Mammary Tumor Cell Cycle, Differentiation, and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer PDF
Preview Mammary Tumor Cell Cycle, Differentiation, and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer
Mammary Tumor Cell Cycle, Differentiation, and Metastasis Cancer Treatment and Research Emil J Freireieh, M.D., D.Se.(Hon.), Series Editor Lippman ME, Dickson R (eds): Breast Cancer: Cellular and Molecular Biology. 1988. ISBN 0-89838-368-4 Kamps WA, Humphrey GB, Poppema S (eds): Hodgkin's Disease in Children: Controversies and Current Practice. 1988. ISBN 0-89838-372-2 Muggia FM (ed): Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances. 1988. ISBN 0-89838-381-1 Nathanson L (ed): Malignant Melanoma: Biology, Diagnosis, and Therapy. 1988. ISBN 0-89838-384-6 Pinedo HM, Verweij J (eds): Treatment of Soft Tissue Sarcomas. 1989. ISBN 0-89838-391-9 Hansen HH (ed): Basic and Clinical Concepts of Lung Cancer. 1989. ISBN 0-7923-0153-6 Lepor H, Ratliff TL (eds): Urologic Oncology. 1989. ISBN 0-7923-0161-7 Benz C, Liu E (eds): Oncogenes. 1989. ISBN 0-7923-0237-0 Ozols RF (ed): Drug Resistance in Cancer Therapy. 1989. ISBN 0-7923-0244-3 Surwit EA, Alberts DS (eds): Endometrial Cancer. 1989. ISBN 0-7923-0286-9 Champlin R (ed): Bone Marrow Transplantation. 1990. ISBN 0-7923-0612-0 Goldenberg D (ed): Cancer Imaging with Radiolabeled Antibodies. 1990. ISBN 0-7923-0631-7 Jacobs C (ed): Carcinomas of the Head and Neck. 1990. ISBN 0-7923-0668-6 Lippman ME, Dickson R (eds): Regulatory Mechanisms in Breast Cancer: Advances in Cellular and Molecular Biology of Breast Cancer. 1990. ISBN 0-7923-0868-9 Nathanson L (ed): Malignant Melanoma: Genetics, Growth Factors, Metastases, and Antigens. 1991. ISBN 0-7923-0895-6 Sugarbaker PH (ed): Management of Gastric Cancer. 1991. ISBN 0-7923-1102-7 Pinedo HM, Verweij J, Suit HD (eds): Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment. 1991. ISBN 0-7923-1139-6 Ozols RF (ed): Molecular and Clinical Advances in Anticancer Drug Resistance. 1991. ISBN 0-7923-1212-0 Muggia FM (ed): New Drugs, Concepts and Results in Cancer Chemotherapy 1991. ISBN 0-7923-1253-8 Dickson RB, Lippman ME (eds): Genes, Oncogenes and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer. 1992. ISBN 0-7923-1748-3 Humphrey G, Bennett, Schraffordt Koops H, MolenaaT WM, Postma A (eds): Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. 1993. rSBN 0-7923-1905-2 Benz CC, Liu ET (eds): Oncogenes and Tumor Suppressor Genes in Human Malignancies. 1993. ISBN 0-7923-1960-5 Freireich EJ, Kantarjian H (eds): Leukemia: Advances in Research and Treatment. 1993. ISBN 0-7923-1967-2 Dana BW (ed): Malignant Lymphomas, Including Hodgkin's Disease: Diagnosis, Management, and Special Problems. 1993. ISBN 0-7923-2171-5 Nathanson L (ed): Current Research and Clinical Managementoi Melanoma. 1993. ISBN 0-7923-2152-9 Verweij J, Pinedo HM, Suit HD (eds): Multidisciplinary Treatment of Soft Tissue Sarcomas. 1993. ISBN 0-7923-2183-9 Rosen ST, Kuzel TM (eds): Immunoconjugate Therapy of Hematologic Malignancies. 1993. ISBN 0-7923-2270-3 Sugarbaker PH (ed): Hepatobiliary Cancer. 1994. ISBN 0-7923-2501-X Rothenberg ML (ed): Gynecologic Oncology: Controversies and New DevelopmeG,!s. 1994. ISBN 0-7923-2634-2 Dickson RB, Lippman ME (eds): Mammary Tumorigenesis and Malignant Progression. 1994. ISBN 0-7923-2647-4 Hansen HH (ed): Lung Cancer. Advances in Basic and Clinical Research. 1994. ISBN 0-7923-2835-3 Goldstein LJ, Ozols RF (eds): Anticancer Drug Resistance. Advances in Molecular and Clinical Research. 1994. ISBN 0-7923-2836-1 Hong WK, Weber RS (eds): Head and Neck Cancer. Basic and Clinical Aspects. 1994. ISBN 0-7923·3015·3 Thall PF (ed): Recent Advances in Clinical Trial Design and Analysis. 1995. ISBN 0-7923·3235·0 Buckner CD (ed): Technical and Biological Components of Marrow Transplantation. 1995. ISBN 0·7923-3394-2 Muggia FM (ed): Concepts, Mechanisms, and New Targets for Chemotherapy. 1995. ISBN 0-7923-3525-2 Klastersky J (ed): Infectious Complications of Cancer. 1995. ISBN 0-7923-3598-8 Kurzrock R, Talpaz M (eds): Cytokines: Interleukins and Their Receptors. 1995. ISBN 0-7923-3636-4 Sugarbaker P (ed): Peritoneal Carcinomatosis: Drugs and Diseases. 1995. ISBN 0-7923-3726-3 Sugarbaker P (ed): Peritoneal Carcinomatosis: Principles of Management. 1995. ISBN 0-7923-3727-1 Mammary Tumor Cell Cycle, Differentiation, and Metastasis Advances in Cellular and Molecular Biology of Breast Cancer edited by Robert B. Dickson Marc E. Lippman Lombardi Cancer Research Center Washington, D.C. KLUWER ACADEMIC PUBLISHERS 1996 BOSTON / DORDRECHT / LONDON Distributors for North America: Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell, Massachusetts 02061 USA Distributors for all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS Library of Congress Cataloging-in-Publication Data Mammary tumor cell cycle, differentiation, and metastasis: advances in cellular and molecular biology of breast cancer / edited by Robert B. Dickson, Marc E. Lippman. p. cm. -- (Cancer treatment and research; v. 83) Includes bibliographical references and index. ISBN-13:978-1-4612-8536-6 e-ISBN-13:978-1-4613-1259-8 DOl: 10.1007/978-1-4613-1259-8 1. Breast--Cancer--Molecular aspects. 2. Cancer cells. 3. Cell differentiation. 4. Metastasis. 5. Cell transformation. I. Dickson, Robert B. (Robert Brent), 1952- . II. Lippman, Marc E., 1945- . III. Series. [DNLM: 1. Breast Neoplasms. 2. Cell Differentiation. 3. Neoplasm Metastasis. WI CA693 v.83 1995/ WP 870 M262 1995] RC280.B8M2651995 616.99' 449071--dc20 DNLM/DLC for Library of Congress 96-4654 CIP Copyright © 1996 by Kluwer Academic Publishers Softcover reprint of the hardcover 1s t edition 1996 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photo-copying, recording, or otherwise, without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061 Printed on acid-free paper. Contents Contributing authors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IX Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. xiii A. Mouse models of mammary development and tumorigenesis . . . . . . 1 1. Programmed cell death and mammary neoplasia . . . . . . . . . . . . . 3 PEPPER J. SCHEDIN, LARISSA B. THACKRAY , PATRICIA MALONE, SUSAN C. FONTAINE, ROBERT R. FRIIS, and ROBERT STRANGE 2. Tissue reconstitution or transgenic mammary gland technique for modeling breast cancer development . . . . . . . . . . . . . . . . . . . . 23 PAUL A.W. EDWARDS 3. Pre neoplasia in mammary tumorigenesis. . . . . . . . . . . . . . . . . . . . 37 DANIEL MEDINA 4. Transgenic models of breast cancer metastasis . . . . . . . . . . . . . . . 71 DAVID L. DANKORT and WILLIAM J. MULLER B. Human breast cancer: Receptors, signaling, and the cell cycle ..... 89 5. Protein kinase C and breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . .. 91 NANCY E. DAVIDSON and M. JOHN KENNEDY 6. Protein tyrosine phosphatases: Cellular regulators of human breast cancer? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 107 YI-FAN ZHAI, JULIE J. WIRTH, CLIFFORD W. WELSCH, and WALTER J. ESSELMAN 7. Role of the nuclear matrix in breast cancer. . . . . . . . . . . . . . . . .. 127 TRACY S. REPLOGLE and KENNETH J. PIENTI 8. Cyclins and breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 141 KIMBERLY J.E. SWEENEY, ELIZABETH A. MUSGROVE, COLIN KW. WATTS, and ROBERT L. SUTHERLAND 9. Nuclear oncogenes in breast cancer ........................ 171 DON DUBIK, PETER H. WATSON, MARCELLO VENDITTI, and ROBERT P.e. SHIU 10. Antiprogestin-progestin interactions ....................... 191 H. MICHNA, KH. FRITZEMEIER, K PARCZYK, Y. NISHINO, and M.R. SCHNEIDER 11. Antiestrogen-estrogen receptor interactions. . . . . . . . . . . . . . . .. 213 MALCOLM G. PARKER e. Human breast cancer: Invastion, Metastasis, Angiogenesis, and Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 225 12. Differentiation antigens in stromal and epithelial cells of the breast. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 227 TEHEREH KAMALATI, BIRUNTHI NIRANJAN, AMANDA ATHERTON, RAMASAW AMY ANBAZHAGAN, and BARRY GUSTERSON 13. Models of progression spanning preneoplasia and metastasis: The human MCF-10A neo T.TGN series and a panel of mouse mammary tumor subpopulations . . . . . . . . . . . . . . . . . . . . . . . . . .. 243 FRED R. MILLER 14. Angiogenesis in breast cancer ............................. 265 NOEL WEIDNER 15. Cell motility in breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 303 JASON D. KANTOR and BRUCE R. ZETTER 16. Cathepsins D and B in breast cancer. . . . . . . . . . . . . . . . . . . . . .. 325 WEI-PING REN and BONNIE F. SLOANE 17. Stromelysin-3 and other stromelysins in breast cancer: Importance of epithelial-stromal interactions during tumor progression ....................................... 353 PAUL BASSETT, JEAN-PIERRE BELLOCQ, PATRICK ANGLARD, MARIE-PIERRE CHENARD, OLIVIER LEFEBVRE, AGNES NOEL, AKIKO OKADA, NICOLAS vi ROUYER, MARIA SANTAV ICCA, ISABELLE STOLL, CATHERINE WOLF, and MARIE-CHRISTINE RIO 18. Endothelins in breast cancer .............................. 369 KIVTI V. PATEL and MICHAEL P. SCHREY 19. Breast cancer immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 395 WEI-ZEN WEI and GLORIA H. HEPPNER Index... . . . . . .. . . . . ... . . . . .. . . . . .. . . . .. ... . . .. . . .. ... . . . . .. . .. 411 vii Contributing Authors RAMASAW AN ANBAZHAGA, Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, London, SMZ 5 NG, UK PATRICK ANGLARD, PHD, Institut de Genetigue et de Biologie Moleculaire at Cellulaire (IGBMC), CNRS/INSERMIULP, P.P. 163, 67404 Illkirch Cedex, CN. de Strasbourg, France AMANDA ATHERTON, PHD, Johns Hopkins University, Baltimore, MD 21205, USA PAUL BASSETT, PHD, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, P.P. 163, 67404 Ilkirch Cedex, CN. de Strasbourg, Cedex, France JEAN PIERRE BELLOCQ, MD, Service d'Anatomic Pathologique Generale, Centre Hospitalier Universitaire, Hopital de Hautepierre, 1 A venue Moliere, 67098 Strasbourg, Cedex, France MARIE-PIERRE CHENARD, MD, Service d'Anatomic Pathologique Generale, Centre Hospitalier Universitaire, Hopital de Hautepierre, 1 Avenue Molier, 67098 Strasbourg, Cedex, France DAVID L. DANKORT, PHD, Institute for Molecular Biology and Biotech nology, Department of Biology, McMaster University, 1280 Main Street W., Hamilton, Ontario, L85 4K1 Canada NANCY E. DAVIDSON, MD, The Johns Hopkins Oncology Center, 422 North Bond St., Baltimore, MD 21231-1001, USA ROBERT B. DICKSON, PHD, Departments of Cell Biology and Pharmacol ogy, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, Washington, DC 20007, USA DON DUBIK, PHD, Department of Physiology, University of Manitoba, Winnipeg, MB, R3E OW3, Canada PAUL A. EDWARDS, PHD, Division of Cellular Pathology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK WALTER J. ESSELMAN, PHD, Department of Microbiology, Michigan State University, East Lansing, MI 48824, USA S.c. FONTAINE, PHD, AMC Cancer Research Center, Lakewood, CO 80214, USA RR FRIIS, PHD, Laboratory of Clinical and Experimental Research, Uni versity of Berne, Berne, Switzerland CH-3004 K.H. FRITZEMEIER, PHD, Experimental Oncology, Research Laborato ries of Schering AG, Berlin, FRG BARRY GUSTERSON, PHD, MRCPATH, Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, London, SMZ 5NG, UK GLORIA H. HEPPNER, PHD, Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren, Detroit, MI 48201, USA TAHEREH KAMALATI, PHD, Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, London, SMZ 5NG, UK JASON D. KANTOR, PHD, Department of Surgery, Children's Hospital, and Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA M. JOHN KENNEDY, MB, FRCPI, The Johns Hopkins Oncology Center, 422 North Bond St., Baltimore, MD 21231-1001, USA OLIVIER LEFEBVRE, PHD, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch Cedex, C.N. de Strasbourg, France MARC E. LIPPMAN, MD, Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, Washington, CD 20007, USA P. MALONE, PHD, AMC Cancer Research Center, Lakewood, CO 80214, USA DANIEL MEDINA, PHD, Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA HORST MICHNA, PHD, Experimental Oncology, Research Laboratories of Schering AG, Berlin, FRG FRED R MILLER, PHD, Breast Cancer Program, Michigan Cancer Founda tion, 110E. Warren Ave., Detroit, MI 48201, USA WILLIAM J. MULLER, PHD, Institute for Molecular Biology and Biotech nology, Departments of Biology and Pathology, McMaster University, 1280 Main St. W., Hamilton, Ontario, L85 4K1, Canada ELIZABETH A. MUSGROVE, PHD, Cancer Biology Division, Garvin In stitute of Medical Research, St. Vincents Hospital, Sydney, N.S.W. 2010 Australia BIRUNTHI NIRANJAN, PHD, Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, London, SM2 5NG, UK Y. NISHINO, PHD, Experimental Oncology, Research Laboratories of Schering AG, Berlin, FRG x AGNES NOEL, PHD, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch Cedex, e.N. de Strasbourg, France AKIKO OKADA, PHD, Institut de Genetique et de Biologie Moleculaireet Cellulaire (IBBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch Cedex, e.N. de Strasbourg, France MALCOLM G. PARKER, PHD, Laboratory of Molecular Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK KIRTI V. PATEL, PHD, Institute of Cancer Research, The Haddow Laboratories, Cell Biology and Experimental Pathology, Belmont, Sutton, UK KENNETH l. PIENTA, PHD, The University of Michigan Comprehensive Cancer Center and Division of Hematology/Oncology, Department of Internal Medicine, 5510 MS RB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680, USA K. PARCYZYK, PHD, Experimental Oncology, Research Laboratories of Schering AG, Berlin, FRG WEI-PING REN, PHD, Department of Pharmacology, Wayne State Univer sity, 540 E. Canfield, Detroit, MI 48201, USA TRACY S. REPLOGLE, PHD, The University of Michigan Comprehensive Cancer Center and Division of Hematology/Oncology, Department of Internal Medicine, 5510 MS RB I, 1150 W. Medical Center Drive, Anlll Arbor, MI 48109-0680, USA MARIE-CHRISTINE RIO, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch Cedex, e.N. de Strasbourg, France NICOLAS ROUYER, MD, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERMIULP, p.p. 163, 67404 Illkirch Cedex, e.N. de Strasbourg, France MARIA SANTAV ICC, PHD, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch Cedex, e.N. de Strasbourg, France P.l. SCHEDIN, PHD, AMC Cancer Research Center, Lakewood, CO 80214, USA MARTIN R. SCHNEIDER, PHD, Experimental Oncology, Research Labo ratories of Schering AG, Berlin, FRG ROBERT P.e. SHIU, PHD, Department of Physiology, University of Manitoba, Winnipeg, MB, R3E OW3, Canada MICHAEL P. SCHREY, PHD, Unit of Metabolic Medicine, St. Mary's Hos pital Medical School, Praed St., Paddington, London W2 lPG, UK BONNIE F. SLOANE, PHD, Department of Pharmacology, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA Xl
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