Mammalian Toxicology PDF
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MaMMalian Tox i c o l o g y E B Mohamed B. Abou-Donia ditEd y Mammalian Toxicology Mammalian Toxicology Edited by Mohamed B. Abou-Donia Thiseditionfirstpublished2015 ©2015JohnWiley&Sons,Ltd Registeredoffice JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UnitedKingdom Fordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapplyforpermissiontoreusethe copyrightmaterialinthisbookpleaseseeourwebsiteatwww.wiley.com. TherightoftheauthortobeidentifiedastheauthorofthisworkhasbeenassertedinaccordancewiththeCopyright,Designsand PatentsAct1988. Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorby anymeans,electronic,mechanical,photocopying,recordingorotherwise,exceptaspermittedbytheUKCopyright,Designsand PatentsAct1988,withoutthepriorpermissionofthepublisher. Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmaynotbeavailablein electronicbooks. 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LibraryofCongressCataloging-in-PublicationData Mammaliantoxicology/editedbyMohamedB.Abou-Donia. pagescm Includesindex. ISBN978-1-119-94041-8(cloth) 1.Mammals–Effectofchemicalson. 2.Toxicitytesting. 3.Toxicology. I.Abou-Donia,MohamedB. QL739.2.M3562015 591.7′14–dc23 2014035960 AcataloguerecordforthisbookisavailablefromtheBritishLibrary. ISBN:9781119940418 Setin10/12.5ptTimesbyAptaraInc.,NewDelhi,India 1 2015 I dedicate this book to my loving wife, Martha, and my children, Rick, Sheref, and Suzy. About the Editor Professor Mohamed Bahie Abou-Donia is Professor of Pharmacology and Cancer Biology at Duke University MedicalCenter.HealsoholdsasecondaryappointmentasaProfessorofNeurobiology.Prof.Abou-Doniaobtained hisBSdegreefromAlexandriaUniversity,EgyptandhisPh.D.fromtheUniversityofCaliforniaatBerkeley.After obtaining his Ph.D. he held a Post-Doctoral position at Texas A&M University followed by an Assistant Professor positionatAlexandriaUniversityjustbeforejoiningDukeUniversityMedicalCenter.HeisaCertifiedToxicologist bytheAmericanBoardofToxicologyandtheAcademyofToxicologicalSciences.HewastheDeputyDirectorofthe ToxicologyProgramatDukeUniversityfrom1981to1995,andin2004wasawardedaprestigiousFulbrightAward tostudytheimpactofpesticidesontheenvironmentinEgypt.Hisresearchprogramisdirectedtowardunderstanding thebasic mechanisms by which chemicals, including pesticides, solvents, industrial chemicals, heavy metals, drugs and nerve agents, adversely affect the nervous system. Prof. Abou-Donia is most well-known for defining two new concepts in toxicology: (i) Organophosphate-Induced Delayed Neurotoxicity (OPIDN); and (ii) Organophosphate- InducedChronicNeurotoxicity(OPICN).Theseconceptshaveledtoanunderstandingofthemechanismsbywhich early exposure to organophosphates can have lasting effects that are manifest late in life, and have also led to the developmentofalikelyexplanationforGulfWarVeterans’Illnesses(GWVI).Prof.Abou-Donia’slaboratorywasthe first to investigate the mechanisms of the GWVI, demonstrate the involvement of combined chemical exposure and stressinthedevelopmentofthisdisease,anddeveloptreatmentfortheveterans.Duringthepastfewyearshehasbeen engagedinresearchtodefinenervoussysteminjuryresultingfromoccupationalexposuretochemicals.Specifically,he hasdevelopedaninnovativenewperipheralbloodtestthatcandeterminethepotentialforbraininjuryfromchemicals, traumaandothernervoussystemdiseases.Hisresearchprogramhasbeenfundedbyprivateorganizations,including theRockefellerFoundationandtheWorldHealthOrganization,aswellasfederalagenciessuchasNIESH,NIOSH, EPA,USDA,andDOD.Prof.Abou-Donia’sresearchhashadapositiveimpactonpublicpolicyinitiativestoregulate environmentalandoccupationalexposuretohazardouschemicals.Hehasbeenaskedtoparticipateinmanylegislative proceedingsandhastestifiedbeforeCongress(US),HouseofLords(UK)andtheBundestag(Germany)onabroad rangeofrelatedtopics,suchasorganophosphateexposureandGulfWarsyndrome,farmersexposedtosheep-dip,and airemissionsinaircraft.HeparticipatedinastudyontheinvolvementofMMRvaccineinthedevelopmentofautism inchildrenintheUK.Prof.Abou-DoniateachesClinicalToxicology,MammalianToxicology,Neurotoxicologyand CaseStudiesinToxicologytograduateandundergraduatestudents.Duringhisacademiccareerhehaspublishedover 300exceptionallywell-citedpapersonvariousaspectsofenvironmentalandmammaliantoxicology,aswellasatext book,Neurotoxicology.Prof.Abou-DoniawasamemberoftheDukeUniversityAnimalCareandUseCommitteefor 15years,andcurrentlyisamemberoftheExecutiveCommitteeforAdmissionofMedicalStudents.
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