Laparoscopic versus open living donor nephrectomy M.Y. Smits-Lind This thesis was fi nancially supported by: Nierstichting Nederland Johnson & Johnson Medical B.V. Fujisawa Holland B.V. Roche Nederland B.V. Tyco Healthcare Nederland B.V. Novartis Pharma B.V. Olympus Nederland B.V. B. Braun Medical B.V. Laparoscopic versus open living donor nephrectomy. Thesis, Erasmus University Rotterdam © M.Y. Smits-Lind All rights reserved. No part of this thesis ma y be reproduced, stored in a retrieval of any nature, or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the permission of the author. Cover: The Kiss by Gustav Klimt. With permission of the Oesterreichische Galerie Belvedere Vienna. Printed by Optima Grafi sche Communicatie, Rotterdam Laparoscopic Versus Open Living Donor Nephrectomy Laparoscopische versus open nier donatie bij leven Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnifi cus Prof.dr. S.W.J. Lamberts en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 12 oktober 2005 om 15.45 uur door May Yvonne Smits-Lin d geboren te ’s Gravenha ge PROMOTIECOMMISSIE Promotor: Prof.dr. J.N.M. IJzermans Overige leden: Prof.dr. W. Weimar Prof.dr. J. Klein Prof.dr. R. Benner Copromotor: Dr. I.P.J. Alwayn CONTENTS Chapter 1 Introduction 9 Adapted from: BJU Int. 2002; 89(2):162-168 . Chapter 2 Right-sided laparoscopic live donor nephrectomy. Is re luctance sti ll 25 justifi ed? Transplantation 2002; 74(7): 1045-1048. Chapter 3 Body image a fter laparoscopic or open donor nephrectom y 33 Surg Endosc. 2004; 18(8): 1276-1279 . Chapter 4 Live donor nephrectomy and return to work. Does the operative 41 technique matter? Surg Endosc. 2003; 17(4): 591-595. Chapter 5 The eff ect of laparoscopic and open donor nephrectomy on the long 51 term renal function in donor and recipient: A retrospective stud y Transplantation 2005; in press. Chapter 6 Eff ect of prolonged warm ischemia and pneumoperitoneum on renal 61 function in a rat syngeneic kidney transplantation model Surg Endosc. 2005; in press. Chapter 7 Laparoscopic versus open donor nephrectom y: Ureteral complications 73 in recipients Urology 2004; 63(1): 36-39. Chapter 8 A randomized, blinded, study comparing laparoscopic and minimal 83 invasive open donor nephrectomy: The short term result s Chapter 9 General discussion and conclusions 95 Discussie en conc lusies 101 Dankwoord 107 Curriculum Vitae 111 To my mother, thank you for your unconditional love . To Loet, thank you for being a part of our lives . To Jeroen, thank you for your love, friendship and support. Chapter 1 Introduction Adapted from: M.Y. Lind, J.N.M. IJzermans, H.J. Bonjer. Department of Surgery Erasmus Medical Center, Rotterdam Open versus laparoscopic donor nephrectomy in renal transplantation. BJU Int. 2002;89(2):162-168.