Lilleys Pharmacology for Canadian Health Care Practice 4e PDF
Preview Lilleys Pharmacology for Canadian Health Care Practice 4e
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Go to evolve.elsevier.com/shop to search and browse for products. 2019v1.0 LILLEY'S Pharmacology for Canadian Health Care Practice i TA B L E O F C O N T E N T S About the Authors, v 35 Women’s Health Drugs, 574 Reviewers, vii 36 Men’s Health Drugs, 596 Preface, ix Acknowledgements, xiii PART 6 Drugs Affecting the Respiratory System PART 1 Pharmacology Basics 37 Antihistamines, Decongestants, Antitussives, and Expectorants, 606 38 Respiratory Drugs, 621 1 Nursing Practice in Canada and Drug Therapy, 1 2 Pharmacological Principles, 14 PART 7 Drugs Affecting the Gastrointestinal System 3 Legal and Ethical Considerations, 36 and Nutrition 4 Patient-Focused Considerations, 47 5 Gene Therapy and Pharmacogenomics, 67 39 Acid-Controlling Drugs, 640 6 Medication Errors: Preventing and Responding, 75 40 Antidiarrheal Drugs and Laxatives, 654 7 Patient Education and Drug Therapy, 88 41 Antiemetic and Antinausea Drugs, 667 8 Over-the-Counter Drugs and Natural Health Products, 98 42 Nutritional Supplements, 679 9 Vitamins and Minerals, 111 10 Principles of Drug Administration, 133 PART 8 Anti-infective and Anti-inflammatory Drugs PART 2 Drugs Affecting the Central Nervous System 43 Antibiotics Part 1: Sulfonamides, Penicillins, Cephalosporins, Macrolides, and Tetracyclines, 691 11 Analgesic Drugs, 164 44 Antibiotics Part 2: Aminoglycosides, Fluoroquinolones, and 12 General and Local Anaesthetics, 195 Other Drugs, 715 13 Central Nervous System Depressants and Muscle Relaxants, 214 45 Antiviral Drugs, 731 14 Central Nervous System Stimulants and Related Drugs, 228 46 Antitubercular Drugs, 753 15 Antiepileptic Drugs, 244 47 Antifungal Drugs, 764 16 Antiparkinsonian Drugs, 262 48 Antimalarial, Antiprotozoal, and Anthelmintic Drugs, 774 17 Psychotherapeutic Drugs, 278 49 Anti-inflammatory and Antigout Drugs, 789 18 Substance Misuse, 308 PART 9 Immune and Biological Modifiers and PART 3 Drugs Affecting the Autonomic Nervous System Chemotherapeutic Drugs 19 Adrenergic Drugs, 325 50 Immunosuppressant Drugs, 804 20 Adrenergic-Blocking Drugs, 338 51 Immunizing Drugs and Pandemic Preparedness, 815 21 Cholinergic Drugs, 350 52 Antineoplastic Drugs Part 1: Cancer Overview and Cell 22 Cholinergic-Blocking Drugs, 361 Cycle–Specific Drugs, 832 53 Antineoplastic Drugs Part 2: Cell Cycle–Nonspecific and Miscellaneous Drugs, 859 PART 4 Drugs Affecting the Cardiovascular and Renal 54 Biological Response–Modifying Drugs and Antirheumatic Systems Drugs, 872 23 Antihypertensive Drugs, 371 24 Antianginal Drugs, 394 PART 10 Miscellaneous Therapeutics: Hematological, 25 Heart Failure Drugs, 408 Dermatological, Ophthalmic, and Otic Drugs 26 Antidysrhythmic Drugs, 423 27 Coagulation Modifier Drugs, 444 55 Anemia Drugs, 892 28 Antilipemic Drugs, 469 56 Dermatological Drugs, 903 29 Diuretic Drugs, 485 57 Ophthalmic Drugs, 918 30 Fluids and Electrolytes, 500 58 Otic Drugs, 939 Appendix: Pharmaceutical Abbreviations, 945 PART 5 Drugs Affecting the Endocrine System Answers to Review Questions, 946 Bibliography, 949 31 Pituitary Drugs, 519 Index of Glossary Terms, 966 32 Thyroid and Antithyroid Drugs, 528 Drug Index, 973 33 Antidiabetic Drugs, 537 General Index, 981 34 Adrenal Drugs, 563 FOURTH EDITION LILLE Y'S Pharmacology for Canadian Health Care Practice Kara SEALOCK, RN, BN, MEd, EdD Senior Instructor, Faculty of Nursing University of Calgary Calgary, Alberta Cydnee SENEVIRATNE, RN, BScN, MN, PhD Senior Instructor, Faculty of Nursing University of Calgary Calgary, Alberta US Authors Linda LANE LILLEY, RN, PhD University Professor and Associate Professor Emeritus (Retired) School of Nursing Old Dominion University Norfolk, Virginia Shelly RAINFORTH COLLINS, PharmD President, Drug Information Consultants Chesapeake, Virginia Julie S. SNYDER, MSN, RN-BC Lecturer School of Nursing Regent University Virginia Beach, Virginia LILLEY’S PHARMACOLOGY FOR CANADIAN HEALTH CARE PRACTICE, FOURTH EDITION ISBN: 978-0-323-69480-3 Copyright © 2021, Elsevier Inc. All rights reserved. Adapted from Pharmacology and the Nursing Process, Ninth Edition, by Linda Lane Lilley, Shelly Rainforth Collins and Julie S. Snyder. Copyright © 2019 by Elsevier Inc. 978-0-323-52949-5 (softcover) All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Reproducing passages from this book without such written permission is an infringement of copyright law. Requests for permission to make copies of any part of the work should be mailed to: College Licensing Offi- cer, access ©, 1 Yonge Street, Suite 1900, Toronto, ON, M5E 1E5. Fax: (416) 868–1621. All other inquiries should be directed to the publisher, www.elsevier.com/permissions. Every reasonable effort has been made to acquire permission for copyright material used in this text and to acknowledge all such indebtedness accurately. Any errors and omissions called to the publisher’s attention will be corrected in future printings. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notice Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. International Standard Book Number: 978-0-323-69480-3 VP Education Content: Kevonne Holloway Content Strategist (Acquisitions, Canada): Roberta A. Spinosa-Millman Director, Content Development Manager: Laurie Gower Content Development Specialist: Theresa Fitzgerald Publishing Services Manager: Julie Eddy Senior Project Manager: Richard Barber Design Direction: Amy Buxton Printed in Canada Last digit is the print number: 9 8 7 6 5 4 3 2 1 A B O U T T H E AU T H O R S KARA SEALOCK LINDA LANE LILLEY Dr. Kara Sealock completed a Bachelor of Nursing in 2000, a Dr. Linda Lilley received her diploma from Norfolk General Masters of Education in 2012, and a Doctorate of Education, School of Nursing, BSN from the University of Virginia, Master specializing in adult learning, in 2019. Kara has been a nurs- of Science (Nursing) from Old Dominion University, and PhD ing educator since 2008 and has worked in various roles such in Nursing from George Mason University. As an Associate Pro- as a preceptor, clinical instructor, and theory instructor with fessor Emeritus and University Professor at Old Dominion Uni- a focus in medical/surgical care, critical care, and gerontol- versity, her teaching experience in nursing education spans over ogy. Kara teaches pathophysiology, assessment, and phar- 25 years, including almost 20 years at Old Dominion. Linda’s macology at the University of Calgary. She has considerable teaching expertise includes drug therapy and the nursing pro- years of clinical experience in medical/surgical environments, cess, adult nursing, physical assessment, fundamentals in nurs- research experience working with cardiology and endocri- ing, oncology nursing, nursing theory, and trends in health care. nology clients; however, the majority of her career has been The awarding of the university’s most prestigious title of Univer- positioned in critical care with an adult focus in intensive sity Professor reflects her teaching excellence as a tenured faculty care and coronary care environments. Kara has substantive member. She has also been a two-time university nominee for the experience in preparing undergraduate nursing students for State Council of Higher Education in Virginia award for excel- NCLEX-RN as she has facilitated preparation workshops and lence in teaching, service, and scholarship. Linda received the mock examination opportunities, and assumes an active role 2012 Distinguished Nursing Alumni Award from Old Domin- in preparing students for success. She currently sits on the ion University School of Nursing for her “continued work on the Nursing Education Program Approval Committee at the Col- successful pharmacology textbook published by Elsevier” and to lege and Association of Registered Nurses (CARNA). Kara’s recognize her “extraordinary work and the impact [the book] knowledge in adult learning, combined with her clinical and has had on baccalaureate education.” While at Old Dominion theoretical experience contributes to an enhanced foundation University, Linda mentored and taught undergraduate and grad- of learning bridging theory and practice for undergraduate uate students as well as registered nurses returning for their BSN. nursing education. Kara is currently a senior instructor with Linda authored the MED ERRORS column for the American a specific focus in teaching for the Faculty of Nursing at the Journal of Nursing between 1994 and 1999, as well as numerous University of Calgary. other peer-reviewed, published articles in professional nursing journals. Since retiring in 2005, Linda continues to be active in nursing, serving as a member on dissertation committees with CYDNEE SENEVIRATNE the College of Health Sciences and maintaining membership and involvement in numerous professional and academic orga- Dr. Cydnee Seneviratne received a diploma in Nursing in 1991 nizations. Since January of 2014, Dr. Lilley continues to serve on and has dedicated her career to advancing neuroscience nurs- the volunteer review panel for the monthly newsletter publica- ing, chronic stroke care, and gerontology. She received a BScN tion Nurse Advise-ERR (ISMP affiliated; the ISMP [Institute for from the University of Victoria in 1995 and a Master of Nurs- Safe Medication Practices] is a nonprofit organization educating ing in 1997 from the University of Calgary. Cydnee received a the healthcare community and consumers about safe medication FUTURE Program for Cardiovascular Nurse Scientists Fellow- practices). Linda has served as a consultant with school nurses ship (a CIHR Strategic Training Program in Health Research) in the city of Virginia Beach and as a member on the City of while completing her PhD in 2007 at the University of Calgary Virginia Beach’s Health Advisory Board. Linda also served as an and completed a post-doctoral fellowship in 2010 funded by appointed member on the national advisory panel on medica- the Heart and Stroke Foundation of Canada. Cydnee has been tion error prevention with the U.S. Pharmacopeia in Rockville, a nursing instructor in clinical, laboratory, and classroom set- Maryland. She continues to educate nursing students and pro- tings (specifically pharmacology and pathophysiology) at the fessional nurses about drug therapy and the nursing process and University of Calgary for 19 years and has remained closely speaks on the topics of drug therapy, safe medication use, humor linked to the clinical setting during her time as the Associate and healing, and grief and loss. Dean of Undergraduate Practice Education. In the Associate Dean role, she was chair of the Nursing Education Program SHELLY RAINFORTH COLLINS Approval Committee at the College and Association of Regis- tered Nurses (CARNA) where she was instrumental in crafting Shelly Rainforth Collins received her Doctor of Pharmacy undergraduate and nurse practitioner program approval pro- degree from the University of Nebraska, College of Pharmacy cesses. Cydnee is currently a senior instructor and is a leader in 1985, with High Distinction. She then completed a clinical in Interprofessional Simulation Education for the Faculty of pharmacy residency at Memorial Medical Center of Long Nursing. Beach in Long Beach, California. She worked as a pediatric v vi ABOUT THE AUTHORS clinical pharmacist (neonatal specialist) at Memorial Med- JULIE S. SNYDER ical Center before moving to Mobile, Alabama, where she was the Assistant Director of Clinical Pharmacy Services at Julie Snyder received her diploma from Norfolk General Hospi- Mobile Infirmary Medical Center. After moving to Chesa- tal School of Nursing and her BSN and MSN from Old Domin- peake, Virginia, she served as the Clinical Pharmacy Special- ion University. After working in medical-surgical nursing, she ist/Coordinator of Clinical Pharmacy Services at Chesapeake worked in nursing staff development and community education. Regional Medical Center in Chesapeake, Virginia for 19 years. Later, she transferred to the academic setting and taught funda- Her practice focused on developing and implementing clini- mentals of nursing, pharmacology, physical assessment, and adult cal pharmacy services as well as medication safety and Joint medical-surgical nursing at a university school of nursing. Julie Commission medication management standards and national has recently worked as a Quality Initiative Coordinator and a patient safety goals. She is president of Drug Information Con- Clinical Nurse Educator in a local hospital. She is now a Lecturer sultants, a business offering consultation and expert witness at the School of Nursing of Regent University in Virginia Beach, review for attorneys on medical malpractice cases. She holds Virginia. She has been certified by the ANCC in Nursing Con- certifications in Medication Therapy Management, Anticoag- tinuing Education and Staff Development and currently holds ulation Management, and Immunizations. Shelly was awarded ANCC certification in Medical-Surgical Nursing. She is a mem- the Clinical Pharmacist of the Year Award in 2007 from the ber of Sigma Theta Tau International and was inducted into Phi Virginia Society of Healthsystem Pharmacists. She led a mul- Kappa Phi as Outstanding Alumni for Old Dominion University. tidisciplinary team that won the Clinical Achievement of the She has worked for Elsevier as a reviewer, ancillary writer, and Year Award from George Mason University School of Public author since 1997. Julie’s professional service has included serving Health in 2007 for promoting safety with narcotics in patients on the Virginia Nurses’ Association Continuing Education Com- with sleep apnea; this program has also received national rec- mittee, serving as Educational Development Committee chair for ognition. She was awarded the Service Excellence Award from the Epsilon Chi chapter of Sigma Theta Tau, serving as an item Chesapeake Regional Medical Center. Shelly’s professional writer for the ANCC, working with a regional hospital educators’ affiliations include the American Society of Healthsystem group, and serving as a consultant on various projects for local Pharmacists, the Virginia Society of Healthsystem Pharma- hospital education departments. In addition, she has conducted cists, and the American Pharmacists Association. pharmacology review classes for recent nursing graduates. R E V I E W E R S Paula Crawford-Dickinson, RN, BScN, BA, BHA, Heather Scarlett-Ferguson, BSP, MEd, EdD, RPh MN-ACNP, EdD Instructor Professor Psychiatric Nursing Sally Horsfall-Eaton School of Nursing MacEwan University George Brown College Edmonton, Alberta Toronto, Ontario Joy Shewchuk, RN, BSc, BSN, MSN Professor, Nursing Kerry Lynn Durnford, RN, MN School of Health Sciences Instructor School of Health and Human Services Humber College Institute of Technology and Advanced Aurora College Learning Yellowknife, Northwest Territories Toronto, Ontario Joanna Gallacher, RN, MN Ruth Swart, EdD, MHS, RN, BN, BSc Professor Senior Instructor Practical Nursing Program Faculty of Nursing School of Health & Community Services University of Calgary Durham College Calgary, Alberta Oshawa, Ontario Nadia Torresan-Doodnaught, BScN, RNC, MN Stacy E. Hunt, RN, BSN, MSN Professor of Nursing Nursing Faculty Faculty of Health Sciences Saskatchewan Collaborative Bachelor of Science in Nursing Seneca College of Applied Arts and Technology Program King City, Ontario School of Nursing Saskatchewan Polytechnic Kari Dawn Ubels, CD, HBScN, RN Regina, Saskatchewan Associate Chair of Practical Nurse Curriculum Faculty of Health and Community Studies NorQuest College Lindsay MacFarlane, HBScN, MEd, OCT, RN Edmonton, Alberta Professor, Practical Nursing School of Health and Community Services Jess White, RN, BN, ENC(C) Confederation College Faculty, Practical Nursing Thunder Bay, Ontario Assiniboine College Winnipeg, Manitoba Wanda Pierson, RN, BSN, MSN, MA, PhD Faculty, Faculty of Nursing Stephanie Zettel, RN, MN, BN, BSc (Honours) Langara College Associate Professor School of Health Sciences Vancouver, British Columbia Department of Nursing School of Nursing and Midwifery Kelly Marie Power-Kean, RN, BN, MHS, NP Faculty of Health, Community and Education Nurse Educator, Nurse Practitioner Mount Royal University Nursing Education Calgary, Alberta Centre for Nursing Studies, and Memorial University of Newfoundland St. John’s, Newfoundland vii viii REVIEWERS PHARMD REVIEWERS Thomas McFarlane, BSc Pharm, Pharm D Clinical Lecturer, Oncology School of Pharmacy, University of Waterloo With special thanks to: Waterloo, Ontario Grace Frankel, BSc Pharm, Pharm D, BCPS Karen Sutton, RN, BScN, MN, CNCC(C) Clinical Pharmacist Professor, Practical Nursing Program Primary Care/Hospital Practice, My Health Team, Southern Coordinator, Critical Care Nursing Program Health Region Durham College Steinbach, Manitoba Oshawa, Ontario
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