LUNG DISEASES – SELECTED STATE OF THE ART REVIEWS Edited by Elvis Malcolm Irusen Lung Diseases – Selected State of the Art Reviews Edited by Elvis Malcolm Irusen Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Romana Vukelic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Lung Diseases – Selected State of the Art Reviews, Edited by Elvis Malcolm Irusen p. cm. ISBN 978-953-51-0180-2 Contents Preface XI Part 1 Airways Disease 1 Chapter 1 Airway Smooth Muscle in Asthma Symptoms: Culprit but Maybe Innocent 3 Ynuk Bossé, Peter D. Paré and Yohan Boss Chapter 2 Polymerization and Oxidation of Alpha-1-Antitrypsin in Pathogenesis of Emphysema 55 Aleksandra Topic and Dragica Radojkovic Chapter 3 Recent Advances in the Research and Development of Alpha-1 Proteinase Inhibitor for Therapeutic Use 83 Elena Karnaukhova Chapter 4 Mechanisms Promoting Chronic Lung Diseases: Will Targeting Stromal Cells Cure COPD and IPF? 105 Lynne A. Murray and Cory M. Hogaboam Part 2 Neoplasia 127 Chapter 5 Cancer Stem Cells (CSCs) in Lung Cancer 129 Hiroyuki Sakashita, Yuki Sumi and Naohiko Inase Chapter 6 Oncogenes and Tumor Suppressor Genes in Small Cell Lung Carcinoma 147 Pankaj Taneja, Robert D. Kendig, Sinan Zhu, Dejan Maglic, Elizabeth A. Fry and Kazushi Inoue Chapter 7 Centrosome Abnormality and Human Lung Cancer 171 Kazuya Shinmura and Haruhiko Sugimura Chapter 8 Defective Expression and DNA Variants of TGFBR2 in Chinese Small Cell Lung Carcinoma 189 ZhenHong Zhao, Jibin Xu, Jun Xie, Yang Bao, Xiaotian Wang, Lei Wang, Junjie Wu, Li Jin, Zhiyun Xu and Jiucun Wang VI Contents Chapter 9 Neuroendocrine Tumours of the Lung 203 Guadalupe Aparicio Gallego, Vanessa Medina Villaamil, Ana Capdevila Puerta, Enrique Grande Pulido and L.M. Antón Aparicio Chapter 10 Chemotherapy for Large Cell Neuroendocrine Carcinoma of the Lung: Should It Be Treated with the Same Strategy as Small Cell Lung Carcinoma? 231 Katsuhiko Naoki, Kenzo Soejima, Takashi Sato, Shinnosuke Ikemura, Hideki Terai, Ryosuke Satomi, Sohei Nakayama, Satoshi Yoda and Koichiro Asano Chapter 11 Radiation Therapy in Management of Small-Cell Lung Cancer 239 Erkan Topkan and Cem Parlak Chapter 12 Lung Parenchyma Sparing Resection for Pulmonary Malignancies 257 Arpad Pereszlenyi Chapter 13 Surgery in Small-Cell Lung Cancer: Past, Present and Future 275 Cristian Rapicetta, Sara Tenconi, Tommaso Ricchetti, Sally Maramotti and Massimiliano Paci Part 3 Immunity and Infection 297 Chapter 14 Interleukin-17 and T Helper 17 Cells in Mucosal Immunity of the Lung 299 M.S. Paats, P.Th.W. van Hal, C.C. Baan, H.C. Hoogsteden, M.M. van der Eerden and R.W. Hendriks Chapter 15 Current Status of the Mollicute (Mycoplasma) Lung Disease: Pathogenesis, Diagnostics, Treatment and Prevention 331 Silvia Giono-Cerezo, Guadalupe Estrada-Gutiérrez, José Antonio Rivera-Tapia, Jorge Antonio Yáñez-Santos and Francisco Javier Díaz-García Chapter 16 Pulmonary Paracoccidioidomycosis: Clinical, Immunological and Histopathological Aspects 359 Luz E. Cano, Ángel González, Damaris Lopera, Tonny W. Naranjo and Ángela Restrepo Chapter 17 Nocardia Infection in Lung Transplantation 393 Pilar Morales, Ana Gil-Brusola and María Santos Chapter 18 In Vivo Models of Lung Disease 407 Tracey L. Bonfield Contents VII Chapter 19 Inhibition of Adhesion and Invasion of Pseudomonas aeruginosa to Lung Epithelial Cells: A Model of Cystic Fibrosis Infection 429 Ayman M. Noreddin, Ghada Sawy, Walid Elkhatib, Ehab Noreddin and Atef Shibl Part 4 Paediatrics 441 Chapter 20 Bronchitis in Children 443 Christian Peiser Chapter 21 Bronchopulmonary Dysplasia 463 Shou-Yien Wu, Sachin Gupta, Chung-Ming Chen and Tsu-Fuh Yeh Chapter 22 Bronchopulmonary Dysplasia: The Role of Oxidative Stress 485 Jean-Claude Lavoie and Ibrahim Mohamed Chapter 23 Partial Liquid Ventilation in the Extremely Preterm Infant: Potential Benefits and Harms 505 Mark William Davies Part 5 Pulmonary Oedema: Cardiogenic and Non-Cardiogenic 523 Chapter 24 Non-Cardiogenic Pulmonary Edema 525 J. Gonzales and A. Verin Chapter 25 High Altitude Pulmonary Edema 539 Zhou Qiquan and Luo Yongjun Chapter 26 Mechanical Forces Impair Alveolar Ion Transport Processes – A Putative Mechanism Contributing to the Formation of Pulmonary Edema 561 Martin Fronius Part 6 Miscellaneous 579 Chapter 27 Functional Evaluation in Respiratory Disorders 581 Cirelene Grobler, David M. Maree and Elvis M. Irusen Chapter 28 Novel Methods for Diagnosis of Pulmonary Microangiopathy in Diabetes Mellitus 603 Kalicka Renata and Kuziemski Krzysztof Chapter 29 The Pneumoconioses 625 Nlandu Roger Ngatu, Ntumba Jean-Marie Kayembe, Benjamin Longo-Mbenza and Narufumi Suganuma VIII Contents Chapter 30 Lung Transplantation: Advances and Roadblocks in Treatment 647 Matthew T. Hardison and J. Edwin Blalock Chapter 31 Bronchial Atresia 671 Lirios Sacristán Bou and Francisco Peña Blas Chapter 32 A Case of Adult Congenital Cystic Adenomatoid Malformation of the Lung with Atypical Adenomatous Hyperplasia 685 Ho Sung Lee, Jae Sung Choi, Ki Hyun Seo, Ju Ock Na, Yong Hoon Kim, Mi Hye Oh and Sung Shick Jou