Mammalian Transient Receptor Potential (TRP) Cation Channels: Volume II PDF
Preview Mammalian Transient Receptor Potential (TRP) Cation Channels: Volume II
Handbook of Experimental Pharmacology 223 Bernd Nilius Veit Flockerzi Editors Mammalian Transient Receptor Potential (TRP) Cation Channels Volume II Handbook of Experimental Pharmacology Volume 223 Editor-in-Chief W. Rosenthal, Berlin Editorial Board J.E. Barrett, Philadelphia V. Flockerzi, Homburg F.B. Hofmann, München P. Geppetti, Florence M.C. Michel, Ingelheim P. Moore, Singapore C.P. Page, London Forfurthervolumes: http://www.springer.com/series/164 . Bernd Nilius (cid:129) Veit Flockerzi Editors Mammalian Transient Receptor Potential (TRP) Cation Channels Volume II Editors BerndNilius VeitFlockerzi LaboratoryIonChannelResearch Institutfu¨rExperimentelleu.Klinische CampusGasthuisberg PharmakologieundToxikologie KULeuvenDepartment Universita¨tdesSaarlandes CellMolMedicin Homburg,Germany Leuven,Belgium ISSN0171-2004 ISSN1865-0325(electronic) ISBN978-3-319-05160-4 ISBN978-3-319-05161-1(eBook) DOI10.1007/978-3-319-05161-1 SpringerChamHeidelbergNewYorkDordrechtLondon LibraryofCongressControlNumber:2014937453 #SpringerInternationalPublishingSwitzerland2014 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerpts inconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeing enteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Duplication ofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthe Publisher’s location, in its current version, and permission for use must always be obtained from Springer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter. ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Preface Whenwe,in2007,editedthefirstissueontransientreceptorpotentialchannelinthe HandbookofExperimentalPharmacology,wewereallveryexcitedbytheprogress inthisfieldalthoughonlyonedecadeaftercloningthefirstTRPchannelhadpassed. At this time, somewhat less than 5,000 papers were published on TRP channel (January1,1960,untilDecember31,2006).Ifwechecknowtheperiod(January1, 2007, until January 13, 2014), additional 9,300 papers can be found in a PubMed search.1 Needlesstosay,thegeneralinterestonthese28membersoftheTrpgene family which encode ion channels is nearly exponentially growing. Therefore, it seemedtobeindicated,althoughmanyexcellentbooksonTRPchannelshavebeen publishedmeanwhile,tojumpintoanewadventureeditingacomprehensivesource bookinthissuccessfulSpringerHandbookseriesagainonthesametopic.Thisisnot onlyanupdateofthe2007bookbutalsoanimpressiveintroductionofnovelareas which TRP channels have entered. The 2007 view that TRP channels are mainly cell sensors with an intriguing variability concerning the modes of activation has dramatically extended into the evolutionary field, the structural approach, and especially the advent of the important role of TRP channels in hereditary and acquired diseases. Important new data concerning the role of TRP channels in intracellular compartments are included. We also refer to the still controversial topic how TRP channels are involved in store-dependent Ca2+ entry. Indeed, the TRPfieldexpansiondidnotlosethefastspeed.Itisextendingintosofarunexpected areas.Thegainofknowledgehasreachedsuchanextentthatwehavenotbeenable to restrict the source book into a single volume; rather, we had to agree on a two-volume publication. In the first volume, we go through all the known TRP channels. Leading experts in the field summarize features of individual TRP channels starting with the description of the gene, expression patters, associated proteins, biophysical and biochemical function properties, and transgenic animal models and closing with cellular TRP functions, dysfunctions, and their role in diseases.Thesecondvolumestartswithachapteronsensorpropertiesandfunctions 1Theusedsearchstringwas(“transientreceptorpotential”ORtrpa*ORtrpc*ORtrpm*ORtrpp* ORtrpv*ORPKD*ORstim1ORstim2ORorai1ORorai2ORorai3ORtrpa*).Notethatthis search included also the main players of store-operated Ca2+ entry, because of the still often reportedlinkstoTRPasalsodiscussedinVolume2. v vi Preface of TRP channels. This was highlighted in the 2007 book but is not very much extended.Surprisingnewfeaturesarereported,e.g.,newinsightsintothermo-and light-sensing,novelrolesorTRPsintasteperceptionandchemesthesis,andespe- ciallytheirfunctionalimportanceaschemosensorsforgasotransmitters,including oxygen sensing, which was evidenced only in the last 5 years. In the second part, more general topics related to TRP functions and features are discussed such as channel structure; TRPs as targets of pharmacological modulation, including a wealth of natural compounds; and the exciting discovery of novel channel toxins. NewaspectsarediscussedconcerningtheroleofTRPsasimportantplayersinthe physiology of reproduction and in neural networks which control reproductive behavior opening a TRP window into neuroendocrinology, i.e., their role in hormone-secreting cells. We finish this book with some critical remarks on the currentstateofTRPresearch,controversies,andsurprises. We hope that this book will guide a large reader community through the fascinatingworldoftheTRPchannelfamilyfrombasicsciencetopathophysiology anddisease.Maythisvoluminoussource/textbookalsohelptoestablishinteractions between the fundamental and clinical research and the research in drug discovery and development! We are convinced that this book is “translational” in the best meaning of this word. Despite the many advances in the understanding of the molecularmechanismsandfunctionfeaturesofTRPchannel,thereisstillatremen- dousneedformorein-depthunderstandingofthestructureofTRPchannels,their implementation in diverse signal cascades, and more mechanistic insight into channel function at the molecular and systemic level, as well as the need for identifyingselectivepharmacologicaltoolsandnewtherapeutictargetsanddevel- opingnewtreatmentoptions.Wehopethisbookstimulatesfurtherresearch.Finally, wemayconcludethatwemightbestillinaperiodoftheendofthebeginningrather than the beginning of the end! The editors wish to thank all authors for excellent contribution and also Wilma McHugh (Springer) for all expert support and very helpfuleditorialadvice! Leuven,Belgium BerndNilius Homburg,Germany VeitFlockerzi Contents for Volume II PartV TRPsasSpecialCellSensors TRPChannelsandThermosensation. . . . . . . . . . . . . . . . . . . . . . . . . . . 729 ThomasVoets TRPsinMechanosensingandVolumeRegulation. . . . . . . . . . . . . . . . . 743 TimD.Plant TRPsasChemosensors(ROS,RNS,RCS,Gasotransmitters). . . . . . . . 767 ShunichiShimizu,NobuakiTakahashi,andYasuoMori PhotosensitiveTRPs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 795 RogerC.Hardie TRPsinTasteandChemesthesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 827 StephenD.Roper TRPsandPain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 873 JaneE.Sexton,JeffreyVernon,andJohnN.Wood TRPsinHearing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 899 DamianoZaniniandMartinC.Go¨pfert TRPsinOlfaction. . . . .. . . . .. . . . .. . . . .. . . . . .. . . . .. . . . .. . . . .. 917 FrankZufall PartVI GeneralTopics EvolutionarilyConserved,MultitaskingTRPChannels: LessonsfromWormsandFlies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 937 KartikVenkatachalam,JunjieLuo,andCraigMontell StructuralBiologyofTRPChannels. . . . . . . . . . . . . . . . . . . . . . . . . . . 963 UteA.HellmichandRachelleGaudet High-ResolutionViewsofTRPV1andTheirImplications fortheTRPChannelSuperfamily. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 991 UteA.HellmichandRachelleGaudet vii viii ContentsforVolumeII PhysiologicalFunctionsandRegulationofTRPCChannels. . . . . . . . . . 1005 HweiLingOng,LorenaB.deSouza,KwongTaiCheng, andInduS.Ambudkar TheTRPCs–STIM1–OraiInteraction. . . . . . . . . . . . . . . . . . . . . . . . . . 1035 SeokChoi,JozsefMaleth,ArchanaJha,KyuPilLee,MinSeukKim, InsukSo,MaliniAhuja,andShmuelMuallem TheTRPCFamilyofTRPChannels:RolesInferred(Mostly) fromKnockoutMiceandRelationshiptoORAIProteins. . . . . . . . . . . 1055 YanhongLiao,JoelAbramowitz,andLutzBirnbaumer TRPs:ModulationbyDrug-LikeCompounds. . . . . . . . . . . . . . . . . . . . 1077 MichaelSchaefer TRPChannelsinReproductive(Neuro)Endocrinology. . . . . . . . . . . . . 1107 TreseLeinders-ZufallandUlrichBoehm ModulationofTRPIonChannelsbyVenomousToxins. . . . . . . . . . . . . 1119 JanSiemensandChristinaHanack PhosphoinositideRegulationofTRPChannels. . . . .. . . . . . .. . . . . . .. 1143 TiborRohacs TRPModulationbyNaturalCompounds. . . . . . . . . . . . . . . . . . . . . . . . 1177 FlaviaCarlaMeotti,Edine´iaLemosdeAndrade,andJoa˜oB.Calixto WhatDoWeReallyKnowandWhatDoWeNeedtoKnow: SomeControversies,Perspectives,andSurprises. . . . . . . . . . . . . . . . . . 1239 BerndNiliusandVeitFlockerzi Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1281 Contents for Volume I TRPs:TrulyRemarkableProteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 VeitFlockerziandBerndNilius PartI TheTRPCSubfamily TRPC1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 VasylNesinandLeonidasTsiokas TRPC2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 BarbaraA.Miller TRPC3:AMultifunctionalSignalingMolecule. . . . . . . . . . . . . . . . . . . 67 MichaelaLichteneggerandKlausGroschner TRPC4-andTRPC4-ContainingChannels. . . . . . . . . . . . . . . . . . . . . . 85 MarcFreichel,VolodymyrTsvilovskyy,andJuanE.Camacho-London˜o TRPC5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 AlexanderV.Zholos TRPC6:PhysiologicalFunctionandPathophysiologicalRelevance. . . . 157 AlexanderDietrichandThomasGudermann TransientReceptorPotentialCanonical7:ADiacylglycerol-Activated Non-selectiveCationChannel. .. . . . . . . .. . . . . . .. . . . . . .. . . . . . . .. 189 XuexinZhangandMohamedTrebak PartII TheTRPVSubfamily TRPV1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 StuartBevan,TalisiaQuallo,andDavidA.Andersson TRPV2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 ItaruKojimaandMasahiroNagasawa ix
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