and oncologists helping them in their clinical deci-
sion making. We also hope our book will be a helpful specialist reference for other
disciplines including pathology, radiology, pharmacology, molecular biology,
genetics, surgery, and various other specialties.
It has been a wonderful opportunity to edit this book. An endeavor like this takes
the help of a multitude of individuals without whom this book would not have been
possible.
We are greatly appreciative of the work of all the authors for the wonderful
review and their expertise.
In conclusion we want to acknowledge the thousands of women with breast can-
cer who have participated in the studies that have provided the information that has
helped to advance the field by leaps and bounds in recent years.
Kochi, Kerala, India Beena Kunheri
Kochi, Kerala, India D. K. Vijaykumar
Acknowledgments
Pranams to Almighty for making this happen. We are indebted to our teachers, and
this work is only a reflection of the inspiration from our teachers who offered us the
grounding and foundations. Our pranams to our teachers.
Bringing out a book is harder than we thought and more rewarding than we could
have ever imagined.
I along with Dr. Vijaykumar would like to thank each and every one who has
helped and supported us in the planning, preparation, and completion of this
textbook.
At the very outset, we express our gratitude to Dr. Prem Nair, Medical Director,
and Dr. (Col) Vishal Marwaha, Principal.
We acknowledge with gratitude and affection our former Additional Medical
Superintendent Dr. Koravangattu Valsraj (Consultant Psychiatrist, NHS, London,
UK) for his guidance, invaluable suggestions, unwavering support, and encourage-
ment throughout the preparation of this book.
It was his suggestion to add a chapter on the psychological impact of breast can-
cer diagnosis and treatment, making this book a truly comprehensive one.
We are thankful and indebted to Dr. Pavithran, Head of Dept. Medical Oncology
for the invaluable suggestions and support.
We are most grateful to all the chapter contributors/authors for agreeing to be
part of this project and spending their time in the midst of their busy clinical
schedules.
Our special thanks to Miss. Bibin Rose Mohan (Physician Assistant) and Mrs.
Sathikumari (Secretary), Department of Radiation Oncology, for their assistance
and support.
We thank the publisher Springer Nature and Ms. Saanthi Shankhararaman for
coordinating the project.
We wholeheartedly acknowledge both our families for their unconditional love,
support, and inspiration.
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