Macro Roles for MicroRNAs in the Life and Death of Neurons PDF
Preview Macro Roles for MicroRNAs in the Life and Death of Neurons
Research and Perspectives in Neurosciences Forfurther volumes: http://www.Springer.com/series/2357 Bart de Strooper Yves Christen l Editors Macro Roles for MicroRNAs in the Life and Death of Neurons Editors Dr.BartdeStrooper Dr.YvesChristen KULeuvenandVIB FondationIPSENpourla CenterHumanGenetics RechercheTherapeutique Lab.NeuronalCellBiology 65quaiGeorgeGorse Herestraat49 92650BoulogneBillancourt 3000Leuven Cedex CampusGasthuisberg6 France Belgium [email protected] [email protected] ISSN:0945-6082 ISBN:978-3-642-04297-3 e-ISBN:978-3-642-04298-0 DOI10.1007/978-3-642-04298-0 SpringerHeidelbergDordrechtLondonNewYork LibraryofCongressControlNumber:2009939121 #Springer-VerlagBerlinHeidelberg2010 Thisworkissubjecttocopyright.Allrightsarereserved,whetherthewholeorpartofthematerialis concerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting, reproductiononmicrofilmorinanyotherway,andstorageindatabanks.Duplicationofthispublication orpartsthereofispermittedonlyundertheprovisionsoftheGermanCopyrightLawofSeptember9, 1965,initscurrentversion,andpermissionforusemustalwaysbeobtainedfromSpringer.Violations areliabletoprosecutionundertheGermanCopyrightLaw. Theuseofgeneraldescriptivenames,registerednames,trademarks,etc.inthispublicationdoesnot imply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotec- tivelawsandregulationsandthereforefreeforgeneraluse. Coverdesign:WMXDesignGmbH,Heidelberg,Germany Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Foreword ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Sincethe initial studies performedinC.elegans, wegave goneafar wayto begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe nervous system. Nevertheless, we know already that microRNA pathways play majorrolesintheproliferation,differentiation,functionandmaintenanceofneuro- nalcells.SeveralintriguingstudieshavelinkedmicroRNAsasmajorregulatorsof theneuronalphenotype,andhaveimplicatedspecificmicroRNAsintheregulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowlyemergingasapotential important contributortothepathogenesisofmajor neurodegenerativedisorderssuchasAlzheimer’sdiseaseandParkinson’sdisease. Thesenovelinsightsappeartobeparticularpromisingfortheunderstandingofthe veryfrequentandbadlyunderstoodsporadicformsofthesediseasesascomparedto thegeneticforms. Thus,thebetterunderstandingoftheimplicationsofthisnovel field ofmolecular biology is crucial for the broad area ofneurosciences,from the fundamental aspects to the clinic, and from novel diagnostic to potentially thera- peutic applications for severe neurological and maybe psychiatric diseases. The presentvolumegatherscontributionstotheColloqueMe´decineetRechercheonthe implications of microRNAs in neuroscience organized by the Fondation Ipsen, in Paris,onApril20,2009.Ithadasobjectivetobringtogetherneuroscientistsfrom differentareasofresearchtodiscusstheircurrentinsightsintothewonderfulworld ofmicroRNAs,andtohearanddiscusstheirresearchandviewsaboutmicroRNA biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents ProfilingthemicroRNAs ...................................................... 1 KennethS.Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionProfiles intheDevelopingandMatureCNS .......................................... 9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem ........................................................ 19 DavidJ.Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons ......... 27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs ............ 35 GerhardM.Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs ......................................................................... 45 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells ................................................................... 57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics ........................................... 69 StephenM.Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis .................................... 79 NancyM.Bonini microRNAsinSporadicAlzheimer’sDiseaseandRelated Dementias ...................................................................... 91 Se´bastienS.He´bert,WimMandemakers,AikateriniS.Papadopoulou, andBartDeStrooper microRNADysregulationinPsychiatricDisorders ........................ 99 BinXu,JosephA.Gogos,andMariaKarayiorgou Index ........................................................................... 119 Contributors Abeliovich Asa Columbia University Medical Center, 630 West 168th Street, Room15-405,NewYork,NY10032,USA,[email protected] Abu-ElneelKawther NeuroscienceResearchInstitute,DepartmentofMolecular CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA Bonini Nancy M. University of Pennsylvania, 306 Leidy Laboratories, Depart- mentofBiology,Philadelphia,PA19104,USA,[email protected] Chang Shuang Department of Human Genetics, Emory University School of Medicine,Atlanta,GA30322,USA CohenStephenM. TemasekLifeSciencesLaboratoryLimited,1ResearchLink National University of Singapore, 117604 Singapore, SINGAPORE, steve@ tll.org.sg De Strooper Bart Center for human genetics, K.U. Leuven and Department of molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM Gogos Joseph A. Department of Physiology & Cellular Biophysics and Depart- mentofNeuroscience,ColumbiaUniversity,NewYork,USA He´bert Se´bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neuros- ciences,Universite´ Laval,De´partementdeBiologieme´dicale,2705Boul.Laurier, LocalRC-9800,Que´bec,Qc,Canada,[email protected] JinPeng DepartmentofHuman Genetics andGraduatePrograminGeneticsand Molecular Biology, Emory University School of Medicine, Atlanta, GA 30322, USA,[email protected] Kapsimali Marika INSERM U784, Ge´ne´tique Mole´culaire du De´veloppement, Ecole Normale Supe´rieure, 46 rue d´Ulm, 75230 PARIS Cedex 05 FRANCE, [email protected] xi xii Contributors Karayiorgou Maria Columbia University, Department of Psychiatry, 1051 RiversideDrive,Unit#28,NewYorkNY10032,USA,[email protected] Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, BiologyII,Room6139A,SantaBarbara,CA93106,USA,[email protected] Kye Min Jeong Neuroscience Research Institute, Department of Molecular CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA LiuTsunglin NeuroscienceResearchInstitute,DepartmentofMolecularCellular andDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA MandemakersWim Centerforhumangenetics,K.U.LeuvenandDepartmentof molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM Papadopoulou Aikaterini S. Center for human genetics, K.U. Leuven and Departmentofmolecularanddevelopmentalgenetics,VIBLeuven,BELGIUM Papagiannakopoulos Thales Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara,USA Rage Florence Institut de Ge´ne´tique mole´culaire de Montpellier, UMR 5535, 1919 route de Mende 34293 Montpellier Cedex 05, FRANCE, florence. [email protected] Schratt Gerhard M. University of Heidelberg, Interdisciplinary Center for Neurosciences (IZN), SFB488 Junior Group, Im Neuenheimer Feld 345, 1.OG, 69120Heidelberg,GERMANY,[email protected] Simon David J. Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Simches 7, Boston, MA 02114, USA, david. [email protected] Szulwach Keith Department of Human Genetics and Graduate Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, GA30322,USA Xu Bin Department of Physiology & Cellular Biophysics and Department of PsychiatryColumbiaUniversity,NewYork,USA Na Xu Neuroscience Research Institute, Departement of Molecular Cellular and DevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA
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