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Kumar and Clark’s Clinical Medicine PDF

4690 Pages·2016·95.88 MB·English
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Kumar & Clark's Clinical Medicine NINTH EDITION Edited by Professor Parveen Kumar CBE BSc MD DM(HC) FRCP(L&E) FRCPath Professor of Medicine and Education, Barts and The London School of Medicine and Dentistry, QMUL, and Honorary Consultant Physician and Gastroenterologist, Barts Health NHS Trust and Homerton University Hospital NHS Foundation Trust, UK Dr Michael Clark MD FRCP Honorary Senior Lecturer, Barts and The London School of Medicine and Dentistry, QMUL, and Princess Grace Hospital, UK Editor, Online Content Adam Feather FRCP FAcadMEd Senior Lecturer in Medical Education and Clinical Lead in Acute Medicine, The Royal London Hospital, Barts Health NHS Trust, UK Edinburgh London New York Oxford Philadelphia St           Louis Sydney Toronto 2017 Table of Contents Cover image Title Page Copyright Acknowledgements Online Special Topics Contributors Online contributors International Advisory Board Preface to the Ninth Edition How to Use This Book Section 1 Good medical practice 1 Ethics, law and communication Ethics and the Law Communication 2 Clinical pharmacology Introduction Why Do Patients Need Drugs? The Choice of Drug The Dose Pharmacokinetics Pharmacodynamics Affordability and Cost-Effectiveness Prescribing in Special Populations Monitoring Drug Therapy Adverse Drug Reactions Drug Interactions Inter-Individual Variability in Drug Response Evidence-Based Medicine Statistical Analyses Information Sources Significant websites 3 Palliative medicine and symptom control Introduction and General Aspects Symptom Control Extending Palliative Care to People with Non-Malignant Disease Palliative Care of the Frail Elderly Care of the Dying Further reading Bibliography Significant websites 4 Global health Introduction Millennium Development Goals Global Burden of Disease Poverty Water and Sanitation Organizations and the Global Health Agenda Education Maternal Health and Child Health Mental Health Accidents and Trauma Conflict and Catastrophe Economics and Politics in Global Health Social Determinants of Health Human Rights and the Value of Engagement in Global Health Bibliography 5 Environmental medicine Disease and the Environment Environmental Temperature Heat Injury Cold Injury High Altitude Diving Drowning Air Pollution Ionizing Radiation Electric Shock Lightning Strike Smoke Noise Bioterrorism/Biowarfare Travel Building-Related Illnesses 6 Poisoning Introduction Clinical approach to the poisoned patient Principles of Management of Poisoning Specific Poisons Significant websites Section 2 Clinical sciences 7 Molecular cell biology and human genetics Cell Biology Human Genetics Bibliography Significant websites 8 The immune system and disease Anatomy and Principles of the Immune System Innate Immune System Adaptive Immune System Cell Migration HLA Molecules and Antigen Presentation The Immune System in Concert Laboratory Investigations of the Immune System Clinical Immunodeficiency Type I (Immediate) Hypersensitivity and Allergic Disease Autoimmune Disease Organ Rejection in Clinical Transplantation Immune-Based Therapies 9 Water, electrolytes and acid–base balance Water and Electrolytes Acid–Base Disorders Further reading Bibliography 10 Nutrition Introduction Water and Electrolyte Balance Dietary Requirements Protein–Energy Malnutrition Vitamins Minerals Nutrition and Ageing Obesity Nutritional Support Food Allergy and Food Intolerance Alcohol Bibliography Significant websites Section 3 Clinical practice 11 Infectious diseases and tropical medicine Infection and Infectious Disease Viral Infections Transmissible Spongiform Encephalopathies (Prion Diseases) Bacterial Infections Fungal Infections Protozoal Infections Helminthic Infections Arthropod Ectoparasites 12 Sexually transmitted infections and human immunodeficiency virus Sexually Transmitted Infections Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome Bibliography 13 Gastrointestinal disease Introduction Clinical Approach to the Patient with Gastrointestinal Disease The Mouth The Salivary Glands The Pharynx and Oesophagus The Stomach and Duodenum Acute and Chronic Gastrointestinal Bleeding The Small Intestine Inflammatory Bowel Disease The Colon and Rectum Diarrhoea Functional Gastrointestinal Disorders The Acute Abdomen The Peritoneum Bibliography Significant websites 14 Liver disease Introduction Anatomy of the Liver and Biliary System Functions of the Liver Clinical Approach to the Patient with Liver Disease Jaundice Hepatitis Acute Hepatic Failure Autoimmune Hepatitis Drug-Induced Chronic Hepatitis Chronic Hepatitis of Unknown Cause Non-Alcoholic Fatty Liver Disease Cirrhosis Alcoholic Liver Disease Budd–Chiari Syndrome Hepatic Sinusoidal Obstruction Syndrome Fibropolycystic Diseases Liver Abscess Other Infections of the Liver Liver Disease in Pregnancy Liver Tumours Miscellaneous Conditions of the Liver Drugs and the Liver Bibliography 15 Biliary tract and pancreatic disease The Gall Bladder and Biliary System The Pancreas 16 Haematological disease The Red Cell The Spleen Blood Transfusion The White Cell Haemostasis and Thrombosis Bibliography Significant websites

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The ninth edition of this best-selling textbook of clinical medicine builds even further on its formidable, prize-winning formula of excellence, comprehensiveness and accessibility. ‘This book is stunning in its breadth and ease-of-use. It still remains the "gold standard", thorough guide to clini
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Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.