Life Sciences and Radiation: Accomplishments and Future Directions

278 Pages·2004·10.58 MB·English

by  Jürgen Kiefer (auth.)

J.Kiefer (Ed.)
LifeSciencesandRadiation
Springer-Verlag Berlin Heidelberg GmbH
Jiirgen Kiefer (Ed.)
Life Sciences and Radiation
Accomplishments and Future Directions
With 67 Figures, 7 in Colour and 12 Tables
Springer
PROF. DR. JORGEN KIEFER
Strahlenzentrum
Justus-Liebig-Universităt Giessen
Leihgestemer Weg 217
35392 Giessen
Germany
juergen. [email protected]
ISBN 978-3-642-62246-5 ISBN 978-3-642-18687-5 (eBook)
DOI 10.1007/978-3-642-18687-5
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Preface
Scope and ideas of the workshop
The workshop which took place at the University of Giessen from Oct. 3 to
Oct.7, 2002 and whose proceedings are collected in this volume started from the
idea to convene a number of scientists with the aim to outline their ”visions” for the
future of radiation research on the basis of their expertise. As radiation research is a
very wide field restrictions were unavoidable. It was decided to concentrate this
time mainly on molecular and cellular biology because it was felt that here action is
par-ticularly needed. This did not exclude contributions from neighbouring fields as
may be seen from the table of contents.It was clearly not planned to have a com-
prehensive account of the present scientifffic achievements but the results presented
should only serve as a starting point for the discussion of future lines of research,
with the emphasis on the ”outreach” to other parts of life sciences.
If you are interested in the future ask the young – we attempted, therefore, to
invite mainly younger colleagues (with a few exceptions) who had, however,
already left their marks in the field. They were asked to describe what they felt is
important in radiation research and may have significant influences on other
branches of life sciences. They were giventhe task to demonstrate what is lost for
science ”if we do no longer exist”. This is clearly not a well structured programme
for a scientific congress but extremely useffful to stimulate discussion. The views pre-
sented are hence quite diverse, and so are the contributions gathered in this volume.
The following sequence of papers is not the one how they were actually given. The
structure for which the editors takes responsibility is intended to guide the reader
who will quickly find out that order of subtopics is only rather vague. Many prob-
lems are addressed in nearly all contributions (e.g. DNA response, repair etc.) nev-
ertheless it was felt that some kind of structuring might be helpful.
Most of the participants came from Germany. Radiation research is, of course,
international and the problems encountered world-wide. So we invited – within the
limitations of the budget also some contributors from abroad to let us share their
views. Their presentations and discussion contributions were highly welcome. One
paper (Srivastava and Sharan) was not actually given at the workshop but only sup-
plied in writing. As it presents ideas from a developing country we felt it should be
included as an example of another view.
The following proceedings contain 20 submitted papers loosely grouped in dif-
ferent categories (by the editor) plus a preface and a postscript. They all give exam-
ples how radiation research could find itsway into the future, some rigorously based
on scientific findings, some more philosophically in a general way. We all hope that
in this way new hope may arise in the people directly concerned but – more impor-
tantly – stimulate more than one second thought in those who are now convinced
that radiation research is out of date and therefore dispensable.
VI Preface
Acknowledgements
To organise a meeting is always a joy and a lot of work. The joy is with the main
organiser, the work with his coworkers. But it also requires some money. We thank
the ”Bundesministerium für Bildung und Forschung” (BMBF) (Drs. Komorowski
and Gelford) for financial support through ”Forschungszentrum Karlsruhe
(Dr.R.Papp) and the ”Bundesministerium für Umwelt, Naturschutz und Reaktor-
sicherheit” (Dr. H. Landfermann) for co-sponsorship. Drs. Gelford, Landfermann
and Papp acted also as co-organisers andgave very valuable help. Karin Rinn, and
InaAllendörfer gave more than their share to the load of administrative work
involved and helped to create a good working atmosphere. The production of this
volume could not have been possible without the efforts and the experience of
HermannWitzenberger and the secretarialassistance of Karin Rinn. I thanks them
all and hope that the workshop and its proceedings are able to supply at least a small
brick to the new building of modern radiation research.
Giessen, August 2003 Jürgen Kiefer
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .V
Jürgen Kiefer
Workshop Participants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .XI
Introductory Remarks: OntheStateofRadiationResearch . . . . . . . . . . . . . .1
Jürgen Kiefer
Cellular Responses, Genomic Stability
Cellular Responses to DNA Damage –aPersonalAccount . . . . . . . . . . . . . . .9
George Iliakis
Prospects for Research in Radiation Biology . . . . . . . . . . . . . . . . . . . . . . . . . .29
Charles L. Limoli
Cellular and Molecular Aspects oftheAnti-inflammatoryAction
ofLowDoseIonizingIrradiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .45
Peter M. Kern
The Network of Radiation Responses andGenomicStability . . . . . . . . . . . .57
Friederike Eckardt-Schupp, Simone Mörtl, and Eberhard Fritz
Topological Factors in Radiation Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . .69
Anna A. Friedl
Signalling
Molecular Radiation Biology – Perspectivesforthe Future . . . . . . . . . . . . . .81
H. Peter Rodemann
P53Stabilization andtheRoleofRadiation-InducedSignalling . . . . . . . . . .93
Christine Blattner, Markus Winter and Roman Kulikov
VIII Contents
Cytogenetics
Molecular Genetic Mechanisms ofRadiocarcinogenesis
andPredictiveMarkers forRadioresistance in Tumors
–PresentWorkand Future Perspectives – . . . . . . . . . . . . . . . . . . . . . . . . . .103
Ludwig Hieber and Horst Zitzelsberger
FISH and CHIPs: Colorful Clues
toRadiation-InducedChromosomalInstability . . . . . . . . . . . . . . . . . . . . . .111
Tanja Hardt, Karen Stout, Frank Guthermuth, Jürgen Kiefer, and Thomas Haaf
Carcinogenesis, Radiation Protection
Recombination and Radiation-Induced Cancer.
MechanismsandGeneticTesting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .121
Jochen Dahm-Daphi , Petra Hubbe
UV-Radiation Biology as Part of Cancer Research . . . . . . . . . . . . . . . . . . . .139
R. Greinert, E.W. Breitbart, B. Volkmer
Contribution of Radiation Research toHuman Space Exploration:
Approachestomitigate Radiation Health Risk in Spaceflight . . . . . . . . . . .157
Marco Durante
Repair
Radiation Damage and Human Cells:
You have to know one to understand the other . . . . . . . . . . . . . . . . . . . . . . .171
Markus Löbrich
Different Means to an End: DNADouble-StrandBreak Repair . . . . . . . . .179
Kai Rothkamm
Impact ofPhysicalDevelopments
Electrostatistics of DNA Complexes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .189
Roland R. Netz
Contents IX
Future Radiobiology at Accelerators:
FromHeavyIonTherapytoBasicResearch . . . . . . . . . . . . . . . . . . . . . . . . .211
Gerhard Kraft
Targeting Radiation at the Subcellular,
CellularandTissueLevels:FutureStrategies . . .. . . . . . . . . . . . . . . . . . . . .225
Kevin M. Prise, M. Folkard, Boris Vojnovic and B.D. Michael
The PTB – a Competent and Reliable Partner forResearch and
DevelopmentProjects intheFieldof Ionizing Radiation . . . . . . . . . . . . . . .235
Jürgen Böhm
General Issues
Life Sciences and Radiation Research – ExamplesfromthePast . . . . . . . .249
Jürgen Kiefer
Need and Importance ofFurtherResearchintheField of Radiation . . . . .259
P. N. Srivastava, R. N. Sharan
Reflections on the Acceptability of the Use
ofIonizingRadiationtoGermanSociety . . . . . . . . . . . . . . . . . . . . . . . . . . . .267
Jürgen Böhm
Janus Face of Radiation Biology andScienceforthe Future . . . . . . . . . . . .271
Ohtsura Niwa
Postscript: ThoughtsontheFutureofRadiationResearch
anditsImpactonLifeSciences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .279
Jürgen Kiefer
Workshop Participants
Radiation Research – Science for the future
Gießen 03. – 07.10.2002
Dr. Andreas Artmann Prof. Dr. Dr. Richard Bauer
Gesellschaft für Anlagen- Klinik für Nuklearmedizin
und Reaktorsicherheit (GRS) mbh Justus-Liebig-Universität Gießen
Schwertnergasse 1 Friedrichstr. 25
50667 Köln 35385 Giessen
[email protected] [email protected]
Dr. Christa Baumstark-Khan Dr. Ulrich Bertsche
Institut für Luft- und Raumfahrtmedizin Referatsleiter
(DLR) Hess. Ministerium für Umwelt, Energie,
Linder Höhe Jugend, Familie und Gesundheit
51147 Köln Mainzer Str. 80
[email protected] 65189 Wiesbaden
[email protected]
Prof. Dr. T. Butz Dr. Christine Blattner
Universität Leipzig Forschungszentrum Karlsruhe
Linnéstr. 5 Institut für Genetik und Toxikologie
04103 Leipzig Postfach 36 40
[email protected] 76021 Karlsruhe
[email protected]
Prof. Dr. Jürgen Böhm Dr. Jochen Dahm-Daphi
PTB Braunschweig Universität Hamburg
Bundesallee 100 Abt. f. Strahlentherapie und Radioonkologie
38116 Braunschweig Martinistr. 52
[email protected] 20246 Hamburg
[email protected]
Prof. Dr. Marco Durante Prof. Dr. Friederike Eckardt-Schupp
Dipartimento di Scienze Fisiche GSF
Universitá ”FedericoII” Institut of Molekular Radiobiology
Monte S. Angelo, via Cintia P.O. Box 11 29
80126 Napoli 85764 Neuherberg
ITALY [email protected]
[email protected]