Life, Love and Children: A Practical Introduction to Bioscience Ethics and Bioethics Life, Love and Children: A Practical Introduction to Bioscience Ethics and Bioethics IRINA POLLARD PhD Associate Professor, Biological Sciences, Macquarie University, Sydney, Australia ,III... " Springer Science+Business Media, LLC ISBN 978-1-4613-5000-2 ISBN 978-1-4615-0278-4 (eBook) DOI 10.1007/978-1-4615-0278-4 Library of Congress Cataloging-in-Publication Data A C.LP. Catalogue record for this book is available from the Library of Congress. Copyright © 2002 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint ofthe hardcover lst edition 2002 AlI rights reserved. 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Contents List of Figures xi Preface Xlll Acknowledgments xv 1 HISTORICAL PERSPECTIVE 1 The Hunter-Gatherers Homo sapiens 4 On the Evolution of Ethics 8 Bioethics 12 Bioscience Ethics 14 Principle of Bioscience Ethics for Discussion 16 2 INAPPROPRIA TE LIFESTYLE AND CONGENITAL DISABILITY IN CHILDREN: BASIC PRINCIPLES OF GROWTH, TOXICOLOGY, TERATOGENESIS AND MUTAGENESIS 19 Patterns of Human Growth 20 The EmbryoniclFetal Periods and Embryo Staging 21 The Placenta as the Maternal-Fetal Interface 23 Abnormal Prenatal Growth Patterns 27 vi CONTENTS Toxicology: Basic Principles 29 Teratogenesis, Mutagenesis, and Carcinogenesis 32 Principle of Bioscience Ethics for Discussion 33 3 SUBSTANCE ABUSE AND PARENTHOOD: BIOLOGICAL MECHANSIMS - ETHICAL RESPONSIBILITIES 35 Behavioral Variables - Biological Consequences 35 The Preconceptional Period: Male-Mediated Effects 36 Specifics 37 The Preconceptional Period: Female-Mediated Effects 39 Drug-Induced Infertility 40 The Prenatal and Neonatal Periods 40 Nicotine 41 Sudden Infant Death Syndrome (SIDS) 42 Passive Smoking 43 Attention-Deficit Hyperactivity Disorder 43 Ethanol (alcohol) 44 Fetal Alcohol Syndrome (FAS) 45 Cocaine 47 Marij uana 48 Narcotics 48 Caffeine 49 Behavioral Variables -Bioethical Challenges 49 Socioeconomic Factors 50 An Ecological-Based Model of Preventative Care 53 Drug Addiction 54 Principle of Bioscience Ethics for Discussion 56 4 OVULATORY METHOD OF BIRTH CONTROL: AGING GAMETES AND CONGENITAL MALFORMATIONS IN CHILD ERN 57 The Laws of Inheritance 58 Human Fecundity 59 Female Libido: Procreational versus Recreational Sex 60 BIOSCIENCE ETHICS & BIOETHICS Vll Principles of Reproductive Aging 61 Aging Gametes and Ovulatory Method of Birth Control 64 The Gametopathy Hypothesis and Congenital Anomalies 67 Principle of Bioscience Ethics for Discussion 71 5 UNDERSTANDING CHILD ABUSE AND ITS BIOLOGICAL CONSEQUENCES 73 Unwanted Birth and Crime 75 Post Traumatic Stress Disorder or the Physical Signature of Unresolved Trauma 78 The Biology of Behaviour and Cognition 81 Stress and Psychosocial Short Stature 83 Future Prospects? 84 Principle of Bioscience Ethics for Discussion 85 6 THE STATE OF WELLBEING: ON HEALTH AND ILL-HEALTH 87 Basic Principles of Wellbeing or in Control of our Destiny 89 The Link Between Population Density and Reproduction 89 Stress -The General Adaptation Syndrome (GAS) and Disease 90 Adaptive Strategies 93 Principle of Bioscience Ethics for Discussion 95 7 THE STATE OF WELLBEING: ON THE END OF LIFE CARE AND EUTHANASIA 97 Criteria for Re-Defining the Beginning and End of a Life 98 Euthanasia, an Evolving Concept 100 Principle of Bioscience Ethics for Discussion 103 viii CONTENTS 8 PROCREATIVE TECHNOLOGY: ACHIEVEMENTS AND DESIRED GOALS 105 Fertility Control -the Evolutionary Perspective 106 Infertility -the Price of Excess Fecundity 108 Assisted Reproduction: Social Considerations 110 Assisted Reproduction: Technological Considerations 112 Artificial Insemination 114 In vitro Fertilization and Related Technologies 118 Intracytoplasmic Sperm Injection and Cytoplasmic Transfer Technologies 121 Maturing Human Eggs in the laboratory 123 Surrogacy 123 Principle of Bioscience Ethics for Discussion 124 9 THE RECOMBINANT DNA TECHNOLOGIES 127 Genetic Engineering and Related Technologies - Biological Perspective 127 Gene Therapy 129 Prenatal Genetic Screening 134 Neonatal Screening 136 Pre-Symptomatic Screening for Individuals and Populations 136 The Use of Genetic Technology for Social Purposes 137 The Human Genome and the Human Genome Diversity Projects 138 Access to the Ownership of Genomes 141 Principle of Bioscience Ethics for Discussion 143 10 CLONING TECHNOLOGY 145 What is a Clone? 146 Reproductive Cloning: Basic Principles 148 Embryonic Stem Cell or Therapeutic Cloning 150 BIOSCIENCE ETHICS & BIOETHICS IX Reproductive cloning: Ethical Considerations 151 Principle of Bioscience Ethics for Discussion 155 11 HUMAN DOMINATED ECOSYSTEMS: RE-EVALUATING ENVIRONMENTAL PRIORITIES 157 Population Growth and Economic Activity - Are we Overstraining our Limits? 157 Extinction and Conservation of Biodiversity 159 Genetic Diversity and Environmental Adaptability 162 Human-Driven Climate Change 165 Stress and Adaptation 166 Living Within Nature's Constraints 167 Understanding Living Cycles and Anticipating Environmental Policies Rather Than Relying on Remedial Measures 169 Fundamental Symbiosis: the Biogeochemical or Nutrient Cycle 171 Losing the Food Race 174 Deep Design: The Synthesis of Nature and Culture 176 Principle of Bioscience Ethics for Discussion 178 12 HUMAN DOMINATED ECOSYSTEMS: RECLAIMING THE FUTURE BY TAKING DUE ACCOUNT OF FOLLOWING GENERA TIONS 181 Self-Destructive Behavior and the Environment 181 The Tragedy of the Commons 182 Synthetic Hormone Disruptors 184 The Endocrine System 188 Wildlife Findings 189 Human Findings and the Precautionary Principle 190 Principle of Bioscience Ethics for Discussion 192 x CONTENTS 13 HUMAN DOMINAT ED ECOSYSTEMS: W AREFA RE FITNESS ENHANCEMENT OR LOSING STRATEGY 195 The Institution of War 196 The Tragedy of Conflict 198 Biological Warfare 201 Virtual Warfare 204 The Legacy of War on Future Generations 204 Principle of Bioscience Ethics for Discussion 206 14 HUMAN DOMINATED ECOSYSTEMS: REWORKING BIOETHICAL FRONTIERS 207 Global Responsibility -a Transboundary Detente to Developmental Needs and Environmental Preservation 208 The Power of the Collective 209 The Power of the Individual 209 Stewardship of Mother Earth -in Defense of the Global Commons 211 The Gaia Hypothesis 212 The Three Principles of Gaia 214 Living Within Nature's Bounty 217 Principle of Bioscience Ethics for Discussion 222 SELECTED BIBLIOGRAPHY 223 INDEX 245 List of Figures 2.1. Schematic diagram of human development 24-25 2.2. The placenta as the maternal-fetal interphase 26 2.3 Diagrammatic representation of the fate of toxic substances in the body 30 3.1. View of the structurally complete fetal brain 46 8.1. Electron micrographs of sperm forms 115 8.2. Electron micrographs of forms continued 116 10.1. Monozygotic twins 148 10.2. Growing spare body parts to order 152 11.1. Exponential growth of human populations 158 11.2. Unique landscapes need protection 163 11.3. Productivity of old-growth tropical rainforests 173 11.4. Clearing and burning disturbance 175 12.1. We must protect our right to roam the commons 185 12.2. The chemical structures of steroids 187 14.1. Clean-Up Australia Sunday 210 14.2. Earth's biological components 218