Knowledge Accumulation and Industry Evolution - The Case of Pharma-Biotech PDF
Preview Knowledge Accumulation and Industry Evolution - The Case of Pharma-Biotech
This page intentionally left blank Knowledge Accumulation and Industry Evolution Written by internationally acclaimed experts in the economics of innovation,thisvolumeexamineshowthebiotechnologyandpharma- ceutical sector isaffectedby thedynamics of innovation, institutions, and publicpolicy. Itcontributes boththeoretically andempiricallyto the increasingly influential Schumpetarian framework in industrial economics, which places innovation at the centre of the analysis of competition. Both quantitative and qualitative studies are included, andthisvariedperspectiveaddstotherichnessofthevolume’sinsights. Thecontributorsexploredifferentideasregardingthehistoricalevolu- tionoftechnologyinthesector,andhowfirmsandindustrystructure havecoevolvedwithinnovationdynamics.Importantpolicyquestions areconsideredregardingthefutureofinnovationinthissectorandits impactontheeconomy. MARIANA MAZZUCATO is Professor of Economics at the Open University, where she is also Director of the inter-faculty research centre,Innovation,KnowledgeandDevelopment(IKD). GIOVANNI DOSI is Professor of Economics at the Sant’Anna School ofAdvancedStudiesinPisa. Knowledge Accumulation and Industry Evolution The Case of Pharma-Biotech Edited by MARIANA MAZZUCATO AND GIOVANNI DOSI cambridge university press Cambridge,NewYork,Melbourne,Madrid,CapeTown,Singapore,SãoPaulo Cambridge University Press TheEdinburghBuilding,Cambridgecb22ru,UK PublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYork www.cambridge.org Informationo nthistitle:www.cambridge.org/9780521858229 ©CambridgeUniversityPress2006 Thispublicationisincopyright.Subjecttostatutoryexceptionandtotheprovisionof relevantcollectivelicensingagreements,noreproductionofanypartmaytakeplace withoutthewrittenpermissionofCambridgeUniversityPress. Firstpublishedinprintformat 2006 isbn-13 978-0-511-16184-1 eBook (NetLibrary) isbn-10 0-511-16184-0 eBook (NetLibrary) isbn-13 978-0-521-85822-9 hardback isbn-10 0-521-85822-4 hardback CambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyofurls forexternalorthird-partyinternetwebsitesreferredtointhispublication,anddoesnot guaranteethatanycontentonsuchwebsitesis,orwillremain,accurateorappropriate. We dedicate this book to the memory of our dear colleagues and mentors Keith Pavitt and Paul Geroski Contents Listoffigures pageix Listoftables xii Listofcontributors xiv Acknowledgments xvii 1 Introduction GiovanniDosiandMarianaMazzucato 1 PartI Innovationandindustryevolution 19 2 Pharmaceuticalinnovationasaprocessof creativedestruction Frank R. Licht enberg 21 3 Theevolutionofpharmaceuticalinnovation PaulNightingaleandSuryaMahdi 73 4 Firmandregionaldeterminantsininnovation models:evidencefrombiotechnologyand traditionalchemicals MyriamMariani 112 5 Innovationandindustryevolution:acomment LouisGalambos 145 PartII Firmgrowthandmarketstructure 161 6 Heterogeneityandfirmgrowthinthe pharmaceuticalindustry ElenaCefis,MatteoCiccarelli,andLuigiOrsenigo 163 7 Growthanddiversificationpatternsoftheworldwide pharmaceuticalindustry GiulioBottazzi,FabioPammolli,andAngeloSecchi 208 vii viii Contents 8 Entry,marketstructure,andinnovationina ‘‘history-friendly’’modeloftheevolutionof thepharmaceuticalindustry ChristianGaravaglia,FrancoMalerba, andLuigiOrsenigo 234 9 Thegrowthofpharmaceuticalfirms:acomment BoyanJovanovic 266 PartIII Policyimplications 275 10 Theeffectsofresearchtoolpatentsandlicensingon biomedicalinnovation JohnP.Walsh,AshishArora,andWesleyM.Cohen 277 11 Upstreampatentsandpublichealth:thecaseof genetictestingforbreastcancer FabienneOrsi,ChristineSevilla,andBenjaminCoriat 327 12 Competition,regulation,andintellectualproperty managementingeneticallymodifiedfoods:evidence fromsurveydata PierreRegibeauandKatharineRockett 346 13 Governance,policy,andindustrystrategies: pharmaceuticalsandagro-biotechnology JoyceTait,JoannaChataway,CatherineLyall, andDavidWield 378 14 Thedynamicsofknowledgeaccumulation,regulation, andappropriabilityinthepharma-biotechsector: policyissues LuigiOrsenigo,GiovanniDosi,and MarianaMazzucato 402 Index 432
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