Lipids Part C

911 Pages·1981·16.351 MB·English

by  John M. Lowenstein (Eds.)

Contributors to Volume 71
Article numbers are ni parentheses following the names of .srotubirtnoc
snoitailiffA listed are .tnerruc
V. P. AGRAWAL (50), Department of JUDITH F. KCOTSNIB (49), Department of
Chemistry, Tribhuvan University, Kirfipur Chemistry, Manhattan College, River-
Kathmandu, Nepal dale, New York 17401
FAZAL AHMAD (2), Papanicolaou Cancer DRAWOH L. NAMKCORB (72), The Hormel
Research Institute, Miami, Florida 10133 Institute, University of Minnesota,
Austin, Minnesota 21955
PATRICIA M. AHMAD (2), Papanicolaou
Cancer Research Institute, Miami, J. S. RENKCUB (13), Metabolism and Radia-
Florida 10133 tion Research Laboratory, Fargo, North
Dakota 20185
DRANREB AXELROD (53), Department of
Biochemistry, Purdue University, West THOMAS M. HGUORBSEEHC (53), Depart-
Lafayette, Indiana 47907 ment of Biochemistry, Purdue University,
West Lafayette, Indiana 47907
YRRET A. BAKER (55), Lipid Metabolism
Laboratory, William S. Middleton Memo- PATRICK C. CHOY (68), Department of
Biochemistry, University of Manitoba,
rial Veterans Hospital, Madison, Wiscon-
Winnipeg, Manitoba R3E OW3, Canada
sin 53705
CLINTON E. BALLOU (29), Department of PHILIP COHEN (3), Biochemistry Depart-
ment, Dundee University, Dundee DDI
Biochemistry, University of California,
4HN, Scotland
Berkeley, California 02749
TREBOR S. CONWAY (51), Department of
C. J. BEDORD (27), Syntex Corporation,
Microbiology, Emory University, Atlanta,
3401 Hillview Avenue, PaiD Alto, Califor-
Georgia 22303
nia 40349
R. C. LLERTTOC (80), The British Industrial
PEa BELFRAGE (74, 75), Department of
Biological Research Association, Carshal-
Physiological Chemistry, University of
ton, Surrey SM5 4DS, England
Lund, S-220 70 Lund, Sweden
JOHN E. CRONAN, JR. (18, 21, 41), Depart-
WILLIAM R. BENSCH (56), Lilly Research
ment of Microbiology, University of
Laboratories, Indianapolis, Indiana 46206
Illinois, Urbana, Illinois 10816
ROLF KRISTIAN BERGE (28), Laboratory of
MAILLIW C. DEAL, JR. (10), Department of
Clinical Biochemistry, University of Ber-
Biochemistry, Michigan State University,
gen, 5016 Haukeland Sykehus, Norway
East Lansing, Michigan 42884
BRADLEY BERGER (58), University of DNOMYAR A. DEEMS (81), Department of
Chicago Medical School, Chicago,
Chemistry, University of California, San
Illinois 21606 Diego, La Jolla, California 39029
JOHN T. BERNERT, JR. (30), United States EDWARD A. DENNIS (81), Department of
Department of Health, Education and Chemistry, University of California, San
Welfare, Center for Disease Control, Diego, La Jolla, California 39029
Atlanta, Georgia 33303
DNOMYAR DILS (26), Department of Phys-
L. L. BIEBER (42), Department of iology & Biochemistry, University of
Biochemistry, Michigan State University, Reading, Whiteknights, Reading RG6
East Lansing, Michigan 48824 2A J, England
xiii
xiv CONTRIBUTORS TO VOLUME 17
PETER F. DODOS (11), Department of tory, University of Texas Health Science
Chemistry, Georgetown University, Wash- Center at Dallas, Southwestern Medical
ington, D.C. 20057 School, Dallas, Texas 75235, and Vete-
rans Administration Medical Center, Dal-
YUKlO DOl (87), Burnsides Research Labo-
las, Texas 61257
ratory, Department of Food Sciences,
University of Illinois, Urbana, Illinois JEANIE FRYE (78), Life Sciences Division,
10816 Meloy Laboratories Inc., 6715 Electronic
Drive, Springfield, Virginia 15122
MAILLIW NAI-lWOD (65, 66), Department of
Biochemistry and Molecular Biology, ADNIL L. GALLO (77), Department of
University of Texas Medical School, Biochemistry, George Washington Uni-
Houston, Texas 52077 versity, Washington, D.C. 20037
REGOR F. DRONG (36), Lipid Metabolism R. E. GARCIA (88), Department of
Laboratory, William S. Middleton Memo- Biochemistry, University of California,
rial Veterans Hospital, Madison, Wiscon- Riverside, California 12529
sin 53705, and Department of Physiologi-
NOMIHS GATT (60), Laboratory of Neuro-
cal Chemistry, University of Wisconsin,
chemistry, Department of Biochemistry,
Madison, Wisconsin 60735
The Hebrew University-Hadassah Medi-
DRAHCIR E. DUGAN (55), Lipid Metabolism cal School, Jerusalem, Israel
Laboratory, William S. Middleton Memo-
rial Veterans Hospital, Madison, Wiscon- J. G. SENAL1VAG (17), Department of
sin 53705 Biochemistry, Faculty of Sciences, Com-
plutensis University, Madrid 3, Spain
PAUL C. ENGEL (43), Department of
Biochemistry, University of Sheffield, JAMES L. GAYLOR (32), Department of
Biochemistry, University of Missouri,
Sheffield SIO 2TN, England
Columbia, Missouri 21256
YRAM LOU GREBNOF-TSNRE (8, 22), De-
partment of Biochemistry, College of DAVID M. GIBSON (57), Department of
Medicine, East Tennessee State Univer- Biochemistry, Indiana University School
sity, Johnson City, Tennessee 10673 of Medicine, Indianapolis, Indiana 46223
R. RAY FALL (91, 92), Department of RAMAT GOLDFLAM (19), Department of
Chemistry, University of Colorado, Boul- Pharmacology, Case Western Reserve
der, Colorado 80309 University, Cleveland, Ohio 60144
LEAKIM DATSRAF (28), Laboratory of Clini- ALAN G. EGDIRDOOG (19), Department of
cal Biochemistry, University of Bergen, Pharmacology, Case Western Reserve
5016 Haukeland Sykehus, Norway University, Cleveland, Ohio 60144
JIM C. FONG (47), Department of Psychi- YRRAH GRIFFIN (78), Agricultural Research
atry, New York University Medical Council, Poultry Research Centre, Edin-
Center, New York, New York 61001 burgh EH9 3JS, Scotland
RICHARD FRANSON (78), Department of LEAHCIM J. GRIFFITH (37), Dental Research
Biochemistry, Medical College of Vir- Center, The University of North Carolina,
ginia, Richmond, Virginia 23219 Chapel Hill, North Carolina 41572
GUDRUN NOSKIRDERF (74), Department of DENNIS W. GROGAN (18), Department of
Physiological Chemistry, University of Microbiology, University of Illinois,
Lund, S-220 70 Lund, Sweden Urbana, Illinois 10816
EUGENE P. FRENKEL (38), Department of INGER GRUNNET (26), Institute of
Internal Medicine, Evelyn L. Overton Biochemistry, University of Odense,
Hematology-Oncology Research Labora- DK-5230 Odense M, Denmark
CONTRIBUTORS TO VOLUME 7 1 xv
PAUL S. GUY (3),Biochemistry Department, TATSUYUKI KAMIRYO (5, 39), Department
Dundee University, Dundee DDl 4HN, of Medical Chemistry, Kyoto University
Scotland Faculty of Medicine, Yoshida, Sakyo-ku,
Kyoto 606, Jupan
CAROLE L. HALL (45, 46), School of
Chemistry, Georgia Institute of Technol- J. N. KANFER (70, 86), Department of
ogy, Aflanta, Georgia 30332 Biochemistry, Faculty of Medicine, Uni-
versity of Manitoba, Winnipeg, Manitoba
D. GRAHAME HARDIE (3), Biochemistry De-
R3E OW3, Canada
partment, Dundee University, Dundee
DDl 4HN. Scotland HIDEO KANOH (62), Department of
Biochemistry, Niigata University School
TAKASHI HASHIMOTO (I), Department of
of Medicine, Niigata 951, Japan
Biochemistry. Shinshu University Faculty
of Medicine, Asahi, Matsumoto 390, SARVAGYA S. KATIYAR (36), Department of
Japan Physiological Chemistry, University of
Wisconsin, Madison, Wisconsin 53706
EDWARD HAWROT (67), Department of
Pharmacology, Yale University School of AKIHIKO KAWAGUCHI (15, 16), Institute of
Medicine, New Haven, Connecticut 06510 Applied Microbiology, The University of
Tokyo, Bunkyo-ku, Tokyo 113, Jupan
TAKASHI HIRABAYASHI (65), Central Re-
search Institute, Suntory Limited, Osaka, JOHN C. KHOO (73), Department of Medi-
Japan cine, Division of Metabolic Disease, Uni-
KOHEI HOSAKA (39, 40, 61), Department of versity of California, San Diego, La Jolla,
Biochemistry, Gunma University School California 92093
of Medicine, Showa-cho, Maebashi 371, I. C. KIM (IO), Department of Biochemistry,
Japan Michigan State University, East Lansing,
ANTHONV H. C. HUANG (93), Department of Michigan 48824
Biology, University of South Carolina, Yu SAM KIM (20), Vepartment of‘ Bio-
Columbia, South Carolina 29208 chemistry, College of Medicine, Yonsei
HIROH IKEZAWA (84), Faculty of Phar- University. Seoul, Korea
maceutical Sciences, Nagoya City Uni- RICHARD L. KITCHENS (38), Department of
v’ersity , 3-I Tanabedori, Mizuhoku, Internal Medicine, Evelyn L. Overton
Nagoya 467, Japan Hematology-Oncology Research Labora-
THOMAS S. INGEBRITSEN (57), Biochemistry tory, University of Texas Health Science
Department, Medical Sciences Institute, Center at Dallas, Southwestern Medical
Dundee University, Dundee DDI 4HN, School, Dallas, Texas 75235, and Vete-
Scotland runs Administration Medical Center, Dal-
las ) Texas 752 16
ROBERT A. JENIK (IZ), Lipid Metabolism
Laboratory, William S. Middleton Memo- DON A. KLEINSEK (55), Department of
riul Veterans Hospital, Madison, Wiscon- Physiologicul Chemistry, University of
sin 53705, and the Department of Physio- Wisconsin Madison, Wisconsin 53706
logical Chemistry, University of Wiscon-
JENS KNUDSEN (26), Institute of Biochemis-
sin, Madison, Wisconsin 53706
try, University of Odense. DK-5230
DEAN P. JONES (32), Department of Odense M, Denmark
Biochemistry, Emory University School of P. E. KOLATTUKUDY (13,20,27,33,50,76),
Medicine, Atlanta, Georgia 30322
Institute of Biological Chemistry and
VASUDEV C. JOSHI (3 I), Marrs McLean De- BiochemistrylBiophysics Program, Wash-
partment of Biochemistry, Baylor College ington State University, Pullman, Wash-
of Medicine, Houston, Texas 77030 ington 99164
xvi CONTRIBUTORS TO VOLUME 71
RUTH REMARK (79), 15 Park Street, Brook- OKURAH MEYER (7), Department of Mi-
,enH Massachusetts 64120 crobiology, College of Medicine, State
University of New York, Upstate Medical
AMOS KUMAR (11), Department of Chemis-
Center, Syracuse, New York 01231
try, Georgetown University, Washington,
D.C. 20057 FRANZ MEYER (7), Department of Mi-
SIMO OSKAAL (53), Department of Biochem- crobiology, College of Medicine, State
istry, University of Turku, SF-20500 University of New York, Upstate Medical
Turku ,05 Finland Center, Syracuse, New York 01231
J. D. LARSON (33), Institute of Biological UBONmSOY MIKI (61), Department of Med-
Chemistry, Washington State University, ical Chemistry, Kyoto University Faculty
Pullman, Washington 46199 of Medicine, Yoshida, Salcyo-ku, Kyoto
606, Japan
TIMOTHY LARSON (66), Fachbereich
Biologie, University of Konstonz, CRAIG MILLER (78), Department of Bio-
Konstonz, Federal Republic of Germany chemistry, Bowman Gray School of Medi-
cine, Winston-Salem, North Carolina
DRAWDE P. LAU (92), Department of
30172
Chemistry, University of Colorado, Boul-
der, Colorado 80309 IHSOYASAM MISHINA (5, 39), Department of
Medical Chemistry, Kyoto University
CLIVE LITTLE (83), Institute of Medical Bi-
Faculty of Medicine, Yoshida, Sakyo-ku,
ology, University of Troms¢, N-9001
Kyoto 606, Japan
Tromso, Norway
T. MIURA (70), The National Institute for
KNARF A. OZTINROL (36), Lipid Metabolism
Environmental Studies, Yatabe-machi,
Laboratory, William S. Middleton Memo-
Tsukuba-gun, Ibaraki Prefecture, Japan
rial Veterans Hospital, Madison, Wiscon-
sin 53705 T. S. MOORE, JR. (71), Department of
Botany, University of Wyoming, Laramie,
MARTIN G. Low (85), Department of
Wyoming 17028
Biophysics, Medical College of Virginia,
Virginia Commonwealth University, TREBOR A. MOREAU (93), Department of
Richmond, Virginia 89232 Biochemistry and Biophysics, University
of California, Davis, California 61659
RODOEF LYNEN* (90), Max-Planck lnstitut
fffr Biochemie, 8033 Martinsried, Federal YENDIS M. ,SIRROM JR. (19),Department of
Republic of Germany Pharmacology, Case Western Reserve
University, Cleveland, Ohio 60144
MOT MCKEON (23, 34), Department of Veg-
etable Crops, University of California, J. B. MUDD (88), Department of Biochemis-
Davis, California 61659 try, University of California, Riverside,
California 12529
I. B. MAITI (76), Department of Microbiol-
ogy, Sherbrooke University, Sherbrooke, A. M. MUNICIO (17), Department of
Quebec JIH 5N4, Canada Biochemistry, Faculty of Sciences, Com-
PAUL MANDEL (60), Centre de Neurochimie plutensis University, Madrid 3, Spain
du CNRS, Universit~ Louis Pasteur, ADATEGIHS NAKANISHI (l), Department of
Strasbourg, France Medical Chemistry, Kyoto University
M. A. K. LLEWKRAM (42), Molecular Biol- Faculty of Medicine, Yoshida, Sakyo-ku,
Kyoto 606, Japan
ogy Institute, University of California-Los
Angeles, Los Angeles, California 42009 NENAD M. NESKOVIC (60), Centre de
Neurochimie du CNRS, Universitd Louis
* Deceased. Pasteur, Strasbourg, France
CONTRIBUTORS TO VOLUME 71 xvii
YRAG NEUDAHL (10), Department of Bio- IHSOTAS 0MURA (15), School of Phar-
chemistry, Michigan State University, maceutical Science, Kitasato University,
East Lansing, Michigan 48824 Minato-ku, Tokyo 108, Japan
NIELS C. NIELSEN (6), USDA-SEA, Ag- STEVEN D. PELECrt (68), Department of
ronomy Department, Purdue University, Biochemistry, University of British Co-
lumbia, Vancouver, British Columbia V6T
West Lafayette, Indiana 47907
I WS , Canada
JUN-IcHI NIKAWA (1), Department of
DAVID O. NOSRETEP (14), Department of
Biochemistry, Gunma University School
Biochemistry and Biophysics, University
of Medicine, Showa-cho, Maebashi 371,
of California, San Francisco, California
Japan
34149
NILS ~3TEN NILSSON (74), Department of ANIGER OKZSURTEIP (89), Center of Alcohol
Physiological Chemistry, University of Studies and Department of Biochemistry,
Lund, S-220 07 Lund, Sweden Rutgers University, New Brunswick, New
Jersey 30980
AYNAKUS NIMMANNIT (54), Department of
Biochemistry, Faculty of Pharmaceutical LEAHCIM R. POLLARD (35), Biochemistry
Sciences, Chulalongkorn University, Department, Dundee University, Dundee
Bangkok 5, Thailand DDI 4HN, Scotland
ORIHSOT NISHIDA (87), Burnsides Research JOHN W. RETROP (12, 36, 54, 55), Lipid Me-
Laboratory, Department of Food Science, tabolism Laboratory, William S. Middle-
University of Illinois, Urbana, Illinois ton Memorial Veterans Hospital, Madi-
10816 son, Wisconsin 53705, and the Department
of Physiological Chemistry, University of
NAHTANOJ S. NISHIMURA (37), Department Wisconsin, Madison, Wisconsin 60735
of Biochemistry, The University of Texas
A. J. ESOLUOP (13, 20, 27),Institute of Bio-
Health Science Center at San Antonio,
logical Chemistry, Washington State Uni-
San Antonio, Texas 48287
versity, Pullman, Washington 46199
UKASOHS NUMA (1, 5, 39, 40, 61, 64), De-
M. RENUKA PRASAD (31), Department of
partment of Medical Chemistry, Kyoto
Biological Chemistry, University of
University Faculty of Medicine, Yoshida,
Illinois Medical Center, Chicago, Illinois
Sakyo-ku, Kyoto 606, Japan
21606
HIDEO OGIWARA (1), Department of R. E. PUaDY (76), Environmental Sciences,
Biochemistry, Gunma University School Chesapeake Bay Program, 2083 West
of Medicine, Showa-cho, Maebashi 371, Street, Annapolis, Maryland 10412
Japan
NILOFER QURESHI (54), Mycobacteriology
KIMIYOSm OHNO (62), Department of Laboratory, William S. Middleton Memo-
Biochemistry, Sapporo Medical College, rial Veterans Hospital, Madison, Wiscon-
Chuo-Ku, West-17, South-I, Sapporo 060, sin 53705, and the Institute for Enzyme
Japan Research, University of Wisconsin, Madi-
son, Wisconsin 60735
A. AKASHO (82), The Second Department of
R. AHTNAMUNAH OAR (78), Department of
Bacteriology, National Institute of Health,
Chemistry, Rust College, Holly Springs,
10-35 Kamiosaki-2-Chome, Shinagawa-
Mississippi 53683
ku, Tokyo 141, Japan
SAMUEL M. TROPOPAR (52), Institut fiir
UBONEGIHS OKUDA (15, 16), Institute of Physiologische und Biologische Chemie,
Applied Microbiology, The University of Humboldt Universitiit, DDR- I040 Berlin,
Tokyo, Bunkyo-ku, Tokyo 113, Japan German Democratic Republic
xviii CONTRIBUTORS TO VOLUME 71
SELRAHC O. ROCK (21, 41), Department of Massachusetts Institute of Technology,
Biochemistry, St. Jude Children's Re- Cambridge, Massachusetts 02139
search Hospital, Memphis, Tennessee
HOWARD SPRECHER (30), Department of
10183
Physiological Chemistry, Ohio State Uni-
ROTCIV W. RODWEEL (56), Department of versity, Columbus, Ohio 43210
Biochemistry, Purdue University, West
K. SREEKRISHNA (31), Department of
Lafayette, Indiana 47907
Biochemistry, University of Kentucky Col-
LINDA SREGOR (27, 33), Institute of Biolog- lege of Medicine, Lexington, Kentucky
ical Chemistry, Washington State Univer- 60504
sity, Pullman, Washington 46199
HAROLD STAACK (48), American Minitor
DANIEL A. K. RONCAR! (9), Institute of Company, Indianapolis, Indiana 46268
Medical Science and Department of Med-
DANIEL STEINBERG (73), Department of
icine, Toronto Western Hospital, Univer- Medicine, Division of Metabolic Disease,
sity of Toronto, Toronto M5S 1A8, Canada
University of California, San Diego, La
TANKRED SCHEWE (52), Institut fiir Jolla, California 39029
Physiologische und Biologische Chemie, PETER SROFL,~RTS (74), Department of
Humboldt Universitdt, DDR-I040 Berlin,
Physiological Chemistry, University of
German Democratic Republic
Lund, S-220 07 Lund, Sweden
ULRICH SCHIELE (90), Hormon Chemie PAUL K. STUMPF (23, 34), Department of
Miinchen GmbH, 8 Munich 45, Federal
Biochemistry and Biophysics, University
Republic of Germany
of California, Davis, California 61659
GNAGFLOW J. REDIENHCS (69), Department
T. ARAHAGUS (82), The Second Department
of Molecular Genetics, University of
of Bacteriology, National Institute of
Texas Health Science Center, Dallas,
Health, 10-35 Kamiosaki-2-Chome,
Texas 53257
Shinagawa-ku, Tokyo 141, Japan
ANN W. ALLAGNOHCS (22), College of Med-
MANFRED SUMPER (4), lnstitut fffr
icine, Cornell University, New York, New
Biochemie, Genetik und Mikrobiologie,
kroY 12001
Lehrstuhl Biochemie, Universitiit
TSROH SCHULZ (47, 48, 49), Department of Regensburg, 8400 Regensburg, Federal
Chemistry, City College of the City Uni- Republic of German),
versity of New York, New York, New York
Rvo TAGUCHI (84), Faculty of Pharma-
13001
ceutical Sciences, Nagoya City Uni-
EKUSUOY SEYAMA (16), Department of versity, 3- I Tanabedori, Mizuhoku,
Biochemistry, Faculty of Medicine, The Nagoya 467, Japan
University of Tokyo, Bunkyo-ku, Tokyo
,311 Japan T. TAKAHASHI (82), Department of Mi-
crobiology, Hoshi College of Pharmacy,
AICIRTAP SISSON (78), Department of
Ebara-2-Chome, Shinagawa-ku, Tokyo
Biochemistry, Bowman Gray School of
,241 Japan
Medicine, Winston-Salem, North Carolina
30172 T. TAKI (70, 86), Department of Biochemis-
try, Shizuoka College of Pharmacy, 2-2-1,
TRAUTS SMITH (24, 25), Bruce Lyon Memo-
Oshika, Shizuoka-Shi 422, Japan
rial Research Laboratory, Children's
Hospital Medical Center of Northern Cal-
TADASHI TANABE (1), Department of
ifornia, Oakland, California 90649
Biochemistry, National Cardiovascular
NITRAM D. SNIDER (63), Center for Cancer Center Research Institute, Fufishiro-dai,
Research and Department of Biology, Suita 565, Japan
CONTRIBUTORS TO VOLUME 17 xix
OAKAT TANAKA (40), Third Division, De- TREBOR M. NOSRETAW (51), Department of
partment of Internal Medicine, Osaka Microbiology, Emory University, Atlanta,
Medical College, 'Daigaku-cho, Takatsuki Georgia 22303
569, Japan
RAINER WIESNER (52), Institut ffir
KCIREDERF R. ROLYAT (18), Department of Physiologische und Biologische Chemie,
Microbiology, Oregon State University, Humboldt Universitiit, DDR-I040 Berlin,
Corvallis, Oregon 13379 German Democratic Republic
NILOC THORPE (44), Department of Chemis- KCAJ S. WOLPERT (8), Department of
try, University of Delaware, Newark, Biochemistry, College of Medicine, East
Delaware 11791 Tennessee State University, Johnson City,
Tennessee 10673
IHSORIH ADOMOT (15), Institute of Applied
Microbiology, The University of Tokyo, WILLIAM I. WOOD (14), Laboratory of Mo-
Bunkyo-ku, Tokyo 113, Japan lecular Biology, National Institute of Ar-
HANS TSlVQNROT (75), Department of Clini- thritis, Metabolism and Digestive Dis-
cal Chemistry, University of Lund, Malm6 eases, National Institutes of Health,
General Hospital, S-214 1O Malm6, Swe- Bethesda, Maryland 50202
den KENICHI K. !KASUBAY (29), Hana Biologics
DENNIS E. VANCE (68, 69), Department of Inc., 1400 53rd Street, Emeryville, Cali-
Biochemistry, University of British -oC fornia 80649
lumbia, Vancouver, British Columbia TAMIO YAMAKAWA (16), Department of
V6T, IW5, Canada Biochemistry, Faculty of Medicine, The
I. NAV NED BOSCH (59), Laboratory of University of Tokyo, Bunkyo-ku, Tokyo
Biochemistry, State University of Utrecht, ,311 Japan
3508 TB Utrecht, The Netherlands !HSOTAS ATIHSAMAY (61, 64), Department
G. P. H. NAV HEUSDEN (59), Laboratory of of Biochemistry, Gunma University School
Biochemistry, State University of Utrecht, of Medicine, Showa-cho, Maebashi 371,
3508 TB Utrecht, The Netherlands Japan
G. M. VIANEN (59), Laboratory of Bio- IHSAKAT YONETANI (89), Department of
chemistry, State University of Utrecht, Biochemistry and Biophysics, University
3508 TB Utrecht, The Netherlands of Pennsylvania, Philadelphia, Pennsyl-
vania 47191
YELESOM WAITE (78), Department of Bio-
chemistry, Bowman Gray School of Medi- YCNAN L. YOUNG (58),Department of Med-
cine, Winston-Salem, North Carolina icine, Cornell University Medical College,
30172 New York, New York 12001
ASEREHT A. WALKER (22), Department of PETER ZAHLER (79), Institute of Biochemis-
Biology, Yale University, New Haven, try, University of Berne, 3012 Berne, Swit-
Connecticut 02560 zerland
Preface
Let me haue men about me, that are fat
Sleek-headed men, and such as sleep a'nights
Julius Caesar Act I, Scene II*
Fat people are no longer the preferred stereotype of placidity and
health, and sleep is a somewhat overestimated commodity. Fat books, on
the other hand, proliferate. A single volume was planned originally to
cover recent developments in the biochemistry of lipids. It would have
been too obese for comfort, so it was decided to divide the book into two
volumes. If only obesity could be controlled so easily in the real word!
Volume 17 deals with enzymes while Volume 72 covers methods useful
to the lipid biochemist. Each section starts with a list of related articles
previously published in the Methods ni Enzymology series. In general, the
enzymes included have been purified highly. A notable exception are
enzymes of lipid metabolism from plants, a number of which are included
even though they have only been purified partially. It is hoped that their
inclusion will provide a stimulus to their isolation in homogeneous form.
The borderline between fatty acid and sterol metabolism has been set
at/3-hydroxy-fl-methylglutaryl-CoA. The inclusion of some enzymes may
strike the reader as odd, but there was in each case good reason. For
example, 3-methylcrotonyl-CoA carboxylase is included because of its
relation to acetyl-CoA carboxylase and its ability to carboxylate free
biotin, a valuable property for understanding acetyl-CoA carboxylase.
I welcome suggestions for future volumes. Please do not hesitate to
draw my attention to errors of omission or commission.
JOHN M. LOWENSTEIN
* H. M. Furness, Jr. (ed.). (1913). J. B. Lippincott Co., Philadelphia and London, p. 45.
xxi
METHODS IN ENZYMOLOGY
EDITED BY
Sidney .P Colowick and Nathan O. Kaplan
VANDERBILT UNIVERSITY DEPARTMENT OF CHEMISTRY
SCHOOL OF MEDICINE UNIVERSITY OF CALIFORNIA
NASHVILLE, TENNESSEE AT SAN DIEGO
LA JOLLA, CALIFORNIA
I. Preparation and Assay of Enzymes
II. Preparation and Assay of Enzymes
III. Preparation and Assay of Substrates
.VI Special Techniques for the Enzymologist
.V Preparation and Assay of Enzymes
VI. Preparation and Assay of Enzymes )deunitnoC(
Preparation and Assay of Substrates
Special Techniques
VII. Cumulative Subject Index
xxiii
METHODS IN ENZYMOLOGY
EDITORS-IN-CHIEF
Sidney P. Colowick Nathan O. Kaplan
VOLUME VIII. Complex Carbohydrates
Edited by HTEBAZILE F. NEUFELD AND VICTOR GINSBURG
VOLUME IX. Carbohydrate Metabolism
Edited by WILLIS A. DOOW
VOLUME X. Oxidation and Phosphorylation
Edited by RONALD W. ESTABROOK AND MAYNARD E. PULLMAN
EMULOV XI. Enzyme Structure
Edited by C. H. W. HIRS
EMULOV XII. Nucleic Acids (Parts A and B)
Edited by LAWRENCE NAMSSORG AND KIVIE MOLDAVE
EMULOV XIII. Citric Acid Cycle
Edited by J. M. NIETSNEWOL
VOLUME XIV. Lipids
Edited by J. M. NIETSNEWOL
EMULOV XV. Steroids and Terpenoids
Edited by DNOMYAR B. NOTYALC
VOLUME XVI. Fast Reactions
Edited by HTENNEK NITSUK
EMULOV XVII. Metabolism of Amino Acids and Amines (Parts A and B)
Edited by HERBERT TABOR AND CELIA WHITE TABOR
EMULOV XVIII. Vitamins and Coenzymes (Parts A, B, and C)
Edited by DONALD B. McCORMICK AND LEMUEL D. WRIGHT
XXV