Male Fertility and Its Regulation PDF
Preview Male Fertility and Its Regulation
Male Fertility and its Regulation Advances in Reproductive Health Care Series Editor: E. S. E. Hafez LHRH and Its Analogs: Contraception and Therapeutic Applications Edited by B.H. Vickery, J.J. Nestor Jr. and E.S.E. Hafez Spontaneous Abortion Edited by E. S. E. Hafez Voluntary Termination of Pregnancy Edited by E. S. E. Hafez Biomedical Aspects of IUDs Edited by H. Hasson, W.A.A. van Os and E.S.E. Hafez Prostaglandins and Fertility Regulation Edited by M. Toppozada, M. Bygdeman and E.S.E. Hafez Male Fertility and Its Regulation Edited by T.J. Lobi and E. S. E. Hafez Advances in Reproductive Health Care Male Fertility and its Regulation Editors T.J. Lobi and E.S. E. Hafez M.TP PRESS LIM.ITED ~ ~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP LANCASTER / BOSTON / THE HAGUE / DORDRECHT Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Library Cataloguing in Publication Data Male fertility and its regulation.- (Advances in reproductive health care) 1. Fertility, Human 2. Birth control I. LobI. T.J. II. Hafez, E.S.E. III. Series 612'.61 QP253 Published in the USA by MTP Press A division of Kluwer Boston Inc 190 Old Derby Street Hingham, MA 02043, USA Library of Congress Cataloging in Publication Data Main entry under title: Male fertility and its regulation. (Advances in reproductive health care) Based on the proceedings from the Symposium on Male Fertility and Its Regulation which was held as part of the Reproductive Health Care Congress, 10-15 Oct. 1982 in Kaanapali, Hawaii. Includes bibliographies and index. 1. Generative organs, Male-Effect of drugs on-Congresses. 2. Contraceptive drugs-Congresses. I. Lobi, T.J. II. Hafez, E.S.E. (Elsayed Saad Eldin), 1922- . III. Symposium on Male Fertility and Its Regulation (1982: Kaanapali, Hawaii) IV. Reproductive Health Care International Symposium (1982: Kaanapali, Hawaii) V. Series. [ONLM: 1. Contraceptive Agents, Male-congresses. 2. Fertility-drug effects congresses. 3. Genitalia, Male-physiology-congresses. 4. Gossypol pharmacodynamics-congresses. QV 177 M2455 1982] RC877.M35 1984 613.9'432 84-23408 ISBN-13: 978-94-010-8667-7 e-ISBN-13: 978-94-009-4894-5 DOl: 10.1007/978-94-009-4894-5 Copyright © 1985 MTP Press Limited Softcover reprint of the hardcover 1s t edition 1985 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical. photocopying, recording or otherwise, without prior permission from the publishers. Contents List of Contributors ix Preface xiii I. NON-HORMONAL ANTIFERTILITY AGENTS 3-lndazole-carboxylic acids as male antifertility agents 3 B. Silvestrini, V. Cio/i, C. DeMartino and P.Scorza Barcellona 2 Chemotherapeutic agents and male reproduction 13 P.K. Bajpai and K.J. Anderson 3 Effects of 5-thio-o-glucose on male fertility 25 J.R. Daniel and R.L. Whistler II. DRUGS AND MALE FERTILITY 4 Therapeutic drug effects on male reproductive function 39 C. G. Smith and J.E. Harclerode 5 Reversible male infertility induced by sulphasalazine 49 C. O'Morain, P. Smethurst and A.J. Levi 6 Effects of illicit drugs on male reproduction 55 J. Harclerode and C. G. Smith 7 Effects of abused substances on male reproductive development 77 S. Dalterio and A. Bartke III. GOSSYPOL 8 Gossypol chemistry and plant distribution 93 L.A. Jones v CONTENTS 9 Toxicological effects of gossypol 111 A.A. Nomeir and M.B.Abou-Donia 10 Biochemical and nutritional considerations of gossypol intake 135 J.E. Braham and R. Bressani 11 Gossypol contraception and mechanism of action 155 S.P. Xue (Shieh) 12 Gossypol inhibition of boar spermatozoal enzymes 175 w.- W. Tso, C.-S. Lee and M.-Y. W. Tso 13 Gossypol modulation of testosterone secretion and metabolism 185 G.F. Paz and Z. T. Homonnai 14 Gossypol inhibition of LDH-X 193 C.-Y.G. Lee, Y.S. Moon, A. Duleba, A.F. Chen and V. Gomel IV. ENVIRONMENTAL AGENTS AFFECTING FERTILITY 15 Environmental chemical effects on testicular function 203 I.P. Lee and L.L. Russell 16 Consequences to the progeny of paternal drug exposure 225 B. Robaire, J.M. Trasler and B.F. Hales 17 Animal tests employed to assess the effects of drugs and chemicals on reproduction 245 T.A.Marks 18 Effects of phenoxy acid herbicides and TCDD on male reproduction 269 J. C. Lamb IV and J.A. Moore 19 Human spermatogenesis and fertility following exposure to dibromochloropropane (DBCP) 287 G. Potashnik V. HORMONES AND HORMONE ANTAGONISTS 20 LHRH and its analogues: potential for male contraception and for therapy of androgen dependent syndromes 303 B.H. Vickery vi CONTENTS 21 Direct regulation of Leydig cell functions by neuropeptides 319 E. Y.Adashi and A.J W. Hsueh 22 Non-steroidal inhibitors of androgen transport and metabolism 331 G. G. Rousseau, JI. Quivy, C.F. Rolin Jacquemyns, D.A.N Sirett, M. T. deReviers, M.C. Viguier-Martinez, S. Delpech and G. Colas 23 Danazol plus testosterone enanthate in male langur monkey 343 NK. Lohiya and D.P. Sharma 24 Inhibin and male contraception 351 A.R. Sheth, B.S. Sarvamangala, K.A. Krishman and G.R.Vanage VI. BLOOD-TESTICULAR AND EPIDIDYMAL BARRIERS 25 The blood-epididymis barrier 371 B. T.Hinton 26 The tenacity of the blood-testis and blood epididymal barriers 383 T. T. Turner and S. S. Howards VII. SPERM PHYSIOLOGY 27 Sperm maturation and transport 397 L. C. Ellis and B.R. Nemetallah 28 Ionic mechanisms of sperm motility initiation 411 P. Y.D. Wong and W.M. Lee 29 Reproductive effects of sperm surface antibodies 417 R. Bronson, G. Cooper and D. Rosenfeld 30 Sperm calcium homeostasis during maturation 437 M.P. Bradley and I. T. Forrester 31 The zona-free hamster egg sperm penetration assay 451 NJ Spirtos, S.A. Hamdi, M.E. Hull and NJ Cossler Index 467 vii List of Contributors M.B. ABOU-DONIA R. BRONSON Department of Pharmacology, Box Department of Obstetrics/Gynecology, 3813, Duke University Medical Center, North Shore University Hospital, Cor Durham, North Carolina 27710, USA nell University Medical College, 300 Community Drive, Manhasset, New E.Y. ADASHI York 11030, USA Department of Obstetrics/Gynecology, University of Maryland Hospital and A.F. CHEN School of Medicine, Room 11 -011, Beckman Microbics Operations, 6200 Frank Bressler Research Bldg, 655 EI Camino Real, Carlbad, Canada W. Baltimore Street, Baltimore, Mary 92008 land 21201, USA V. F. CIOLI K.J. ANDERSON F. Angelini Research Institute, Viale Kettering Medical Center, Kettering, Amelia 70, 00181 Rome, Italy Ohio 45429, USA P.K. BAJPAI G.COLAS Department of Biology, University of IN RA, Reproductive Physiology Dayton, Dayton, Ohio 45469, USA Laboratory, F-37380 Nouzilly, France A.BARTKE G. COOPER Department of Obstetrics/Gynecology, Department of Obstetrics/Gynecology, Southern Illinois University School of North Shore University Hospital, Cor Medicine, Southern Illinois University nell University Medical College, 300 at Carbondale, Carbondale, Illinois, Community Drive, Manhasset, New 62901, USA York 11030, USA M.P. BRADLEY N.J. COSSLER Department of Surgery, Adams Bldg., Department of Obstetrics/Gynecology, University of Otogo, Dunedin, New Wayne State University, 4707 St. An Zealand toine, Detroit, Michigan 48201, USA J.E. BRAHAM S. DALTERIO Agricultural Sciences, Institute of Nu Department of Pharmacology, The trition of Central America and Panama, University of Texas Health Science P.O. Box 1188, Guatemala City, Gua Center, 7703 Floyd Curl Drive, San temala, Central America Antonio, Texas 78284, USA R. BRESSANI Agricultural Sciences, Institute of Nu J.R. DANIEL trition of Central America and Panama, Department of Food & Nutrition, Pur P.O. Box 1188, Guatemala City, Gua due University, West Lafayette, Indi temala, Central America ana 47907, USA ix LIST OF CONTRIBUTORS S. DELPECH B.T. HINTON Reproductive Physiology Laboratory, Department of Anatomy, Box 439, INRA. F-37380 Nouzilly, France University of Virginia, School of Med icine, Charlottesville, Virginia 22908, C. DE MARTINO USA Regina Elena Institute for Cancer Re search, Via Ie Regina Elena 291, 00161 Z.T. HOMONNAI Rome, Italy Institute for the Study of Fertility, Ma ternity Hospital, Tel Aviv Medical Centre, Tel Aviv University Medical M.T.de REVIERS School, P.O. Box 7079, Tel Aviv Reproductive Physiology Laboratory, 61070, Israel INRA. F-37380 Nouzilly, France S.S. HOWARDS A. DULEBA Department of Urology, Box 422, Uni Department of Obstetrics/Gynecology, versity of Virginia, School of Medicine, The University of British Columbia, Charlottesville, Virginia 22908, USA Vancouver, BC, V6T 2B5, Canada A.J.W. HSUEH L.C. ELLIS Department of Reproductive Medi Department of Biology UMC-53, Utah cine, M-025, University of California, State University, Logan, Utah 84322, School of Medicine,San Diego, La USA Jolla, California 92093, USA M.E. HULL I.T. FORRESTER Department of Reproductive Endocri Department of Biochemistry, Univer nolgy and Infertility, Wayne State Uni sity of Otago, Box 56, Dunedin, New versity, 275 E. Hancock Avenue, De Zealand troit, Michigan, 48201, USA V. GOMEL L.A. JONES Department of Obstetrics/Gynecology, National Cottonseed Products New Grace Hospital, 4900 Oak Street, Association, Inc., P.O. Box 12023, Vancouver, Canada V6H 3V5 Memphis, Tennessee 38112, USA E.S. E. HAFEZ K.A. KRISHNAN Reproductive Life Center, Medical Institute for Research in Reproduction, University of South Carolina, Depart Jehangir Merwanji Street Parel, Bom ment of Physiology, 171 Ashley, Char bay 400 012, India leston, South Carolina 29425, USA J.C. LAMB IV B.F. HALES Fertility & Reproduction Group, Na Centre for the Study of Reproduction, tional Institute of Environmental Department of Pharmacology, McGill Health Sciences, National Toxicology University, 3655 Drummond Street Program, P.O. Box 12233, Research Montreal, Quebec H3G 1 Y6, Canada Triangle Park, North Carolina 27709, USA S.A. HAMDI C.-S. LEE Department of Obstetrics/Gynecology, Department of Biochemistry, The Wayne State University, 275 E. Han Chinese University of Hong Kong, cock Avenue, Detroit, Michigan, Shatin, N.T., Hong Kong 48201, USA C.-Y.G. LEE J. HARCLERODE Department of Obstetrics/Gynecology, Department of Biology, Bucknell Uni The University of British Columbia, versity, Lewisburg, Pennsylvania Vancouver, British Columbia V6T 2B5, 17837, USA Canada x LIST OF CONTRIBUTORS I. P. LEE G.F. PAZ Laboratory of Reproductive & Devel Institute for the Study of Fertility, Ma opmental Toxicology, National Insti ternity Hospital, Tel Aviv Medical Cen tute of Environmental Health Sciences, ter, Tel Aviv University Medical Research Triangle Park, North Carolina School, P.O. Box 7079, Tel Aviv 27709, USA 61070, Israel W.M. LEE G. POTASHNIK Department of Physiology, University Infertility Clinic, Department of of Hong Kong, Li Shu Fan Bldg., Sas Obstetrics/Gynecology, Soroka Uni soon Road, Hong Kong versity Hospital and Faculty of Health Sciences at the Ben Gurion University A.J. LEVI of the Negev, Beer-Sheba, Israel Sheva, Israel 84 101 Northwich Park Hospital, Clinical Re search Centre, Watford Road, Harrow, J.1. QUIVY Middlesex HA1 3UJ, UK International Institute of Cellular & Molecular Pathology, UCL 7529, Av T.J. LOBL enue Hippocrate 75, B-1200 Brussels, Biotechnology Research, The Upjohn Belgium Company, Kalamazoo, Michigan 49001, USA B. ROBAIRE Centre for the Study of Reproduction, N.K. LOHIYA Department of Pharmacology, McGill Reproductive Physiology Section, De University, 3655 Drummond Street, partment of Zoology, University of Ra Montreal, Quebec H3G 1 Y6, Canada jasthan, Jaipur 302 004, India C.F.ROLIN JACQUEMYNS T.A. MARKS International Institute of Cellular ,\ Teratology & Reproduction, The Up Molecular Pathology, UCL 7529, Av john Company, 301 Henrietta Street, enne Hippocrate 75, B-1200 Brussels, Kalamazoo, Michigan 49001, USA Belgium D. ROSENFELD V.S. MOON Department of Obstetrics/Gynecology, Department of Obstetrics/Gynecology, North Shore University Hospital, Cor The University of British Columbia, nell University Medical College, 300 Vancouver, BC, V6T 2B5, Canada Community Drive, Manhasset. New York 11030, USA J.A. MOORE Environmental Protection Agency, Rm. G.G. ROUSSEAU 637, East Tower, TS-788, 401 M St., UCL 7529, Avenue Hippocrate 75, B- SW, Washington, DC 20460, USA 1200 Brussels, Belgium C.O'MORAIN L. L. RUSSELL Department of Medical Physiology & Northwich Park Hospital, Clinical Re Pharmacology, Southern Illinois Uni search Centre, Watford Road, Harrow, versity, School of Medicine, Carbon Middlesex HA1 3UJ, UK dale, Illinois 62901, USA B.R. NEMETALLAH B.S. SARVAMANGALA Department of Physiology, Faculty of Institute for Research in Reproduction, Veterinary Medicine, Edfina, Alexan Indian Council of Medical Research, dria University, Egypt Jehangir Merwanji Street. Parel, Bom bay 400 012, India A.A. NOMEIR Department of Pharmacology, Duke P.SCORZA BARCELLONA University Medical Center, Box 3813, F. Angelini Research Institute, Via Ie Durham, North Carolina 27710, USA Amelia 70, 00181 Rome, Italy xi
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