https://t.me/MedicalBooksStore Kucers’ THE USE OF ANTIBIOTICS A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs SEVENTH EDITION Kucers’ THE USE OF ANTIBIOTICS A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs Editor in Chief M. LINDSAY GRAYSON Section Editors SARA E. COSGROVE JAMES S. MCCARTHY SUZANNE M. CROWE JOHN MILLS M. LINDSAY GRAYSON JOHAN W. MOUTON WILLIAM HOPE DAVID L. PATERSON CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2018 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper International Standard Book Number-13: 978-1-4987-4795-0 (Pack – Book and eBook) This book contains information obtained from authentic and highly regarded sources. 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Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging‑in‑Publication Data Names: Grayson, M. Lindsay, editor. Title: Kucers’ the use of antibiotics : a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs / [edited by] M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, William Hope, James S. Mccarthy, John Mills, Johan W. Mouton and David L. Paterson. Other titles: Use of antibiotics. Description: Seventh edition. | Boca Raton : CRC Press, [2017] | Includes bibliographical references and index. Identifiers: LCCN 2017023817| ISBN 9781498747950 (hardback : alk. paper) | ISBN 9781315152110 (e-book). Subjects: | MESH: Anti-Infective Agents—therapeutic use. Classification: LCC RM267 | NLM QV 250 | DDC 615/.329—dc23 LC record available at https://lccn.loc.gov/2017023817 Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Contributors xvii Foreword to the 7th Edition xxxi John Bartlett Foreword to the 6th Edition xxxiii The Late Robert C. Moellering, Jr. Obituary: Dr. Alvis Kucers xxxv Hail the Greats xxxvii Preface xli M. Lindsay Grayson Abbreviations xliii VOLUME 1 Section I INTRODUCTION 1 Principles of Antimicrobial Use 3 M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, James S. McCarthy, William Hope, John Mills, Johan W. Mouton, and David L. Paterson 2 Use of Critically Important Antimicrobials in Food Production 9 Peter Collignon Section 2 ANTIBIOTICS Part 2:1 PENICILLINS AND RELATED DRUGS 3 Benzylpenicillin (Penicillin G) 23 Alasdair M. Geddes, Ian M. Gould, Jason A. Roberts, Jason A. Trubiano, and M. Lindsay Grayson 4 Phenoxypenicillins 92 Alasdair M. Geddes, Ian M. Gould, and Jason A. Roberts 5 Ampicillin and Amoxicillin 100 Alasdair M. Geddes, Ian M. Gould, and Jason A. Roberts, M. Lindsay Grayson, and Sara E. Cosgrove 6 Methicillin 136 Kathryn Dzintars 7 Isoxazolyl Penicillins: Oxacillin, Cloxacillin, Dicloxacillin, and Flucloxacillin 143 Janessa M. Smith 8 Nafcillin 162 Edina Avdic 9 Carbenicillin, Carindacillin, Carfecillin, and Ticarcillin 173 Kathryn Dzintars 10 Mezlocillin, Azlocillin, Apalcillin, and Piperacillin 187 Adrian Tramontana and Karin Thursky 11 Mecillinam (Amdinocillin) and Pivmecillinam 207 Edina Avdic v vi Contents 12 Temocillin 218 Tiffeny T. Smith and Sara E. Cosgrove 13 Beta-Lactamase Inhibitors 225 Pascalis Vergidis and Matthew E. Falagas 14 Amoxicillin–Clavulanic Acid 254 David Gordon 15 Ampicillin–Sulbactam 280 Petros I. Rafailidis and Matthew E. Falagas 16 Ticarcillin–Clavulanic Acid 299 Kirsty Buising 17 Piperacillin–Tazobactam 319 Jasmine Teng and Karin Thursky Part 2:2 CEPHALOSPORINS AND RELATED DRUGS 18 Cephalothin and Cefazolin 347 Kerina J. Denny, Jeffrey Lipman, and Jason A. Roberts 19 Cephalexin 361 Nastaran Rafiei 20 Cephadroxil, Cephaloridine, Cephacetrile, Cephapirin, Cephradine, and Other Rarely Used First-Generation Cephalosporins 370 David L. Paterson 21 Cefaclor, Cefprozil, and Loracarbef 376 David L. Paterson and Yohei Doi 22 Cefuroxime 383 Maria Diletta Pezzani 23 Cefotiam, Cefuzonam, Cefamandole, Cefonicid, and Ceforanide 396 Hisashi Baba and David L. Paterson 24 Cefoxitin, Cefotetan, and Other Cephamycins 403 Kathryn Daveson 25 Cefoperazone and Cefoperazone–Sulbactam 415 Syamhanin Adnan 26 Cefotaxime 426 Baek-Nam Kim and David L. Paterson 27 Ceftriaxone 464 Baek-Nam Kim, Anna Maria Peri, and David L. Paterson 28 Ceftizoxime, Cefdinir, Cefditoren, Cefpodoxime, Ceftibuten, Cefsulodin, and Cefpiramide 530 Mesut Yilmaz and David L. Paterson 29 Cefixime 539 David Guay 30 Ceftazidime and Ceftazidime–Avibactam 548 Hugh Wright and Andrea Endimiani 31 Cefepime, Cefpirome, and Cefepime–Tazobactam 578 Andrea Endimiani and Parham Sendi 32 Ceftaroline and Ceftaroline–Avibactam 603 Elda Righi 33 Ceftobiprole 619 Andrew Henderson, Baek-Nam Kim, and David L. Paterson 34 Ceftolozane–Tazobactam 636 John F. McNamara 35 Aztreonam and Aztreonam–Avibactam 644 Hisashi Baba 36 Cefiderocol (S-649266) 658 David L. Paterson Part 2:3 CARBAPENEMS 37 Imipenem–Cilastatin and Imipenem–Relebactam 663 Yoshiro Hayashi and David L. Paterson Contents vii 38 Meropenem and Meropenem–Vaborbactam 697 Anton Y. Peleg and Patrick N. A. Harris 39 Doripenem 723 Benjamin A. Rogers 40 Ertapenem 743 Pilar Retamar and Luis-Eduardo López-Cortés 41 Faropenem 765 Yoshiro Hayashi and Hisashi Baba 42 Biapenem, Ritipenem, Panipenem, and Sulopenem 772 Kunikazu Yamane Part 2:4 GLYCOPEPTIDES AND LIPOPEPTIDES 43 Vancomycin 785 Inge C. Gyssens and Natasha E. Holmes 44 Teicoplanin 836 Anouk E. Muller and Inge C. Gyssens 45 Daptomycin 866 Anouk E. Muller and Inge C. Gyssens 46 Oritavancin 908 Wonhee So and David P. Nicolau 47 Dalbavancin 917 Marguerite L. Monogue and David P. Nicolau 48 Telavancin 930 Islam M. Ghazi, Joseph L. Kuti, and David. P. Nicolau 49 Ramoplanin 940 Ed J. Kuijper 50 Surotomycin 944 Johan W. Mouton Part 2:5 AMINOGLYCOSIDES 51 Kanamycin 949 Karen Urbancic and M. Lindsay Grayson 52 Gentamicin 964 Jesús Sojo-Dorado and Jesús Rodríguez-Baño 53 Tobramycin 992 Juan Gálvez-Acebal and Jesús Rodríguez-Baño 54 Amikacin 1009 Whitney J. Nesbitt and David Aronoff 55 Sisomicin and Netilmicin 1028 Johan W. Mouton 56 Isepamicin 1039 Johan W. Mouton 57 Neomycin 1046 Johan W. Mouton 58 Plazomicin 1053 Karen Bush Part 2:6 MACROLIDES AND KETOLIDES 59 Erythromycin 1065 Françoise Van Bambeke 60 Roxithromycin 1087 Françoise Van Bambeke 61 Clarithromycin 1097 Jakko van Ingen 62 Azithromycin 1122 Claire L. Gordon viii Contents 63 Josamycin and Rosaramicin 1150 Françoise Van Bambeke 64 Telithromycin 1156 Eric Wenzler and Keith A. Rodvold 65 Cethromycin 1172 Johan W. Mouton 66 Solithromycin 1179 Andrew Henderson Part 2:7 TETRACYCLINES AND RELATED DRUGS 67 Tetracycline 1195 Damon P. Eisen 68 Doxycycline 1204 Damon P. Eisen 69 Minocycline 1230 M. Lindsay Grayson 70 Tigecycline 1249 Marrigje H. Nabuurs-Franssen, Bram P. A. Lestrade, and Johan W. Mouton 71 Omadacycline 1267 Johan W. Mouton and Marrigje H. Nabuurs-Franssen 72 Eravacycline 1273 Keith A. Rodvold Part 2:8 OTHER ANTIBIOTICS 73 Linezolid 1293 Sarah J. Sparham and Benjamin P. Howden 74 Cadazolid 1348 Francis Magro and Helen W. Boucher 75 Radezolid 1354 Francis Magro and Helen W. Boucher 76 Tedizolid 1356 Monique R. Bidell, George L. Drusano, and Thomas P. Lodise 77 Quinupristin–Dalfopristin 1374 Denis Frasca, Olivier Mimoz, and Wiliam Couet 78 Pristinamycin 1386 Denis Frasca, Olivier Mimoz, and Wiliam Couet 79 Fosfomycin 1392 Niels Frimodt-Møller 80 Fusidate Sodium 1407 Niels Frimodt-Møller 81 Polymyxins 1420 Roger L. Nation and Jian Li 82 Novobiocin 1540 Johan W. Mouton 83 Bacitracin and Gramicidin 1454 Jean-Luc Murk and Jan Kluytmans 84 Mupirocin 1460 Nelianne J. Verkaik and Margreet C. Vos 85 Clindamycin and Lincomycin 1468 Larry Danziger and Gail S. Itokazu 86 Chloramphenicol and Thiamphenicol 1515 Graeme MacLaren and Frank Shann 87 Spectinomycin 1542 Johan W. Mouton 88 Fidaxomicin 1547 Ed J. Kuijper and Martijn P. Bauer Contents ix 89 Lefamulin 1556 Christabelle Min Chen and Timothy W. Felton 90 Retapamulin 1561 Christabelle Min Chen and Timothy W. Felton Index I-1 VOLUME 2 Part 2:9 ANTIFOLATE AGENTS AND OTHER SYNTHETIC ANTIBACTERIALS 91 Sulfonamides 1571 Natasha E. Holmes and M. Lindsay Grayson 92 Trimethoprim and Trimethoprim–Sulfamethoxazole (Cotrimoxazole) 1625 Jason A. Trubiano and M. Lindsay Grayson 93 Pyrimethamine 1725 Bianca Graves, David Looke, and M. Lindsay Grayson 94 Dapsone 1746 David Looke 95 Trimetrexate 1769 Sabine De Silva and M. Lindsay Grayson 96 Iclaprim 1775 Andrew Stewardson and M. Lindsay Grayson 97 Nitrofurans: Nitrofurazone, Furazidine, and Nitrofurantoin 1784 Angela Huttner and Andrew Stewardson 98 Methenamine Mandelate and Methenamine Hippurate 1799 Matthew A. Murphy and M. Lindsay Grayson Part 2:10 NITROIMIDAZOLES 99 Metronidazole 1807 Kyra Yu Lin Chua 100 Tinidazole 1850 Fiona Doukas, Eunice Liu, and Thomas Gottlieb Part 2:11 QUINOLONES AND FLUOROQUINOLONES 2:11A NEW AND COMMONLY USED FLUOROQUINOLONES 101 Ciprofloxacin 1867 Jason Kwong and M. Lindsay Grayson 102 Norfloxacin 1986 Rhonda L. Stuart 103 Ofloxacin 2004 Wendy J. Munckhof 104 Levofloxacin 2055 David C. Hooper 105 Moxifloxacin 2085 Rhonda L. Stuart 106 Gemifloxacin 2110 George M. Eliopoulos 107 Sitafloxacin 2122 Rhonda L. Stuart and Ashwin Swaminathan 108 Delafloxacin 2132 Rekha Pai Mangalore, Jason Kwong, and M. Lindsay Grayson 109 Finafloxacin 2139 David C. Hooper 110 Prulifloxacin/Ulifloxacin 2147 G. Khai Lin Huang and M. Lindsay Grayson