K Y EEP OUR B Y RAIN OUNG T C G P HE OMPLETE UIDE TO HYSICAL AND E H L MOTIONAL EALTH AND ONGEVITY o Guy McKhann, M.D. Marilyn Albert, Ph.D. John Wiley & Sons, Inc. 8776_McKhann_fm.r.qxd 1/31/02 11:39 AM Page iv 8776_McKhann_fm.r.qxd 2/12/02 9:19AM Pagei K Y EEP OUR B Y RAIN OUNG T C G P HE OMPLETE UIDE TO HYSICAL AND E H L MOTIONAL EALTH AND ONGEVITY o Guy McKhann, M.D. Marilyn Albert, Ph.D. John Wiley & Sons, Inc. fcopyebk.qxd 3/8/02 3:15PM Pageii Copyright © 2002 by Guy McKhann and Marilyn Albert. All rights reserved. Published by John Wiley & Sons, Inc., New York No part ofthis publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 ofthe 1976 United States Copyright Act, without either the prior written permission ofthe Publisher, or authorization through payment ofthe appropriate per-copy fee to the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4744. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 605 Third Avenue, New York, NY 10158-0012, (212) 850-6011, fax (212) 850-6008, e-mail: [email protected]. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold with the understanding that the publisher is not engaged in rendering professional services. Ifprofessional advice or other expert assistance is required, the services ofa competent professional person should be sought. This title is also available in print as ISBN 0-471-40792-5. Some content that appears in the print version ofthis book may not be available in this electronic edition. For more information about Wiley products, visit our web site at www.Wiley.com 8776_McKhann_fm.r.qxd 1/31/02 11:39AM Pageiii Dedication To David and Hillie Mahoney— a remarkable couple and good friends who were always there when we needed them. David—a retired businessman who, as chairman of The Charles A. Dana Foundation, brought excitement and vision to the promotion of brain research. We all miss him. Hillie—a partner with David in all his endeavors. She continues to bring her unique talents to continuing David’s vision, both individually and as a director of the Dana Foundation and as president of the Harvard- Mahoney Neuroscience Institute. 8776_McKhann_fm.r.qxd 1/31/02 11:39 AM Page iv Contents Acknowledgments vii PARTONETHEBRAINANDEVERYDAYCONCERNS INTRODUCTION Healthy But Realistic in the Second Half 2 1 Maintaining Your Memory 6 2 Nutrition for the Brain: Food, Fuel, and Protection 24 3 Sleep and the Brain 39 4 Managing Stress 53 5 Unmasking Depression 61 6 Alcohol and Your Brain 74 PARTTWOTHEBRAINANDYOURBODY 7 Pain and Your Brain 82 8 Body Functions and Your Brain 107 9 Protecting Your Senses 119 10 How to Keep Your Balance—Literally 132 11 Fainting, Dizziness, and Your Brain 141 PARTTHREETHEBRAINANDPREVENTINGANDTREATINGSERIOUSPROBLEMS 12 Understanding Acute Memory Loss 148 13 Acute Confusion and How to Prevent It 156 14 Dealing with Alzheimer’s Disease and Other Dementias 165 15 Treatable Dementias 188 v vi CONTENTS 16 Cancer and the Brain 198 17 New Options for Parkinson’s Disease 209 18 Shaking, Weakness, ALS, and Your Brain 234 19 Stroke: The Brain-Heart Connection 246 20 Taking Charge of Your Brain 270 Appendix 279 Index 289 Acknowledgments T his book has been a long time in coming. Its inception was related to the many years we’ve spent talking with patients, disease advocacy groups, students, and young doctors about the brain and its disorders. Many of these people have either discussed parts of this book with us or read specific chapters—we cannot list them all. We have also gotten advice from colleagues of ours with expertise in specific areas. Again, we cannot list them all; we would like to par- ticularly acknowledge Dr. Carol Johns, Dr. Robert Wityk, Dr. Steve Riech, Dr. Bill Falk, Dr. Ray DePaulo, Dr. Kay Jamison, and Dr. Guy McKhann II. We also asked relatives and friends to read parts of this book as we considered them a subset of our potential audience. We would particu- larly like to acknowledge Harry and Pam Harrick, Carolyn and Arthur Kofler, Jeannette Albert, Emily McKhann, and Jeanette Glover. We have been guided throughout this endeavor by the advice and assistance of colleagues at The Charles A. Dana Foundation. These include Francis Harper, Barbara Gill, Barbara Rich, and the current chairman, William Safire, and the current president, Ed Rover. We’d particularly like to acknowledge the assistance of people at The Dana Press, Jane Nevins and her associate, Elizabeth Lasley. We also got editorial assistance from William Patrick and editorial guidance from Tom Miller and Mark Steven Long of John Wiley & Sons. Finally, we wish to acknowledge the continuing help and guidance of Susan L. Soohoo, our administrative assistant. vii
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