Leukemia and Related Disorders: Integrated Treatment Approaches PDF
Preview Leukemia and Related Disorders: Integrated Treatment Approaches
contemporary hematology Judith E. Karp, M.D., Series Editor For further volumes: http://www.springer.com/series/7681 Elihu H. Estey Frederick R. Appelbaum ● Editors Leukemia and Related Disorders Integrated Treatment Approaches Editors Elihu H. Estey, M.D. Frederick R. Appelbaum, M.D. Professor of Medicine Professor of Medicine Division of Hematology Head, Division of Oncology University of Washington Director, Clinical Research Division Fred School of Medicine Hutchinson Cancer Research Center Member, Fred Hutchinson Cancer Research Executive Director, Seattle Cancer Care Center Alliance Attending Physician, Seattle Cancer Care University of Washington Alliance School of Medicine Seattle, WA USA Seattle, WA USA ISBN 978-1-60761-564-4 e-ISBN 978-1-60761-565-1 DOI 10.1007/978-1-60761-565-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011944980 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identifi ed as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com) Preface There is no shortage of multiauthored books describing management of acute and chronic leukemias and myelodysplastic syndromes. However, we believe that this book has several distinctive features. All the authors are members of a single academic center. While the authors’ views on treatment approaches necessarily differ, the book’s single-center nature will hopefully provide the reader with a relatively unifi ed approach to management. This theme is furthered by the inclusion of three chapters on the role of allogeneic transplant, befi tting the Fred Hutchinson Cancer Research Center’s long history of leadership in this discipline. There are both chap- ters on supportive care and on long-term complications of successful treatment, another long-standing interest of the center. The authors’ expertise has prompted the editors to give them wide latitude in writing the chapters. In general, the chapter s combine a thorough review of the literature and their own perspectives. The editors are confi dent that the chapters are uniformly excellent and informative. The focus of this book is clinical. The intended audience is thus all physicians treating patients with acute or chronic leukemias or myelodysplasia. The many questions the authors receive from community oncologists suggest that this audience is large. Seattle, WA, USA Elihu H. Estey Seattle, WA, USA Frederick R. Appelbaum v Acknowledgment The editors appreciate the authors’ expertise and hard work, which made this book possible. vii Contents 1 Acute Myeloid Leukemia (AML)........................................................... 1 Elihu H. Estey 2 The Treatment of Adult Acute Lymphoblastic Leukemia (ALL): Risk Stratifi cation and Strategies .......................................................... 37 Andrei R. Shustov 3 Chronic Lymphocytic Leukemia (CLL) ............................................... 67 Jonathan A. Gutman, Kelly M. Smith, and John M. Pagel 4 Chronic Myeloid Leukemia (CML) ....................................................... 97 Andrew Coveler and Vivian G. Oehler 5 Myelodysplastic Syndromes (MDS) ...................................................... 149 Bart Lee Scott 6 Myeloablative Transplant (HCT) .......................................................... 169 Gunnar Bjarni Ragnarsson and Paul J. Martin 7 Reduced-Intensity and Non-Myeloablative Conditioning Followed by Hematopoietic Cell Transplantation ................................................ 187 Aravind Ramakrishnan and Brenda M. Sandmaier 8 Alternative Donor Hematopoietic Stem Cell Transplantation: A Role for Umbilical Cord Blood Transplantation for Hematologic Malignancies ............................................................... 219 Laura F. Newell, Jonathan A. Gutman, and Colleen Delaney 9 The Detection and Signifi cance of Minimal Residual Disease ............ 251 Jerald P. Radich and Brent L. Wood ix
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