Malignant Tumors of the Lung: Evidence-based Management PDF
Preview Malignant Tumors of the Lung: Evidence-based Management
Jean-Palu Sculier • Willard A. Fry (Eds). Malignant Tumors of the Lung Evidence-basde Management Springer-Verlag Berlin Heidelberg GmbH Jean-Palu Soulier • Willar d A. Fry (Editors) Malignant Tumor s of th e Lung Evidence-basde Management With 60 Figures and 78 Tables Springer Professor Jean-Palu Soulier, M.D., Ph.D. Institut Jules Bordet Service de Medicine 1, rue Heger-Bordet 1000 Bruxelles Belgium Professor em. Willard A. Fry, M.D. 1111 Sunset Road Winnetka, IL 60093 USA ISBN 978-3-642-62253-3 ISBN 978-3-642-18698-1 (eBook) DOI 10.1007/978-3-642-18698-1 Cataloging-in-Publication Data applied for Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is availabel in the Internet at http://dnb.ddb.de This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specificalyl the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of Septembre 9,1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. http ://www. springer, de © Springer-Verlag Berlin Heidelberg 2004 Originally published by Springer-Verlag Berlin Heidelberg New York in 2004 Softcover reprint of the hardcover 1st edition 2004 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absenec of a specifci statemen,t that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by con- sulting the relevant literature. Production: PRO EDIT GmbH, 69126 Heidelberg, Germany Typesetting: K. Detzner, 67346 Speye,r Germany Cover design: Frido Steinen-Broo, EStudoi Calama,r Spani Printed on acid-free paper 21 /3150 ML 5 4 3 2 1 0 Preface Thistextbookhasbeenwrittenforallphysicianscaringforpatientswithlungcancer,es peciallysurgeons, chest physicians, radiation oncologists, and medical oncologists. Our goalwastoprovide asynthesis ofthe basicscienceinformationand state-of-the-artde scriptionsofthe diagnosis and treatmentoflungcancerbycoveringthe most important fields dealing with this disease: biology,pathology, epidemiology, screening,diagnosis, therapy,supportivecare,and prognosis. Formoretechnical issueslikemolecularbiology, radiologic techniques(diagnosticand therapeutic),or methodologyofclinicaltrials,the reader should consultmore themore specializedliterature. Wehavestriventoputtogetheratextbookapplicableineverypartoftheworld;chap tershavebeencontributedbyadistinguishedandbalancedpanelofauthorsfromEurope, Asia,and NorthAmerica.Wehavealsotriedtoapply,wheneverpossible,theprinciplesof evidence-basedmedicinein the editing ofthe various chapters by providingdata from systematicreviews,meta-analyses,methodology-basedguidelines,and randomizedclini caltrials.Thisapproachshould reducethewell-known heterogeneityofpracticesamong institutions,countries,andcontinents. Wethankallofthecontributorstothistextbookfortheirskillfulcollaboration,andwe hopethatourreaders willobtain theinformationthatbestmeetstheirneeds. JEAN-PAULSCULIER WILLARDA.FRY Contents MolecularandCellBiologyofLung Carcinoma 3 W.A.FRANKLIN,F.R.HIRSCH 2 ClinicallyUseful Biomarkers .. 29 0 • • • • 0 • 0 0 J.-L.PUJOL,W.JACOT,Jo-Mo BOHER,X.QUANTIN 3 PathologyofLung Cancer 39 0 0 • • • EoBRAMBILLA,W. TRAVIS 4 The EpidemiologyofLung Cancer 57 K.M.DINEEN,GoA.SILVESTRI 5 Lung CancerandTobacco: HistoricalIssues,Epidemiology,andIntervention 77 T.PoHousrox 6 ProfessionalRisks andEnvironmentalFactors 91 PoBOFFETTA 7 RadiologicScreeningfor Lung Cancer 103 0 0 0 • 0 • 0 0 • 0 • 0 0 • 0 0 • • • 0 0 0 0 • C.I. HENSCHKE,D.F.YANKELEVITZ 8 Lung CancerScreening:the RoleofBronchoscopy 111 • 0 • • • • 0 0 • 0 0 • 0 • J.A.Nakhosteen,V.Ninane 9 ClinicalPresentationofLungCancer 119 •••••••••• 0 • 0 0 G.A.MASTERS,K.OH 10 DifferentialDiagnosis 131 0 0 • 0 • 0 ••••• 0 • • 0 • •• •• 0 •• 0 0 • 0 0 0 • 0 0 • N.SCHOENFELD 11 Imaging .. 139 0 0 • • •• 0 • 0 0 • 0 • • • 0 • 0 • 0 0 • 0 ••••••••••• •• 0 • • T. BERGHMANS,JoBosMANs 12 PETScan .... 151 0 • 0 • 0 0 • 0 ••••• 0 0 • 0 0 0 ••••••• 0 0 0 0 • • 0 • • • JoF.VANSTEENKISTE,SoGoSTROOBANTS 13 PathologicalDiagnosis 161 o ••••• 0 0 • • 0 0 • • 0 0 • 0 0 • 0 • V.NINANE 14 MediastinalStaging 171 o • • • • • • • • • • G.MASSARD 15 AssessmentofOperabilityandResectabilityin Lung Cancer 0...... 0. . . 179 WoA.FRY VIII Contents 16 TNMStaging 183 M.].LIPTAY,C.MASCAUX,J.-P.SCULIER ~Treatment ~t,w~""'lr.t~~'t&:~;<;:~",, ·;.ll:!4!'M'~:}£l,tlll'..;z..~1~~ 'i;c~"llJ:i~~ Non-SmallCellLungCancer 17 Surgeryfor Non-SmallCellLungCancer .. ..... 191 R.RAMI-PORTA,M.SERRA-MITJANS 18 NeoadjuvantTreatmentsin ResectableNon-SmallCellLungCancer 205 V.WESTEEL,A.DEPIERRE 19 AdjuvantTreatmentsin ResectableNSCLC 215 H.DouBRE,C.LE PECHOUX,T.LE CHEVALIER 20 ExclusiveRadiotherapy . . . 227 D.G.PAYNE 21 CombinedModalityTherapyfor UnresectableNon-SmallCellLungCancer . . 237 1.].HAZARD,W.T.SAUSE 22 ChemotherapyforAdvancedNon-Small CellLungCancer 253 T. BERGHMANS,J.-P.SCULIER 23 SalvageTherapyin Non-SmallCellLungCancer . .... . . . . . . . . . . . . . 265 E.QUOIX,B. MENNECIER SmallCellLungCancer 24 Small CellLungCancer:LimitedDisease 277 P.VAN HOUTTE,M.ROELANDTS,M.CAPPELLO,F.MORNEX 25 Small CellLungCancer:TreatmentforExtensiveStageDisease . . . . . . . . . . 287 N.H.HANNA,1.H.EINHORN 26 SurgeryforSmall CellLung Cancer 303 ].-P.SCULIER,P.LOTHAIRE,T. BOSSCHAERTS,V.NINANE 27 ProphylacticCranialIrradiation . . ........... 307 A.-P.MEERT,M.PAESMANS 28 SalvageTherapyinSmallCellLungCancer 313 E.F.SMIT,P.E.POSTMUS 29 EndoscopicTreatments 321 H.KATO,N.IKEDA,T. OKUNAKA,K.FURUKAWA,M.TSUBOI 30 BiologicalTreatmentsforLungCancer . . . . .. . .. . . 333 S.SINGHAL,J.B. SHRAGER,1.R.KAISER Contents IX 31 BoneMarrowAplasia 353 T.BERGHMANS,J.-P.SCULIER 32 ManagementofSuperiorVenaCavaSyndrome . . . . . . . . . . . . . . . . . . . 361 N.PEREZ,C.H.MARQUETTE,J.P.BEREGI,D.COLLET,J.-J.LAFITTE 33 Complicationsand SupportiveCare:AirwayObstruction .... . . 367 R.M.HUBER,D.STRATAKIS 34 MalignantPleuralEffusion 375 P.VAN SCHIL 35 SymptomaticTreatmentinLungCancer . . 383 M.F.MuERS 36 End-of-LifeCareinPatientswith LungCancer 393 J.H.VON ROENN,J.P.BRANDMAN 37 PrognosticFactors inNon-Small CellLungCancer . . . . . . . . . . . . . . . . . 405 M.I.QUEJADA,K.S.ALBAIN 38 SCLC- Prognosis ....... .. ... ............ ..... 423 M.PAESMANS SubjectIndex . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 433 Index ofFirst Authors ALBAIN,K.S.,MD H.DOUBRE,MD DivisionofHematology/Oncology InstitutGustave Roussy LoyolaUniversityMedicalCenter 39-53rueCamilleDesmoulins 2160SouthFirstAvenue 94800Villejuif Maywood,IL60153 France USA W.FRANKLIN,MD T.BERGHMANS,MD DepartmentofPathology InstitutJulesBordet UniversityofColoradoHealthSciences 1,rueHeger-Bordet Center 1000Brussels 4200East 9thAvenue,BoxB-216 Belgium Denver,CO80206 USA P.BOFFETTA,MD Unit ofEnvironmentalCancer W.A.FRy,MD Epidemiology 1111SunsetRoad InternationalAgency Winnetka,IL60093 forResearchon Cancer(IARe) USA 150coursAlbert-Thomas 69008Lyon N.H.HANNA,MD France IndianaUniversity DepartmentofMedicine E.BRAMBILLA,MD DivisionofOncology LaboratoiredePathologieCellulaire 535BarnhillDrive,Room 473 CHUAlbertMichallon,BP217 Indianapolis,IN46202 38043GrenobleCedex9 USA France 1.J.HAZARD,MD K.M.DINEEN,MD RadiationTherapyDepartment DivisionofPulmonary LDSHospital andCriticalCare Medicine,Allergy 400C.Street andClinicalImmunology SaltLakeCity,UT84143 MedicalUniversityofSouthCarolina USA 96JonathanLucasBlvd. P.O.Box250623 C.I.HENSCHKE,PHD,MD Charleston,SC29425 DepartmentofRadiology USA WeillMedicalCollege ofCornellUniversity 525East68thStreet NewYork,NY10021 USA XII IndexofFirstAuthors T.P.HOUSTON,MD M.F.MUERS,MD LSUHealthScienceCenter ConsultantPhysician School ofPublic Health DepartmentofRespiratoryMedicine 1600Canal Street The GeneralInfirmaryatLeeds NewOrleans Great GeorgeStreet Louisiana70112 LeedsLSI3EX USA UK R.M.HuBER J.A.NAKHOSTEEN Professor,MedizinischeKlinikInnenstadt Professor,ResearchInstituteforDiagnosis DivisionofPneumology andTreatmentofEarlyLungCancer Ludwig-MaximiliansUniversityofMunich UnterfeldstraBe8 Ziemssenstrasse1 44797Bochum 80336Munich Germany Germany V.NINANE,MD H.KATo,MD H6pitalSaint-Pierre DepartmentofSurgery ServicedePneumologie TokyoMedicalUniversity 322,rueHaute 6-7-1Nishishinjuku,Shinjuku-ku 1000Brussels Tokyo160-0023 Belgium Japan M.PAESMANS,MD M.J.LIPTAY,MD InstitutJulesBordet EvanstonNorthwesternHealthcare 1,rue Heger-Border 2650RidgeAvenue 1000Brussels Evanston,IL60201 Belgium USA D.G.PAYNE G.MASSARD PrincessMargaretHospital Professor,Service deChirurgie 610UniversityAvenue Thoracique Toronto,ONM5G2M9 HopitalCivil Canada 67091Strasbourg France N.PEREZ CliniquedePneumo-Physiologie G.A.MASTERS,MD HopitalAlbertCalmette EvanstonNorthwesternHealthcare Boulevarddu ProfesseurJ.Leclercq 2650RidgeAvenue,Room5134 59037LilleCedex Evanston,IL60201 France USA J.-L.PUJOL A.-P.MEERT,MD MontpellierAcademicHospital InstitutJulesBordet and"LanguedocMutualite" 1,rueHeger-Border NewTechnologies 1000Brussels Montpellier Belgium France
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