Leukocyte Adhesion Molecules

293 Pages·1990·9.01 MB·English

by  Alan S. Rosenthal (auth.)

Leukocyte Adhesion Molecules
Proceedings of the First International Conference on:
"Structure, Function and Regulation of Molecules
Involved in Leukocyte Adhesion"
Held in Titisee, West Germany
September 28 - October 2, 1988
Co-Chairmen:
Donald C. Anderson, M.D.
Timothy A. Springer, Ph.D.
T .A. Springer D. C. Anderson
A.S. Rosenthal R. Rothlein
Editors
Leukocyte
Adhesion Molecules
Springer-Verlag
New York Berlin Heidelberg
London Paris Tokyo
Timothy A. Springer Robert Rothlein
Latham Family Professor of Pathology Principle Scientist
Harvard Medical School and Center for Department of Immunology
Blood Research Boehringer Ingelheim Pharmaceuticals Inc.
Boston, Massachusetts 02115 Ridgefield, Connecticut 06877
Donald C. Anderson Alan S. Rosenthal
Professor of Pediatrics & Cell Biology Vice President
Head Research & Development
Section of Leukocyte Biology Boehringer Ingelheim Pharmaceuticals Inc.
Baylor College of Medicine and Texas Ridgefield, Connecticut 06877
Children's Hospital
Houston, Texas 77054
Art on cover © Boehringer Ingelheim International GmbH.
Library of Congress Cataloging in Publication Data
Leukocyte adhesion molecules.
Based on a meeting held in Titisee in 1988
I. Leucocytes-Congresses. 2. Cell adhesion-Con
gresses. I. Springer, Timothy A. [DNLM: 1. Cell
Adhesion-congresses. 2. Leukocytes-congresses.
QH 623 L652]
QRI85.8.L48L46 1989 616.07'9 89-21917
ISBN-13: 978-1-4612-7927-3 e-ISBN-13: 978-1-4612-3234-6
DOl: 10.1007/978-1-4612-3234-6
© 1990 by Springer-Verlag New York Inc.
Softcover reprint of the hardcover 1s t edition 1990
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987654321
Dedication
Dr. P. Brian Stewart, Senior Vice President, Research and Development,
Boehringer Ingelheim Pharmaceuticals, Inc., and Vice President, Re
search and Development, Boehringer Ingelheim Corporation, died April
1, 1987.
Dr. Stewart was a graduate of Middlesex Hospital Medical School,
University of London, and attended Harvard Graduate School of Busi
ness. He served for five years during World War II in the Royal Air
Force, as a fighter pilot, for which he won the Distinguished Flying Cross.
Throughout his 30-year career with Boehringer Ingelheim, Dr. Stewart
was a dedicated scientist-clinician whose personal and professional stan
dards of excellence were the foundation of Boehringer Ingelheim's Re
search and Development programs. Prior to joining Boehringer Ingelheim
Pharmaceuticals, he was Managing Director from 1962 to 1977 of Boeh
ringer's Pharma Research Ltd. in Montreal. Beginning in 1978, he and
his colleagues moved to Ridgefield, Connecticut, to build Boehringer's
U.S. Research and Development site. His vision and dedication were
responsible for our current research commitment efforts to discover ways
to therapeutically regulate clinically relevant aspects of leukocyte adhe
sion. His colleagues remember him with fondness. We wish to dedicate
this scientific meeting to that memory.
Alan S. Rosenthal, M.D.
December 12, 1988
Acknowledgments
The editors wish to offer their sincere thanks to Dr. Ronald Faanes and
Ms. Leah Neumaier for their organizational and administrative contri
butions. It was their enthusiasm and perseverance that accounted for the
reality of having a symposium on leukocyte adhesion at Titisee, West
Germany and for the successful completion of this book.
We would also like to thank Dr. med Hasso Schroeder for his assistance
in arranging for the symposium and details during our stay.
Contents
Contributors ............................................................................... xi
Introduction ............................................................................... .
PART 1 STRUCTURE AND FUNCTION OF THE INTEGRIN
FAMILY .................................................................... 5
1 Leukocyte Integrins
Takashi K. Kishimoto, Richard S. Larson, Angel L. Corbi,
Michael L. Dustin, Donald E. Staunton, and Timothy A.
Springer ....................................................................................... 7
2 Structure and Functions for the Adhesion Receptors VLA-2
and VLA-4: Comparisons to other Members of the Integrin
Superfamily
Martin E. Hemler, Y oshikazu Takada, Mariano Elices, and
Carol Crouse .. ...... .... .......... ............. ... ........ ......... ..... ........... ... ..... 44
3 Fibronectin Receptor Expression on Thymocytes
Michael D. Pierschbacher and Pina M. Cardarelli .................. 58
4 Mechanism Regulating Recruitment of CDllb/CDI8 to the
Cell Surface is Distinct From That Which Induces Adhesion
in Homotypic Neutrophil Aggregation
Jill P. Buyon, Mark R. Philips, Steven B. Abramson, Seth
G. Slade, Gerald Weissmann, and Robert Winchester ........... 72
PART 2 ADHESION IN DISEASE AND THERAPy.................... 85
5 Mechanisms of Neutrophil Emigration
C.M. Doerschuk, R.K. Winn, and J.M. Harlan ...................... 87
6 Leukocyte Adhesion Deficiency as a Model for the Study of
the Functional Role of LFA -I
A. Fischer, B. Lisowska-Grospierre, F. Mazerolles, F. Le
Deist, N. Perez, M.T. Dimanche-Boitrel, and C. Griscelli ..... 95
viii Contents
7 Role of Cellular Adhesion in Inflammatory Cutaneous
Disorders
Gunhilde Lange Vejlsgaard, Nils Lauge Hansen, Elisabeth
Ralfkiaer, and Robert Rothlein ................................................ 101
8 Characterization of a New Mobilizable Mac-l (CD11b/
CD18) Pool That Co-Localizes with Gelatinase in Human
Neutrophils
Douglas H. Jones, Frank C. Schmalstieg, Hal K. Hawkins,
Bean L. Burr, Helen E. Rudloff, Sharon Krater, C. Wayne
Smith, and Donald C. Anderson ........................................ ...... 106
9 Anti-Inflammatory Properties of Monoclonal Anti-Mol
(CD11b/CD18) Antibodies In Vitro and In Vivo
Robert F. Todd III, Paul J. Simpson, and Benedict R.
Lucchesi ...................................................................................... 125
10 CDw18 Dependent Adhesion of Leukocytes to Endothelium
and Its Relevance for Cardiac Reperfusion
Elke Seewaldt-Becker, Robert Rothlein, and Jiirgen W.
Dammgen ................................................................................... 138
11 Role of Anti-Adhesion Monoclonal Antibodies in Rabbit
Lung Inflammation
Randall W. Barton, Robert Rothlein, John Ksiazek, and
Charles Kennedy .................................................................. ...... 149
PART 3 MYELOID CELL ADHESION ...................................... 157
12 The Role of LFA-l and Related Antigens in Adhesion-
Mediated Functions of Human Monocytes
Carl G. Figdor, Anje te Velde, and Jan E. de Vries ............... 159
13 Role of ICAM-l in the Adherence of Human Neutrophils to
Human Endothelial Cells In Vitro
C. Wayne Smith, Steven D. Marlin, Robert Rothlein,
Michael B. Lawrence, Larry V. McIntire, and Donald C.
Anderson ..................................................................................... 170
14 Specificity and Regulation of CD18-Dependent Adhesions
Samuel D. Wright, Siu Kong Lo, and Patricia A. Detmers .. , 190
15 CD18 Dependence of Primate Eosinophil Adherence In
Vitro
Craig D. Wegner, C. Wayne Smith, and Robert Rothlein ..... 208
16 Identification and Characterization of Endothelial-Leukocyte
Adhesion Molecule 1
((;' .M.Pli~V'i:lacqldppand: Mo\{-6!imbilQ)ne, .Ji:J\~. .. x;:\~(L:;': .. ,.Lj:l.l. 215
Contents
IX
PART 4 LYMPHOCYTE ADHESION ........................................ 225
17 Homing Receptors in Lymphocyte, Neutrophil, and
Monocyte Interaction with Endothelial Cells
Mark A. Jutila, David M. Lewinsohn, Ellen L. Berg, and
Eugene C. Butcher ...................................................................... 227
18 Antigen-Independent Adhesion: A Critical Process in
Human Cytotoxic T Cell Recognition
Stephen Shaw, M. William Makgoba, and Yoji Shimizu ....... 236
19 Inhibition of Human Mixed Lymphocyte Reactions by
Monoclonal Antibodies to Intercellular Adhesion Molecule-l
(ICAM-l)
Vincent J. Merluzzi, Robert Rothlein, Chester Wood, Carol
D. Stearns, Ronald B. Faanes, and Kathleen Last-Barney ..... 244
20 Lymphocyte Function-Associated Antigen-l (LFA-l) is a
Signaling Molecule for Human T Lymphocytes
Mary C. Wacholtz, Sunil S. Patel, and Peter E. Lipsky .......... 254
21 Involvement of Lymphocyte Function-Associated Antigen-l
and Intercellular Adhesion Molecule-l in Monocyte and T-
Cell Antigen-Specific Interactions
Nancy Hogg, Graeme Dougherty, and Anne-Marie Buckle ... 265
22 Immunosuppression of Cynomolgus Recipients of Renal
Allografts by R6.5, a Monoclonal Antibody to Intercellular
Adhesion Molecule-l
A. Benedict Cosimi, Cheryl Geoffrion, Terri Anderson,
David Conti, Robert Rothlein, and Robert B. Colvin ........... 274
Index ........................................................................................... 283
Participants
Donald C. Anderson, Randall W. Barton, Sarah Bodary, Eric Brown,
Eugene C. Butcher, Jill P. Buyon, George Cianciolo, Robert B. Colvin,
Angel Corbi, A. Benedict Cosimi, J iirgen Dammgen, Michael Diamond,
Michael Dustin, Ronald B. Faanes, Carl G. Figdor, Alain Fischer, David
Frankhouser, William M. Gallatin, Nils Lauge Hansen, John M. Harlan,
Martin Hemler, Nancy Hogg, Jeffrey Huth, Douglas Jones, Takashi Kish
imoto, Steve Kohl, Richard Krogsrud, Richard Larson, Peter E. Lipsky,
Steven D. Marlin, Vincent J. Merluzzi, Leah C. Neumaier, Michael
Pierschbacher, Suman Rakhit, Alan B. Rickinson, Alan S. Rosenthal,
Robert Rothlein, Hasso Schroeder, Elke Seewaldt-Becker, Stephen Shaw,
C. Wayne Smith, Timothy A. Springer, Christian Stratowa, Robert F.
Todd III, Craig D. Wegner, Peter C. Wilkinson, Chester Wood, Samuel
Wright.