Macrocyclic Lactones in Antiparasitic Therapy

436 Pages·2002·2.15 MB·English

by  J. Vercruysse

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Macrocyclic Lactones in Antiparasitic Therapy
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Macrocyclic Lactones in
Antiparasitic Therapy
Edited by
J. VERCRUYSSE
Faculty of Veterinary Medicine
Department of Virology, Parasitology, Immunology
Ghent University
Belgium
and
R.S. REW
PfizerAnimal Health
Exton
Pennsylvania
USA
CABIPublishing
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CABIPublishingis a division of CABInternational
CABIPublishing CABIPublishing
CAB International 10E 40th Street
Wallingford Suite 3203
Oxon OX10 8DE New York, NY10016
UK USA
Tel: [phone] Tel: [phone]
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Website:www.cabi-publishing.org
©CABInternational2002. All rights reserved. No part of this publication may
be reproduced in any form or by any means, electronically, mechanically, by
photocopying, recording or otherwise, without the prior permission of the
copyright owners.
Acatalogue record for this book is available from the British Library, London,
UK.
Library of Congress Cataloging-in-Publication Data
Macrocycliclactonesinantiparasitictherapy / edited by J.Vercruysse
and R.S.Rew
p. cm.
Includes bibliographical references (p. ).
ISBN 0-85199-617-5 (alk. paper)
1. Avermectins. 2. Lactones. 3. Macrocycliccompounds.
4. Antiparasiticagents. I. Vercruysse, J. (Jozef) II. Rew, Robert S.
RM412 .M33 2002
616.9′6061--dc21 2002004075
ISBN 0 85199 617 5
Typeset by AMADataSetLtd, UK
Printed and bound in the UK byCromwellPress,Trowbridge
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Contents
Contributors ix
Preface xiii
1. Chemistry, Pharmacology and Safety of theMacrocyclic
Lactones 1
1.1. Ivermectin,AbamectinandEprinomectin 1
W.Shoopand M.Soll
1.2. DoramectinandSelamectin 30
G.A.Conderand W.J. Baker
1.3. MilbemycinOxime 51
M. Jung, A.Saito, G.Buescher, M. Maurer and J.-F. Graf
1.4. Moxidectin 75
D.W. Rock, R.L.DeLayand M.J.Gliddon
2. Pharmacokineticsof theMacrocyclicLactones: Conventional
Wisdom and New Paradigms 97
D.R. Hennessy and M.R.Alvinerie
3. Mode of Action of theMacrocyclicLactones 125
R.J. Martin, A.P. Robertson and A.J.Wolstenholme
4. Ecological Impact ofMacrocyclicLactoneson Dung Fauna 141
J.W. Steel and K.G.Wardhaugh
5. Resistance AgainstMacrocyclicLactones 163
R.K.Prichard
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vi Contents
6. The Use ofMacrocyclicLactonesto Control Parasites of
Cattle 183
6.1. General Efficacy of theMacrocyclicLactonesto Control
Parasites of Cattle 185
J.Vercruysseand R.Rew
6.2. Use ofMacrocyclicLactonesto Control Cattle Parasites in
Europe 223
J.Vercruysseand R.Rew
6.3. Use ofMacrocyclicLactonesto Control Cattle Parasites in
the USA and Canada 248
R.Rewand J.Vercruysse
6.4. Use ofMacrocyclicLactonesto Control Cattle Parasites in
South America 262
C.Eddi, A.Nariand J.Caracostantogolo
6.5. Use ofMacrocyclicLactonesto Control Cattle Parasites in
Australia and New Zealand 288
P.A.Holdsworth
7. The Use ofMacrocyclicLactonesto Control Parasites of
Sheep and Goats 303
R.L. Coop, I.Bargerand F. Jackson
8. The Use ofMacrocyclicLactonesto Control Parasites of
Horses 323
C.M.Monahanand T.R.Klei
9. The Use ofMacrocyclicLactonesto Control Parasites of Pigs 339
J.Arendsand J.Vercruysse
10. The Use ofMacrocyclicLactonesin the Control and Prevention
ofHeartwormand Other Parasites in Dogs and Cats 353
J.Guerrero,J.W. McCall andC.Genchi
11. The Use ofMacrocyclicLactonesto Control Parasites of
Domesticated Wild Ruminants 371
S.E. Marley and G.A.Conder
12. The Use ofMacrocyclicLactonesto Control Parasites of
Exotic Pets 395
S.E. Little, C.B.Greenacreand R.M. Kaplan
13. The Use ofMacrocyclicLactonesto Control Parasites of
Humans 405
K.R. Brown
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Contents vii
14. MacrocyclicLactonesasAntiparasiticAgents in the Future 413
T.G. Geary
Index 425
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Contributors
M.R. Alvinerie, INRA Laboratoire de Phamacologie, 180 Chemin de
Tournefeuille, F-31931 Toulouse, France.
J. Arends, S&J Farms Animal Health, 2340 Sanders Road, Willow Springs,
NC 27592, USA.
W.J. Baker, Pfizer Central Research, Eastern Point Road, Mailstop 8200-40,
Groton, CT 06340, USA.
I.Barger,597RockvaleRoad, Armidale,NSW2350, Australia.
K.R. Brown,8111 Winston Road, Philadelphia, PA 19118, USA.
G.Buescher,NovartisAnimal Health Inc., CH-4002 Basel, Switzerland.
J.Caracostantogolo,JosePaulaRodriguezAlvez794,1408CiudaddeBuenos
Aires, Argentina.
G.A.Conder,PfizerCentralResearch,EasternPointRoad,Mailstop8200-40,
Groton, CT 06340, USA.
R.L. Coop, Moredun Research Institute, Pentlands Science Park, Bush Loan,
Penicuik,MidlothianEH26 0PZ, UK.
R.L. DeLay, Fort Dodge Animal Health, Agricultural Research Center,
PO Box 400, Princeton, NJ 08543-0400, USA.
C. Eddi, Alberti 664, 1714 Ituzalogo, Argentina. New address: Animal
Production and Health Division, Room C-528, FAO, Vialle delle Terme di
Caracalla-00100, Rome, Italy.
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x Contributors
T.G. Geary, Pharmacia & Upjohn Co., 301 Henrietta Street, Kalamazoo,
MI 49007-4940, USA.
C. Genchi, Dipartimento di Patologia Animale, Igiene e Sanita Pubblica
Veterinaria,SezionediPatologiageneraleeParassitologia,UniversitádegliStudi
diMilano, ViaCeloria10, I-20122 Milan, Italy.
M.J. Gliddon, Fort Dodge Animal Health, Agricultural Research Center,
PO Box 400, Princeton, NJ 08543-0400, USA.
J.-F. Graf,NovartisAnimal Health Inc., CH-4002 Basel, Switzerland.
C.B. Greenacre, Department of Comparative Medicine, College of Veterinary
Medicine, University of Tennessee, PO Box 1071, Knoxville, TN 37902-1071,
USA.
J. Guerrero, Department of Pathobiology, School of Veterinary Medicine,
University of Pennsylvania, Philadelphia, PA 19104, USA.
D.R. Hennessy, CSIRO Animal Production McMaster Laboratory, Clunies
Ross St., Private Bag 1, Delivery Center Blacktown, Sydney, NSW 2148,
Australia. New address: Veterinary Health Research Pty Ltd, 1 Rivett Rd,
Riverside Corporate Park, North Ryde,NSW2113, Australia.
P.A.Holdsworth,DirectorScientific&RegulatoryAffairs,Avcare,LockedBag
916, Canberra, ACT 2601, Australia.
F. Jackson, Moredun Research Institute, Pentlands Science Park, Bush Loan,
Penicuik,MidlothianEH26 0PZ, UK.
M.Jung,NovartisCentredeRechercheSantéAnimalSA,CH-1566St.-Aubin,
Switzerland.
R.M.Kaplan,DepartmentofMedicalMicrobiologyandParasitology,Collegeof
Veterinary Medicine, University of Georgia, Athens, GA 30602-7387, USA.
T.R. Klei, Department of Veterinary Microbiology and Parasitology, School of
VeterinaryMedicine,LouisianaStateUniversity,BatonRouge,LA70803,USA.
S.E. Little, Department of Medical Microbiology and Parasitology, College of
Veterinary Medicine, University of Georgia, Athens, GA 30602-7387, USA.
S.E. Marley,Merial, 3239 Satellite Blvd, Duluth, GA 30096, USA.
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Contributors xi
R.J. Martin, Department of Biomedical Sciences, College of Veterinary
Medicine, Iowa State University, Ames, IA 50011, USA.
M. Maurer, Novartis Centre de Recherche Santé Animal SA, CH-1566
St.-Aubin, Switzerland.
J.W.McCall,DepartmentofMedicine,MicrobiologyandParasitology,College
of Veterinary Medicine, University of Georgia, Athens, GA 300602, USA.
C.M. Monahan, College of Veterinary Medicine, Ohio State University, 1900
Coffey Rd, Columbus, Ohio 43210, USA.
A.Nari,ViaOdoardoBeccari14 apt. 6, I-00154 Rome, Italy.
R.K. Prichard, Institute of Parasitology, McGill University, MacDonald
Campus, 21111 Lakeshore Road, Ste-Anne-DeBellevue, Quebec H9X3V9,
Canada.
R.S. Rew, formerly Pfizer Animal Health, 812 Springdale Drive, Exton,
PA 19341, USA, now at Rewsearch Inc., 400 N Wawaset Road, West Chester,
PA 19382, USA.
D.W. Rock, Fort Dodge Animal Health, Agricultural Research Center,
PO Box 400, Princeton, NJ 08543-0400, USA.
A.P. Robertson, Department of Biomedical Sciences, College of Veterinary
Medicine, Iowa State University, Ames, IA 50011, USA.
A.Saito,Sankyo Co. Ltd, Tokyo 104, Japan.
W.L.Shoop,Merck & Co., PO Box 2000,Rahway, NJ 07065, USA.
M.D.Soll,Merial3239 Satellite Boulevard, Duluth, GA 30096, USA.
J.W.Steel,CSIROAnimalProductionMcMasterLaboratory,CluniesRossSt.,
Private Bag 1, Delivery Centre, Blacktown, Sydney, NSW 2148, Australia.
New address: CSIRO Livestock Industries, 5 Julius Avenue (off Delhi Road),
Riverside Corporate Park, North Ryde,NSW1670, Australia.
J. Vercruysse, Faculty of Veterinary Medicine, Department of Virology,
Parasitology, Immunology, Ghent University, Salisbury Laan 133, B-9820
Merelbeke, Belgium.
K. Wardhaugh, CSIRO Entomology, Black Mountain Laboratories,
GPO Box 1700, Canberra, ACT 2602, Australia.
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xii Contributors
A.J. Wolstenholme, Department of Biology and Biochemistry, University of
Bath, Bath BA2 7AY, UK.
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