Lymphoproliferative Diseases of the Skin PDF
Preview Lymphoproliferative Diseases of the Skin
Lymphoproliferative Diseases of the Skin Edited by M. Goos and E. Christophers With 149 Figures and 82 Tables Springer-Verlag Berlin Heidelberg New York 1982 Priv.-Doz. Dr. med. Manfred Goos, Prof. Dr. med. Enno Christophers, Universitats-Hautklinik, SchittenhelmstraBe 7, D-2300 Kie1, Federal Republic of Germany ISBN-13: 978-3-540-11222-8 e-lSBN: 978-3-642-68363-3 rot lO.lCXl7B78-3-642-68363-3 Library of Congress Cataloging in Publication Data Main entry under title: Lymphoproliferative diseases of the skin. Bibliography: p. Includes index. 1. Skin-Tumors. 2. Lymphoma. I. Christophers, Enno. II. Goos, M. (Manfred), 1938-. [DNLM: 1. Lym phoma. 2. Lymphoproliferative disorders. 3. Skin neoplasms. 4. Skin diseases. WH 525 L9855] RC280.S5L89 616.99'477 81-22859 ISBN 0-387-11222-7 (U.S.) AACR2 This work is subject to copyright. All rights are reserved, whether, the whole or part ofthe material is con cerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use a fee is pay able to "Verwertungsgesellschaft Wort", Munich. © Springer-Verlag Berlin Heidelberg 1982 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Composition, printing and binding: Meisenbach KG, Bamberg 2127/3321-543210 Contents List of Contributors IX Preface .... XV Structure and Function of the Immune System Lennert, K., Stein, H.: The Germinal Centre: Morphology, Histo- chemistry, and Immunohistology ............. 3 Miiller-Hermelink, H.K., Steinmann, G.G., v. Gaudecker, B.: Histo- genesis of T Cells ................... 16 Heusermann, U., Schroeder, L., Zurborn, K.H., Stutte, H.J.: Struc- ture and Function of Stroma Cells in Lymphoid Tissues .... 25 Stingl, G., Wolff, K.: Origin and Functions of Langerhans Cells and Their Role in Disease . . . . . . . . . . . . . . . . 34 Miiller-Ruchholtz, W: Lymphocyte Hybridomas: Present State 41 Pathogenetic Aspects Chu, A., Berger, C.L., Lynfie1d, Y., Esseesse, J., Edelson, R.L.: Pathogenesis of Cutaneous T Cell Lymphoma ........ 57 Pierard, G.E., Franchimont, C., Le, T., dela Brassine, M., Lapiere, Ch.M.: Proliferation Rate of Cutaneous T Cell Lymphomas in the Skin - Relationship with Histologic Pattern and Cytology 65 Kummermehr, J., Burg, G.: Autoradiographic Pattern of Cell Proliferation in Cutaneous Malignant Lymphoma ...... 71 Solbach, W, Barth, S., R611inghoff, M., Wagner, H.: Lymphokines in Human Lymphomas: Evidence for Malignant Proliferation ofT Cells Producing Interleukin-2 in Sezary's Syndrome ........ 79 Schmitt, D., Gaucherand, M., Souteyrand, P., Thivolet, J.: In vitro Chemotaxis of Lymphocytes in Cutaneous Lymphoma .... 84 Morphology and Immunohistology Schwarze, E.-W, Geerts, M.-L., Lennert, K.: Comparative Histologic Study of Non-Hodgkin's Lymphomas in Skin and Lymph Nodes 93 Burg, G., Braun-Falco, 0., Hoffmann-Fezer, G., Schmoeckel, Ch.: Differentiation Between Pseudolymphomas and Malignant B Cell Lymphomas of the Skin . . . . . . . . . . . . . . . .. 10 1 Bleehen, S. S.: Light and Electron Microscopic Studies on Mycosis Fungoides During Long-Term PUVA-Treatment ....... 110 Meijer, C.J.L.M., van der Loo, E.M., Scheffer, E., Cornelisse, C.J., van Vloten, W A.: Relevance of Morphometry in the Diagnosis and Prognosis of Cutaneous T Cell Lymphomas . . . . . . . .. 117 V Thomas, J.A., Janossy, G.: Phenotypic Analysis of Cells in Cutane- ous Lymphoma - An Immunohistologic Study ....... 128 Thivolet, J., Schmitt, D., Fulton, R., Souteyrand, P.: Ultrastructural Demonstration of the Helper Phenotype of Sezary Cells Using Monoclonal Antibodies ................. 13 7 Willemze, R., Ruiter, D.J., Van Vloten, w'A., Meijer, C.J.L.M.: Primary "Reticulum Cell Sarcoma" of the Skin: High Frequency of True Histiocytic Lymphoma (Histiocytic Sarcoma) ...... 142 Trost, T.H.: Light and Electron Microscopical Investigations on the Helix Pomatia Lectin Receptor on Normal and Malignant Lymphocytes with Peroxidase-Bound Helix Pomatia Lectin 150 Sterry, w" Steigleder, G.-K.: Identification of Malignant Lympho- cytes in Cutaneous Infdtrates by the Colchicine Sensitivity Index 154 Konrad, K.: Mycosis Fungoides Bullosa .......... 157 Nikolowski, J., Burg, G., Schmoeckel, Ch., Braun-Falco, 0., Hoff mann-Fezer, G.: Lymphomatoid Papulosis: A Cutaneous T Cell Pseudolymphoma? . . . . . . . . . . . . . . . . . .. 163 Clinical Features Goos, M., Christophers, E.: Clinical, Morphological and Functional Aspects of Cutaneous T Cell Lymphomas ........ . 171 Kerl, H., Rauch, H.-J., Hodl, St.: Cutaneous B Cell Lymphomas 179 Guggenberger, K., Burg, G., Schmoeckel, Ch., Detmar, U.: Follow- ups in Cutaneous Immunocytomas ........... . 192 Winkelmann, R.K., Li, C. Y., Banks, P.M.: Cutaneous Histiocytic Lymphoma ..................... . 197 Lange Wantzin, G., Petri, J., Nielsen, M., Thomsen, K.: Benign Lymphocytomas - Clinical and Histologic Aspects ..... 212 "Pagetoid Reticulosis" Schmoeckel, Ch., Burg, G., Hoffmann-Fezer, G., Wolff, H.H., Braun-Falco, 0.: Pagetoid Reticulosis - A Rare Entity? 217 MacDonald, D.M.: Pagetoid Reticulosis - A Problem of Histo- genesis ...................... . 222 Geerts, M.-L., Kaiserling, E., Kint, A.: T Cell Microenvironment in Woringer-Kolopp's Disease ..... ... 230 Sidhu, G.S.: Merkel Cell Neoplasms of the Skin 237 Cooperative Study Groups, Staging and Treatment Brittinger, G.: Kiel Lymphoma Study Group . . . . . . 249 Braun-Falco, 0., Kresbach, H., Burg, G., Kerl, H.: German-Austrian Cutaneous Lymphoma Cooperative Study Group 256 van Vloten, w'A.: Dutch Mycosis Fungoides Study Group 260 Thomsen, K.: Scandinavian Mycosis Fungoides Trial 266 Bunn, P. A., Fishman, A. B., Glatstein, E.: Staging and Treatment of Cutaneous T Cell Lymphomas (Mycosis Fungoides and the Sezary Syndrome) at the National Cancer Institute (USA) ..... . 270 Hamminga, L., Mulder, J.A., Scheffer, E., Meijer, C.J.L., van Vloten, w'A.: Staging in Mycosis Fungoides with Respect to Lymphography and Lymph Node Histology ....... . 283 VI Winkelmann, R. K., Revuz, J., Pineda, A. A., Touraine, R.: Leuka- pheresis in the Sezary Syndrome 288 Subject Index 295 VII List of Contnbutors Banks, P.M., Burg, G., Mayo Foundation, Dermatologische Klinik Department of Pathology, und Poliklinik der Universitat, Rochester, Minnesota 55901, USA Frauenlobstr. 9-11, D-8000 Miinchen 2, Barth, S., Federal Republic of Germany Institut fUr Med. Mikrobiologie, Johannes-Gutenberg -U niversitat, Christophers, E., Obere Zahlbacher Str. 67, D-6500 Mainz, Universitats-Hautklinik, Federal Republic of Germany Schittenhelmstr. 7, D-2300 Kiel, Berger, C.L., Federal Republic of Germany College of Physicians & Surgeons of Columbia-University, Chu, A., Department of Dermatology, College of Physicians 630 West 168th Street, & Surgeons New York, N.Y. 10032, USA of Columbia-University, Department of Dermatology, Bleehen, S. S., 630 West 168th Street, Department of Dermatology, New York, N.Y. 10032, USA Royal Hallamshire Hospital, Sheffield SlO 2JF, England Cornelisse, C.J., Department of Pathology, de la Brassine, M., University Medical Center, Universite de Liege, NL-2300 RC Leiden, The Netherlands Clinique Dermatologique, Hopital de Baviere, B-4020 Liege, Belgium Detmar, U., Dermatologische Klinik Braun-Falco, 0., und Poliklinik der Universitat, Dermatologische Klinik Frauenlobstr.9-11, und Poliklinik der Universitat, D-8000 Miinchen 2, Frauenlobstr. 9-11, D-8000 Miinchen 2, Federal Republic of Germany Federal Republic of Germany Edelson, R. L., Brittinger, G., College of Physicians & Surgeons Hamatologische Abteilung der Universitat, of Columbia-University, Hufelandstr. 55, D-4300 Essen, Department of Dermatology, Federal Republic of Germany 630 West 168th Street, New York, N.Y. 10032, USA Bunn, P.A., Jr., NCI-VA Medical Oncology Branch, Esseesse, J., V A Medical Center, Hematology Department, 50 Irving Street, Veterans Administration Hospital, NW Washington, DC 20422, USA Brooklyn, N.Y. 11209, USA IX Fishman, A. B., Hamminga, L., NCI-VA Medical Oncology Branch, Department of Dermatology, VA Medical Center, University Hospital, 50 Irving Street, Rijnsburgerweg 10, NW Washington, DC 20422, USA NL-2333 AA Leiden, The Netherlands Franchimont, C., Heusermann, U., Universite de Liege, Abtlg. AUg. Pathologie der Universitat, Clinique Dermatologique, Hospitalstr. 42, D-2300 Kie1, Hopital de Baviere, Federal Republik of Germany B-4020 Liege, Belgium Hodl, St., Fulton, R., Universitatsklinik fUr Dermatologie Unite INSERM 209 - und Venerologie, Laboratoire de Recherche, Auenbrugger Platz 8, Dermatologique et Immunologie - A-8036 Graz, Austria Clinique Dermatologique - Hopital E. Herriot, Hoffmann-Fezer, G., F-69374 Lyon Cedex 2, France Institut fUr Hamatologie, Abtlg. Immunologie GSF, Gaucherand, M., D-8000 Munchen, Unite INSERM 209 - Federal Republic of Germany Laboratoire de Recherche, Dermatologique et Immunologie - Janossy, G., Clinique Dermatologique - Department of Immunology, Hopital E. Herriot, Royal Free Hospital, F-69374 Lyon Cedex 2, France School of Medicine, London, NW3 2QG, England v. Gaudecker, B., Abtlg. Anatomie Kaiserling, E., der Universitat Kiel, Abtlg. Allgemeine Pathologie, D-2300 Kiel, Universitat Kiel, Federal Republic of Germany Hospitalstr. 42, D-2300 Kiel, Federal Republic of Germany Geerts, M. L., Kliniek voor Huidziekten, Kerl, H., Akademisch Ziekenhuis, Universitatsklinik fUr Dermatologie de Bintelaan 135, B-9000 Gent, Belgium und Venerologie, Auenbrugger Platz 8, Glatstein, E., A-8036 Graz, Austria NCI-VA Medical Oncology Branch, VA Medical Center, Kint, A., 50 Irving Street, Kliniek voor Huidziekten, NW Washington, DC 20422, USA Akademisch Ziekenhuis, de Bintelaan 135, B-9000 Gent, Belgium Goos, M., Universitats-Hautklinik, Konrad, K., Schittenhelmstr. 7, D-2300 Kiel, 1. Universitats-Hautklinik, Federal Republic of Germany Alserstr. 4, A-1090 Wien, Austria Guggenberger, K., Kresbach, H., Dermatologische Klinik Universitatsklinik fUr Dermatologie und Poliklinik der Universitat, und Venerologie, Frauenlobstr. 9-11, D-8000 Munchen 2, Auenbrugger Platz 8, Federal of Republic of Germany A-8036 Graz, Austria x Kummermehr, J., Miiller-Hermelink, H.K., Institut fiir Biologie, Abtlg. Allgemeine Pathologie Abtlg. Strahlenbiologie und Biophysik, der Universitat Kiel, Ingolstadter Landstr. 1, Hospitalstr. 42, D-2300 Kiel, D-8042 Neuherberg, Federal Republic of Germany Federal Republic of Germany w., Miiller-Ruchholtz, Lange Wantzin, G., Abtlg. Immunologi~der Universitat Kiel, Dermatologisk afdeling, Brunswiker Str. 2-6, D-2300 Kiel, Finseninstitutet, Federal Republic of Germany Strandboulevarden 49, D-2100 Kobenhavn, Denmark Mulder, J., Department of Dermatology, Lapiere, Ch. M., University Hospital, U niversite de Liege, Rijnsburgerweg 10, Clinique Dermatologique, NL-2333 AA Leiden, The Netherlands Hopital de Baviere, B-4020 Liege, Belgium Nielsen, M., Dermatologisk afdeling, Finseninstitutet, Le, T., Strandboulevarden 49, Universite de Liege, DK-2100 Kobenhavn, Denmark Clinique Dermatologique, Hopital de Baviere, Nikolowski, J., B-4020 Liege, Belgium Dermatologische Klinik und Poliklinik der Universitat, Lennert, K., Frauenlobstr. 9-11, D-8000 Miinchen 2, Abtlg. Allgemeine Pathologie Federal Republic of Germany der UniversiHit Kiel, Hospitalstr. 42, D-2300 Kiel, Petri, J., Federal Republic of Germany Dermatologisk afdeling, Finseninstitutet, Li, C. Y., Strandboulevarden 49, Mayo Foundation, DK-2100 Kobenhavn, Denmark Rochester, Minnesota 55901, USA Pierard, G. E., van der Loo, E. M., Universite de Liege, Department of Pathology, Clinique Dermatologique, University Medical Center, Hopital de Baviere, NL-2300 RC Leiden, The Netherlands B-4020 Liege, Belgium Lynfield, Y., Pineda, A., Dermatology Section, Department of Dermatology, Veterans Administration Hospital, Mayo Foundation, Brooklyn, N.Y. 11209, USA Rochester, Minnesota 55901, USA MacDonald, D. M., Rauch, H. J., Guy's Hospital, Universitatsklinik fiir Dermatologie Dermatology Department, und Venerologie, St. Thomas' Street, Auenbrugger Platz 8, London SE1 9RT, England A-8036 Graz, Austria Meijer, C.J.L.M., Ruiter, D.J., Department of Pathology, Department of Dermatology, University Medical Center, Rijnsburgerweg 10, NL-2300 RC Leiden, The Netherlands NL-2333 AA Leiden, The Netherlands XI Revuz, J., Souteyrand, P., Hopital Henri Mondor, Unite INSERM 209, Service de Dermatologie, Laboratoire de Recherche, 51, Avenue du Mal Dermatologique et Immunologie, de Lattre de Tassigny, Clinique Dermatologique, F-94010 CreteiI, France Hopital E. Herriot, F-69374 Lyon Cedex 2, France Rollinghoff, M., Institut fiir Medizinische Mikrobiologie, Steigleder, G. K., Johannes-Gutenberg -U niversitat, U niversitats-Hautklinik Koln, Obere Zahlbacher Str. 67, Josef-Stelzmann-Str. 9, D-6500 Mainz, D-5000 K61n 41, Federal Republic of Germany Federal of Republic of Germany Scheffer, E., Stein, H., Department of Pathology, Abteilung Allgemeine Pathologie University Medical Center, der Universitat, NL-2300 RC Leiden, The Netherlands Hospitalstr. 42, D-2300 Kie1, Federal Republic of Germany Schmitt D., Unite INSERM 209, Steinmann, G.G., Laboratoire de Recherche, Abtlg. Allgemeine Pathologie Dermatologique et Immunologie, der Universitat Kiel, Clinique Dermatologique, Hospitalstral3e 42, D-2300 Kiel, Hopital E. Herriot, Federal Republic of Germany F-69374 Lyon Cooex 2, France Sterry, W., Schmoeckel, Ch., Universitats-Hautklinik Koln, Dermatologische Klinik Josef-Stelzmann-Str. 9, D-5000 Koln 41, und Poliklinik der Universitat, Federal of Republic of Germany Frauenlobstr. 9-11, D-8000 Miinchen 2 Federal Republic of Germany Stingl, G., I. Universitats-Hautklinik, Schroder, L., Alserstr. 4, A-I090 Wien, Austria Abtlg., Unfallchirurgie, Hospitalstr. 40, D-2300 Kiel, Stutte, H. J., Federal Republic of Germany Senckenbergisches Zentrum der Pathologie im Klinikum Schwarze, E. W., der J.-W.-Goethe-Universitat, Abtlg. Allgemeine Pathologie Theodor-Stern-Kai 7, der Universitat, D-6000 Frankfurt a. M. 70, Hospitalstr. 42, D-2300 Kiel, Federal Republic of Germany Federal Republic of Germany Thivolet, J., Sidhu, G. S., Unite INSERM 209, New York V.A. Medical Center, Laboratoire de Recherche, pt A venue at 24th Street, Dermatologique et Immunologie, New York, N.Y 10010, USA Clinique Dermatologique, Hopital E. Herriot, w., Solbach, F-69374 Lyon Cooex 2, France Institut fUr Medizinische Mikrobiologie, Johannes-Gutenberg -Universitat, Thomas, A., Obere Zahlbacher Str. 67, Department of Immunology, D-6500 Mainz, Royal Free Hospital, School of Medicine, Federal Republic of Germany London, NW3 CQG, England XII
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