Table Of Content

In Clinical Practice Tim Cross Editor Liver Disease in Clinical Practice Second Edition In Clinical Practice Taking a practical approach to clinical medicine, this series of smaller reference books is designed for the trainee physician, primary care physician, nurse practitioner and other general medical professionals to understand each topic covered. The coverage is comprehensive but concise and is designed to act as a primary reference tool for subjects across the field of medicine. Tim Cross Editor Liver Disease in Clinical Practice Second Edition Editor Tim Cross Royal Liverpool University Hospital Liverpool, UK ISSN 2199-6652 ISSN 2199-6660 (electronic) In Clinical Practice ISBN 978-3-031-10011-6 ISBN 978-3-031-10012-3 (eBook) https://doi.org/10.1007/978-3-031-10012-3 © Springer Nature Switzerland AG 2022 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduc- tion on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland I would like to dedicate this book to all keyworkers, hospital and healthcare workers who worked so tirelessly and selflessly during the global pandemic. Preface The first edition of Liver Disease in Clinical Practice was published in 2017. It was hoped to get a second edition out in 2020, but as many of us will only be too aware, the COVID-19 pandemic has had a significant impact on our lives and this has led to a significant delay in its publication. There have been many developments since the last edition, and as a result, some chapters have been added and others have been omitted particularly where there were con- cerns about duplication. Thus, we have included new chapters on IgG4 disease, drug-induced liver disease and Fontan- associated liver disease (FALD). Given the nature of the series, the book is not intended to be a comprehensive text- book of all aspects of liver disease, and so we have omitted chapters on primary biliary cholangitis, primary sclerosing cholangitis, nutrition, end of life care and alcohol-related liver disease. It is hoped that the first edition will provide a frame- work and guide to help clinicians manage these conditions. Given the rapidly changing landscape in information on COVID-19, a decision was made not to include this topic, as the concern would be the information would be out of date by the time of publication. I hope this will not be a disappointment. I’d like to thank all the authors for the generosity in pro- viding time to write these chapters and hope it has given an opportunity for trainee doctors and researchers to sharpen their writing skills. It is a reflection on the wonderful interna- tional nature of hepatology community that we have had contributors from Australia, Canada, the USA and the UK. Finally, I’d also like to thank the production team at viii Preface Springer, in particular Siva, for being so generous with their time and for being so patient in waiting for this edition to finally materialize. Liverpool, UK Tim Cross January 2022 Contents 1 Assessment of Liver Function .................... 1 Ioannis Papamargaritis and Cyril Sieberhagen 2 Acute Liver Failure ............................. 19 Gregory Packer and Brian J. Hogan 3 Drug-Induced Liver Injury ...................... 37 Edmond Atallah and Guruprasad P. Aithal 4 Liver Decompensation and Acute on Chronic Liver Failure ........................... 57 R. Nathwani, N. Selvapatt, and A. Dhar 5 Portal Hypertension: Varices ..................... 81 Amardeep Khanna, Ashish Goel, and Dhiraj Tripathi 6 Frailty and Sarcopenia in Cirrhosis ............... 105 Osama Siddiqui, Sydney Olson, Avesh Thuluvath, and Daniela Ladner 7 Non-alcoholic Fatty Liver Disease ................ 127 David Koeckerling, Thomas Marjot, and Jeremy Cobbold 8 Chronic Hepatitis B ............................ 151 Navjyot Hansi, Loey Lung-Yi Mak, Upkar Gill, and Patrick Kennedy 9 Chronic Hepatitis C ............................ 177 Ruth Tunney, Martin Prince, and Varinder Athwal 10 Autoimmune Hepatitis and Overlap Syndromes .... 195 Kristel K. Leung and Gideon M. Hirschfield x Contents 11 IgG4-Related Hepato- Pancreato- Biliary Disease ... 223 Eoghan McNelis and Emma Culver 12 Hereditary Haemochromatosis ................... 245 William J. H. Griffiths 13 Pregnancy and Liver Disease .................... 261 Hamish M. Miller and Rachel H. Westbrook 14 The Orphan Liver Disease ...................... 287 Reenam Khan and Philip Newsome 15 Fontan-Associated Liver Disease (FALD) ......... 307 Hera Asad, Tehreem P. Chaudhry, and Petra Jenkins 16 Diagnosis and Management of Hepatocellular Carcinoma .................................... 327 Elizabeth Sweeney and Tim Cross 17 Liver Transplantation ........................... 355 Rohit Gupta and James O’Beirne 18 The Hepatological Curiosities .................... 381 Charmaine Matthews and Tim Cross Index ............................................ 405