headaches menopause indigestion dementia stress vision inconLtineinvce ing a Healthy Barllearginies Lifestyle to Prevmeigraninets shingles Dementia and influenza Alzheimer’s Disease back pain heart health respiratory disease asthma diabetes arthritis skin conditions migraines stds obesity depression childhood diseases indigestion chronic pain incontinence periodontal disease stomach disorders prostate health skin conditions urinary tract infection Lauren Russel, ND Living a Healthy Brain Lifestyle to Prevent Dementia and Alzheimer’s Disease Living a Healthy Brain Lifestyle to Prevent Dementia and Alzheimer’s Disease Lauren Russel, ND i DISCLAIMER Ideas and information in this book are based upon the experience and training of the author and the scientific information currently avail- able. The suggestions in this book are definitely not meant to be a substitute for careful medical evaluation and treatment by a qualified, licensed health professional. The author and publisher do not recom- mend changing or adding medication or supplements without con- sulting your personal physician. They specifically disclaim any liability arising directly or indirectly from the use of this book. Praktikos Books PO Box 457 Edinburg, VA 22824 888.542.9467 [email protected] Living a Healthy Brain Lifestyle to Prevent Dementia and Alzheimer’s Disease by Lauren Russel, ND is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecom- mons.org/licenses/by/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA. Praktikos Books are produced in alliance with Axios Press. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 The Emerging Picture of Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . 3 A Global Problem . . . . . . . . . . . . . . . . . . . . . . . . . 4 Why Conventional Medicine Cannot Fix the Problem of Dementia and Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 New Ways of Thinking about Brain Aging and Dementia . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1: What is Normal Brain Aging? . . . . . . . . . . . . 13 Looking into Your Medical History for Clues . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 2: Where Do We Begin? Causes of Abnormal Brain Aging . . . . . . . . . . . . . . . . . . 21 What is Really Happening to the Brain? . . . . 25 Other Types of Dementia Affecting the Brain . . . . . . . . . . . . . . . . . . 32 • v vi • Dementia anD alzheimer’s Disease 3: What You Don’t Know Can Lead to a Big Problem Later On: Understanding the Symptoms of Dementia and Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Assessment and Diagnostic Recommendations for Alzheimer’s and Dementia . . . . . . . . 48 4: What Increases Your Risk of Abnormal Brain Aging? . . . . . . . . . . . . . . . . . 57 Chronic Inflammation . . . . . . . . . . . . . . . . . . . 58 Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Insulin Resistance and Diabetes . . . . . . . . . . 61 Oxidative Stress . . . . . . . . . . . . . . . . . . . . . . . . 64 Chronic Stress and Risk for Cognitive Impairment and Alzheimer’s Disease . . 65 Glycation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 Methylation Deficit . . . . . . . . . . . . . . . . . . . . . 69 Homocysteine . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Vitamin B Deficiency . . . . . . . . . . . . . . . . . . 71 12 Mitochondrial Dysfunction . . . . . . . . . . . . . . 72 Increased Risk with Lower Hormone Levels that Naturally Occur with Aging . . . . . . . 74 Vitamin and Mineral Deficiencies . . . . . . . . . 77 Toxic Exposures . . . . . . . . . . . . . . . . . . . . . . . . 81 Sleep Deficit . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 Immune Response and Infectious Agents as Triggers for Alzheimer’s Pathology . . . . 85 Thyroid/Iodine Deficiency . . . . . . . . . . . . . . . 87 Calcification . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 Fatty Acid Imbalances . . . . . . . . . . . . . . . . . . . 89 DNA Gene Mutations . . . . . . . . . . . . . . . . . . . 90 Excitotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . . 93 Cholesterol . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 Contents • vii Periodontal Disease and Alzheimer’s Disease . . . . . . . . . . . . . . . . . 94 Anesthetics, Isoflurane and Halothane May Trigger Onset . . . . . . . . . . . . . . . . . . . . . . 95 5: What is Conventional Medicine Doing to Treat Dementia and Alzheimer’s Disease? What Do Drug Companies Actually Say? . . . . . . . . . . .97 Drug Treatment Philosophy . . . . . . . . . . . . . . 97 Drug Categories . . . . . . . . . . . . . . . . . . . . . . . . 98 Secondary Prevention—Drugs that Are Intended to be Disease Modifying . . . . 104 Why Conventional Therapies May Make It Worse . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6: There Is a Better Way . . . . . . . . . . . . . . . . . 113 Here’s What You Can Do to Begin a Therapeutic Lifestyle Strategy Now . . . 114 Your Strategy for Natural Prevention . . . . . 115 7: In Your Brain Healthy Lifestyle, Add In Specific Supplements with Exceptional Benefits . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 Lithium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130 Niacinamide . . . . . . . . . . . . . . . . . . . . . . . . . . 132 Increase Antioxidants . . . . . . . . . . . . . . . . . . 132 Curry, Turmeric, and Curcumin . . . . . . . . . . 134 The Case for Supplementing with Vitamins B, C, D, and E . . . . . . . . . 135 High Dose B Vitamins and Mild Cognitive Impairment . . . . . . . . . . 136 Dietary Folate and Supplemental Folate, B12 . . . . . . . . . . . 138 Antioxidant Benefits of Vitamins C and E . 139 Powerful Botanicals to Help . . . . . . . . . . . . . 140 viii • Dementia anD alzheimer’s Disease 8: What We Know Reduces Risk: Recent Research . . . . . . . . . . . . . . . . . . . . . 143 Cancer History . . . . . . . . . . . . . . . . . . . . . . . . 143 NSAIDs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144 9: Natural Therapies—What to Do if Cognitive Decline is a Problem . . . . . . . . . . . . . . . . . 145 Improvement and Enhancement versus Therapy and Cure . . . . . . . . . . . . 145 Cognitive Training—Use Your Brain to Protect Your Brain . . . . . . . . . . . . . . . 146 Chicago Health and Aging Project (CHAP) . 147 Controlling Hypertension and Diabetes . . . . . . . . . . . . . . . . . . . . . . 148 Benfotiamine . . . . . . . . . . . . . . . . . . . . . . . . . 148 Dietary Intake of Flavonoids . . . . . . . . . . . . 148 Anodyne Therapy . . . . . . . . . . . . . . . . . . . . . . 149 Ayurvedic Herbs . . . . . . . . . . . . . . . . . . . . . . . 150 Minerals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 Botanicals and Plant Constituents . . . . . . . 153 Sea and Other Naturally Derived Sources . 167 Supplements . . . . . . . . . . . . . . . . . . . . . . . . . . 169 10: Effective Pharmacologic Therapies . . . . . 175 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 Endnotes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 About the Author . . . . . . . . . . . . . . . . . . . . . . . 243 Preface A diagnosis of alzheimer’s disease or any other cause of dementia that would shorten your cognitive lifespan is very frightening . While we hear so much about this disease, many of us may not understand what it is and what some of its early warning signs are . What is even more alarming, many of us do not know some of the simple things that can be done to prevent or reduce risk factors years before it occurs, mostly because there are very few actually talking about what can be done . This book will tell you what dementia is, some of the things that contribute to it, and what you can do now to prevent or stall its progression . If you have a friend or loved one with Alzheimer’s, they may benefit from some of the information to be covered . • 1
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