Liposome-Based Drug Delivery Systems PDF
Preview Liposome-Based Drug Delivery Systems
Biomaterial Engineering Series Editor: Youqing Shen Wan-Liang Lu Xian-Rong Qi Editors Liposome-Based Drug Delivery Systems Biomaterial Engineering SeriesEditor YouqingShen CollegeofChemicalandBiologicalEngineering ZhejiangUniversity Hangzhou,China Theuseofhumanbodycompatiblematerialsformedicaldiagnosis,treatment,and surgery is always critical in enhancing life-saving therapies and quality of life of patients. With the massive research efforts in this field in both universities and industries, there is a continuous growth in our knowledge/technique in design and useofsuchbiomaterialstoeffectivelydeliverspecifictherapeutics,includingDNA, protein, and contrast reagents, to the targeted cells and organs for treatment or diagnosis; to repair or replace tissues; or even to construct artificial organs like cartilages, bones, and skins to regain the body functions. The inherent interdisci- plinarynatureofbiomaterialsmakesresearchersoftenusemethodstoprepareawide range of materialsand various bioassays to evaluatetheir diverse bio-related prop- erties. However, it is generally very difficult to find and tell reliable sources and detailed know-how for the needed methods and protocols, which are buried in the vastliteratureandonlydescribedingenerallackofdetails.Onestillhastofindthe bestbytrialanderror. The aim of this series is to provide a complete reference for researchers, engi- neers, and graduate students who are engaged in R&D of biomaterials. It provides newcomers the fundamental concepts and overall status of the areas they work on and provides researchers comprehensive, in-depth, and authoritative information including preparation/fabrication protocols of most biomaterials and bioassay pro- tocolsaswellasawidevarietyofadvancedexperimentalmethodsusedinpractice, numerousexamples,andpracticalapplications. Moreinformationaboutthisseriesathttp://www.springer.com/series/13484 (cid:129) Wan-Liang Lu Xian-Rong Qi Editors Liposome-Based Drug Delivery Systems With158Figuresand17Tables Editors Wan-LiangLu Xian-RongQi BeijingKeyLaboratoryofMolecular DepartmentofPharmaceutics PharmaceuticsandNewDrugSystem SchoolofPharmaceuticalScience Beijing,China PekingUniversity Beijing,China BeijingKeyLaboratoryofMolecular PharmaceuticsandNewDrugSystem Beijing,China ISSN2523-8809 ISSN2523-8817(electronic) ISBN978-3-662-49318-2 ISBN978-3-662-49320-5(eBook) ISBN978-3-662-49319-9(printandelectronicbundle) https://doi.org/10.1007/978-3-662-49320-5 ©Springer-VerlagGmbHGermany,partofSpringerNature2021 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthe materialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation, broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformation storageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodology nowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthors,andtheeditorsaresafetoassumethattheadviceandinformationinthisbook arebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsorthe editorsgiveawarranty,expressedorimplied,withrespecttothematerialcontainedhereinorforanyerrors oromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictionalclaims inpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringer-VerlagGmbH,DEpartofSpringer Nature. Theregisteredcompanyaddressis:HeidelbergerPlatz3,14197Berlin,Germany Series Preface Theuseofhumanbodycompatiblematerialsformedicaldiagnosis,treatment,and surgery is always critical in enhancing life-saving therapies and quality of life of patients. With the massive research efforts in this field in both universities and industries, there is a continuous growth in our knowledge/technique in design and useofsuchbiomaterialstoeffectivelydeliverspecifictherapeutics,includingDNA, protein, and contrast reagents, to the targeted cells and organs for treatment or diagnosis; to repair or replace tissues; or even to construct artificial organs like cartilages, bones, and skins to regain the body functions. The inherent interdisci- plinarynatureofbiomaterialsmakesresearchersoftenusemethodstoprepareawide range of materialsand various bioassays to evaluatetheir diverse bio-related prop- erties. However, it is generally very difficult to find and tell reliable sources and detailed know-how for the needed methods and protocols, which are buried in the vastliteratureandonlydescribedingenerallackofdetails.Onestillhastofindthe bestbytrialanderror. The aim of this series is to provide a complete reference for researchers, engi- neers, and graduate students who are engaged in R&D of biomaterials. It provides newcomers the fundamental concepts and overall status of the areas they work on and provides researchers comprehensive, in-depth, and authoritative information including preparation/fabrication protocols of most biomaterials and bioassay pro- tocolsaswellasawidevarietyofadvancedexperimentalmethodsusedinpractice, numerousexamples,andpracticalapplications. This reference work, tentatively composed of 10 volumes, covers the most popular topics of biomaterials, from drug delivery to gene and protein delivery, from biomedical biodetection to diagnosis, from cardiovascular diseases to tissue engineering.Thecontentiscreatedbyleadingscientistsineachfieldandwillevolve constantly,thusitpresentsbothhigh-qualityandup-to-datescientificandtechnical information. June,2021 YouqingShen v Volume Preface Liposomes are the sealed vesicles that are generally formed by phospholipids, cholesterol, and other materials. Liposomes are not only a convenient platform for studyingmembranekineticsanddrugorbiomoleculetransport,butalsoapotential drugdeliverycarriersystem.Liposomeshaveauniqueroleinovercomingbiological barriers and carrying biological drugs. As a drug carrier, liposomes have a broad prospect in basic research and clinical application, such as delivering anticancer agents,anti-parasitedrugs,hormones,andgenes. This volume mainly describes the protocols for fabrication of liposomal drug delivery system, and consists of two parts. The first part emphasizes the basic protocols and concepts for fabrication of drug-loaded liposomes. For new investi- gators, laying the groundwork is the first step. This part focuses on the fabrication detailsinliposomesformulations,whicharetheso-calledsmalltrickswhileusually notdisclosedinmostpublishedresearcharticles.However,theseprocessingdetails are crucial for the preparation of liposomes. And the second part focuses on the strategies in modified and/or functionalized liposomes to adapt to pathophysiolog- icalenvironment,aswellastheirapplicationintreatingdiseases.Asnewanalytical andsynthetictechnologiesbecomeavailable,andimprovedunderstandingofpath- ophysiology,variousfunctionalizeddrugliposomesaredevelopedtofittherequire- ments of different therapeutic purposes, exhibiting a broad range of applications. Accordingly,theobjectivesofthispartareaimedatdeeplyunearthingtheformula- tion of drug-loaded liposomes, describing the detailed operation of liposomal for- mulation, and further demonstrating their potential applications. Therefore, this volume shows the features of experimental report or protocol for proving a guide to scientists, research students, and young investigators in pharmaceutical enterprises. Editorialmembersofthisvolumeinvolverenownedexpertsandyoungscholars in the research field of liposomes, and some graduate students who have research experience in liposomes field also participate in the editing work. They are mainly fromPekingUniversity,FudanUniversity,SichuanUniversity,ChinaPharmaceuti- calUniversity,ShenyangPharmaceuticalUniversity,SecondMilitaryMedicalUni- versity, Hebei Medical University, Beijing Institute of Petrochemical Technology, Shihezi University, Liaoning University of Traditional Chinese Medicine, Shanxi UniversityofTraditionalChineseMedicine,JilinMedicalUniversity,Universityof vii viii VolumePreface North Carolina at Chapel Hill, University of Nebraska Medical Center, and Chap- manUniversity,aswellastheiraffiliatedhospitals. This volume is included in the reference series – Biomaterial Engineering, proposed by Prof. Youqing Shen. The volume is expected to be used by graduate students,postdoctoralresearchers,andresearchersusinglipid-basedsystemsinthe fields of drug delivery, physical chemistry, and cellular and molecular biology. We aregratefultoalltheauthorsfortheircontributions.Wearealsoverygratefultothe serieseditor,Dr.JubyGeorge,andtheoutstandingstaffatSpringerNaturefortheir support,help,andencouragement. SchoolofPharmaceuticalSciences Wan-LiangLu PekingUniversity Xian-RongQi June,2021 Contents PartI GeneralProtocolsforFabricationofDrugLiposomes ...... 1 1 LiposomesinDrugDelivery:StatusandAdvances ............ 3 Ying-JieHu,Rui-JunJu,FanZeng,Xian-RongQi,andWan-LiangLu 2 PreparationofDrugLiposomesbyThin-FilmHydrationand Homogenization ....................................... 25 BaiXiangandDe-YingCao 3 PreparationofDrugLiposomesbyReverse-PhaseEvaporation ... 37 Nian-QiuShiandXian-RongQi 4 PreparationandCharacterizationofDrugLiposomesby pH-GradientMethod .................................... 47 Nian-QiuShi,Xian-RongQi,andBaiXiang 5 PreparationandCharacterizationofDrugLiposomesby AmmoniumSulfateGradient ............................. 59 Rui-JunJuandXue-TaoLi 6 PreparationofDrugLiposomesbyEDTAGradientMethods .... 79 YanzhiSongandYihuiDeng 7 Lipid-CoatedCisplatinNanoparticlesforInsoluble DrugLoading ......................................... 97 YangLiuandLeafHuang 8 PurificationMethodofDrug-LoadedLiposome ............... 111 MengLinandXian-RongQi 9 QualityEvaluationofDrug-LoadedLiposomes ............... 123 MengLin,RudongWang,andXian-RongQi ix x Contents PartII FunctionalizedLiposome-BasedDrugDeliverySystems andPotentialApplication .................................. 141 10 CouplingMethodsofAntibodiesandLigandsforLiposomes .... 143 MingChen,Qiu-RanMa,andWan-LiangLu 11 PreparationandEvaluationofFolateReceptorMediated TargetingLiposomes .................................... 167 WeiGao 12 PreparationofCellPenetratingPeptides-MediatedTargeting DrugLiposomes ....................................... 179 YangWangandQinHe 13 PreparationofMultifunctionalPaclitaxelLiposomesfor TreatmentofBrainGlioma ............................... 193 Xiu-YingLi 14 PreparationandEvaluationofIntegrinReceptor-Mediated TargetingDrugLiposomes ............................... 213 FeiWang,GangWei,andWeiyueLu 15 PreparationofFunctionalVincristineLiposomesforTreatment ofInvasiveBreastCancer ................................ 239 FanZeng 16 PreparationandCharacterizationofDNALiposomesVaccine ... 259 Ya-FeiDu,MingChen,Jia-RuiXu,QianLuo,andWan-LiangLu 17 PreparationandEvaluationofBiomineral-BindingAntibiotic Liposomes ............................................ 277 Xin-MingLiu,KeRen,GeoffreyWu,andDongWang 18 Dual-ModifiedsiRNA-LoadedLiposomesforProstateCancer Therapy .............................................. 293 BaiXiangandDe-YingCao 19 FabricationandEvaluationofDualPeptides-ModifiedLiposomes CoencapsulatingsiRNAandDocetaxel ...................... 309 ZhenzhenYangandBaiXiang 20 PreparationandEvaluationofRivastigmineLiposomesfor IntranasalDelivery ..................................... 325 ZhenzhenYang 21 Dequalinium-MediatedMitochondria-TargetingDrugLiposomes fortheTreatmentofDrug-ResistantLungCancer ............ 345 XueYing
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