Kinins IV: Part A Proceedings of the Fourth International Kinin Congress, held October 21–25, 1984, in Savannah, Georgia PDF
Preview Kinins IV: Part A Proceedings of the Fourth International Kinin Congress, held October 21–25, 1984, in Savannah, Georgia
KININS IV Part A ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo NICHOLAS R. DI LUZIO, Tulane University School of Medicine EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, Rockland Research Institute RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 192 MECHANISMS OF STIMULUS-RESPONSE COUPLING IN PLATELETS Edited by J. Westwick, M. F. Scully, D. E. MacIntyre, and V. V. Kakkar Volume 193 METHODS IN PORPHYRIN PHOTOSENSITIZATION Edited by David Kessel Volume 194 MYOCARDIAL AND SKELETAL MUSCLE BIOENERGETICS Edited by Nachman Brautbar Volume 195A PURINE AND PYRIMIDINE METABOLISM IN MAN V, Part A: Clinical Aspects Including Molecular Genetics Edited by W. L. Nyhan, L. F. Thompson, and R. W. E. Watts Volume 195B PURINE AND PYRIMIDINE METABOLISM IN MAN V, Part B: Basic Science Aspects Edited by W. L. Nyhan, L. F. Thompson, and R. W. E. Watts Volume 196 STEROID HORMONE RESISTANCE: Mechanisms and Clinical Aspects Edited by George P. Chrousos, D. Lynn Loriaux, and Mortimer B. Lipsett Volume 197 BIOLOGICAL REACTIVE INTERMEDIATES III: Mechanisms of Action in Animal Models and Human Disease Edited by James J. Kocsis, David J. Jollow, Charlotte M. Witmer, Judd O. Nelson, and Robert Snyder Volume 198A KIN INS IV, Part A Edited by Lowell M. Greenbaum and Harry S. Margolius Volume 198B KININS IV, Part B Edited by Lowell M. Greenbaum and Harry S. Margolius A Continuation Order Plan in available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. KININS IV Part A Editedhy Lowell M. Greenbaum Medical College of Georgia Augusta, Georgia and Harry S. Margolius Medical University of South Carolina Charleston, South Carolina PLENUM PRESS • NEW YORK AND LONDON Library of Congress Cataloging in Publication Data International Kinin Congress (4th: 1984: Savannah, Ga.) Kinins IV. (Advances in experimental medicine and biology; v. 198) "Proceedings of the Fourth International Kinin Congress, held October 21-25, 1984, in Savannah, Georgia" - T.p. verso. Includes bibliographies and index. 1. Kinins-Congresses. 2. Kallikrein-Congresses. I. Greenbaum, Lowell M. II. Margolius, Harry S. III. Title. IV. Title: Kinins 4. V. Series. [DNLM: 1. Kinins congresses. WI AD559 v.198/QU 68 1593 1984k] QP552.K5154 1984 599/.019/24 86-9403 ISBN-13: 978-1-4684-5145-0 e-ISBN-13: 978-1-4684-5143-6 DOl: 10.1007/978-1-4684-5143-6 Proceedings of the Fourth International Kinin Congress, held October 21-25, 1984, in Savannah, Georgia © 1986 Plenum Press, New York Softcover reprint of the hardcover 1s t edition 1986 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE Scientists from 25 countries came together at the Hyatt Regency Hotel on October 21-25, 1984, for the 4th International Kinin Congress in the beautiful city of Savannah, Georgia. Many of the delegates enjoyed southern hospitality for the first time. The friendly city with its streets lined with the Live Oak Tree (symbol of the Congress), the balmy weather, and the excellent facilities of the hotel set the stage for scientific events and exchange that proved so successful. The organ ization of the meeting was the result of many hours, days and weeks of effort by many, including from Augusta Drs. James H. Sutherland, John Catravas, William Davis, Jr., and Hiroshi Okamoto; and from Charleston, SC, Julie Chao, Ronald Mayfield and Donald Miller. Special thanks go to Ms. Cher Cornett of the Department of Medical Illustration at the Medical College of Georgia for her talent in the design of the logo, as well as the graphics of the program and abstracts. We are indeed indebted to Dr. Paul Brucker, Director of the Division of Health Communi cations at the Medical College of Georgia, for his considerable aid in spending time with us to arrange the programming format and continuity. Ms. Sandra Usry provided very excellent and devoted secretarial help for several years while the Congress was in the making. Thanks also to the secretarial staff of the Department of Pharmacology at MCG, including Rosiland Simmons and Jennie Doby for their expert assistance during the meeting. We also wish to thank the many sponsors (NIH, Johnson & Johnson, Bayer AG and Bayer AG/Miles, KabiVitrum AB, American Heart Association, Medical College of Georgia Research Institute, Rich's Travel, Bayer Yakhuin, Ltd., Bristol-Myers Co., Drug Science Foundation of S.C., Sanwa Kagaku Ltd., Upjohn Co., Hoffmann-La Roche, Inc., Boehringer Ingelheim, Ltd., Burroughs Wellcome Co., Ciba Geigy Pharma ceutical, E. R. Squibb & Sons, Inc., Fujimoto Pharmaceutical Co., Ltd., Am. Cyanamid Co., G. D. Searle, E. I. DuPont de Nemours & Co.). During the early planning of the Congress, we learned of the death of one of the world's great pharmacologists and discoverer of brady kinin, Professor Mauricio Rocha e Silva of Brazil. Professor Rocha e Silva not only coined the name for bradykinin but was a staunch advocate in his own special way for research allover the world to elucidate the importance of kin ins and kallikreins in health and in disease. It is more than fitting that the 4th International Congress of Kinins was dedicated to his memory and efforts. We were most fortunate that his collaborator in the discovery of bradykinin and a great scientist in his own right, Dr. Wilson Beraldo of Belo Horizonte, attended the Congress. All of us were moved by his sincere tribute, as well as the tribute of Dr. Mauricio Rocha e Silva, Jr., to Professor Rocha e Silva's contribu tions to science and society. Since the close of the Congress we learned of the deaths of three pioneers in kinin research, Dr. John Pisano (suddenly) of the NIH, Dr. Ulla Hamburg of Finland and Dr. Marion Webster, formerly of the NIH. Each of these have left lasting impres- v sions on us because of their pioneering contributions, their strength of purpose in kinin research and their love of aiding others in our discipline. We will miss them. We are privileged that these volumes contain the last scientific communications of Drs. Pisano and Hamburg. "Kinin '84 Savannah" had a number of "firsts". It was the first Kinin Congress to encompass four full days. It was the first Congress to institute "Frontier Lecturers" which provided us with information about areas of research which may be vital to our growth but with which we may not be familiar at this time. We are all indebted to the superb lecturers which included Dr. Hans Fritz (FRG), Dr. Robert Colman (USA), Dr. S. Nakanishi (Japan), Dr. John Shine (Australia), Dr. Allen Cuthbert (England) and Dr. T. Hokfelt (Sweden). This was the first Congress to utilize the concept of formal "Poster Discussions" so that all investi gators had a chance to comment on their efforts in addition to the 200 posters on display. We are indebted to the discussion leaders who made the 14 sessions so meaningful. It was the first of the Kinin Congresses to have "competing" oral sessions and we wish to thank the Chairman and Co-chairman of these sessions, as well as the delegates themselves, for the excellence of the 80 oral presentations. This was the first inter national meeting at which the T-kinin - T-kininogen sysem was intro duced, as well as several components of the kallikrein-kinin system in brain including kinins and kininases. The long sought-after antagonist to bradykinin as well as the isolation and characterization of the genes expressing kininogen synthesis was described. It was the first of our meetings to pay tribute to our pioneers in kinin research and we again salute the recipients, Drs. Melville Schachter (Canada), Ervin Erdos (USA), Wilson Beraldo (Brazil), Hector Croxatto (Chile), Tomoji Suzuki (Japan), and Gert Haberland (FRG). It was the first meeting at which six young investigators from five countries were nominated as KabiVitrum Scholars and given special travel awards. Our social times together also left some unforgettable memories. All of us will remember the warm friendship and the beauty of the evening and as we glided down the Savannah River on the riverboat to shuck oysters under the torchlight and accompanied by the southern jazz music of Fort Jackson. We were truly a "Kinin Family." The satellite meeting in Hilton Head and the visitations to Charleston and Augusta provided additional opportunities for interactions and friendships. The 4th International Kinin Congress was a stimulating experience for us and we hope the pages of these volumes will keep the spirit and science of Kinin '84 Savannah alive for many years to come. Lowell H. Greenbaum, Ph.D President, IKC Augusta, Georgia Harry S. Margolius, Ph.D, H.D. Vice President, IKC Charleston, South Carolina vi CONTENTS - PART A TISSUE KININOGENASES The Varied Localization and Functional Significance of Kallikrein-Like Enzymes in Salivary Glands, Pancreas, Colon, Sex Glands and Spermatozoa, Including Evidence for the Presence of Nerve Growth Factor (NGF) in Bull Sperm Acrosome.......................... I M. Schachter, M.W. Peret, The Late C. Moriwaki, G.D. Wheeler, R.W. Matthews, J.G. Mehta and T. Labedz Kininogenase from Rat Vascular Tissue.............................. 11 H. Nolly, A.G. Scicli, G. Scicli, M.C. Lama, A.M. Guercio and O.A. Carretero Intracellular and Intercellular Distributions of Acid Kininogenases in Spleen...................................... 19 M. Watanabe and K. Yamafuji Localization of Kallikreins in the Human Parotid and Gland in the Human Kidney: A Comparative Study of Immunohistochemistry and Enzyme Histochemistry............................................... 27 K. Kimura and H. Moriya Studies on Carbohydrate Structure and Immunological Properties of Human Urinary Kallikreins...................... 35 H. Moriya, M. Ikekita and K. Kizuki Initial Observations of a Kallikrein-Like Enzyme Associated with the Plasma Membranes of Rat Adipocytes............................................... 41 F. Mulholland, A. Ashford and G.S. Bailey Bile Acids and the Intestinal Kallikrein-Kinin System....................................................... 47 I.J. Zeitlin, H.A.R. AI-Dhahir, S. Cook, A. Currie and K. Donovan KININOGENS T-Kinin and T-Kininogen - An Historical Overview................... 55 L.M. Greenbaum Increased Plasma Level of T-Kininogen in Rats Treated with Freund s Adjuvant............................... 61 I A. Barlas, H. Okamoto and L.M. Greenbaum Isolation and Properties of Two Rat Plasma T-Kininogens. . • • • . . . . • • • • • • • • • • • • • . • . • • • • • . • . • • • • • • • • • • • • • • • • 69 H. Okamoto and L.M. Greenbaum Characterization of Kininogen Deficiency of Brown Norway Rat Mutant Katholiek Strain........................... 77 S. Oh-ishi, I. Hayashi, T. Ino, H. Kato, S. Iwanaga and T. Nakano Amino Acid Sequence of the Light Chain of Human Low Molecular Mass Kininogen..................................... 91 F. Lottspeich, J. Kellermann, A. Henschen, G. Rauth and W. Muller-Esterl Limited Proteolysis of HMW Kininogen by Plasma Kallikrein in Man- Evidence for a Processing Mechanism Different from the Bovine System................... 97 W. Muller-Esterl, H. Hock, G. Rauth, J. Kellermann, F. Lottspeich, and A. Henschen Interaction of Human Low Molecular Weight Kininogen with Human Mast Cell Tryptase................................ 105 L.B. Schwartz, M. Maier and J. Spragg Independent Consumption of High and Low Holecular Weight Kininogens In Vivo........................................... 113 Y. Uchida and M. Katori Urinary Kininogen: A Possible Regulator of Kinin Formation in Normal Individuals and Subjects with Essential Hypertension, End-Stage Renal and Liver Disease.............. 119 M.S. Weinberg, U.M. Trebbin, and R.J. Solomon Monoclonal Antibodies to Rat Plasma Kininogen...................... 127 G.S. Bedi and N. Back Hydrolysis of Rat High Molecular Weight Kininogen by Purified Rat Urinary Kallikrein: Identification of Bradykinin as the Kinin Formed............................ 137 J.P. Girolami, F. Alhenc-Gelas, M.L. Dos Reis, J.L. Bascands, J.M. Suc, P. Corvol. and J. Menard Reduced or Unchanged Cofactor Function of Human High Molecular Weight Kininogen Induced by Human Plasma Kallikrein............................................ 147 H.T. Johansen and K. Briseid Studies on the Antigenic Determinants of Human Low Molecular Weight Kininogen................................... 155 T. Karkkainen, A.-C. Syvanen and U. Hamberg Kininogen by the SRI Method in Human Serum During an Acute Phase Inflammatory Reaction......................... 161 U. Hamberg, T. Karkkainen and T. Tallberg Kininogen as a Pregnancy-Associated Plasma Protein................. 167 T. Karkkainen and U. Hamberg viii Hemodynamics of the Isolated Perfused Rat Kidney in the Absence and Presence of Kallikrein Substrate.................................................... 173 M. Maier, Z. Zhegu and B.R. Binder TISSUE KALLIKREINS, KININS, AND KININASES Active Kallikrein, Preproka11ikrein, and Kallikrein-Inhibitor Complex................................. 181 J. Chao, L. Chao, C.M. Woodley, W. Gerald and H.S. Margo1ius Characterization of Rat Kallikrein-Like Mu1tigene Family and Its Expression in the Submandibular Gland......................................... 189 L. Chao, W. Gerald and J. Chao Processing of Apo1ipoprotein B-l00 of Human Plasma Low Density Lipoproteins by Tissue and Plasma Ka11ikreins........................................... 195 A.D. Cardin, R.L. Jackson, V.H. Donaldson, J. Chao and H.S. Margo1ius Transporting Epithelia as Targets for Kinin Effects................ 203 A.W. Cuthbert and L.J. MacVinish Purification and Partial Characterization of Cat Colon and Submandibular Gland Ka11ikreins.................... 211 H. Fujimori, P.R. Levison and M. Schachter Purification and Partial Characterization of Cat Pancreatic and Urinary Ka11ikreins - Comparison With Other Cat Tissue Ka11ikreins and Related Proteases............................................ 219 H. Fujimori, P.R. Levison and M. Schachter The Liver is the Main Organ to Clear Plasma and Tissue Kallikreins from Rat Plasma. In Vivo.................. 229 D. Borges, C. Sampaio, P. de la Llosa and J.L. Prado Receptor-Mediated Clearance of Tissue Ka1likreins by Rat Liver................................................. 235 D.R. Borges, M. Kouyoumdjian, E.S. Prado and J.L. Prado Tissue Kal1ikreins and Related Enzymes: Characterization by Model 01igopeptides...................... 241 E.S. Prado, L. Juliano, M.S. Araujo-Vie1 and M.A. Juliano Release of Kallikrein and Tonin from the Rat Submandibular Gland.......................................... 247 S.R. Maitra, S.F. Rabito and O.A. Carretero Effect of Sodium Restriction and Corticosteroids on Glandular Kallikrein in Plasma and in the Submandibular Gland.......................................... 255 S.Seto, S.F. Rabito. S.R. Maitra, J.N. Wu and O.A. Carretero Kallikrein and Kinins Independently Stimulate Renin Release from Isolated Rat Glomeruli.......................... 265 W.H. Beierwa1tes and O.A. Carretero Regulation of Parotid Kallikrein Secretion-Role of the A1pha2- and Beta-Adrenergic System................... 273 A. Rockel, A. Preiss1er, A. Heid1and Effect of Furosemide on the Rat Submandibular Gland Kallikrein Secretion................................... 279 O.L. Catanzaro, S.B. Vila, A. Zuccolo and A.M. Seeber Individual Reaction Steps in the Release of Kallidin From Kininogen by Tissue Kallikrein.......................... 283 F. Fiedler, H. Hinz and F. Lottspeich The Tissue Kallikrein-Kinin System in Human Seminal Plasma - Biochemical and Functional Aspects.................. 291 E. Fink, W.-B. Schill, F. Fiedler, K. Shimamoto, F. Krassnigg and J. Frick New Synthetic Substrate for Kallikrein and Its Application.............................................. 299 S. Fujii, Y. Hitomi, K. Kimura, M. Ishii, M. Kurumi and T. Aoyama Plasma Half-Live and Organ Uptake Ratio of Radio1abe1ed Glandular Kallikrein in Control and Nephrectomized Rats...................................... 309 K. Nishimura, T. Iwata and T. Kokubu Hormonal Regulation of Glandular Kallikrein Activity and Its Inhibitor in Human Plasma............................ 315 H. Koh, K. Uchida, S. Nambu and M. Ikeda A Comparative Study of Proka11ikreins and Kallikreins from Rat Pancreatic Tissue and Juice............. 323 A.A. Jaffa, M. Hussain, Z. Rashid and G.S. Bailey An Inactive Form of Kallikrein in Human Urine...................... 329 K. Kizuki, Y. Shimamoto, M. Ikekita and H. Moriya Purification of Inactive Kallikrein from Rat Urine................. 339 M. Takaoka, H. Okamura. T. Iwamoto and S. Morimoto Release of Tissue Kallikrein from the Isolated Perfused Kidney.............................................. 347 N. Lauar and K. Bhoola Analytical Study of Kallikrein and Kallikrein-Like Esterase Activity in Subfractions from Rat Kidney Cortex Microsomes and Isolated Subce 11u1ar Membranes........................................ 355 K.-J. Andersen and J. Ofstad Endogenous Kallikrein Inhibitor in Rat Kidney Cortex-Effect of Glucocorticoid Administration............... 361 K. Ito, K. Yamada, S. Yoshida, K. Hasunuma, Y. Tamura and S. Yoshida x
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